Result of FASTA (omim) for
pFN21AB3134
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3134, 1230 aa
1>>>pF1KB3134 1230 - 1230 aa - 1230 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.3561+/-0.000531; mu= -1.5741+/- 0.033
mean_var=271.0442+/-55.201, 0's: 0 Z-trim(115.9): 307 B-trim: 72 in 1/49
Lambda= 0.077903
statistics sampled from 26257 (26613) to 26257 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.312), width: 16
Scan time: 15.460
The best scores are: opt bits E(85289)
NP_004013 (OMIM: 300376,300377,302045,310200) dyst (1230) 8129 928.6 0
XP_006724533 (OMIM: 300376,300377,302045,310200) P (3690) 8135 929.5 0
XP_016884817 (OMIM: 300376,300377,302045,310200) P (3672) 7942 907.8 0
XP_016884820 (OMIM: 300376,300377,302045,310200) P (1761) 6332 726.7 3.2e-208
NP_004004 (OMIM: 300376,300377,302045,310200) dyst (1225) 6326 725.9 3.9e-208
NP_004012 (OMIM: 300376,300377,302045,310200) dyst (1243) 6326 725.9 3.9e-208
XP_006724536 (OMIM: 300376,300377,302045,310200) P (3657) 6332 726.9 5.8e-208
XP_011543769 (OMIM: 300376,300377,302045,310200) P (3662) 6332 726.9 5.8e-208
XP_006724532 (OMIM: 300376,300377,302045,310200) P (3695) 6332 726.9 5.9e-208
XP_006724531 (OMIM: 300376,300377,302045,310200) P (3703) 6332 726.9 5.9e-208
NP_004003 (OMIM: 300376,300377,302045,310200) dyst (2341) 6326 726.1 6.5e-208
NP_004002 (OMIM: 300376,300377,302045,310200) dyst (2344) 6326 726.1 6.5e-208
NP_004001 (OMIM: 300376,300377,302045,310200) dyst (3562) 6326 726.2 9.1e-208
NP_000100 (OMIM: 300376,300377,302045,310200) dyst (3677) 6326 726.2 9.4e-208
NP_004000 (OMIM: 300376,300377,302045,310200) dyst (3681) 6326 726.2 9.4e-208
NP_003997 (OMIM: 300376,300377,302045,310200) dyst (3685) 6326 726.2 9.4e-208
NP_004011 (OMIM: 300376,300377,302045,310200) dyst (1115) 6302 723.2 2.3e-207
NP_004014 (OMIM: 300376,300377,302045,310200) dyst (1133) 6302 723.2 2.3e-207
XP_006724538 (OMIM: 300376,300377,302045,310200) P (3575) 6308 724.2 3.7e-207
XP_006724537 (OMIM: 300376,300377,302045,310200) P (3593) 6308 724.2 3.7e-207
XP_011543770 (OMIM: 300376,300377,302045,310200) P (3295) 5320 613.1 9.3e-174
XP_016866733 (OMIM: 128240) PREDICTED: utrophin is (3456) 4938 570.2 8.1e-161
NP_004005 (OMIM: 300376,300377,302045,310200) dyst ( 956) 4531 524.1 1.7e-147
NP_004009 (OMIM: 300376,300377,302045,310200) dyst ( 622) 4133 479.3 3.5e-134
XP_005267190 (OMIM: 128240) PREDICTED: utrophin is (3424) 4018 466.8 1.1e-129
XP_011534409 (OMIM: 128240) PREDICTED: utrophin is (3424) 4018 466.8 1.1e-129
XP_005267187 (OMIM: 128240) PREDICTED: utrophin is (3433) 4018 466.8 1.1e-129
XP_011534408 (OMIM: 128240) PREDICTED: utrophin is (3433) 4018 466.8 1.1e-129
NP_009055 (OMIM: 128240) utrophin [Homo sapiens] (3433) 4018 466.8 1.1e-129
XP_005267184 (OMIM: 128240) PREDICTED: utrophin is (3438) 4018 466.8 1.1e-129
XP_016866732 (OMIM: 128240) PREDICTED: utrophin is (3468) 4018 466.8 1.1e-129
XP_011534404 (OMIM: 128240) PREDICTED: utrophin is (3469) 4018 466.8 1.1e-129
XP_011534403 (OMIM: 128240) PREDICTED: utrophin is (3469) 4018 466.8 1.1e-129
NP_004008 (OMIM: 300376,300377,302045,310200) dyst ( 604) 3940 457.6 1.2e-127
XP_006715623 (OMIM: 128240) PREDICTED: utrophin is ( 957) 3312 387.1 3e-106
XP_011534411 (OMIM: 128240) PREDICTED: utrophin is ( 988) 3309 386.8 3.8e-106
NP_001164655 (OMIM: 300052) dystrophin-related pro ( 879) 3290 384.6 1.5e-105
NP_001930 (OMIM: 300052) dystrophin-related protei ( 957) 3290 384.6 1.6e-105
XP_016884823 (OMIM: 300052) PREDICTED: dystrophin- ( 611) 2415 286.2 4.6e-76
NP_004006 (OMIM: 300376,300377,302045,310200) dyst ( 617) 2330 276.6 3.5e-73
NP_004007 (OMIM: 300376,300377,302045,310200) dyst ( 635) 2330 276.6 3.6e-73
NP_004010 (OMIM: 300376,300377,302045,310200) dyst ( 340) 2295 272.5 3.3e-72
XP_016884822 (OMIM: 300052) PREDICTED: dystrophin- ( 932) 2014 241.2 2.4e-62
XP_016866734 (OMIM: 128240) PREDICTED: utrophin is (2675) 1174 147.1 1.5e-33
NP_068707 (OMIM: 602415) dystrobrevin beta isoform ( 627) 687 92.0 1.4e-17
NP_899204 (OMIM: 602415) dystrobrevin beta isoform ( 609) 668 89.8 5.9e-17
NP_001307865 (OMIM: 602415) dystrobrevin beta isof ( 625) 668 89.8 6e-17
