FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KA0213, 1558 aa 1>>>pF1KA0213 1558 - 1558 aa - 1558 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4735+/-0.000601; mu= -6.1843+/- 0.038 mean_var=719.8189+/-152.080, 0's: 0 Z-trim(119.9): 1440 B-trim: 0 in 0/61 Lambda= 0.047804 statistics sampled from 32609 (34555) to 32609 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.405), width: 16 Scan time: 18.060 The best scores are: opt bits E(85289) NP_006715 (OMIM: 602425) mitogen-activated protein (1558) 10475 739.9 3.9e-212 XP_005267046 (OMIM: 602425) PREDICTED: mitogen-act (1554) 10421 736.1 5.2e-211 NP_005913 (OMIM: 602425) mitogen-activated protein (1608) 7919 563.6 4.6e-159 NP_001288001 (OMIM: 602425) mitogen-activated prot (1604) 7875 560.6 3.8e-158 XP_016866358 (OMIM: 602425) PREDICTED: mitogen-act (1517) 7258 518.0 2.4e-145 NP_001278887 (OMIM: 602425) mitogen-activated prot (1061) 4080 298.6 1.8e-79 NP_001317360 (OMIM: 602539) mitogen-activated prot ( 622) 671 63.2 7.8e-09 NP_002392 (OMIM: 602539) mitogen-activated protein ( 626) 671 63.2 7.9e-09 XP_005257433 (OMIM: 602539) PREDICTED: mitogen-act ( 653) 671 63.2 8.1e-09 NP_976226 (OMIM: 602539) mitogen-activated protein ( 657) 671 63.2 8.1e-09 NP_006600 (OMIM: 609487) mitogen-activated protein ( 619) 642 61.2 3.1e-08 XP_011543813 (OMIM: 300820) PREDICTED: mitogen-act ( 748) 565 56.0 1.4e-06 XP_011543812 (OMIM: 300820) PREDICTED: mitogen-act ( 871) 565 56.1 1.5e-06 XP_016864974 (OMIM: 600982,613762) PREDICTED: mito (1349) 570 56.7 1.6e-06 XP_016864973 (OMIM: 600982,613762) PREDICTED: mito (1375) 570 56.7 1.6e-06 XP_016866366 (OMIM: 602448) PREDICTED: mitogen-act (1181) 568 56.5 1.6e-06 XP_016866365 (OMIM: 602448) PREDICTED: mitogen-act (1191) 568 56.5 1.6e-06 XP_011534141 (OMIM: 602448) PREDICTED: mitogen-act (1286) 568 56.5 1.7e-06 NP_005912 (OMIM: 600982,613762) mitogen-activated (1512) 570 56.7 1.7e-06 NP_005914 (OMIM: 602448) mitogen-activated protein (1374) 568 56.5 1.7e-06 XP_016866364 (OMIM: 602448) PREDICTED: mitogen-act (1447) 568 56.6 1.8e-06 XP_016866363 (OMIM: 602448) PREDICTED: mitogen-act (1458) 568 56.6 1.8e-06 XP_016866362 (OMIM: 602448) PREDICTED: mitogen-act (1483) 568 56.6 1.8e-06 XP_016866361 (OMIM: 602448) PREDICTED: mitogen-act (1484) 568 56.6 1.8e-06 XP_016866360 (OMIM: 602448) PREDICTED: mitogen-act (1493) 568 56.6 1.8e-06 XP_016866359 (OMIM: 602448) PREDICTED: mitogen-act (1494) 568 56.6 1.8e-06 XP_011543810 (OMIM: 300820) PREDICTED: mitogen-act (1295) 565 56.3 1.9e-06 XP_016858260 (OMIM: 604468) PREDICTED: mitogen-act ( 869) 560 55.7 1.9e-06 NP_001001671 (OMIM: 300820) mitogen-activated prot (1313) 565 56.3 1.9e-06 XP_011543809 (OMIM: 300820) PREDICTED: mitogen-act (1324) 565 56.3 2e-06 NP_001284538 (OMIM: 604468) mitogen-activated prot (1280) 560 56.0 2.4e-06 NP_004663 (OMIM: 604468) mitogen-activated protein (1288) 560 56.0 2.4e-06 XP_011538703 (OMIM: 616563) PREDICTED: STE20-like ( 783) 531 53.7 7.3e-06 XP_016873338 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06 XP_016873339 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06 XP_016873337 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06 XP_016873336 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06 XP_016873335 (OMIM: 602590) PREDICTED: serine/thre ( 545) 525 53.0 7.8e-06 NP_002567 (OMIM: 602590) serine/threonine-protein ( 545) 525 53.0 7.8e-06 NP_002568 (OMIM: 605022) serine/threonine-protein ( 524) 524 53.0 8e-06 XP_016861990 (OMIM: 605022) PREDICTED: serine/thre ( 524) 524 53.0 8e-06 XP_011511172 (OMIM: 605022) PREDICTED: serine/thre ( 524) 524 53.0 8e-06 NP_001311255 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06 NP_001311261 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06 XP_016885050 (OMIM: 300142,300558) PREDICTED: seri ( 544) 524 53.0 8.2e-06 NP_001311263 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06 NP_001121639 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06 NP_001311260 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06 NP_002569 (OMIM: 300142,300558) serine/threonine-p ( 544) 524 53.0 8.2e-06 NP_001311254 (OMIM: 300142,300558) serine/threonin ( 544) 524 53.0 8.2e-06 >>NP_006715 (OMIM: 602425) mitogen-activated protein kin (1558 aa) initn: 10475 init1: 10475 opt: 10475 Z-score: 3929.5 bits: 739.9 E(85289): 3.9e-212 Smith-Waterman score: 10475; 100.0% identity (100.0% similar) in 1558 