Result of FASTA (omim) for
pFN21AE0487
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0487, 357 aa
1>>>pF1KE0487 357 - 357 aa - 357 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0755+/-0.000358; mu= 17.9756+/- 0.022
mean_var=63.0132+/-12.513, 0's: 0 Z-trim(112.4): 14 B-trim: 0 in 0/55
Lambda= 0.161569
statistics sampled from 21310 (21319) to 21310 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.25), width: 16
Scan time: 6.850
The best scores are: opt bits E(85289)
XP_016873774 (OMIM: 616587) PREDICTED: protein FAM ( 350) 1025 247.6 3.2e-65
NP_001317375 (OMIM: 616587) protein FAM118B isofor ( 350) 1025 247.6 3.2e-65
XP_011541279 (OMIM: 616587) PREDICTED: protein FAM ( 351) 1025 247.6 3.2e-65
NP_078832 (OMIM: 616587) protein FAM118B isoform 1 ( 351) 1025 247.6 3.2e-65
XP_016873775 (OMIM: 616587) PREDICTED: protein FAM ( 195) 471 118.3 1.5e-26
XP_011541280 (OMIM: 616587) PREDICTED: protein FAM ( 196) 471 118.3 1.5e-26
>>XP_016873774 (OMIM: 616587) PREDICTED: protein FAM118B (350 aa)
initn: 1065 init1: 639 opt: 1025 Z-score: 1292.0 bits: 247.6 E(85289): 3.2e-65
Smith-Waterman score: 1025; 52.4% identity (81.1% similar) in 296 aa overlap (13-306:26-321)
10 20 30 40
pF1KE0 MDSVEKTTNRSEQKSRKFLKSLIRKQPQELLLVIGTGVSAAVAPGIP
.: ::.: :: :.:.::.::::::.:::::: .:
XP_016 MASTGSQASDIDEIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 ALCSWRSCIEAVIEAAEQLEVLHPGDVAEFRRKVTKDRDLLVVAHDLIRKMSPRTGDAKP
:: ::.. :.:...:: ....:. . .:.. . .:..:. ::::::.:.::::....
XP_016 ALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 SFFQDCLMEVFDDLEQHIRSP--LVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPME
.::.:::.:::::::..... .:::.: ::. ::.:::::.::::: .. :.: .:
XP_016 TFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 SLDLKDKTKVLEWARGHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYR
:::: :. ::::::. . : .::::::.::.: :.:: :.::..: ...:::. .:.::.
XP_016 SLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 TKSFLFVGCGETLHDQIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKV
.:::::.::: :. : :::::: .: .: ::::.::: . . :.: : . .:: .::::
XP_016 NKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 VSYGDCFDHFPGYVQDLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKK
.:::: . .: : . :. .:
XP_016 ISYGDDYADLPEYFKRLTCEISTRGTSGMVREGQLNGSSAAHSEIRGCST
310 320 330 340 350
>>NP_001317375 (OMIM: 616587) protein FAM118B isoform 2 (350 aa)
initn: 1065 init1: 639 opt: 1025 Z-score: 1292.0 bits: 247.6 E(85289): 3.2e-65
Smith-Waterman score: 1025; 52.4% identity (81.1% similar) in 296 aa overlap (13-306:26-321)
10 20 30 40
pF1KE0 MDSVEKTTNRSEQKSRKFLKSLIRKQPQELLLVIGTGVSAAVAPGIP
.: ::.: :: :.:.::.::::::.:::::: .:
NP_001 MASTGSQASDIDEIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 ALCSWRSCIEAVIEAAEQLEVLHPGDVAEFRRKVTKDRDLLVVAHDLIRKMSPRTGDAKP
:: ::.. :.:...:: ....:. . .:.. . .:..:. ::::::.:.::::....
NP_001 ALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 SFFQDCLMEVFDDLEQHIRSP--LVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPME
.::.:::.:::::::..... .:::.: ::. ::.:::::.::::: .. :.: .:
NP_001 TFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 SLDLKDKTKVLEWARGHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYR
:::: :. ::::::. . : .::::::.::.: :.:: :.::..: ...:::. .:.::.
NP_001 SLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 TKSFLFVGCGETLHDQIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKV
.:::::.::: :. : :::::: .: .: ::::.::: . . :.: : . .:: .::::
NP_001 NKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 VSYGDCFDHFPGYVQDLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKK
.:::: . .: : . :. .:
NP_001 ISYGDDYADLPEYFKRLTCEISTRGTSGMVREGQLNGSSAAHSEIRGCST
310 320 330 340 350
>>XP_011541279 (OMIM: 616587) PREDICTED: protein FAM118B (351 aa)
initn: 1065 init1: 639 opt: 1025 Z-score: 1291.9 bits: 247.6 E(85289): 3.2e-65
Smith-Waterman score: 1025; 52.4% identity (81.1% similar) in 296 aa overlap (13-306:26-321)
10 20 30 40
pF1KE0 MDSVEKTTNRSEQKSRKFLKSLIRKQPQELLLVIGTGVSAAVAPGIP
.: ::.: :: :.:.::.::::::.:::::: .:
XP_011 MASTGSQASDIDEIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 ALCSWRSCIEAVIEAAEQLEVLHPGDVAEFRRKVTKDRDLLVVAHDLIRKMSPRTGDAKP
:: ::.. :.:...:: ....:. . .:.. . .:..:. ::::::.:.::::....
XP_011 ALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 SFFQDCLMEVFDDLEQHIRSP--LVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPME
.::.:::.:::::::..... .:::.: ::. ::.:::::.::::: .. :.: .:
XP_011 TFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 SLDLKDKTKVLEWARGHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYR
:::: :. ::::::. . : .::::::.::.: :.:: :.::..: ...:::. .:.::.