NP_149159 (OMIM: 602415) dystrobrevin beta isoform ( 597) 656 88.5 1.5e-16
XP_016881072 (OMIM: 601239,604169) PREDICTED: dyst ( 712) 654 88.3 2e-16
XP_005264239 (OMIM: 602415) PREDICTED: dystrobrevi ( 602) 641 86.8 4.8e-16
>>NP_004013 (OMIM: 300376,300377,302045,310200) dystroph (1230 aa)
initn: 8129 init1: 8129 opt: 8129 Z-score: 4952.9 bits: 928.6 E(85289): 0
Smith-Waterman score: 8129; 99.9% identity (100.0% similar) in 1230 aa overlap (1-1230:1-1230)
10 20 30 40 50 60
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
NP_004 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPASSPQLSHDDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPASSPQLSHDDT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 HSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQ
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 ILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSP
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 RDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB3 PSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGH
1150 1160 1170 1180 1190 1200
1210 1220 1230
pF1KB3 NVGSLFHMADDLGRAMESLVSVMTDEEGAE
::::::::::::::::::::::::::::::
NP_004 NVGSLFHMADDLGRAMESLVSVMTDEEGAE
1210 1220 1230
>>XP_006724533 (OMIM: 300376,300377,302045,310200) PREDI (3690 aa)
initn: 8135 init1: 8135 opt: 8135 Z-score: 4949.6 bits: 929.5 E(85289): 0
Smith-Waterman score: 8135; 100.0% identity (100.0% similar) in 1230 aa overlap (1-1230:2461-3690)
10 20 30
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLD
::::::::::::::::::::::::::::::
XP_006 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
2440 2450 2460 2470 2480 2490
40 50 60 70 80 90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
2500 2510 2520 2530 2540 2550
100 110 120 130 140 150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
2560 2570 2580 2590 2600 2610
160 170 180 190 200 210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
2620 2630 2640 2650 2660 2670
220 230 240 250 260 270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
2680 2690 2700 2710 2720 2730
280 290 300 310 320 330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
2740 2750 2760 2770 2780 2790
340 350 360 370 380 390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
2800 2810 2820 2830 2840 2850
400 410 420 430 440 450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
2860 2870 2880 2890 2900 2910
460 470 480 490 500 510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
2920 2930 2940 2950 2960 2970
520 530 540 550 560 570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
2980 2990 3000 3010 3020 3030
580 590 600 610 620 630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
3040 3050 3060 3070 3080 3090
640 650 660 670 680 690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
3100 3110 3120 3130 3140 3150
700 710 720 730 740 750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
3160 3170 3180 3190 3200 3210
760 770 780 790 800 810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
3220 3230 3240 3250 3260 3270
820 830 840 850 860 870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
3280 3290 3300 3310 3320 3330
880 890 900 910 920 930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
3340 3350 3360 3370 3380 3390
940 950 960 970 980 990
pF1KB3 RMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNE
3400 3410 3420 3430 3440 3450
1000 1010 1020 1030 1040 1050
pF1KB3 SIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAE
3460 3470 3480 3490 3500 3510
1060 1070 1080 1090 1100 1110
pF1KB3 YDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHN
3520 3530 3540 3550 3560 3570
1120 1130 1140 1150 1160 1170
pF1KB3 KQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEE
3580 3590 3600 3610 3620 3630
1180 1190 1200 1210 1220 1230
pF1KB3 DLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
3640 3650 3660 3670 3680 3690
>--
initn: 257 init1: 158 opt: 313 Z-score: 198.5 bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1985-2426)
10 20
pF1KB3 MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
: .. ::. . . . :.... : .