aa overlap (1-1558:1-1558) 10 20 30 40 50 60 pF1KA0 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KA0 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRH 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KA0 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYR 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KA0 EMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KA0 MKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KA0 SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KA0 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 pF1KA0 NFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1510 1520 1530 1540 1550 >>XP_005267046 (OMIM: 602425) PREDICTED: mitogen-activat (1554 aa) initn: 7992 init1: 7614 opt: 10421 Z-score: 3909.4 bits: 736.1 E(85289): 5.2e-211 Smith-Waterman score: 10421; 99.7% identity (99.7% similar) in 1558 aa overlap (1-1558:1-1554) 10 20 30 40 50 60 pF1KA0 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP ::::::::::::::::::::::::::::::::::::.::::::::::::::::::::::: XP_005 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT-- 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KA0 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 --AIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRH 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KA0 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYR 1200 1210 1220 1230 1240 1250 1270 1280 1290 1300 1310 1320 pF1KA0 EMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA 1260 1270 1280 1290 1300 1310 1330 1340 1350 1360 1370 1380 pF1KA0 MKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEV 1320 1330 1340 1350 1360 1370 1390 1400 1410 1420 1430 1440 pF1KA0 SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKN 1380 1390 1400 1410 1420 1430 1450 1460 1470 1480 1490 1500 pF1KA0 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEH 1440 1450 1460 1470 1480 1490 1510 1520 1530 1540 1550 pF1KA0 NFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1500 1510 1520 1530 1540 1550 >>NP_005913 (OMIM: 602425) mitogen-activated protein kin (1608 aa) initn: 7910 init1: 7910 opt: 7919 Z-score: 2976.6 bits: 563.6 E(85289): 4.6e-159 Smith-Waterman score: 10248; 96.9% identity (96.9% similar) in 1590 aa overlap (1-1540:1-1590) 10 20 30 40 50 60 pF1KA0 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL 1090 1100 1110 1120 1130 1140 1150 1160 1170 pF1KA0 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF-------------------------- :::::::::::::::::::::::::::::::::: NP_005 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 pF1KA0 ------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP :::::::::::::::::::::::::::::::::::: NP_005 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1210 1220 1230 1240 1250 1260 1220 1230 1240 1250 1260 1270 pF1KA0 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1270 1280 1290 1300 1310 1320 1280 1290 1300 1310 1320 1330 pF1KA0 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1330 1340 1350 1360 1370 1380 1340 1350 1360 1370 1380 1390 pF1KA0 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1390 1400 1410 1420 1430 1440 1400 1410 1420 1430 1440 1450 pF1KA0 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1450 1460 1470 1480 1490 1500 1460 1470 1480 1490 1500 1510 pF1KA0 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1510 1520 1530 1540 1550 1560 1520 1530 1540 1550 pF1KA0 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE :::::::::::::::::::::::::::::: NP_005 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1570 1580 1590 1600 >>NP_001288001 (OMIM: 602425) mitogen-activated protein (1604 aa) initn: 10195 init1: 7624 opt: 7875 Z-score: 2960.2 bits: 560.6 E(85289): 3.8e-158 Smith-Waterman score: 10226; 96.6% identity (96.6% similar) in 1594 aa overlap (1-1544:1-1590) 10 20 30 40 50 60 pF1KA0 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KA0 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KA0 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KA0 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KA0 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KA0 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMEL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KA0 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KA0 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KA0 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KA0 