FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2667, 1105 aa 1>>>pF1KE2667 1105 - 1105 aa - 1105 aa Library: /omim/omim.rfq.tfa 61127809 residues in 85815 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.8838+/-0.000415; mu= -9.3833+/- 0.026 mean_var=304.0232+/-63.215, 0's: 0 Z-trim(121.4): 62 B-trim: 365 in 1/56 Lambda= 0.073556 statistics sampled from 37931 (37997) to 37931 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.443), width: 16 Scan time: 12.950 The best scores are: opt bits E(85815) NP_001295104 (OMIM: 249420,613293) SH3 and PX doma ( 430) 746 93.4 3.2e-18 NP_001017995 (OMIM: 249420,613293) SH3 and PX doma ( 911) 746 93.5 6.1e-18 XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 ( 939) 746 93.5 6.3e-18 NP_000256 (OMIM: 233700,608512) neutrophil cytosol ( 390) 517 69.1 6e-11 NP_751907 (OMIM: 611256) NADPH oxidase organizer 1 ( 371) 355 51.9 8.6e-06 XP_016878417 (OMIM: 611256) PREDICTED: NADPH oxida ( 376) 355 51.9 8.7e-06 XP_005255156 (OMIM: 611256) PREDICTED: NADPH oxida ( 376) 355 51.9 8.7e-06 NP_751908 (OMIM: 611256) NADPH oxidase organizer 1 ( 376) 355 51.9 8.7e-06 XP_016878416 (OMIM: 611256) PREDICTED: NADPH oxida ( 376) 355 51.9 8.7e-06 NP_653204 (OMIM: 611256) NADPH oxidase organizer 1 ( 370) 345 50.8 1.8e-05 NP_001254650 (OMIM: 611256) NADPH oxidase organize ( 375) 345 50.8 1.8e-05 >>NP_001295104 (OMIM: 249420,613293) SH3 and PX domain-c (430 aa) initn: 1188 init1: 746 opt: 746 Z-score: 448.2 bits: 93.4 E(85815): 3.2e-18 Smith-Waterman score: 1544; 55.4% identity (74.4% similar) in 446 aa overlap (6-448:7-396) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFP . .. :.::.::: :.::::::: ::::......::::::::::::::.::::: NP_001 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFR .:::::::::::::::::::::::::::::::::: ::::::.::..:::.:::::::.. NP_001 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 FFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATA-EPMILEQYVVVSNYK :::.::::.:::::.. .:.:: :.: :. .::.:::::::.::. NP_001 FFETRPEDLNPPKEEH-IGKKKS---------------GGDQTSVDPMVLEQYVVVANYQ 130 140 150 160 180 190 200 210 220 230 pF1KE2 KQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTG :::.::.::..:.:::.:::::::::::::.::::::::: ::.:.:..:. ... NP_001 KQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE--- 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE2 EEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDD :::::... :::....::...:.:..::::.::::::: ::: ::::::::::::: NP_001 EEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK---- 230 240 250 260 270 300 310 320 330 340 350 pF1KE2 LPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNA : . :. :: : : .: ..: . NP_001 ------NSGEPL-----------------------PPKPGPG--SPSHPGALDLDGVSRQ 280 290 300 360 370 380 390 400 410 pF1KE2 SNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPP .: ::: . .: .: . :. ::..: ::::::. .. :..::::: NP_001 QN--AVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPP 310 320 330 340 350 360 420 430 440 450 460 470 pF1KE2 EPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDK ::.:: :::::::::. : :::::..: :.: NP_001 IPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEDHKNVHLESPVEVPLRRIKMRTALGKHV 370 380 390 400 410 420 480 490 500 510 520 530 pF1KE2 RKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFG NP_001 AASMEM 430 >>NP_001017995 (OMIM: 249420,613293) SH3 and PX domain-c (911 aa) initn: 1634 init1: 746 opt: 746 Z-score: 443.1 bits: 93.5 E(85815): 6.1e-18 Smith-Waterman score: 1971; 37.1% identity (58.7% similar) in 1112 aa overlap (6-1104:7-910) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFP . .. :.::.::: :.::::::: ::::......::::::::::::::.::::: NP_001 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFR .:::::::::::::::::::::::::::::::::: ::::::.::..:::.:::::::.. NP_001 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 FFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATA-EPMILEQYVVVSNYK :::.::::.:::::.. .:.:: :.: :. .::.:::::::.::. NP_001 FFETRPEDLNPPKEEH-IGKKKS---------------GGDQTSVDPMVLEQYVVVANYQ 130 140 150 160 180 190 200 210 220 230 pF1KE2 KQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTG :::.::.::..:.:::.:::::::::::::.::::::::: ::.:.:..:. ... NP_001 KQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE--- 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE2 EEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDD :::::... :::....::...:.:..::::.::::::: ::: ::::::::::::: NP_001 EEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK---- 230 240 250 260 270 300 310 320 330 340 350 pF1KE2 LPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNA : . :. :: : : .: ..: . NP_001 ------NSGEPL-----------------------PPKPGPG--SPSHPGALDLDGVSRQ 280 290 300 360 370 380 390 400 410 pF1KE2 SNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPP .: ::: . .: .: . :. ::..: ::::::. .. :..::::: NP_001 QN--AVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPP 310 320 330 340 350 360 420 430 440 450 460 470 pF1KE2 EPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDK ::.:: :::::::::. : :::::..: :.:::.:: .::::.:: .:::::::..::: NP_001 IPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDK 370 380 390 400 410 420 480 490 500 510 520 530 pF1KE2 RKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFG :: ::. .::. : : . . . : ..: :.. . . .: : : NP_001 YKK------TSNASRPNFLAPLP-HEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGV 430 440 450 460 470 540 550 560 570 580 590 pF1KE2 FDSEPELSEE-----PVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETI .:: :.. : .::.. . .. .... . .. .:.. : . NP_001 MDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEE-KPSLPPRKESIIKSEGEL 480 490 500 510 520 530 600 610 620 630 640 650 pF1KE2 YENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQA : : : .:. :: . :: . :. : . ..: . : .:. NP_001 LERERERQRTEQL---RGPT--PKPPGVILPMMPAKHIPPA---RDSRRPEPKPDKSRLF 540 550 560 570 580 660 670 680 690 700 710 pF1KE2 EMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKD .. :: . . .. . . .. . .::.. :: :. :: ::. NP_001 QL-KNDMGLECGHKVLAKEV----KKPNLRPISKSKTDL-PEEKPDA----TPQ------ 590 600 610 620 630 720 730 740 750 760 770 pF1KE2 ADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSED : : : :...:. :.: . :.....:: .:: .::: .::.: NP_001 ---NPFLKSRPQVRPKPAPSP--KTEPPQGEDQVDICNLRSKLRP----------AKSQD 640 650 660 670 780 790 800 810 820 830 pF1KE2 SELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEI . : .:: . ... ... . : :::. ..:: NP_001 KSL-------LDGEGPQAVGGQDVAFSRSFLPG------EGPG----------RAQD--- 680 690 700 710 840 850 860 870 880 890 pF1KE2 SFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQN : :. .: .:.. .. : :. : : : NP_001 ---------------------RTGKQDGLSPKE---ISCRAPPRPA-KTTDPV------- 720 730 900 910 920 930 940 pF1KE2 EGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTS-GTPAVK---MRNGVRQV .:: . :. . :.. ..:: :: ...: : :. .. .. NP_001 -SKSVPV--------PLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRA 740 750 760 770 780 790 950 960 970 980 990 1000 pF1KE2 AVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAER : : ... :: :: .:: . : :: . ..:.. :. :. NP_001 APTPGRALLVPPKAKPFLS------NSLGGQDDTRGKGSLGPWGTGKI------GENREK 800 810 820 830 1010 1020 1030 1040 1050 1060 pF1KE2 AASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKD-VYVSIADYEGDEETAGFQE ::. :.: . ..::: .::..::.:::..:..::: NP_001 AAAA------------SVPNA--------------DGLKDSLYVAVADFEGDKDTSSFQE 840 850 860 870 1070 1080 1090 1100 pF1KE2 GVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN :. .:: :.: .:::.::.:.:. ..::.:::::.:: NP_001 GTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP 880 890 900 910 >>XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 and (939 aa) initn: 1630 init1: 746 opt: 746 Z-score: 442.9 bits: 93.5 E(85815): 6.3e-18 Smith-Waterman score: 1925; 36.3% identity (57.6% similar) in 1137 aa overlap (6-1104:7-938) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFP . .. :.::.::: :.::::::: ::::......::::::::::::::.::::: XP_016 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFR .:::::::::::::::::::::::::::::::::: ::::::.::..:::.:::::::.. XP_016 MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 FFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATA-EPMILEQYVVVSNYK :::.::::.:::::.. .:.:: :.: :. .::.:::::::.::. XP_016 FFETRPEDLNPPKEEH-IGKKKS---------------GGDQTSVDPMVLEQYVVVANYQ 130 140 150 160 180 190 200 210 220 pF1KE2 KQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDD--------- :::.::.::..:.:::.:::::::::::::.::::::::: ::.:.:..:. XP_016 KQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVS 170 180 190 200 210 220 230 240 250 260 270 pF1KE2 ----------------SDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLE .:. . . .::::... :::....::...:.:..::::.:::: XP_016 WRYWSLPRPVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLE 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE2 GWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKET ::: ::: ::::::::::::: : . :. XP_016 GWWKIRYQGKEGWAPASYLKK----------NSGEPL----------------------- 290 300 310 340 350 360 370 380 390 pF1KE2 PPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISS :: : : .: ..: . .: ::: . .: .: . :. : XP_016 PPKPGPG--SPSHPGALDLDGVSRQQN--AVGREKELLSSQRDGRFEGRPVPDGDAKQRS 320 330 340 350 360 400 410 420 430 440 450 pF1KE2 PNLRTRPPPRRESSL--GFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVID :..: ::::::. .. :..::::: ::.:: :::::::::. : :::::..: :.:::. XP_016 PKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIE 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE2 KNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPT :: .::::.:: .:::::::..::: :: ::. .::. : : . . . : . XP_016 KNLSGWWYIQIEDKEGWAPATFIDKYKK------TSNASRPNFLAPLP-HEVTQLRLGEA 430 440 450 460 470 480 520 530 540 550 560 pF1KE2 GASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEE-----PVEDRASGERRPAQPHRPSP .: :.. . . .: : : .:: :.. : .::.. . .. XP_016 AALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEIS 490 500 510 520 530 540 570 580 590 600 610 620 pF1KE2 ASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTR .... . .. .:.. : . : : : .:. :: . :: . XP_016 DPDMEE-KPSLPPRKESIIKSEGELLERERERQRTEQL---RGPT--PKPPGVILPMMPA 550 560 570 580 590 630 640 650 660 670 680 pF1KE2 KNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKT :. : . ..: . : .:. .. :: . . .. . . .. . .::. XP_016 KHIPPA---RDSRRPEPKPDKSRLFQL-KNDMGLECGHKVLAKEV----KKPNLRPISKS 600 610 620 630 640 690 700 710 720 730 740 pF1KE2 SGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMD . :: :. :: ::. : : : :...:. :.: . :.....: XP_016 KTDL-PEEKPDA----TPQ---------NPFLKSRPQVRPKPAPSP--KTEPPQGEDQVD 650 660 670 680 690 750 760 770 780 790 800 pF1KE2 ISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPT : .:: .::: .::.:. : .:: . ... ... . : XP_016 ICNLRSKLRP----------AKSQDKSL-------LDGEGPQAVGGQDVAFSRSFLPG-- 700 710 720 730 810 820 830 840 850 860 pF1KE2 KKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL :::. ..:: : :. .: .:.. XP_016 ----EGPG----------RAQD------------------------RTGKQDGLSPKE-- 740 750 870 880 890 900 910 920 pF1KE2 VLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPP .. : :. : : : .:: . :. . :.. ..:: :: XP_016 -ISCRAPPRPA-KTTDPV--------SKSVPV--------PLQEAPQQRPVVPPRRPPPP 760 770 780 790 930 940 950 960 970 980 pF1KE2 GGFGKTS-GTPAVK---MRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLR ...: : :. .. ..: : ... :: :: .:: . : : XP_016 KKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLS------NSLGGQDDTR 800 810 820 830 840 990 1000 1010 1020 1030 1040 pF1KE2 GVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIH : . ..:.. :. :.::. :.: . XP_016 GKGSLGPWGTGKI------GENREKAAAA------------SVPNA-------------- 850 860 870 1050 1060 1070 1080 1090 1100 pF1KE2 NNLKD-VYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYL ..::: .::..::.:::..:..::::. .:: :.: .:::.::.:.:. ..::.::::: XP_016 DGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYL 880 890 900 910 920 930 pF1KE2 EKKN .:: XP_016 RKKP >>NP_000256 (OMIM: 233700,608512) neutrophil cytosol fac (390 aa) initn: 714 init1: 254 opt: 517 Z-score: 317.6 bits: 69.1 E(85815): 6e-11 Smith-Waterman score: 714; 35.5% identity (69.4% similar) in 301 aa overlap (6-306:6-294) 10 20 30 40 50 60 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPI .. ... ::: ::.::::.. : :.: . ...:::........ : . ::: NP_000 MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRF :.: .:..:::: ::. : .. .: .: . ::: .:. :: .::.: ... : NP_000 EAGAINPENRIIPHLPAPKWFDGQR---AAENRQGTLTEYCSTLMSLPTKISRCPHLLDF 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 FEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ :..::.:.. : : ..: .. . . ..: :.:: :.::. : ...::.: NP_000 FKVRPDDLKLPT-DNQTKKPETYLMPKDGKSTATDITG------PIILQTYRAIANYEKT 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 ENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEE .::..:..:.::.:.::.:::::: . . ..::.::..:: .. . : . . .:: NP_000 SGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGE- 