XP_006 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
1960 1970 1980 1990 2000 2010
30 40 50 60 70 80
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
.:.... . . :.::. .. . : ..:.: ... .: . .. .... :.
XP_006 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
2020 2030 2040 2050 2060 2070
90 100 110 120 130
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
. . . ... ::..:.. ..:. .... .: .::: :::: : ..
XP_006 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
2080 2090 2100 2110 2120 2130
140 150 160 170 180 190
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
. :.:... : :.: . : :: : . : . ..... : :. .
XP_006 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
2140 2150 2160 2170 2180
200 210 220 230 240 250
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
. ..: :. . :..:.:. ::: . .:..: ::..:. :: ::.. :.. .
XP_006 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
2190 2200 2210 2220 2230 2240
260 270 280 290 300 310
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
....: : . :: :... :: . ..:.:.. .: : : .. :. .
XP_006 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
2250 2260 2270 2280 2290
320 330 340 350 360
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
: . :..: .. . :. .:..... .. :.:. .:..::.::. .... :.
XP_006 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
2300 2310 2320 2330 2340 2350
370 380 390 400 410 420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
: : : ::: :: ::.. ... .: ..:. . . . .. . .: ..
XP_006 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
2360 2370 2380 2390 2400 2410
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
...: :: : :.
XP_006 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
2420 2430 2440 2450 2460 2470
>>XP_016884817 (OMIM: 300376,300377,302045,310200) PREDI (3672 aa)
initn: 8185 init1: 7942 opt: 7942 Z-score: 4832.4 bits: 907.8 E(85289): 0
Smith-Waterman score: 7942; 99.9% identity (100.0% similar) in 1201 aa overlap (1-1201:2461-3661)
10 20 30
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLD
::::::::::::::::::::::::::::::
XP_016 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
2440 2450 2460 2470 2480 2490
40 50 60 70 80 90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
2500 2510 2520 2530 2540 2550
100 110 120 130 140 150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
2560 2570 2580 2590 2600 2610
160 170 180 190 200 210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
2620 2630 2640 2650 2660 2670
220 230 240 250 260 270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
2680 2690 2700 2710 2720 2730
280 290 300 310 320 330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
2740 2750 2760 2770 2780 2790
340 350 360 370 380 390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
2800 2810 2820 2830 2840 2850
400 410 420 430 440 450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
2860 2870 2880 2890 2900 2910
460 470 480 490 500 510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
2920 2930 2940 2950 2960 2970
520 530 540 550 560 570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
2980 2990 3000 3010 3020 3030
580 590 600 610 620 630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
3040 3050 3060 3070 3080 3090
640 650 660 670 680 690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
3100 3110 3120 3130 3140 3150
700 710 720 730 740 750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
3160 3170 3180 3190 3200 3210
760 770 780 790 800 810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
3220 3230 3240 3250 3260 3270
820 830 840 850 860 870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
3280 3290 3300 3310 3320 3330
880 890 900 910 920 930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
3340 3350 3360 3370 3380 3390
940 950 960 970 980 990
pF1KB3 RMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMGYLPVQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNE
3400 3410 3420 3430 3440 3450
1000 1010 1020 1030 1040 1050
pF1KB3 SIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAE
3460 3470 3480 3490 3500 3510
1060 1070 1080 1090 1100 1110
pF1KB3 YDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHN
3520 3530 3540 3550 3560 3570
1120 1130 1140 1150 1160 1170
pF1KB3 KQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEE
3580 3590 3600 3610 3620 3630
1180 1190 1200 1210 1220 1230
pF1KB3 DLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
:::::::::::::::::::::::::::::.:
XP_016 DLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
3640 3650 3660 3670
>--
initn: 257 init1: 158 opt: 313 Z-score: 198.5 bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1985-2426)
10 20
pF1KB3 MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
: .. ::. . . . :.... : .
XP_016 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
1960 1970 1980 1990 2000 2010
30 40 50 60 70 80
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
.:.... . . :.::. .. . : ..:.: ... .: . .. .... :.
