Result of FASTA (omim) for
pFN21AB6367
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6367, 269 aa
1>>>pF1KB6367 269 - 269 aa - 269 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5822+/-0.000386; mu= 13.2834+/- 0.024
mean_var=74.2848+/-14.940, 0's: 0 Z-trim(112.7): 30 B-trim: 0 in 0/54
Lambda= 0.148807
statistics sampled from 21665 (21695) to 21665 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.254), width: 16
Scan time: 5.850
The best scores are: opt bits E(85289)
NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 1820 400.1 2.2e-111
XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 1612 355.4 5.5e-98
NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157) 206 53.5 2.9e-07
XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157) 206 53.5 2.9e-07
XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158) 191 50.3 2.7e-06
XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158) 191 50.3 2.7e-06
XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158) 191 50.3 2.7e-06
NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158) 191 50.3 2.7e-06
XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143) 184 48.7 7e-06
NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143) 184 48.7 7e-06
NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143) 184 48.7 7e-06
XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143) 184 48.7 7e-06
NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159) 184 48.8 7.6e-06
NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177) 184 48.8 8.3e-06
NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180) 184 48.8 8.4e-06
NP_000566 (OMIM: 147760) interleukin-1 alpha precu ( 271) 183 48.7 1.4e-05
XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218) 162 44.1 0.00026
NP_055254 (OMIM: 605510) interleukin-37 isoform 1 ( 218) 162 44.1 0.00026
NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155) 157 43.0 0.00041
NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155) 157 43.0 0.00041
NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169) 156 42.8 0.00052
NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134) 152 41.9 0.00077
NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152) 147 40.8 0.0018
NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152) 147 40.8 0.0018
NP_775297 (OMIM: 605510) interleukin-37 isoform 5 ( 192) 145 40.4 0.003
NP_775294 (OMIM: 605510) interleukin-37 isoform 2 ( 197) 145 40.4 0.003
XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178) 142 39.8 0.0043
NP_775296 (OMIM: 605510) interleukin-37 isoform 4 ( 178) 142 39.8 0.0043
>>NP_000567 (OMIM: 137215,147720) interleukin-1 beta pro (269 aa)
initn: 1820 init1: 1820 opt: 1820 Z-score: 2120.7 bits: 400.1 E(85289): 2.2e-111
Smith-Waterman score: 1820; 100.0% identity (100.0% similar) in 269 aa overlap (1-269:1-269)
10 20 30 40 50 60
pF1KB6 MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
190 200 210 220 230 240
250 260
pF1KB6 SQAENMPVFLGGTKGGQDITDFTMQFVSS
:::::::::::::::::::::::::::::
NP_000 SQAENMPVFLGGTKGGQDITDFTMQFVSS
250 260
>>XP_016859477 (OMIM: 137215,147720) PREDICTED: interleu (238 aa)
initn: 1612 init1: 1612 opt: 1612 Z-score: 1880.1 bits: 355.4 E(85289): 5.5e-98
Smith-Waterman score: 1612; 100.0% identity (100.0% similar) in 238 aa overlap (32-269:1-238)
10 20 30 40 50 60
pF1KB6 AEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGF
::::::::::::::::::::::::::::::
XP_016 MKCSFQDLDLCPLDGGIQLRISDHHYSKGF
10 20 30
70 80 90 100 110 120
pF1KB6 RQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRS
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB6 LNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEK
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB6 NLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTS
160 170 180 190 200 210
250 260
pF1KB6 QAENMPVFLGGTKGGQDITDFTMQFVSS
::::::::::::::::::::::::::::
XP_016 QAENMPVFLGGTKGGQDITDFTMQFVSS
220 230
>>NP_775270 (OMIM: 605508) interleukin-36 beta isoform 2 (157 aa)
initn: 78 init1: 78 opt: 206 Z-score: 251.5 bits: 53.5 E(85289): 2.9e-07
Smith-Waterman score: 206; 32.9% identity (61.0% similar) in 146 aa overlap (126-267:14-156)
100 110 120 130 140 150
pF1KB6 FIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQ
.:::.: :.:: : : :. . .