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 EKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLP ::... ::. ::... .: .::::.: :.::: :: :. :. ::.:. .:. NP_000 -PYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE2 TRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASN .... NP_000 QAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGS 290 300 310 320 330 340 >>NP_751907 (OMIM: 611256) NADPH oxidase organizer 1 iso (371 aa) initn: 193 init1: 164 opt: 355 Z-score: 225.0 bits: 51.9 E(85815): 8.6e-06 Smith-Waterman score: 361; 25.7% identity (56.8% similar) in 292 aa overlap (6-293:10-287) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD :: :..:.... .. . ..: :::... . : ...: .:. : . NP_751 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 KFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDE ::.:.: ..:..: : :. : . .. ::. .. : : :. .... NP_751 TFPVEAGLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 VFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSN . :: .: :..: :: : : . :.: . ..: . . . .. .. NP_751 ITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSLRCLQP 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 YKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTRDDSDI . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : : .. NP_751 FCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGP 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE2 NTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYL . ...: .. . . : :. ::.. :. :.:.. . .::: :: . : :: : NP_751 SLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE2 KKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISL . NP_751 RPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRA 290 300 310 320 330 340 >>XP_016878417 (OMIM: 611256) PREDICTED: NADPH oxidase o (376 aa) initn: 193 init1: 164 opt: 355 Z-score: 224.9 bits: 51.9 E(85815): 8.7e-06 Smith-Waterman score: 355; 25.6% identity (56.6% similar) in 297 aa overlap (6-293:10-292) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD :: :..:.... .. . ..: :::... . : ...: .:. : . XP_016 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 KFPIEGGQKDPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHI ::.:.: ..:..: : :. :. : . .. ::. .. : : :. .. XP_016 TFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQY .. . :: .: :..: :: : : . :.: . ..: . . . .. XP_016 ARSPTITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSL 120 130 140 150 160 180 190 200 210 220 pF1KE2 VVVSNYKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTR .. . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : : XP_016 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA .. . ...: .. . . : :. ::.. :. :.:.. . .::: :: . : XP_016 REGGPSLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLL 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 PASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK :: :. XP_016 PAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCT 290 300 310 320 330 340 >>XP_005255156 (OMIM: 611256) PREDICTED: NADPH oxidase o (376 aa) initn: 193 init1: 164 opt: 355 Z-score: 224.9 bits: 51.9 E(85815): 8.7e-06 Smith-Waterman score: 355; 25.6% identity (56.6% similar) in 297 aa overlap (6-293:10-292) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD :: :..:.... .. . ..: :::... . : ...: .:. : . XP_005 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 KFPIEGGQKDPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHI ::.:.: ..:..: : :. :. : . .. ::. .. : : :. .. XP_005 TFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQY .. . :: .: :..: :: : : . :.: . ..: . . . .. XP_005 ARSPTITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSL 120 130 140 150 160 180 190 200 210 220 pF1KE2 VVVSNYKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTR .. . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : : XP_005 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA .. . ...: .. . . : :. ::.. :. :.:.. . .::: :: . : XP_005 REGGPSLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLL 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 PASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK :: :. XP_005 PAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCT 290 300 310 320 330 340 >>NP_751908 (OMIM: 611256) NADPH oxidase organizer 1 iso (376 aa) initn: 193 init1: 164 opt: 355 Z-score: 224.9 bits: 51.9 E(85815): 8.7e-06 Smith-Waterman score: 355; 25.6% identity (56.6% similar) in 297 aa overlap (6-293:10-292) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD :: :..:.... .. . ..: :::... . : ...: .:. : . NP_751 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 KFPIEGGQKDPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHI ::.:.: ..:..: : :. :. : . .. ::. .. : : :. .. NP_751 TFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQY .. . :: .: :..: :: : : . :.: . ..: . . . .. NP_751 ARSPTITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSL 120 130 140 150 160 180 190 200 210 220 pF1KE2 VVVSNYKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTR .. . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : : NP_751 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA .. . ...: .. . . : :. ::.. :. :.:.. . .::: :: . : NP_751 REGGPSLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLL 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 PASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK :: :. NP_751 PAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCT 290 300 310 320 330 340 >>XP_016878416 (OMIM: 611256) PREDICTED: NADPH oxidase o (376 aa) initn: 193 init1: 164 opt: 355 Z-score: 224.9 bits: 51.9 E(85815): 8.7e-06 Smith-Waterman score: 355; 25.6% identity (56.6% similar) in 297 aa overlap (6-293:10-292) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD :: :..:.... .. . ..: :::... . : ...: .:. : . XP_016 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKKTLKE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 KFPIEGGQKDPKQRIIPFLPGKI-----LFRRSHIRDVAVKRLKPIDEYCRALVRLPPHI ::.:.: ..:..: : :. :. : . .. ::. .. : : :. .. XP_016 TFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 SQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQY .. . :: .: :..: :: : : . :.: . ..: . . . .. XP_016 ARSPTITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSL 120 130 140 150 160 180 190 200 210 220 pF1KE2 VVVSNYKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTR .. . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : : XP_016 RCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQG 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE2 DDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWA .. . ...: .. . . : :. ::.. :. :.:.. . .::: :: . : XP_016 REGGPSLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLL 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 PASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAK :: :. XP_016 PAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCT 290 300 310 320 330 340 >>NP_653204 (OMIM: 611256) NADPH oxidase organizer 1 iso (370 aa) initn: 193 init1: 164 opt: 345 Z-score: 219.3 bits: 50.8 E(85815): 1.8e-05 Smith-Waterman score: 351; 25.7% identity (56.8% similar) in 292 aa overlap (6-293:10-286) 10 20 30 40 50 pF1KE2 MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLD :: :..:.... .. . ..: :::... . : ...: .:. : . NP_653 MAGPRYPVSVQGAALVQIKRLQT------FAFSVRWSDGSDTFVRRSWDEFRQLKT-LKE 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 KFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDE ::.:.: ..:..: : :. : . .. ::. .. : : :. .... NP_653 TFPVEAGLLRRSDRVLPKLLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 VFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSN . :: .: :..: :: : : . :.: . ..: . . . .. .. NP_653 ITGFFAPQPLDLEPALPP-GSR----VILPTPEEQPLSRAAGR-LSIHSLEAQSLRCLQP 120 130 140 150 160 180 190 200 210 220 230 pF1KE2 YKKQENSE--LSLQAGEVVDVIEKNESGWWFVSTSEEQ-GWVPATYLE-AQNGTRDDSDI . :.. . .. :: : .::. .. ::::.: . ..: .: :: ::: : : .. NP_653 FCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGP 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE2 NTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYL . ...: .. . . : :. ::.. :. :.:.. . .::: :: . : :: : NP_653 SLGSSGP--QFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE2 KKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISL . NP_653 RPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRA 290 300 310 320 330 340 1105 residues in 1 query sequences 61127809 residues in 85815 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Jan 20 09:31:52 2017 done: Fri Jan 20 09:31:53 2017 Total Scan time: 12.950 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]