XP_016 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
2020 2030 2040 2050 2060 2070
90 100 110 120 130
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
. . . ... ::..:.. ..:. .... .: .::: :::: : ..
XP_016 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
2080 2090 2100 2110 2120 2130
140 150 160 170 180 190
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
. :.:... : :.: . : :: : . : . ..... : :. .
XP_016 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
2140 2150 2160 2170 2180
200 210 220 230 240 250
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
. ..: :. . :..:.:. ::: . .:..: ::..:. :: ::.. :.. .
XP_016 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
2190 2200 2210 2220 2230 2240
260 270 280 290 300 310
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
....: : . :: :... :: . ..:.:.. .: : : .. :. .
XP_016 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
2250 2260 2270 2280 2290
320 330 340 350 360
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
: . :..: .. . :. .:..... .. :.:. .:..::.::. .... :.
XP_016 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
2300 2310 2320 2330 2340 2350
370 380 390 400 410 420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
: : : ::: :: ::.. ... .: ..:. . . . .. . .: ..
XP_016 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
2360 2370 2380 2390 2400 2410
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
...: :: : :.
XP_016 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
2420 2430 2440 2450 2460 2470
>>XP_016884820 (OMIM: 300376,300377,302045,310200) PREDI (1761 aa)
initn: 6356 init1: 6309 opt: 6332 Z-score: 3859.1 bits: 726.7 E(85289): 3.2e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:519-1761)
10 20 30
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLD
::::::::::::::::::::::::::::::
XP_016 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
490 500 510 520 530 540
40 50 60 70 80 90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
550 560 570 580 590 600
100 110 120 130 140 150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
610 620 630 640 650 660
160 170 180 190 200 210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
670 680 690 700 710 720
220 230 240 250 260 270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
730 740 750 760 770 780
280 290 300 310 320 330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
790 800 810 820 830 840
340 350 360 370 380 390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
850 860 870 880 890 900
400 410 420 430 440 450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
910 920 930 940 950 960
460 470 480 490 500 510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
970 980 990 1000 1010 1020
520 530 540 550 560 570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
1030 1040 1050 1060 1070 1080
580 590 600 610 620 630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
1090 1100 1110 1120 1130 1140
640 650 660 670 680 690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
1150 1160 1170 1180 1190 1200
700 710 720 730 740 750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
1210 1220 1230 1240 1250 1260
760 770 780 790 800 810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
1270 1280 1290 1300 1310 1320
820 830 840 850 860 870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
1330 1340 1350 1360 1370 1380
880 890 900 910 920 930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
1390 1400 1410 1420 1430 1440
940 950 960 970
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
::::::::::::::::::: ::::::::::::::::::::::::::::
XP_016 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
1450 1460 1470 1480 1490 1500
980 990 1000 1010 1020 1030
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
1510 1520 1530 1540 1550 1560
1040 1050 1060 1070 1080 1090
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
1570 1580 1590 1600 1610 1620
1100 1110 1120 1130 1140 1150
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
1630 1640 1650 1660 1670 1680
1160 1170 1180 1190 1200 1210
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
1690 1700 1710 1720 1730 1740
1220 1230
pF1KB3 SLVSVMTDEEGAE
:::::::::::::
XP_016 SLVSVMTDEEGAE
1750 1760
>--
initn: 234 init1: 158 opt: 313 Z-score: 203.1 bits: 50.2 E(85289): 0.00014
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:43-484)
10 20
pF1KB3 MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
: .. ::. . . . :.... : .
XP_016 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
20 30 40 50 60 70
30 40 50 60 70 80
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
.:.... . . :.::. .. . : ..:.: ... .: . .. .... :.
XP_016 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
80 90 100 110 120 130
90 100 110 120 130
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
. . . ... ::..:.. ..:. .... .: .::: :::: : ..
XP_016 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
140 150 160 170 180
140 150 160 170 180 190
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
. :.:... : :.: . : :: : . : . ..... : :. .
XP_016 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
190 200 210 220 230
200 210 220 230 240 250
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
. ..: :. . :..:.:. ::: . .:..: ::..:. :: ::.. :.. .
XP_016 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
240 250 260 270 280 290
260 270 280 290 300 310
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
....: : . :: :... :: . ..:.:.. .: : : .. :. .
XP_016 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
300 310 320 330 340 350
320 330 340 350 360
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
: . :..: .. . :. .:..... .. :.:. .:..::.::. .... :.
XP_016 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
360 370 380 390 400 410
370 380 390 400 410 420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
: : : ::: :: ::.. ... .: ..:. . . . .. . .: ..
XP_016 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
420 430 440 450 460 470
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
...: :: : :.