NP_775 MNPQREAAPKSYAIRDSRQMVWVLSGN-SLIAAPLSRSI--KP
10 20 30 40
160 170 180 190 200 210
pF1KB6 VVFSMSFVQGEESNDKIP---VALGLKEKNLYLSCVLKDDKPTLQLESVDPKN-YPKKKM
:.. . . : .:: : ::.: :.: : :. . ::::::. . . : .::
NP_775 VTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKA
50 60 70 80 90 100
220 230 240 250 260
pF1KB6 EKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
.: :.: . . .. :.:...:.:.:.:: . ..:.:: .: . :.: .. :
NP_775 QKPFLFFHNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE
110 120 130 140 150
>>XP_011509264 (OMIM: 605508) PREDICTED: interleukin-36 (157 aa)
initn: 78 init1: 78 opt: 206 Z-score: 251.5 bits: 53.5 E(85289): 2.9e-07
Smith-Waterman score: 206; 32.9% identity (61.0% similar) in 146 aa overlap (126-267:14-156)
100 110 120 130 140 150
pF1KB6 FIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQ
.:::.: :.:: : : :. . .
XP_011 MNPQREAAPKSYAIRDSRQMVWVLSGN-SLIAAPLSRSI--KP
10 20 30 40
160 170 180 190 200 210
pF1KB6 VVFSMSFVQGEESNDKIP---VALGLKEKNLYLSCVLKDDKPTLQLESVDPKN-YPKKKM
:.. . . : .:: : ::.: :.: : :. . ::::::. . . : .::
XP_011 VTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKA
50 60 70 80 90 100
220 230 240 250 260
pF1KB6 EKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
.: :.: . . .. :.:...:.:.:.:: . ..:.:: .: . :.: .. :
XP_011 QKPFLFFHNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE
110 120 130 140 150
>>XP_016859295 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 159 init1: 96 opt: 191 Z-score: 234.1 bits: 50.3 E(85289): 2.7e-06
Smith-Waterman score: 191; 34.5% identity (59.3% similar) in 113 aa overlap (157-266:46-158)
130 140 150 160 170 180
pF1KB6 RDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS
..: :. :.. :. :::. :: :
XP_016 QDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLM
20 30 40 50 60 70
190 200 210 220 230 240
pF1KB6 CVLKDDKPTLQLESVDPKN-YPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAEN
:. :.:::::. : . : . . : :.: . . . . :::. ::.:.:..:. .
XP_016 CAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGG
80 90 100 110 120 130
250 260
pF1KB6 MPVFLGGTKGGQDITDF--TMQFVSS
:..: : . ::: :: :
XP_016 CPLILTQELGKANTTDFGLTMLF
140 150
>>XP_011509267 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 159 init1: 96 opt: 191 Z-score: 234.1 bits: 50.3 E(85289): 2.7e-06
Smith-Waterman score: 191; 34.5% identity (59.3% similar) in 113 aa overlap (157-266:46-158)
130 140 150 160 170 180
pF1KB6 RDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS
..: :. :.. :. :::. :: :
XP_011 QDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLM
20 30 40 50 60 70
190 200 210 220 230 240
pF1KB6 CVLKDDKPTLQLESVDPKN-YPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAEN
:. :.:::::. : . : . . : :.: . . . . :::. ::.:.:..:. .