XP_011 SLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 TKSFLFVGCGETLHDQIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKV
.:::::.::: :. : :::::: .: .: ::::.::: . . :.: : . .:: .::::
XP_011 NKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 VSYGDCFDHFPGYVQDLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKK
.:::: . .: : . :. .:
XP_011 ISYGDDYADLPEYFKRLTCEISTRGTSAGMVREGQLNGSSAAHSEIRGCST
310 320 330 340 350
>>NP_078832 (OMIM: 616587) protein FAM118B isoform 1 [Ho (351 aa)
initn: 1065 init1: 639 opt: 1025 Z-score: 1291.9 bits: 247.6 E(85289): 3.2e-65
Smith-Waterman score: 1025; 52.4% identity (81.1% similar) in 296 aa overlap (13-306:26-321)
10 20 30 40
pF1KE0 MDSVEKTTNRSEQKSRKFLKSLIRKQPQELLLVIGTGVSAAVAPGIP
.: ::.: :: :.:.::.::::::.:::::: .:
NP_078 MASTGSQASDIDEIFGFFNDGEPPTKKPRKLLPSLKTKKPRELVLVIGTGISAAVAPQVP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 ALCSWRSCIEAVIEAAEQLEVLHPGDVAEFRRKVTKDRDLLVVAHDLIRKMSPRTGDAKP
:: ::.. :.:...:: ....:. . .:.. . .:..:. ::::::.:.::::....
NP_078 ALKSWKGLIQALLDAAIDFDLLEDEESKKFQKCLHEDKNLVHVAHDLIQKLSPRTSNVRS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 SFFQDCLMEVFDDLEQHIRSP--LVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPME
.::.:::.:::::::..... .:::.: ::. ::.:::::.::::: .. :.: .:
NP_078 TFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLTTNFDNLLELYAADQGKQLE
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 SLDLKDKTKVLEWARGHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYR
:::: :. ::::::. . : .::::::.::.: :.:: :.::..: ...:::. .:.::.
NP_078 SLDLTDEKKVLEWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYE
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 TKSFLFVGCGETLHDQIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKV
.:::::.::: :. : :::::: .: .: ::::.::: . . :.: : . .:: .::::
NP_078 NKSFLFLGCGWTVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 VSYGDCFDHFPGYVQDLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKK
.:::: . .: : . :. .:
NP_078 ISYGDDYADLPEYFKRLTCEISTRGTSAGMVREGQLNGSSAAHSEIRGCST
310 320 330 340 350
>>XP_016873775 (OMIM: 616587) PREDICTED: protein FAM118B (195 aa)
initn: 493 init1: 468 opt: 471 Z-score: 597.8 bits: 118.3 E(85289): 1.5e-26
Smith-Waterman score: 471; 47.5% identity (73.1% similar) in 160 aa overlap (148-306:7-166)
120 130 140 150 160 170
pF1KE0 FDDLEQHIRSPLVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPMES-LDLKDKTKVL
: : : . :.. . . : : ..::
XP_016 MQQIRGNSLNPLTLLMRKRCSALPSWLGYMCVVQVL
10 20 30
180 190 200 210 220 230
pF1KE0 EWARGHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYRTKSFLFVGCGE
:::. . : .::::::.::.: :.:: :.::..: ...:::. .:.::..:::::.:::
XP_016 EWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGW
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE0 TLHDQIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKVVSYGDCFDHFP
:. : :::::: .: .: ::::.::: . . :.: : . .:: .::::.:::: . .:
XP_016 TVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGDDYADLP
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE0 GYVQDLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKKRTQSDTDDAGG
: . :. .:
XP_016 EYFKRLTCEISTRGTSGMVREGQLNGSSAAHSEIRGCST
160 170 180 190
>>XP_011541280 (OMIM: 616587) PREDICTED: protein FAM118B (196 aa)
initn: 493 init1: 468 opt: 471 Z-score: 597.8 bits: 118.3 E(85289): 1.5e-26
Smith-Waterman score: 471; 47.5% identity (73.1% similar) in 160 aa overlap (148-306:7-166)
120 130 140 150 160 170
pF1KE0 FDDLEQHIRSPLVLQSILSLMDRGAMVLTTNYDNLLEAFGRRQNKPMES-LDLKDKTKVL
: : : . :.. . . : : ..::
XP_011 MQQIRGNSLNPLTLLMRKRCSALPSWLGYMCVVQVL
10 20 30
180 190 200 210 220 230
pF1KE0 EWARGHMKYGVLHIHGLYTDPCGVVLDPSGYKDVTQDAEVMEVLQNLYRTKSFLFVGCGE
:::. . : .::::::.::.: :.:: :.::..: ...:::. .:.::..:::::.:::
XP_011 EWAQEKRKLSVLHIHGVYTNPSGIVLHPAGYQNVLRNTEVMREIQKLYENKSFLFLGCGW
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE0 TLHDQIFQALFLYSVPNKVDLEHYMLVLKENEDHFFKHQADMLLHGIKVVSYGDCFDHFP
:. : :::::: .: .: ::::.::: . . :.: : . .:: .::::.:::: . .:
XP_011 TVDDTTFQALFLEAVKHKSDLEHFMLVRRGDVDEFKKLRENMLDKGIKVISYGDDYADLP
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE0 GYVQDLATQICKQQSPDADRVDSTTLLGNACQDCAKRKLEENGIEVSKKRTQSDTDDAGG
: . :. .:
XP_011 EYFKRLTCEISTRGTSAGMVREGQLNGSSAAHSEIRGCST
160 170 180 190
357 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 04:52:07 2016 done: Thu Nov 3 04:52:08 2016
Total Scan time: 6.850 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]