XP_016 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
480 490 500 510 520 530
>>NP_004004 (OMIM: 300376,300377,302045,310200) dystroph (1225 aa)
initn: 7981 init1: 6303 opt: 6326 Z-score: 3857.8 bits: 725.9 E(85289): 3.9e-208
Smith-Waterman score: 7900; 98.8% identity (98.9% similar) in 1214 aa overlap (1-1201:1-1214)
10 20 30 40 50 60
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
NP_004 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
850 860 870 880 890 900
910 920 930 940
pF1KB3 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETP-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB3 --ASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB3 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB3 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB3 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230
pF1KB3 EQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
::::::::::::.:
NP_004 EQLNNSFPSSRGRNTPGKPMREDTM
1210 1220
>>NP_004012 (OMIM: 300376,300377,302045,310200) dystroph (1243 aa)
initn: 6350 init1: 6303 opt: 6326 Z-score: 3857.7 bits: 725.9 E(85289): 3.9e-208
Smith-Waterman score: 8093; 98.9% identity (99.0% similar) in 1243 aa overlap (1-1230:1-1243)
10 20 30 40 50 60
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
NP_004 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
850 860 870 880 890 900
910 920 930 940
pF1KB3 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETP-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KB3 --ASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB3 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB3 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB3 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230
pF1KB3 EQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
:::::::::::::::::::::::::::::::::::::::::::
NP_004 EQLNNSFPSSRGHNVGSLFHMADDLGRAMESLVSVMTDEEGAE
1210 1220 1230 1240
>>XP_006724536 (OMIM: 300376,300377,302045,310200) PREDI (3657 aa)
initn: 6309 init1: 6309 opt: 6332 Z-score: 3854.5 bits: 726.9 E(85289): 5.8e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:2415-3657)
10 20 30
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLD
::::::::::::::::::::::::::::::
XP_006 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
2390 2400 2410 2420 2430 2440
40 50 60 70 80 90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
2450 2460 2470 2480 2490 2500
100 110 120 130 140 150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
2510 2520 2530 2540 2550 2560
160 170 180 190 200 210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
2570 2580 2590 2600 2610 2620
220 230 240 250 260 270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
2630 2640 2650 2660 2670 2680
280 290 300 310 320 330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
2690 2700 2710 2720 2730 2740
340 350 360 370 380 390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
2750 2760 2770 2780 2790 2800
400 410 420 430 440 450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
2810 2820 2830 2840 2850 2860
460 470 480 490 500 510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
2870 2880 2890 2900 2910 2920
520 530 540 550 560 570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
2930 2940 2950 2960 2970 2980
580 590 600 610 620 630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
2990 3000 3010 3020 3030 3040
640 650 660 670 680 690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
3050 3060 3070 3080 3090 3100
700 710 720 730 740 750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
3110 3120 3130 3140 3150 3160
760 770 780 790 800 810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
3170 3180 3190 3200 3210 3220
820 830 840 850 860 870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
3230 3240 3250 3260 3270 3280
880 890 900 910 920 930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
3290 3300 3310 3320 3330 3340
940 950 960 970
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
::::::::::::::::::: ::::::::::::::::::::::::::::
XP_006 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
3350 3360 3370 3380 3390 3400
980 990 1000 1010 1020 1030
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
3410 3420 3430 3440 3450 3460
1040 1050 1060 1070 1080 1090
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
3470 3480 3490 3500 3510 3520
1100 1110 1120 1130 1140 1150
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
3530 3540 3550 3560 3570 3580
1160 1170 1180 1190 1200 1210
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
3590 3600 3610 3620 3630 3640
1220 1230
pF1KB3 SLVSVMTDEEGAE
:::::::::::::
XP_006 SLVSVMTDEEGAE
3650
>--
initn: 257 init1: 158 opt: 313 Z-score: 198.5 bits: 50.4 E(85289): 0.00025
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1939-2380)
10 20
pF1KB3 MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
: .. ::. . . . :.... : .
XP_006 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
1910 1920 1930 1940 1950 1960
30 40 50 60 70 80
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
.:.... . . :.::. .. . : ..:.: ... .: . .. .... :.
XP_006 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
1970 1980 1990 2000 2010 2020
90 100 110 120 130
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
. . . ... ::..:.. ..:. .... .: .::: :::: : ..
XP_006 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
2030 2040 2050 2060 2070 2080
140 150 160 170 180 190
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
. :.:... : :.: . : :: : . : . ..... : :. .
XP_006 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
2090 2100 2110 2120 2130
200 210 220 230 240 250
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
. ..: :. . :..:.:. ::: . .:..: ::..:. :: ::.. :.. .