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KA0 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KA0 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASH 670 680 690 700 710 720 730 740 750 760 770 780 pF1KA0 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KA0 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KA0 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAY 850 860 870 880 890 900 910 920 930 940 950 960 pF1KA0 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRK 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KA0 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEV 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KA0 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTK 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KA0 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVT-- 1090 1100 1110 1120 1130 1150 1160 1170 pF1KA0 YLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF-------------------------- :::::::::::::::::::::::::::::::: NP_001 --AIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAV 1140 1150 1160 1170 1180 1190 1180 1190 1200 1210 pF1KA0 ------------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP :::::::::::::::::::::::::::::::::::: NP_001 AASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEP 1200 1210 1220 1230 1240 1250 1220 1230 1240 1250 1260 1270 pF1KA0 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQ 1260 1270 1280 1290 1300 1310 1280 1290 1300 1310 1320 1330 pF1KA0 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPND 1320 1330 1340 1350 1360 1370 1340 1350 1360 1370 1380 1390 pF1KA0 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI 1380 1390 1400 1410 1420 1430 1400 1410 1420 1430 1440 1450 pF1KA0 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVN 1440 1450 1460 1470 1480 1490 1460 1470 1480 1490 1500 1510 pF1KA0 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGM 1500 1510 1520 1530 1540 1550 1520 1530 1540 1550 pF1KA0 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE :::::::::::::::::::::::::::::::::: NP_001 GHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1560 1570 1580 1590 1600 >>XP_016866358 (OMIM: 602425) PREDICTED: mitogen-activat (1517 aa) initn: 7249 init1: 7249 opt: 7258 Z-score: 2730.5 bits: 518.0 E(85289): 2.4e-145 Smith-Waterman score: 9587; 96.6% identity (96.7% similar) in 1499 aa overlap (92-1540:1-1499) 70 80 90 100 110 120 pF1KA0 KSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPN :::::::::::::::::::::::::::::: XP_016 MKRMSTKHQRNNVGRPASRSNLKEKMNAPN 10 20 30 130 140 150 160 170 180 pF1KA0 QPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDHKKNVQCSFMLDSVGGSLPKKSIPD :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: XP_016 QPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPD 40 50 60 70 80 90 190 200 210 220 230 240 pF1KA0 VDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKK 100 110 120 130 140 150 250 260 270 280 290 300 pF1KA0 KDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTF 160 170 180 190 200 210 310 320 330 340 350 360 pF1KA0 KVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELL 220 230 240 250 260 270 370 380 390 400 410 420 pF1KA0 EYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSD 280 290 300 310 320 330 430 440 450 460 470 480 pF1KA0 IGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNS 340 350 360 370 380 390 490 500 510 520 530 540 pF1KA0 FDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRK 400 410 420 430 440 450 550 560 570 580 590 600 pF1KA0 LILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSW 460 470 480 490 500 510 610 620 630 640 650 660 pF1KA0 EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKG 520 530 540 550 560 570 670 680 690 700 710 720 pF1KA0 GLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHS 580 590 600 610 620 630 730 740 750 760 770 780 pF1KA0 LKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSA 640 650 660 670 680 690 790 800 810 820 830 840 pF1KA0 DDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDL 700 710 720 730 740 750 850 860 870 880 890 900 pF1KA0 LDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYL 760 770 780 790 800 810 910 920 930 940 950 960 pF1KA0 LLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKA 820 830 840 850 860 870 970 980 990 1000 1010 1020 pF1KA0 FQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVD 880 890 900 910 920 930 1030 1040 1050 1060 1070 1080 pF1KA0 ESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKC 940 950 960 970 980 990 1090 1100 1110 1120 1130 1140 pF1KA0 ESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLY 1000 1010 1020 1030 1040 1050 1150 1160 1170 pF1KA0 LAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF--------------------------- ::::::::::::::::::::::::::::::::: XP_016 LAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVA 1060 1070 1080 1090 1100 1110 1180 1190 1200 1210 pF1KA0 -----------------------RGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA ::::::::::::::::::::::::::::::::::::: XP_016 ASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA 1120 1130 1140 1150 1160 1170 1220 1230 1240 1250 1260 1270 pF1KA0 YPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQV 1180 1190 1200 1210 1220 1230 1280 1290 1300 1310 1320 1330 pF1KA0 CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDH 1240 1250 1260 1270 1280 1290 1340 1350 1360 1370 1380 1390 pF1KA0 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIR 1300 1310 1320 1330 1340 1350 1400 1410 1420 1430 1440 1450 pF1KA0 LYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNS 1360 1370 1380 1390 1400 1410 1460 1470 1480 1490 1500 1510 pF1KA0 TLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMG 1420 1430 1440 1450 1460 1470 1520 1530 1540 1550 pF1KA0 HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE ::::::::::::::::::::::::::::: XP_016 HKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1480 1490 1500 1510 >>NP_001278887 (OMIM: 602425) mitogen-activated protein (1061 aa) initn: 4062 init1: 4062 opt: 4080 Z-score: 1547.7 bits: 298.6 E(85289): 1.8e-79 Smith-Waterman score: 6409; 93.8% identity (94.3% similar) in 1040 aa overlap (552-1540:4-1043) 530 540 550 560 570 580 pF1KA0 LTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDR-PVEFSEFPDPMWGS ::.:. : . .. .::::::::::: NP_001 MYIGSIQKDRTTRSRDGACRSQFSEFPDPMWGS 10 20 30 590 600 610 620 630 640 pF1KA0 DYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPA 40 50 60 70 80 90 650 660 670 680 690 700 pF1KA0 GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMV 100 110 120 130 140 150 710 720 730 740 750 760 pF1KA0 YFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLK 160 170 180 190 200 210 770 780 790 800 810 820 pF1KA0 STGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAK 220 230 240 250 260 270 830 840 850 860 870 880 pF1KA0 MLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLL 280 290 300 310 320 330 890 900 910 920 930 940 pF1KA0 NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSM 340 350 360 370 380 390 950 960 970 980 990 1000 pF1KA0 QVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNR 400 410 420 430 440 450 1010 1020 1030 1040 1050 1060 pF1KA0 ISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQ 460 470 480 490 500 510 1070 1080 1090 1100 1110 1120 pF1KA0 KIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQA 520 530 540 550 560 570 1130 1140 1150 1160 1170 pF1KA0 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGF------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMP 580 590 600 610 620 630 1180 1190 pF1KA0 --------------------------------------------RGSSVPENDRLASIAA :::::::::::::::: NP_001 SDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAA 640 650 660 670 680 690 1200 1210 1220 1230 1240 1250 pF1KA0 ELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKS 700 710 720 730 740 750 1260 1270 1280 1290 1300 1310 pF1KA0 VRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTC 760 770 780 790 800 810 1320 1330 1340 1350 1360 1370 pF1KA0 ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFME 820 830 840 850 860 870 1380 1390 1400 1410 1420 1430 pF1KA0 YCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLG 880 890 900 910 920 930 1440 1450 1460 1470 1480 1490 pF1KA0 DFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVT 940 950 960 970 980 990 1500 1510 1520 1530 1540 1550 pF1KA0 GKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1000 1010 1020 1030 1040 1050 pF1KA0 VKVCTDEE NP_001 VKVCTDEE 1060 >>NP_001317360 (OMIM: 602539) mitogen-activated protein (622 aa) initn: 527 init1: 216 opt: 671 Z-score: 279.5 bits: 63.2 E(85289): 7.8e-09 Smith-Waterman score: 676; 30.2% identity (60.6% similar) in 467 aa overlap (1101-1553:190-620) 1080 1090 1100 1110 1120 1130 