Result of FASTA (omim) for
pFN21AB8892
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8892, 215 aa
1>>>pF1KB8892 215 - 215 aa - 215 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1566+/-0.000282; mu= 8.6990+/- 0.018
mean_var=171.7542+/-35.390, 0's: 0 Z-trim(124.0): 60 B-trim: 443 in 2/54
Lambda= 0.097863
statistics sampled from 44794 (44859) to 44794 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.824), E-opt: 0.2 (0.526), width: 16
Scan time: 7.500
The best scores are: opt bits E(85289)
NP_004812 (OMIM: 602406) heart- and neural crest d ( 215) 1507 223.4 2.3e-58
XP_005268588 (OMIM: 602406) PREDICTED: heart- and ( 214) 1488 220.7 1.4e-57
NP_068808 (OMIM: 602407) heart- and neural crest d ( 217) 689 107.9 1.3e-23
NP_004600 (OMIM: 601010) transcription factor 15 [ ( 199) 250 45.9 5.7e-05
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 224 42.2 0.00073
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 224 42.2 0.00073
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189) 206 39.6 0.0041
NP_005589 (OMIM: 162360) helix-loop-helix protein ( 133) 202 38.9 0.0047
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 196 38.1 0.0093
>>NP_004812 (OMIM: 602406) heart- and neural crest deriv (215 aa)
initn: 1507 init1: 1507 opt: 1507 Z-score: 1168.9 bits: 223.4 E(85289): 2.3e-58
Smith-Waterman score: 1507; 100.0% identity (100.0% similar) in 215 aa overlap (1-215:1-215)
10 20 30 40 50 60
pF1KB8 MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELREC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELREC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 IPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRE
130 140 150 160 170 180
190 200 210
pF1KB8 LQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
:::::::::::::::::::::::::::::::::::
NP_004 LQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
190 200 210
>>XP_005268588 (OMIM: 602406) PREDICTED: heart- and neur (214 aa)
initn: 1319 init1: 1264 opt: 1488 Z-score: 1154.5 bits: 220.7 E(85289): 1.4e-57
Smith-Waterman score: 1488; 99.5% identity (99.5% similar) in 215 aa overlap (1-215:1-214)
10 20 30 40 50 60
pF1KB8 MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 PPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELREC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELREC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 IPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRE
130 140 150 160 170 180
190 200 210
pF1KB8 LQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
:: ::::::::::::::::::::::::::::::::
XP_005 LQ-HEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
190 200 210
>>NP_068808 (OMIM: 602407) heart- and neural crest deriv (217 aa)
initn: 678 init1: 386 opt: 689 Z-score: 544.7 bits: 107.9 E(85289): 1.3e-23
Smith-Waterman score: 689; 54.2% identity (73.6% similar) in 227 aa overlap (1-215:1-217)
10 20 30 40 50
pF1KB8 MNLVGSYAHH---HHHHHPHPAHPMLHEPFLFGPASRC-HQERPYFQSWLLS-PADAAPD
:.:::.. :: ::. .: : . :::: :.: :::..::.. : . ::
NP_068 MSLVGGFPHHPVVHHEGYPFAAAAAAAAA---AAASRCSHEENPYFHGWLIGHPEMSPPD
10 20 30 40 50
60 70 80 90 100
pF1KB8 FPAG---GPPPAAAAAA---TAYGPDARPGQSPGRLEALGG-RLGRRKGSGPKKERRRTE
. . .: :..::. . :: . :: .: .::: : .:.:.. .::::::.
NP_068 YSMALSYSPEYASGAAGLDHSHYG-GVPPGAGP---PGLGGPRPVKRRGTANRKERRRTQ
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB8 SINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKK
::::::::::::::::::::::::::::::::::::::::.:::: :.:. ::::::.::
NP_068 SINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKK
120 130 140 150 160 170
170 180 190 200 210
pF1KB8 ADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
.: .: :::.:: .: . ... .:. ::::::::.::::::.:
NP_068 TDV-KEEKRKKEL--NEILKSTVSSNDKKTKGRTGWPQHVWALELKQ
180 190 200 210
>>NP_004600 (OMIM: 601010) transcription factor 15 [Homo (199 aa)
initn: 252 init1: 201 opt: 250 Z-score: 210.2 bits: 45.9 E(85289): 5.7e-05
Smith-Waterman score: 250; 43.0% identity (65.3% similar) in 121 aa overlap (73-176:43-162)
50 60 70 80 90
pF1KB8 QSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDAR---PGQSPGRLEALGGRLG-----R
::.: :: . :: . :: : :
NP_004 VLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPVVVVR
20 30 40 50 60 70
100 110 120 130 140 150
pF1KB8 RKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVL--AK
.. .. .:: ::.:.:.::. :: ::. :.: :::::.:::::.::::.: .:: .
NP_004 QRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLGD
80 90 100 110 120 130
160 170 180 190 200
pF1KB8 DAQSGDPEAFKAELKK-------ADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWP
.:..:.: :.: . :::::. .