XP_006 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
2140 2150 2160 2170 2180 2190
260 270 280 290 300 310
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
....: : . :: :... :: . ..:.:.. .: : : .. :. .
XP_006 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
2200 2210 2220 2230 2240
320 330 340 350 360
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
: . :..: .. . :. .:..... .. :.:. .:..::.::. .... :.
XP_006 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
2250 2260 2270 2280 2290 2300
370 380 390 400 410 420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
: : : ::: :: ::.. ... .: ..:. . . . .. . .: ..
XP_006 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
2310 2320 2330 2340 2350 2360
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
...: :: : :.
XP_006 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
2370 2380 2390 2400 2410 2420
>>XP_011543769 (OMIM: 300376,300377,302045,310200) PREDI (3662 aa)
initn: 6309 init1: 6309 opt: 6332 Z-score: 3854.5 bits: 726.9 E(85289): 5.8e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:2420-3662)
10 20 30
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLD
::::::::::::::::::::::::::::::
XP_011 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
2390 2400 2410 2420 2430 2440
40 50 60 70 80 90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
2450 2460 2470 2480 2490 2500
100 110 120 130 140 150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
2510 2520 2530 2540 2550 2560
160 170 180 190 200 210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
2570 2580 2590 2600 2610 2620
220 230 240 250 260 270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
2630 2640 2650 2660 2670 2680
280 290 300 310 320 330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
2690 2700 2710 2720 2730 2740
340 350 360 370 380 390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
2750 2760 2770 2780 2790 2800
400 410 420 430 440 450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
2810 2820 2830 2840 2850 2860
460 470 480 490 500 510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
2870 2880 2890 2900 2910 2920
520 530 540 550 560 570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
2930 2940 2950 2960 2970 2980
580 590 600 610 620 630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
2990 3000 3010 3020 3030 3040
640 650 660 670 680 690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
3050 3060 3070 3080 3090 3100
700 710 720 730 740 750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
3110 3120 3130 3140 3150 3160
760 770 780 790 800 810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
3170 3180 3190 3200 3210 3220
820 830 840 850 860 870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
3230 3240 3250 3260 3270 3280
880 890 900 910 920 930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
3290 3300 3310 3320 3330 3340
940 950 960 970
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
::::::::::::::::::: ::::::::::::::::::::::::::::
XP_011 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
3350 3360 3370 3380 3390 3400
980 990 1000 1010 1020 1030
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
3410 3420 3430 3440 3450 3460
1040 1050 1060 1070 1080 1090
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
3470 3480 3490 3500 3510 3520
1100 1110 1120 1130 1140 1150
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
3530 3540 3550 3560 3570 3580
1160 1170 1180 1190 1200 1210
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
3590 3600 3610 3620 3630 3640
1220 1230
pF1KB3 SLVSVMTDEEGAE
:::::::::::::
XP_011 SLVSVMTDEEGAE
3650 3660
>--
initn: 257 init1: 158 opt: 313 Z-score: 198.5 bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1944-2385)
10 20
pF1KB3 MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
: .. ::. . . . :.... : .
XP_011 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
1920 1930 1940 1950 1960 1970
30 40 50 60 70 80
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
.:.... . . :.::. .. . : ..:.: ... .: . .. .... :.
XP_011 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
1980 1990 2000 2010 2020 2030
90 100 110 120 130
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
. . . ... ::..:.. ..:. .... .: .::: :::: : ..
XP_011 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
2040 2050 2060 2070 2080
140 150 160 170 180 190
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
. :.:... : :.: . : :: : . : . ..... : :. .
XP_011 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
2090 2100 2110 2120 2130 2140
200 210 220 230 240 250
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
. ..: :. . :..:.:. ::: . .:..: ::..:. :: ::.. :.. .
XP_011 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
2150 2160 2170 2180 2190 2200
260 270 280 290 300 310
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
....: : . :: :... :: . ..:.:.. .: : : .. :. .
XP_011 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
2210 2220 2230 2240 2250
320 330 340 350 360
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
: . :..: .. . :. .:..... .. :.:. .:..::.::. .... :.
XP_011 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
2260 2270 2280 2290 2300 2310
370 380 390 400 410 420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
: : : ::: :: ::.. ... .: ..:. . . . .. . .: ..
XP_011 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
2320 2330 2340 2350 2360 2370
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
...: :: : :.