pF1KA0 RKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVI : . .. : : .:. . ..:. . NP_001 PRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS--EQCMLDPL 160 170 180 190 200 210 1140 1150 1160 1170 1180 pF1KA0 GKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTP-----EGFRGSSVPENDRL .. .. ..: .. : : .. : .: : : . .: .:.. :. NP_001 SSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPR---- 220 230 240 250 260 270 1190 1200 1210 1220 1230 1240 pF1KA0 ASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIE ... .:.. .. : ..:: :.. .: ::. .:.. ... : : NP_001 -------RYHVSVHHKDYSDGRR--TFPR-----IRRHQGNLFTLVPSSRSLSTN-G--E 280 290 300 310 1250 1260 1270 1280 1290 1300 pF1KA0 AIQKSVRLFEEK-RYREMRRKNIIG-QVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQ . .:. .. . : : .: .. : ..: . .. ..:.::. .:.: NP_001 NMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSA--------PINWRRGKLLGQGA 320 330 340 350 360 1310 1320 1330 1340 1350 1360 pF1KA0 YGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVEL .:.:: : .::::. .: :...:.:.. .: ::.. :........: .:.:.: NP_001 FGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLR 370 380 390 400 410 420 1370 1380 1390 1400 1410 pF1KA0 HREE--MYIFMEYCDEGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKG : : . ::::: :.. .... : : : : : :..:: ... :: . :::::::: NP_001 DRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKG 430 440 450 460 470 480 1420 1430 1440 1450 1460 1470 pF1KA0 ANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAA :::. :.: .:::::: : .:.. .. : . :. :: .:.::::. :::.:: : NP_001 ANILRDSAGNVKLGDFGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKA 490 500 510 520 530 540 1480 1490 1500 1510 1520 1530 pF1KA0 DIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDP :.:::::.:.::.: : :: ::: :. . . .: .: ..: .:.::: . . . NP_001 DVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEA 550 560 570 580 590 600 1540 1550 pF1KA0 KMRWTASQLLDHSFVKVCTDEE ..: .: .:: : :... NP_001 RQRPSAEELLTHHFAQLMY 610 620 >>NP_002392 (OMIM: 602539) mitogen-activated protein kin (626 aa) initn: 561 init1: 216 opt: 671 Z-score: 279.5 bits: 63.2 E(85289): 7.9e-09 Smith-Waterman score: 682; 32.3% identity (59.5% similar) in 452 aa overlap (1132-1553:186-624) 1110 1120 1130 1140 1150 1160 pF1KA0 IEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR-PMKVPRCHSD . : : : .:. .. : .: : NP_002 QPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLD 160 170 180 190 200 210 1170 1180 1190 1200 1210 pF1KA0 PPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA------YPR : . . :. ..: :: :. . . : .:: .: ..:.: . : . NP_002 P------LSSAENSLSGSCQSLDRSADSPSFRKSR-MSRAQSFPDNRQEYSDRETQLYDK 220 230 240 250 260 1220 1230 1240 1250 1260 1270 pF1KA0 GDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQV : ..:. : ... . .. .: . :. : .. : .: .:. : NP_002 GVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQY 270 280 290 300 310 320 1280 1290 1300 1310 pF1KA0 CDTPKSY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGEL : :.. .:.. : :.: : :.::. .:.: .:.:: : .::::. NP_002 LD-PRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE 330 340 350 360 370 380 1320 1330 1340 1350 1360 1370 pF1KA0 MAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCD .: :...:.:.. .: ::.. :........: .:.:.: : : . ::::: NP_002 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP 390 400 410 420 430 440 1380 1390 1400 1410 1420 1430 pF1KA0 EGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD :.. .... : : : : : :..:: ... :: . :::::::::::. :.: .:::: NP_002 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGD 450 460 470 480 490 500 1440 1450 1460 1470 1480 1490 pF1KA0 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG :: : .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.: NP_002 FGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTE 510 520 530 540 550 560 1500 1510 1520 1530 1540 1550 pF1KA0 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV : :: ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :. NP_002 KPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFA 570 580 590 600 610 620 pF1KA0 KVCTDEE .. NP_002 QLMY >>XP_005257433 (OMIM: 602539) PREDICTED: mitogen-activat (653 aa) initn: 561 init1: 216 opt: 671 Z-score: 279.3 bits: 63.2 E(85289): 8.1e-09 Smith-Waterman score: 676; 30.2% identity (60.6% similar) in 467 aa overlap (1101-1553:221-651) 1080 1090 1100 1110 1120 