FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8414, 913 aa 1>>>pF1KB8414 913 - 913 aa - 913 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7436+/-0.000624; mu= 9.2691+/- 0.038 mean_var=211.3155+/-42.393, 0's: 0 Z-trim(112.9): 282 B-trim: 340 in 3/50 Lambda= 0.088228 statistics sampled from 21719 (22058) to 21719 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.259), width: 16 Scan time: 10.620 The best scores are: opt bits E(85289) NP_006191 (OMIM: 600488) proprotein convertase sub ( 913) 6576 851.6 0 NP_001177411 (OMIM: 600488) proprotein convertase (1860) 6322 819.6 0 XP_011517071 (OMIM: 600488) PREDICTED: proprotein (1886) 6322 819.6 0 XP_005252096 (OMIM: 600488) PREDICTED: proprotein (1887) 6322 819.6 0 XP_016870289 (OMIM: 600488) PREDICTED: proprotein (1450) 3272 431.2 1.7e-119 XP_011517072 (OMIM: 600488) PREDICTED: proprotein (1441) 3214 423.9 2.9e-117 NP_612192 (OMIM: 167405) proprotein convertase sub ( 956) 3014 398.2 9.9e-110 NP_002561 (OMIM: 167405) proprotein convertase sub ( 969) 2948 389.8 3.4e-107 NP_612196 (OMIM: 167405) proprotein convertase sub ( 623) 2785 368.9 4.4e-101 NP_612197 (OMIM: 167405) proprotein convertase sub ( 652) 2785 368.9 4.5e-101 NP_612198 (OMIM: 167405) proprotein convertase sub ( 664) 2785 368.9 4.6e-101 NP_001278238 (OMIM: 167405) proprotein convertase ( 895) 2175 291.4 1.3e-77 NP_612195 (OMIM: 167405) proprotein convertase sub ( 487) 2128 285.1 5.6e-76 NP_000430 (OMIM: 162150,600955,612362) neuroendocr ( 753) 1968 265.0 1e-69 NP_001276753 (OMIM: 136950) furin preproprotein [H ( 794) 1941 261.6 1.1e-68 NP_001276752 (OMIM: 136950) furin preproprotein [H ( 794) 1941 261.6 1.1e-68 NP_002560 (OMIM: 136950) furin preproprotein [Homo ( 794) 1941 261.6 1.1e-68 NP_001171346 (OMIM: 162150,600955,612362) neuroend ( 706) 1893 255.4 7.2e-67 XP_011526394 (OMIM: 600487) PREDICTED: proprotein ( 644) 1776 240.5 2.1e-62 XP_011526393 (OMIM: 600487) PREDICTED: proprotein ( 658) 1776 240.5 2.1e-62 XP_011526390 (OMIM: 600487) PREDICTED: proprotein ( 720) 1776 240.5 2.2e-62 NP_060043 (OMIM: 600487) proprotein convertase sub ( 755) 1776 240.5 2.3e-62 XP_011526387 (OMIM: 600487) PREDICTED: proprotein ( 782) 1776 240.5 2.4e-62 XP_011526395 (OMIM: 600487) PREDICTED: proprotein ( 593) 1642 223.4 2.7e-57 XP_011526389 (OMIM: 600487) PREDICTED: proprotein ( 724) 1642 223.5 3.1e-57 NP_001188457 (OMIM: 162151) neuroendocrine convert ( 619) 1623 221.0 1.5e-56 NP_002585 (OMIM: 162151) neuroendocrine convertase ( 638) 1623 221.0 1.5e-56 NP_004707 (OMIM: 604872) proprotein convertase sub ( 785) 1545 211.1 1.7e-53 NP_001188458 (OMIM: 162151) neuroendocrine convert ( 603) 1528 208.9 6.3e-53 XP_011526388 (OMIM: 600487) PREDICTED: proprotein ( 773) 1511 206.8 3.3e-52 XP_011526396 (OMIM: 600487) PREDICTED: proprotein ( 567) 1332 183.9 2e-45 XP_005259643 (OMIM: 600487) PREDICTED: proprotein ( 567) 1332 183.9 2e-45 XP_016882386 (OMIM: 600487) PREDICTED: proprotein ( 377) 1198 166.6 2e-40 XP_016874035 (OMIM: 604872) PREDICTED: proprotein ( 426) 680 100.8 1.5e-20 XP_006719003 (OMIM: 604872) PREDICTED: proprotein ( 426) 680 100.8 1.5e-20 XP_011526398 (OMIM: 600487) PREDICTED: proprotein ( 533) 526 81.3 1.4e-14 XP_011526392 (OMIM: 600487) PREDICTED: proprotein ( 661) 526 81.4 1.7e-14 XP_011526391 (OMIM: 600487) PREDICTED: proprotein ( 688) 526 81.4 1.7e-14 NP_001159605 (OMIM: 219000,607830) extracellular m (1976) 342 58.4 3.9e-07 XP_006714379 (OMIM: 219000,607830) PREDICTED: extr (3936) 342 58.8 6.3e-07 NP_079350 (OMIM: 219000,607830) extracellular matr (4012) 342 58.8 6.4e-07 XP_011526397 (OMIM: 600487) PREDICTED: proprotein ( 537) 297 52.1 8.6e-06 XP_005261794 (OMIM: 607171) PREDICTED: cysteine-ri ( 403) 275 49.2 4.9e-05 NP_001128573 (OMIM: 607171) cysteine-rich with EGF ( 402) 268 48.3 9.1e-05 XP_016884427 (OMIM: 607171) PREDICTED: cysteine-ri ( 252) 263 47.4 0.0001 NP_077300 (OMIM: 607171) cysteine-rich with EGF-li ( 353) 263 47.6 0.00013 XP_005261795 (OMIM: 607171) PREDICTED: cysteine-ri ( 373) 263 47.6 0.00013 XP_011518550 (OMIM: 611747) PREDICTED: signal pept ( 695) 266 48.3 0.00016 XP_016873571 (OMIM: 611747) PREDICTED: signal pept ( 844) 266 48.4 0.00018 XP_016873570 (OMIM: 611747) PREDICTED: signal pept ( 892) 266 48.4 0.00019 >>NP_006191 (OMIM: 600488) proprotein convertase subtili (913 aa) initn: 6576 init1: 6576 opt: 6576 Z-score: 4541.6 bits: 851.6 E(85289): 0 Smith-Waterman score: 6576; 100.0% identity (100.0% similar) in 913 aa overlap (1-913:1-913) 10 20 30 40 50 60 pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKV 850 860 870 880 890 900 910 pF1KB8 LQQLCCKTCTFQG ::::::::::::: NP_006 LQQLCCKTCTFQG 910 >>NP_001177411 (OMIM: 600488) proprotein convertase subt (1860 aa) initn: 6298 init1: 6298 opt: 6322 Z-score: 4363.1 bits: 819.6 E(85289): 0 Smith-Waterman score: 6322; 97.1% identity (97.9% similar) in 910 aa overlap (1-909:1-906) 10 20 30 40 50 60 pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI 790 800 810 820 830 840 850 860 870 880 890 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNL-CQRK :::::::::::::::::::::::::::::::::::. : : : :. . . :: NP_001 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHCQTCEASCAKCQGP 850 860 870 880 890 900 910 pF1KB8 VLQQLCCKTCTFQG . .. : :: NP_001 TQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGAD 900 910 920 930 940 950 >-- initn: 436 init1: 187 opt: 422 Z-score: 304.4 bits: 68.6 E(85289): 3.3e-10 Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1459-1720) 600 610 620 630 640 650 pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC .: :: : :: .: . : ::. :.: NP_001 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC 1430 1440 1450 1460 1470 1480 660 670 680 690 700 710 pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF . : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.: NP_001 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 1490 1500 1510 1520 1530 1540 720 730 740 750 760 pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C :..: :. .: .: : :.. . :..:...:: : . .: : . : :. : NP_001 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC 1550 1560 1570 1580 1590 1600 770 780 790 800 810 820 pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD :: : : . : :. :: : : : :: .:..:. .: . : :...: .. : NP_001 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY-- 1610 1620 1630 1640 1650 830 840 850 860 870 880 pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG . .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : : NP_001 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC 1660 1670 1680 1690 1700 1710 890 900 910 pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG : NP_001 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG 1720 1730 1740 1750 1760 1770 >-- initn: 375 init1: 149 opt: 292 Z-score: 214.9 bits: 52.0 E(85289): 3.1e-05 Smith-Waterman score: 590; 31.9% identity (51.3% similar) in 298 aa overlap (623-909:922-1190) 600 610 620 630 640 650 pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH :. . :. :: :.. :.: :: : NP_001 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH 900 910 920 930 940 660 670 680 690 700 pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM :..: :. :. . : .::: ::: .. . : : ::: : . : : NP_001 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT 950 960 970 980 990 1000 710 720 730 740 750 760 pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL : :::. ...: .: .: :: . : : :.: :. . .:: : : NP_001 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR 1010 1020 1030 1040 1050 1060 770 780 790 800 810 820 pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY .: .: . : . .:. : :..: .:: : ::.:. : ::..:. .. NP_001 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF 1070 1080 1090 1100 1110 830 840 850 860 870 880 pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA : :. : : :..: .: ::.::: .:.:: : : ::: . :.: NP_001 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC----VHATKTQE--- 1120 1130 1140 1150 1160 890 900 910 pF1KB8 EGGF-CMLVKKNNLCQRKVLQQLCCKTCTFQG :: : ...: . :. . :::: NP_001 EGKFWNDILRKLQPCHSS------CKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPS 1170 1180 1190 1200 1210 1220 >-- initn: 386 init1: 149 opt: 292 Z-score: 214.9 bits: 52.0 E(85289): 3.1e-05 Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:1225-1455) 610 620 630 640 650 660 pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY .: :. .:.:. : : :. : .. . NP_001 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH 1200 1210 1220 1230 1240 1250 670 680 690 700 710 720 pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV : . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . : NP_001 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ 1260 1270 1280 1290 1300 730 740 750 760 770 780 pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD .::. . . :..:..: : :. : . ..: :: . :. . : :: : : ... NP_001 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH 1310 1320 1330 1340 1350 1360 790 800 810 820 830 840 pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI : :::. : :.: :: : : :. . . :: :.. : . :... . : :. : NP_001 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK 1370 1380 1390 1400 1410 1420 850 860 870 880 890 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK :::::.. : .::.: .: ... : :. . : NP_001 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP 1430 1440 1450 1460 1470 1480 900 910 pF1KB8 VLQQLCCKTCTFQG NP_001 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG 1490 1500 1510 1520 1530 1540 >>XP_011517071 (OMIM: 600488) PREDICTED: proprotein conv (1886 aa) initn: 6298 init1: 6298 opt: 6322 Z-score: 4363.0 bits: 819.6 E(85289): 0 Smith-Waterman score: 6322; 97.1% identity (97.9% similar) in 910 aa overlap (1-909:1-906) 10 20 30 40 50 60 pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI 790 800 810 820 830 840 850 860 870 880 890 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNL-CQRK :::::::::::::::::::::::::::::::::::. : : : :. . . :: XP_011 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHCQTCEASCAKCQGP 850 860 870 880 890 900 910 pF1KB8 VLQQLCCKTCTFQG . .. : :: XP_011 TQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGAD 900 910 920 930 940 950 >-- initn: 436 init1: 187 opt: 422 Z-score: 304.3 bits: 68.6 E(85289): 3.3e-10 Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1485-1746) 600 610 620 630 640 650 pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC .: :: : :: .: . : ::. :.: XP_011 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC 1460 1470 1480 1490 1500 1510 660 670 680 690 700 710 pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF . : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.: XP_011 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 1520 1530 1540 1550 1560 720 730 740 750 760 pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C :..: :. .: .: : :.. . :..:...:: : . .: : . : :. : XP_011 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC 1570 1580 1590 1600 1610 1620 770 780 790 800 810 820 pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD :: : : . : :. :: : : : :: .:..:. .: . : :...: .. : XP_011 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY-- 1630 1640 1650 1660 1670 1680 830 840 850 860 870 880 pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG . .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : : XP_011 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC 1690 1700 1710 1720 1730 1740 890 900 910 pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG : XP_011 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG 1750 1760 1770 1780 1790 1800 >-- initn: 375 init1: 149 opt: 292 Z-score: 214.9 bits: 52.1 E(85289): 3.1e-05 Smith-Waterman score: 589; 32.6% identity (50.9% similar) in 291 aa overlap (623-903:922-1189) 600 610 620 630 640 650 pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH :. . :. :: :.. :.: :: : XP_011 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH 900 910 920 930 940 660 670 680 690 700 pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM :..: :. :. . : .::: ::: .. . : : ::: : . : : XP_011 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT 950 960 970 980 990 1000 710 720 730 740 750 760 pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL : :::. ...: .: .: :: . : : :.: :. . .:: : : XP_011 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR 1010 1020 1030 1040 1050 1060 770 780 790 800 810 820 pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY .: .: . : . .:. : :..: .:: : ::.:. : ::..:. .. XP_011 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF 1070 1080 1090 1100 1110 830 840 850 860 870 880 pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA : :. : : :..: .: ::.::: .:.:: : : ::: . :.: XP_011 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC----VHATKTQE--- 1120 1130 1140 1150 1160 890 900 910 pF1KB8 EGGFCMLVKKNNLCQRKVLQQLCCKTCTFQG :: : :. :: : : : XP_011 EGKFWNAVSTANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPK 1170 1180 1190 1200 1210 1220 >-- initn: 303 init1: 149 opt: 292 Z-score: 214.9 bits: 52.1 E(85289): 3.1e-05 Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:1251-1481) 610 620 630 640 650 660 pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY .: :. .:.:. : : :. : .. . XP_011 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH 1230 1240 1250 1260 1270 670 680 690 700 710 720 pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV : . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . : XP_011 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ 1280 1290 1300 1310 1320 1330 730 740 750 760 770 780 pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD .::. . . :..:..: : :. : . ..: :: . :. . : :: : : ... XP_011 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH 1340 1350 1360 1370 1380 1390 790 800 810 820 830 840 pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI : :::. : :.: :: : : :. . . :: :.. : . :... . : :. : XP_011 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK 1400 1410 1420 1430 1440 850 860 870 880 890 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK :::::.. : .::.: .: ... : :. . : XP_011 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP 1450 1460 1470 1480 1490 1500 900 910 pF1KB8 VLQQLCCKTCTFQG XP_011 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG 1510 1520 1530 1540 1550 1560 >>XP_005252096 (OMIM: 600488) PREDICTED: proprotein conv (1887 aa) initn: 6298 init1: 6298 opt: 6322 Z-score: 4363.0 bits: 819.6 E(85289): 0 Smith-Waterman score: 6322; 97.1% identity (97.9% similar) in 910 aa overlap (1-909:1-906) 10 20 30 40 50 60 pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NIGQIGALKDYYHFYHSRTIKRSVISSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDFSR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI 790 800 810 820 830 840 850 860 870 880 890 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNL-CQRK :::::::::::::::::::::::::::::::::::. : : : :. . . :: XP_005 SCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHCQTCEASCAKCQGP 850 860 870 880 890 900 910 pF1KB8 VLQQLCCKTCTFQG . .. : :: XP_005 TQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTSCGAD 900 910 920 930 940 950 >-- initn: 436 init1: 187 opt: 422 Z-score: 304.3 bits: 68.6 E(85289): 3.3e-10 Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1486-1747) 600 610 620 630 640 650 pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC .: :: : :: .: . : ::. :.: XP_005 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC 1460 1470 1480 1490 1500 1510 660 670 680 690 700 710 pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF . : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.: XP_005 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 1520 1530 1540 1550 1560 1570 720 730 740 750 760 pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C :..: :. .: .: : :.. . :..:...:: : . .: : . : :. : XP_005 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC 1580 1590 1600 1610 1620 770 780 790 800 810 820 pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD :: : : . : :. :: : : : :: .:..:. .: . : :...: .. : XP_005 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY-- 1630 1640 1650 1660 1670 1680 830 840 850 860 870 880 pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG . .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : : XP_005 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC 1690 1700 1710 1720 1730 1740 890 900 910 pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG : XP_005 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG 1750 1760 1770 1780 1790 1800 >-- initn: 375 init1: 149 opt: 292 Z-score: 214.9 bits: 52.1 E(85289): 3.1e-05 Smith-Waterman score: 586; 31.3% identity (50.8% similar) in 313 aa overlap (623-909:922-1217) 600 610 620 630 640 650 pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH :. . :. :: :.. :.: :: : XP_005 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH 900 910 920 930 940 660 670 680 690 700 pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM :..: :. :. . : .::: ::: .. . : : ::: : . : : XP_005 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT 950 960 970 980 990 1000 710 720 730 740 750 760 pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL : :::. ...: .: .: :: . : : :.: :. . .:: : : XP_005 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR 1010 1020 1030 1040 1050 1060 770 780 790 800 810 820 pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY .: .: . : . .:. : :..: .:: : ::.:. : ::..:. .. XP_005 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF 1070 1080 1090 1100 1110 830 840 850 860 870 880 pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA : :. : : :..: .: ::.::: .:.:: : : ::: . : . . : XP_005 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC-VHATKTQEEGKFWN 1120 1130 1140 1150 1160 1170 890 900 910 pF1KB8 EG--GFCMLVKKNNLCQRK---------VLQQL--C---CKTCTFQG :. . : :. : .:. .:..: : :::: XP_005 EAVSTANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL 1180 1190 1200 1210 1220 1230 XP_005 AQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCP 1240 1250 1260 1270 1280 1290 >-- initn: 386 init1: 149 opt: 292 Z-score: 214.9 bits: 52.1 E(85289): 3.1e-05 Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:1252-1482) 610 620 630 640 650 660 pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY .: :. .:.:. : : :. : .. . XP_005 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH 1230 1240 1250 1260 1270 1280 670 680 690 700 710 720 pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV : . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . : XP_005 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ 1290 1300 1310 1320 1330 730 740 750 760 770 780 pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD .::. . . :..:..: : :. : . ..: :: . :. . : :: : : ... XP_005 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH 1340 1350 1360 1370 1380 1390 790 800 810 820 830 840 pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI : :::. : :.: :: : : :. . . :: :.. : . :... . : :. : XP_005 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK 1400 1410 1420 1430 1440 1450 850 860 870 880 890 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK :::::.. : .::.: .: ... : :. . : XP_005 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP 1460 1470 1480 1490 1500 900 910 pF1KB8 VLQQLCCKTCTFQG XP_005 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG 1510 1520 1530 1540 1550 1560 >>XP_016870289 (OMIM: 600488) PREDICTED: proprotein conv (1450 aa) initn: 3248 init1: 3248 opt: 3272 Z-score: 2266.2 bits: 431.2 E(85289): 1.7e-119 Smith-Waterman score: 3272; 94.3% identity (96.0% similar) in 473 aa overlap (438-909:1-469) 410 420 430 440 450 460 pF1KB8 WRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHV .::::::::::::::::::::::::::::: XP_016 MSHLYGFGLMDAEAMVMEAEKWTTVPRQHV 10 20 30 470 480 490 500 510 520 pF1KB8 CVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLT 40 50 60 70 80 90 530 540 550 560 570 580 pF1KB8 SPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGK 100 110 120 130 140 150 590 600 610 620 630 640 pF1KB8 LKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDG 160 170 180 190 200 210 650 660 670 680 690 700 pF1KB8 PGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSC 220 230 240 250 260 270 710 720 730 740 750 760 pF1KB8 KYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRC 280 290 300 310 320 330 770 780 790 800 810 820 pF1KB8 SVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHS 340 350 360 370 380 390 830 840 850 860 870 880 pF1KB8 SENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFC ::::::::::::::::::::::::::::::::::::::::::::::::. : : : : XP_016 SENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHC 400 410 420 430 440 890 900 910 pF1KB8 MLVKKNNL-CQRKVLQQLCCKTCTFQG . . . :: . .. : :: XP_016 QTCEASCAKCQGPTQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQ 450 460 470 480 490 500 >-- initn: 436 init1: 187 opt: 422 Z-score: 305.7 bits: 68.5 E(85289): 2.7e-10 Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1049-1310) 600 610 620 630 640 650 pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC .: :: : :: .: . : ::. :.: XP_016 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC 1020 1030 1040 1050 1060 1070 660 670 680 690 700 710 pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF . : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.: XP_016 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 1080 1090 1100 1110 1120 1130 720 730 740 750 760 pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C :..: :. .: .: : :.. . :..:...:: : . .: : . : :. : XP_016 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC 1140 1150 1160 1170 1180 1190 770 780 790 800 810 820 pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD :: : : . : :. :: : : : :: .:..:. .: . : :...: .. : XP_016 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY-- 1200 1210 1220 1230 1240 830 840 850 860 870 880 pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG . .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : : XP_016 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC 1250 1260 1270 1280 1290 1300 890 900 910 pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG : XP_016 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG 1310 1320 1330 1340 1350 1360 >-- initn: 375 init1: 149 opt: 292 Z-score: 216.3 bits: 51.9 E(85289): 2.6e-05 Smith-Waterman score: 586; 31.3% identity (50.8% similar) in 313 aa overlap (623-909:485-780) 600 610 620 630 640 650 pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH :. . :. :: :.. :.: :: : XP_016 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH 460 470 480 490 500 510 660 670 680 690 700 pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM :..: :. :. . : .::: ::: .. . : : ::: : . : : XP_016 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT 520 530 540 550 560 710 720 730 740 750 760 pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL : :::. ...: .: .: :: . : : :.: :. . .:: : : XP_016 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR 570 580 590 600 610 620 770 780 790 800 810 820 pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY .: .: . : . .:. : :..: .:: : ::.:. : ::..:. .. XP_016 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF 630 640 650 660 670 680 830 840 850 860 870 880 pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA : :. : : :..: .: ::.::: .:.:: : : ::: . : . . : XP_016 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC-VHATKTQEEGKFWN 690 700 710 720 730 890 900 910 pF1KB8 EG--GFCMLVKKNNLCQRK---------VLQQL--C---CKTCTFQG :. . : :. : .:. .:..: : :::: XP_016 EAVSTANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL 740 750 760 770 780 790 XP_016 AQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCP 800 810 820 830 840 850 >-- initn: 386 init1: 149 opt: 292 Z-score: 216.3 bits: 51.9 E(85289): 2.6e-05 Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:815-1045) 610 620 630 640 650 660 pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY .: :. .:.:. : : :. : .. . XP_016 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH 790 800 810 820 830 840 670 680 690 700 710 720 pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV : . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . : XP_016 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ 850 860 870 880 890 730 740 750 760 770 780 pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD .::. . . :..:..: : :. : . ..: :: . :. . : :: : : ... XP_016 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH 900 910 920 930 940 950 790 800 810 820 830 840 pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI : :::. : :.: :: : : :. . . :: :.. : . :... . : :. : XP_016 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK 960 970 980 990 1000 1010 850 860 870 880 890 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK :::::.. : .::.: .: ... : :. . : XP_016 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP 1020 1030 1040 1050 1060 1070 900 910 pF1KB8 VLQQLCCKTCTFQG XP_016 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG 1080 1090 1100 1110 1120 1130 >>XP_011517072 (OMIM: 600488) PREDICTED: proprotein conv (1441 aa) initn: 3190 init1: 3190 opt: 3214 Z-score: 2226.4 bits: 423.9 E(85289): 2.9e-117 Smith-Waterman score: 3214; 94.4% identity (95.9% similar) in 464 aa overlap (447-909:1-460) 420 430 440 450 460 470 pF1KB8 RTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQI :::::::::::::::::::::::::::::: XP_011 MDAEAMVMEAEKWTTVPRQHVCVESTDRQI 10 20 30 480 490 500 510 520 530 pF1KB8 KTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQL 40 50 60 70 80 90 540 550 560 570 580 590 pF1KB8 LANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLY 100 110 120 130 140 150 600 610 620 630 640 650 pF1KB8 GTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC 160 170 180 190 200 210 660 670 680 690 700 710 pF1KB8 LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEE 220 230 240 250 260 270 720 730 740 750 760 770 pF1KB8 TNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRY 280 290 300 310 320 330 780 790 800 810 820 830 pF1KB8 FNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCK 340 350 360 370 380 390 840 850 860 870 880 890 pF1KB8 KCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNL- :::::::::::::::::::::::::::::::::::::::. : : : :. . . XP_011 KCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDG--EYVDEHGHCQTCEASCAK 400 410 420 430 440 900 910 pF1KB8 CQRKVLQQLCCKTCTFQG :: . .. : :: XP_011 CQGPTQED--CTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPTHCTS 450 460 470 480 490 500 >-- initn: 436 init1: 187 opt: 422 Z-score: 305.7 bits: 68.5 E(85289): 2.7e-10 Smith-Waterman score: 615; 34.6% identity (58.1% similar) in 272 aa overlap (626-887:1040-1301) 600 610 620 630 640 650 pF1KB8 YGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAG--PCDPECSEVGCDGPGPDHC .: :: : :: .: . : ::. :.: XP_011 SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH--CMGPAEDQC 1010 1020 1030 1040 1050 1060 660 670 680 690 700 710 pF1KB8 NDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYF . : . : :.: ::..:: :.: :..:: .: .:..: : :. :: ::. :.: XP_011 QTC-PMNSLLLNTT--CVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWF 1070 1080 1090 1100 1110 1120 720 730 740 750 760 pF1KB8 -LNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSLQGSR--C :..: :. .: .: : :.. . :..:...:: : . .: : . : :. : XP_011 QLGKE---CLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGEC 1130 1140 1150 1160 1170 1180 770 780 790 800 810 820 pF1KB8 SVSCEDGRYF--NGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFD :: : : . : :. :: : : : :: .:..:. .: . : :...: .. : XP_011 HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEY-- 1190 1200 1210 1220 1230 830 840 850 860 870 880 pF1KB8 HSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGG . .:. .:.:: ::. :.::: :::: ::.. .: . . :. . : : XP_011 RVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECC 1240 1250 1260 1270 1280 1290 890 900 910 pF1KB8 FCMLVKKNNLCQRKVLQQLCCKTCTFQG : XP_011 DCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLGAAVVVWKKSRGRVQPAAKAG 1300 1310 1320 1330 1340 1350 >-- initn: 375 init1: 149 opt: 292 Z-score: 216.3 bits: 51.9 E(85289): 2.6e-05 Smith-Waterman score: 586; 31.3% identity (50.8% similar) in 313 aa overlap (623-909:476-771) 600 610 620 630 640 650 pF1KB8 LVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDH :. . :. :: :.. :.: :: : XP_011 CAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQR--CQGSGPTH 450 460 470 480 490 500 660 670 680 690 700 pF1KB8 CNDC-------LHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCM :..: :. :. . : .::: ::: .. . : : ::: : . : : XP_011 CTSCGADNYGREHFLYQGE-----CGDSCPEGHYATEGNTCLPCPDNCELCHSVH--VCT 510 520 530 540 550 710 720 730 740 750 760 pF1KB8 SCKYGYFLNEETNSCVT-HCPDGSYQDTKKNLCRKCSENCKTCT--EFHNCTECRDGLSL : :::. ...: .: .: :: . : : :.: :. . .:: : : XP_011 RCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSLDDPGTCTSCAMGYYR 560 570 580 590 600 610 770 780 790 800 810 820 pF1KB8 QGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISY .: .: . : . .:. : :..: .:: : ::.:. : ::..:. .. XP_011 FDHHCYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLLGGSCVRKCGPGF 620 630 640 650 660 670 830 840 850 860 870 880 pF1KB8 YFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWA : :. : : :..: .: ::.::: .:.:: : : ::: . : . . : XP_011 YGDQ--EMG--ECESCHRACETCTGPGHDECSSCQEGLQLLRGMC-VHATKTQEEGKFWN 680 690 700 710 720 890 900 910 pF1KB8 EG--GFCMLVKKNNLCQRK---------VLQQL--C---CKTCTFQG :. . : :. : .:. .:..: : :::: XP_011 EAVSTANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL 730 740 750 760 770 780 XP_011 AQACVSSCPQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCP 790 800 810 820 830 840 >-- initn: 386 init1: 149 opt: 292 Z-score: 216.3 bits: 51.9 E(85289): 2.6e-05 Smith-Waterman score: 541; 31.6% identity (58.2% similar) in 244 aa overlap (633-873:806-1036) 610 620 630 640 650 660 pF1KB8 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDC-LHYYY .: :. .:.:. : : :. : .. . XP_011 TLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCE-NCTEACAICSGADLCKKCQMQPGH 780 790 800 810 820 830 670 680 690 700 710 720 pF1KB8 KLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCV : . : :.:: : : : :..:. :..: :. . .: ::. :. :.. . : XP_011 PLFLHEGRCYSKCPEGSYAEDGI-CERCSSPCRTCEGN-ATNCHSCEGGHVLHH--GVCQ 840 850 860 870 880 890 730 740 750 760 770 780 pF1KB8 THCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQD .::. . . :..:..: : :. : . ..: :: . :. . : :: : : ... XP_011 ENCPE--RHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRH 900 910 920 930 940 790 800 810 820 830 840 pF1KB8 CQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDI : :::. : :.: :: : : :. . . :: :.. : . :... . : :. : XP_011 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKET----KECRDCHK 950 960 970 980 990 1000 850 860 870 880 890 pF1KB8 SCLTCNGPGFKNCTSCPSGYLLD-LGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRK :::::.. : .::.: .: ... : :. . : XP_011 SCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGP 1010 1020 1030 1040 1050 1060 900 910 pF1KB8 VLQQLCCKTCTFQG XP_011 AEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPG 1070 1080 1090 1100 1110 1120 >>NP_612192 (OMIM: 167405) proprotein convertase subtili (956 aa) initn: 3329 init1: 2474 opt: 3014 Z-score: 2091.0 bits: 398.2 E(85289): 9.9e-110 Smith-Waterman score: 3777; 56.3% identity (78.3% similar) in 932 aa overlap (2-913:38-956) 10 20 30 pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCR : : : : : .::: ..: : : NP_612 APGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPR 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 TRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH ::::::::.. :: ::.:.:. .:..:.:::: :.::::::::.:.:::..:::: : NP_612 P-VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 SFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMN .:. :.:.:.:.::: ::.:.::. : :. ::::: : .:::.::.:.. :.:.:: NP_612 TFLRMDPQVKWLQQQEVKRRVKRQVR-SDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB8 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK ...::::::::::.:::::::::::.:::: :::. :: :::::: :: :::::::::: NP_612 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB8 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS :::::::::::.::::.: ::::.::::::.:::::::::.:::::... :... ::::: NP_612 HGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSAS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB8 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY :::::::::::::. :..:::: :.. ::.::::.:::::::::: :.::::::::::: NP_612 WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIY 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB8 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM :::.::..:.: ::::::::.:::::::::: :..::.::::::::::.:::::.:::: NP_612 TISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB8 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEA .::::::::::: ::::::::..:.::: .::.:.:::.:.:: ::::.:::::.:::: NP_612 VAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB8 MVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVR .:.::.:::.:: ::.:: ..:.. ..: ...:. .:.:... ...: :::::::: NP_612 LVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVR 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB8 ITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLE .:.::::::: :::.:::::.:::::.::.: : ::: ::::::.:::::.: :.:.:: NP_612 TSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLE 550 560 570 580 590 600 580 590 600 610 pF1KB8 VYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY----------------SPTNEFPKVERF . : :::.:: . ::::::::.::::. .:: .: : ::. . NP_612 IQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAA-L 610 620 630 640 650 660 620 630 640 650 660 670 pF1KB8 RYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCP :.:: : :. :::.: : :::.. :::::. :.: .:.:. ...: ::: :: NP_612 SPSQVEVPEDE---EDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCP 670 680 690 700 710 720 680 690 700 710 720 730 pF1KB8 PGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKK :.. . .:::.: .::.: . . ::.::. :.. ..: :.::: :: : : : .. NP_612 LGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQ 730 740 750 760 770 780 740 750 760 770 780 790 pF1KB8 NLCRKCSENCKTCT-EFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ--DCQPCHRFCAT . : :: .:: :. : ..:: :..:.:: . : .:: : ::... : ::. :.: NP_612 KNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGT 790 800 810 820 830 840 800 810 820 830 840 850 pF1KB8 CAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFK :.: : . ::.:.... ..: .:: .:. ..: .. .: :..:: .::.: : . . NP_612 CVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSS-R 850 860 870 880 890 900 860 870 880 890 900 910 pF1KB8 NCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQLCCKTCTF ::. : .:. :.:. : : :. :: .::.: ::.::.. :.::.:: . NP_612 NCSRCKTGFT------QLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLL 910 920 930 940 950 pF1KB8 QG : NP_612 AG >>NP_002561 (OMIM: 167405) proprotein convertase subtili (969 aa) initn: 3290 init1: 2474 opt: 2948 Z-score: 2045.5 bits: 389.8 E(85289): 3.4e-107 Smith-Waterman score: 3744; 55.6% identity (77.5% similar) in 942 aa overlap (2-913:38-969) 10 20 30 pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCR : : : : : .::: ..: : : NP_002 APGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPR 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 TRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH ::::::::.. :: ::.:.:. .:..:.:::: :.::::::::.:.:::..:::: : NP_002 P-VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 SFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMN .:. :.:.:.:.::: ::.:.::. : :. ::::: : .:::.::.:.. :.:.:: NP_002 TFLRMDPQVKWLQQQEVKRRVKRQVR-SDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB8 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK ...::::::::::.:::::::::::.:::: :::. :: :::::: :: :::::::::: NP_002 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB8 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS :::::::::::.::::.: ::::.::::::.:::::::::.:::::... :... ::::: NP_002 HGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSAS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB8 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY :::::::::::::. :..:::: :.. ::.::::.:::::::::: :.::::::::::: NP_002 WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIY 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB8 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM :::.::..:.: ::::::::.:::::::::: :..::.::::::::::.:::::.:::: NP_002 TISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB8 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEA .::::::::::: ::::::::..:.::: .::.:.:::.:.:: ::::.:::::.:::: NP_002 VAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB8 MVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVR .:.::.:::.:: ::.:: ..:.. ..: ...:. .:.:... ...: :::::::: NP_002 LVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVR 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB8 ITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLE .:.::::::: :::.:::::.:::::.::.: : ::: ::::::.:::::.: :.:.:: NP_002 TSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLE 550 560 570 580 590 600 580 590 600 610 pF1KB8 VYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY----------------SPTNEFPKVERF . : :::.:: . ::::::::.::::. .:: .: : ::. . NP_002 IQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPPKAA-L 610 620 630 640 650 660 620 630 640 650 660 pF1KB8 RYSRVEDPTD--DYGTEDYAGP--------CDPECSEVGCDGPGPDHCNDCLHYYYKLKN :.:: : : :: ... : : :::.. :::::. :.: .:.:. . NP_002 SPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSLGSVK 670 680 690 700 710 720 670 680 690 700 710 720 pF1KB8 NTRICVSSCPPGHY-HADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHC ..: ::: :: :.. . .:::.: .::.: . . ::.::. :.. ..: :.::: : NP_002 TSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLC 730 740 750 760 770 780 730 740 750 760 770 780 pF1KB8 PDGSYQDTKKNLCRKCSENCKTCT-EFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQ--D : : : : ... : :: .:: :. : ..:: :..:.:: . : .:: : ::... NP_002 PAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIR 790 800 810 820 830 840 790 800 810 820 830 840 pF1KB8 CQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDIS : ::. :.::.: : . ::.:.... ..: .:: .:. ..: .. .: :..:: . NP_002 CGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDEN 850 860 870 880 890 900 850 860 870 880 890 900 pF1KB8 CLTCNGPGFKNCTSCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVL ::.: : . .::. : .:. :.:. : : :. :: .::.: ::.::.. NP_002 CLSCAGSS-RNCSRCKTGFT------QLGTSCITNHTCSNADETFCEMVKSNRLCERKLF 910 920 930 940 950 910 pF1KB8 QQLCCKTCTFQG :.::.:: . : NP_002 IQFCCRTCLLAG 960 >>NP_612196 (OMIM: 167405) proprotein convertase subtili (623 aa) initn: 2376 init1: 2376 opt: 2785 Z-score: 1935.7 bits: 368.9 E(85289): 4.4e-101 Smith-Waterman score: 2785; 66.6% identity (86.5% similar) in 587 aa overlap (2-588:38-622) 10 20 30 pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCR : : : : : .::: ..: : : NP_612 APGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPR 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 TRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH ::::::::.. :: ::.:.:. .:..:.:::: :.::::::::.:.:::..:::: : NP_612 P-VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 SFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMN .:. :.:.:.:.::: ::.:.::. : :. ::::: : .:::.::.:.. :.:.:: NP_612 TFLRMDPQVKWLQQQEVKRRVKRQVR-SDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB8 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK ...::::::::::.:::::::::::.:::: :::. :: :::::: :: :::::::::: NP_612 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB8 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS :::::::::::.::::.: ::::.::::::.:::::::::.:::::... :... ::::: NP_612 HGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSAS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB8 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY :::::::::::::. :..:::: :.. ::.::::.:::::::::: :.::::::::::: NP_612 WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIY 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB8 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM :::.::..:.: ::::::::.:::::::::: :..::.::::::::::.:::::.:::: NP_612 TISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB8 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEA .::::::::::: ::::::::..:.::: .::.:.:::.:.:: ::::.:::::.:::: NP_612 VAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB8 MVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVR .:.::.:::.:: ::.:: ..:.. ..: ...:. .:.:... ...: :::::::: NP_612 LVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVR 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB8 ITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLE .:.::::::: :::.:::::.:::::.::.: : ::: ::::::.:::::.: :.:.:: NP_612 TSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLE 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB8 VYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTED . : :::.:: . :.: NP_612 IQDLPSQVRNPEKQGNLD 610 620 >>NP_612197 (OMIM: 167405) proprotein convertase subtili (652 aa) initn: 2376 init1: 2376 opt: 2785 Z-score: 1935.5 bits: 368.9 E(85289): 4.5e-101 Smith-Waterman score: 2785; 66.5% identity (86.4% similar) in 588 aa overlap (2-589:38-623) 10 20 30 pF1KB8 MGWGSRCCCPGRLDLLCVLALLGGCLLPVCR : : : : : .::: ..: : : NP_612 APGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAACSAPPPR 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB8 TRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH ::::::::.. :: ::.:.:. .:..:.:::: :.::::::::.:.:::..:::: : NP_612 P-VYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB8 SFISMEPKVEWIQQQVVKKRTKRDYDFSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMN .:. :.:.:.:.::: ::.:.::. : :. ::::: : .:::.::.:.. :.:.:: NP_612 TFLRMDPQVKWLQQQEVKRRVKRQVR-SDPQALYFNDPIWSNMWYLHCGDKNSRCRSEMN 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB8 IEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENK ...::::::::::.:::::::::::.:::: :::. :: :::::: :: :::::::::: NP_612 VQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDASNENK 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB8 HGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSAS :::::::::::.::::.: ::::.::::::.:::::::::.:::::... :... ::::: NP_612 HGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDIYSAS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB8 WGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIY :::::::::::::. :..:::: :.. ::.::::.:::::::::: :.::::::::::: NP_612 WGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYTNSIY 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB8 TISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPM :::.::..:.: ::::::::.:::::::::: :..::.::::::::::.:::::.:::: NP_612 TISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSVSAPM 370 380 390 400 410 420 400 410 420 430 440 450 pF1KB8 AAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEA .::::::::::: ::::::::..:.::: .::.:.:::.:.:: ::::.:::::.:::: NP_612 VAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLVDAEA 430 440 450 460 470 480 460 470 480 490 500 510 pF1KB8 MVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVR .:.::.:::.:: ::.:: ..:.. ..: ...:. .:.:... ...: :::::::: NP_612 LVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEHVVVR 490 500 510 520 530 540 520 530 540 550 560 570 pF1KB8 ITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLE .:.::::::: :::.:::::.:::::.::.: : ::: ::::::.:::::.: :.:.:: NP_612 TSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQWTLE 550 560 570 580 590 600 580 590 600 610 620 630 pF1KB8 VYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTED . : :::.:: . : :. NP_612 IQDLPSQVRNPEKQGDLETPVANQLTTEEREPGLKHVFRWQIEQELW 610 620 630 640 650 913 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:43:45 2016 done: Tue Nov 8 06:43:47 2016 Total Scan time: 10.620 Total Display time: 0.450 Function used was FASTA [36.3.4 Apr, 2011]