XP_011 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
2380 2390 2400 2410 2420 2430
>>XP_006724532 (OMIM: 300376,300377,302045,310200) PREDI (3695 aa)
initn: 6309 init1: 6309 opt: 6332 Z-score: 3854.5 bits: 726.9 E(85289): 5.9e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:2453-3695)
10 20 30
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLD
::::::::::::::::::::::::::::::
XP_006 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
2430 2440 2450 2460 2470 2480
40 50 60 70 80 90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
2490 2500 2510 2520 2530 2540
100 110 120 130 140 150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
2550 2560 2570 2580 2590 2600
160 170 180 190 200 210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
2610 2620 2630 2640 2650 2660
220 230 240 250 260 270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
2670 2680 2690 2700 2710 2720
280 290 300 310 320 330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
2730 2740 2750 2760 2770 2780
340 350 360 370 380 390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
2790 2800 2810 2820 2830 2840
400 410 420 430 440 450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
2850 2860 2870 2880 2890 2900
460 470 480 490 500 510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
2910 2920 2930 2940 2950 2960
520 530 540 550 560 570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
2970 2980 2990 3000 3010 3020
580 590 600 610 620 630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
3030 3040 3050 3060 3070 3080
640 650 660 670 680 690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
3090 3100 3110 3120 3130 3140
700 710 720 730 740 750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
3150 3160 3170 3180 3190 3200
760 770 780 790 800 810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
3210 3220 3230 3240 3250 3260
820 830 840 850 860 870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
3270 3280 3290 3300 3310 3320
880 890 900 910 920 930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
3330 3340 3350 3360 3370 3380
940 950 960 970
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
::::::::::::::::::: ::::::::::::::::::::::::::::
XP_006 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
3390 3400 3410 3420 3430 3440
980 990 1000 1010 1020 1030
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
3450 3460 3470 3480 3490 3500
1040 1050 1060 1070 1080 1090
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
3510 3520 3530 3540 3550 3560
1100 1110 1120 1130 1140 1150
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
3570 3580 3590 3600 3610 3620
1160 1170 1180 1190 1200 1210
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
3630 3640 3650 3660 3670 3680
1220 1230
pF1KB3 SLVSVMTDEEGAE
:::::::::::::
XP_006 SLVSVMTDEEGAE
3690
>--
initn: 257 init1: 158 opt: 313 Z-score: 198.5 bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1977-2418)
10 20
pF1KB3 MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
: .. ::. . . . :.... : .
XP_006 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
1950 1960 1970 1980 1990 2000
30 40 50 60 70 80
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
.:.... . . :.::. .. . : ..:.: ... .: . .. .... :.
XP_006 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
2010 2020 2030 2040 2050 2060
90 100 110 120 130
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
. . . ... ::..:.. ..:. .... .: .::: :::: : ..
XP_006 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
2070 2080 2090 2100 2110 2120
140 150 160 170 180 190
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
. :.:... : :.: . : :: : . : . ..... : :. .
XP_006 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
2130 2140 2150 2160 2170
200 210 220 230 240 250
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
. ..: :. . :..:.:. ::: . .:..: ::..:. :: ::.. :.. .
XP_006 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
2180 2190 2200 2210 2220 2230
260 270 280 290 300 310
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
....: : . :: :... :: . ..:.:.. .: : : .. :. .
XP_006 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
2240 2250 2260 2270 2280
320 330 340 350 360
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
: . :..: .. . :. .:..... .. :.:. .:..::.::. .... :.
XP_006 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
2290 2300 2310 2320 2330 2340
370 380 390 400 410 420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
: : : ::: :: ::.. ... .: ..:. . . . .. . .: ..
XP_006 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
2350 2360 2370 2380 2390 2400
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
...: :: : :.