XP_011 CAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGG
80 90 100 110 120 130
250 260
pF1KB6 MPVFLGGTKGGQDITDF--TMQFVSS
:..: : . ::: :: :
XP_011 CPLILTQELGKANTTDFGLTMLF
140 150
>>XP_005263696 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa)
initn: 159 init1: 96 opt: 191 Z-score: 234.1 bits: 50.3 E(85289): 2.7e-06
Smith-Waterman score: 191; 34.5% identity (59.3% similar) in 113 aa overlap (157-266:46-158)
130 140 150 160 170 180
pF1KB6 RDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS
..: :. :.. :. :::. :: :
XP_005 QDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLM
20 30 40 50 60 70
190 200 210 220 230 240
pF1KB6 CVLKDDKPTLQLESVDPKN-YPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAEN
:. :.:::::. : . : . . : :.: . . . . :::. ::.:.:..:. .
XP_005 CAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGG
80 90 100 110 120 130
250 260
pF1KB6 MPVFLGGTKGGQDITDF--TMQFVSS
:..: : . ::: :: :
XP_005 CPLILTQELGKANTTDFGLTMLF
140 150
>>NP_055255 (OMIM: 605509) interleukin-36 alpha [Homo sa (158 aa)
initn: 159 init1: 96 opt: 191 Z-score: 234.1 bits: 50.3 E(85289): 2.7e-06
Smith-Waterman score: 191; 34.5% identity (59.3% similar) in 113 aa overlap (157-266:46-158)
130 140 150 160 170 180
pF1KB6 RDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS
..: :. :.. :. :::. :: :
NP_055 QDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLM
20 30 40 50 60 70
190 200 210 220 230 240
pF1KB6 CVLKDDKPTLQLESVDPKN-YPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAEN
:. :.:::::. : . : . . : :.: . . . . :::. ::.:.:..:. .
NP_055 CAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGG
80 90 100 110 120 130
250 260
pF1KB6 MPVFLGGTKGGQDITDF--TMQFVSS
:..: : . ::: :: :
NP_055 CPLILTQELGKANTTDFGLTMLF
140 150
>>XP_005263718 (OMIM: 137215,147679,612628,612852) PREDI (143 aa)
initn: 174 init1: 94 opt: 184 Z-score: 226.6 bits: 48.7 E(85289): 7e-06
Smith-Waterman score: 184; 30.3% identity (57.2% similar) in 145 aa overlap (128-265:8-140)
100 110 120 130 140 150
pF1KB6 FEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVV
: .::.. . . .: : .::: .
XP_005 MQAFRIWDVNQKTFYLRNN-QLVAGYLQGPN------
10 20 30
160 170 180 190 200 210
pF1KB6 FSMSFVQGEESNDKIPVA-----LGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPK-KKM
:. ::. : .:. ::.. .. :::: . :. ::::.:. . . .:.
XP_005 -----VNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQ
40 50 60 70 80
220 230 240 250 260
pF1KB6 EKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKG-GQDITDFTMQFVSS
.:::.: . . . :::: :.:.. :.. ..:: : . : .: : .:
XP_005 DKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
90 100 110 120 130 140
>>NP_001305843 (OMIM: 137215,147679,612628,612852) inter (143 aa)
initn: 174 init1: 94 opt: 184 Z-score: 226.6 bits: 48.7 E(85289): 7e-06
Smith-Waterman score: 184; 30.3% identity (57.2% similar) in 145 aa overlap (128-265:8-140)
100 110 120 130 140 150
pF1KB6 FEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVV
: .::.. . . .: : .::: .
NP_001 MQAFRIWDVNQKTFYLRNN-QLVAGYLQGPN------
10 20 30
160 170 180 190 200 210
pF1KB6 FSMSFVQGEESNDKIPVA-----LGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPK-KKM
:. ::. : .:. ::.. .. :::: . :. ::::.:. . . .:.
NP_001 -----VNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQ
40 50 60 70 80
220 230 240 250 260
pF1KB6 EKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKG-GQDITDFTMQFVSS
.:::.: . . . :::: :.:.. :.. ..:: : . : .: : .:
NP_001 DKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
90 100 110 120 130 140
269 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 22:48:37 2016 done: Fri Nov 4 22:48:38 2016
Total Scan time: 5.850 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]