1130 pF1KA0 RKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVI : . .. : : .:. . ..:. . XP_005 PRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETS--EQCMLDPL 200 210 220 230 240 1140 1150 1160 1170 1180 pF1KA0 GKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTP-----EGFRGSSVPENDRL .. .. ..: .. : : .. : .: : : . .: .:.. :. XP_005 SSAENSLSGSCQSLDSPSFRKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPR---- 250 260 270 280 290 300 1190 1200 1210 1220 1230 1240 pF1KA0 ASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIE ... .:.. .. : ..:: :.. .: ::. .:.. ... : : XP_005 -------RYHVSVHHKDYSDGRR--TFPR-----IRRHQGNLFTLVPSSRSLSTN-G--E 310 320 330 340 1250 1260 1270 1280 1290 1300 pF1KA0 AIQKSVRLFEEK-RYREMRRKNIIG-QVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQ . .:. .. . : : .: .. : ..: . .. ..:.::. .:.: XP_005 NMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSA--------PINWRRGKLLGQGA 350 360 370 380 390 1310 1320 1330 1340 1350 1360 pF1KA0 YGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVEL .:.:: : .::::. .: :...:.:.. .: ::.. :........: .:.:.: XP_005 FGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLR 400 410 420 430 440 450 1370 1380 1390 1400 1410 pF1KA0 HREE--MYIFMEYCDEGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKG : : . ::::: :.. .... : : : : : :..:: ... :: . :::::::: XP_005 DRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKG 460 470 480 490 500 510 1420 1430 1440 1450 1460 1470 pF1KA0 ANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAA :::. :.: .:::::: : .:.. .. : . :. :: .:.::::. :::.:: : XP_005 ANILRDSAGNVKLGDFGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKA 520 530 540 550 560 570 1480 1490 1500 1510 1520 1530 pF1KA0 DIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDP :.:::::.:.::.: : :: ::: :. . . .: .: ..: .:.::: . . . XP_005 DVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEA 580 590 600 610 620 630 1540 1550 pF1KA0 KMRWTASQLLDHSFVKVCTDEE ..: .: .:: : :... XP_005 RQRPSAEELLTHHFAQLMY 640 650 >>NP_976226 (OMIM: 602539) mitogen-activated protein kin (657 aa) initn: 527 init1: 216 opt: 671 Z-score: 279.3 bits: 63.2 E(85289): 8.1e-09 Smith-Waterman score: 682; 32.3% identity (59.5% similar) in 452 aa overlap (1132-1553:217-655) 1110 1120 1130 1140 1150 1160 pF1KA0 IEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPR-PMKVPRCHSD . : : : .:. .. : .: : NP_976 QPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLD 190 200 210 220 230 240 1170 1180 1190 1200 1210 pF1KA0 PPNPHLIIPTPEGFRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA------YPR : . . :. ..: :: :. . . : .:: .: ..:.: . : . NP_976 P------LSSAENSLSGSCQSLDRSADSPSFRKSR-MSRAQSFPDNRQEYSDRETQLYDK 250 260 270 280 290 1220 1230 1240 1250 1260 1270 pF1KA0 GDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSV-RLFEEKRYREMRRKNI--IGQV : ..:. : ... . .. .: . :. : .. : .: .:. : NP_976 GVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQY 300 310 320 330 340 350 1280 1290 1300 1310 pF1KA0 CDTPKSY------DNVMHVGLRKVTFK-------WQRGNKIGEGQYGKVYTCISVDTGEL : :.. .:.. : :.: : :.::. .:.: .:.:: : .::::. NP_976 LD-PRGRLRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRE 360 370 380 390 400 410 1320 1330 1340 1350 1360 1370 pF1KA0 MAMKEIRFQPNDHKTIKETAD---ELKIFEGIKHPNLVRYFGVELHREE--MYIFMEYCD .: :...:.:.. .: ::.. :........: .:.:.: : : . ::::: NP_976 LASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMP 420 430 440 450 460 470 1380 1390 1400 1410 1420 1430 pF1KA0 EGTL-EEVSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGD :.. .... : : : : : :..:: ... :: . :::::::::::. :.: .:::: NP_976 GGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGD 480 490 500 510 520 530 1440 1450 1460 1470 1480 1490 pF1KA0 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG :: : .:.. .. : . :. :: .:.::::. :::.:: ::.:::::.:.::.: NP_976 FGASKRLQTICMSGTG-MRSVTGTPYWMSPEVIS---GEGYGRKADVWSLGCTVVEMLTE 540 550 560 570 580 590 1500 1510 1520 1530 1540 1550 pF1KA0 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV : :: ::: :. . . .: .: ..: .:.::: . . . ..: .: .:: : :. NP_976 KPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELLTHHFA 600 610 620 630 640 650 pF1KA0 KVCTDEE .. NP_976 QLMY 1558 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 06:55:02 2016 done: Sun Nov 6 06:55:05 2016 Total Scan time: 18.060 Total Display time: 0.740 Function used was FASTA [36.3.4 Apr, 2011]