XP_006 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
2410 2420 2430 2440 2450 2460
>>XP_006724531 (OMIM: 300376,300377,302045,310200) PREDI (3703 aa)
initn: 6309 init1: 6309 opt: 6332 Z-score: 3854.5 bits: 726.9 E(85289): 5.9e-208
Smith-Waterman score: 8099; 99.0% identity (99.0% similar) in 1243 aa overlap (1-1230:2461-3703)
10 20 30
pF1KB3 MPSSLMLEVPALADFNRAWTELTDWLSLLD
::::::::::::::::::::::::::::::
XP_006 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD
2440 2450 2460 2470 2480 2490
40 50 60 70 80 90
pF1KB3 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTII
2500 2510 2520 2530 2540 2550
100 110 120 130 140 150
pF1KB3 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP
2560 2570 2580 2590 2600 2610
160 170 180 190 200 210
pF1KB3 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW
2620 2630 2640 2650 2660 2670
220 230 240 250 260 270
pF1KB3 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG
2680 2690 2700 2710 2720 2730
280 290 300 310 320 330
pF1KB3 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR
2740 2750 2760 2770 2780 2790
340 350 360 370 380 390
pF1KB3 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRA
2800 2810 2820 2830 2840 2850
400 410 420 430 440 450
pF1KB3 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEE
2860 2870 2880 2890 2900 2910
460 470 480 490 500 510
pF1KB3 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNTEWEKLNLHSADWQRKIDETLERLRELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS
2920 2930 2940 2950 2960 2970
520 530 540 550 560 570
pF1KB3 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVA
2980 2990 3000 3010 3020 3030
580 590 600 610 620 630
pF1KB3 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTE
3040 3050 3060 3070 3080 3090
640 650 660 670 680 690
pF1KB3 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQI
3100 3110 3120 3130 3140 3150
700 710 720 730 740 750
pF1KB3 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAH
3160 3170 3180 3190 3200 3210
760 770 780 790 800 810
pF1KB3 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFA
3220 3230 3240 3250 3260 3270
820 830 840 850 860 870
pF1KB3 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLK
3280 3290 3300 3310 3320 3330
880 890 900 910 920 930
pF1KB3 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHP
3340 3350 3360 3370 3380 3390
940 950 960 970
pF1KB3 RMGYLPVQTVLEGDNMETP-------------ASSPQLSHDDTHSRIEHYASRLAEMENS
::::::::::::::::::: ::::::::::::::::::::::::::::
XP_006 RMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENS
3400 3410 3420 3430 3440 3450
980 990 1000 1010 1020 1030
pF1KB3 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERIL
3460 3470 3480 3490 3500 3510
1040 1050 1060 1070 1080 1090
pF1KB3 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
3520 3530 3540 3550 3560 3570
1100 1110 1120 1130 1140 1150
pF1KB3 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
3580 3590 3600 3610 3620 3630
1160 1170 1180 1190 1200 1210
pF1KB3 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFHMADDLGRAME
3640 3650 3660 3670 3680 3690
1220 1230
pF1KB3 SLVSVMTDEEGAE
:::::::::::::
XP_006 SLVSVMTDEEGAE
3700
>--
initn: 257 init1: 158 opt: 313 Z-score: 198.5 bits: 50.4 E(85289): 0.00026
Smith-Waterman score: 313; 21.8% identity (57.1% similar) in 464 aa overlap (1-434:1985-2426)
10 20
pF1KB3 MPSSLMLEVPAL-ADFNRAWTELTDWLSLL
: .. ::. . . . :.... : .
XP_006 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
1960 1970 1980 1990 2000 2010
30 40 50 60 70 80
pF1KB3 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI
.:.... . . :.::. .. . : ..:.: ... .: . .. .... :.
XP_006 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAALQSATPVERVK
2020 2030 2040 2050 2060 2070
90 100 110 120 130
pF1KB3 ITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQA
. . . ... ::..:.. ..:. .... .: .::: :::: : ..
XP_006 LQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT---EAEQFLRKT
2080 2090 2100 2110 2120 2130
140 150 160 170 180 190
pF1KB3 RAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKV
. :.:... : :.: . : :: : . : . ..... : :. .
XP_006 QIP-ENWEHAKYKW--------YLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL
2140 2150 2160 2170 2180
200 210 220 230 240 250
pF1KB3 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDAT
. ..: :. . :..:.:. ::: . .:..: ::..:. :: ::.. :.. .
XP_006 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPG
2190 2200 2210 2220 2230 2240
260 270 280 290 300 310
pF1KB3 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRR
....: : . :: :... :: . ..:.:.. .: : : .. :. .
XP_006 KEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENK
2250 2260 2270 2280 2290
320 330 340 350 360
pF1KB3 LDNMNFKWSELRK----KSLNIRSHLEASSDQWKRLH---LSLQELLVWLQ-LKDD-ELS
: . :..: .. . :. .:..... .. :.:. .:..::.::. .... :.
XP_006 LKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIY
2300 2310 2320 2330 2340 2350
370 380 390 400 410 420
pF1KB3 RQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEG
: : : ::: :: ::.. ... .: ..:. . . . .. . .: ..
XP_006 NQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW--KA
2360 2370 2380 2390 2400 2410
430 440 450 460 470 480
pF1KB3 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQ
...: :: : :.
XP_006 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL
2420 2430 2440 2450 2460 2470
1230 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 23:17:58 2016 done: Fri Nov 4 23:18:00 2016
Total Scan time: 15.460 Total Display time: 0.670
Function used was FASTA [36.3.4 Apr, 2011]