NP_004 SADDGQP-CFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGV
140 150 160 170 180 190
210
pF1KB8 QQVWALELNQ
NP_004 APLRGPRR
>>NP_001073983 (OMIM: 609067) basic helix-loop-helix tra (201 aa)
initn: 218 init1: 218 opt: 224 Z-score: 190.3 bits: 42.2 E(85289): 0.00073
Smith-Waterman score: 230; 35.2% identity (54.5% similar) in 145 aa overlap (64-208:56-178)
40 50 60 70 80 90
pF1KB8 RCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLG
:.. : . :: .:::. :
NP_001 EDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRRAGGGGPGGRPGREP-----------
30 40 50 60 70
100 110 120 130 140 150
pF1KB8 RRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKD
:.. .. .:: ::.:.:.::. :: ::. ::: :::::.:::::.:::..: .::
NP_001 RQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLAG
80 90 100 110 120 130
160 170 180 190 200 210
pF1KB8 AQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALEL
:: . .. : . : : :: : :.. :.:.
NP_001 EACGDGQPCHS------GPAFFHAARA-----GSPPPPPPPPPARDGENTQPKQICTFCL
140 150 160 170 180
pF1KB8 NQ
NP_001 SNQRKLSKDRDRKTAIRS
190 200
>>XP_006716679 (OMIM: 609067) PREDICTED: basic helix-loo (201 aa)
initn: 218 init1: 218 opt: 224 Z-score: 190.3 bits: 42.2 E(85289): 0.00073
Smith-Waterman score: 230; 35.2% identity (54.5% similar) in 145 aa overlap (64-208:56-178)
40 50 60 70 80 90
pF1KB8 RCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLG
:.. : . :: .:::. :
XP_006 EDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRRAGGGGPGGRPGREP-----------
30 40 50 60 70
100 110 120 130 140 150
pF1KB8 RRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKD
:.. .. .:: ::.:.:.::. :: ::. ::: :::::.:::::.:::..: .::
XP_006 RQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLAG
80 90 100 110 120 130
160 170 180 190 200 210
pF1KB8 AQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALEL
:: . .. : . : : :: : :.. :.:.
XP_006 EACGDGQPCHS------GPAFFHAARA-----GSPPPPPPPPPARDGENTQPKQICTFCL
140 150 160 170 180
pF1KB8 NQ
XP_006 SNQRKLSKDRDRKTAIRS
190 200
>>NP_803238 (OMIM: 608606) class A basic helix-loop-heli (189 aa)
initn: 233 init1: 150 opt: 206 Z-score: 176.9 bits: 39.6 E(85289): 0.0041
Smith-Waterman score: 228; 32.8% identity (56.5% similar) in 177 aa overlap (33-200:5-173)
10 20 30 40 50 60
pF1KB8 LVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPD--FPAGG
.: ..: :. .:....:: .: :
NP_803 MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPG
10 20 30
70 80 90 100 110
pF1KB8 PPPAAAAAATAYGPDAR-PGQSPGRLEALGGRLGRRKGS------GPKKERRRTESINSA
: :: . . :: ::.. : . .: ::: .: . ..::.: ...:.:
NP_803 PEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNA
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB8 FAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGR
: ::: ::.: :: :::::.:: :: .:: : .. ..: : .. : .
NP_803 FQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGL------EGPGPK
100 110 120 130 140
180 190 200 210
pF1KB8 ESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
.. .. :: : ::: .: . .:
NP_803 LYQHYQQQQQVAG--GALGATEAQPQGHLQRYSTQIHSFREGT
150 160 170 180
>>NP_005589 (OMIM: 162360) helix-loop-helix protein 1 [H (133 aa)
initn: 197 init1: 175 opt: 202 Z-score: 175.8 bits: 38.9 E(85289): 0.0047
Smith-Waterman score: 211; 43.1% identity (63.3% similar) in 109 aa overlap (52-150:30-131)
30 40 50 60 70 80
pF1KB8 MLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQS
:.:: : :.. ... : ::. ::.
NP_005 MMLNSDTMELDLPPTHSETESGFSDCGGGAGPD----GAGPGGPGGGQARGPE--PGE-
10 20 30 40 50
90 100 110 120 130
pF1KB8 PGR--LEALGGRLGRRKGSGPKK--------ERRRTESINSAFAELRECIPNVPADTKLS
::: :. :. . ::. . : :: :.:..: ::::::. .:..: : :::
NP_005 PGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLS
60 70 80 90 100 110
140 150 160 170 180 190
pF1KB8 KIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPAL
::. :::: ::.:: ::
NP_005 KIEILRLAICYISYLNHVLDV
120 130
>>NP_660161 (OMIM: 609875) protein atonal homolog 7 [Hom (152 aa)
initn: 198 init1: 162 opt: 196 Z-score: 170.5 bits: 38.1 E(85289): 0.0093
Smith-Waterman score: 196; 38.2% identity (61.8% similar) in 102 aa overlap (57-157:6-103)
30 40 50 60 70 80
pF1KB8 FLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPD-ARPGQSPGRL
:.: : : .: : : . : . :::
NP_660 MKSCKPSGPPAGARVAPPCAGGTECAGTCAGAGRL
10 20 30
90 100 110 120 130 140
pF1KB8 EALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAY
:. . ::. .. .:::: ...:.:: .::. .:. : :::: .::..: :::
NP_660 ESAA----RRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIMA
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB8 LMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWP
: .::. . :
NP_660 LTRILAEAERFGSERDWVGLHCEHFGRDHYLPFPGAKLPGESELYSQRLFGFQPEPFQMA
100 110 120 130 140 150
215 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:20:08 2016 done: Fri Nov 4 20:20:09 2016
Total Scan time: 7.500 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]