FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0462, 227 aa 1>>>pF1KE0462 227 - 227 aa - 227 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7460+/-0.000332; mu= 12.3163+/- 0.021 mean_var=73.2734+/-14.987, 0's: 0 Z-trim(115.9): 11 B-trim: 677 in 1/55 Lambda= 0.149831 statistics sampled from 26595 (26605) to 26595 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.312), width: 16 Scan time: 6.340 The best scores are: opt bits E(85289) NP_872353 (OMIM: 612038) transmembrane emp24 domai ( 227) 1519 337.1 1.5e-92 NP_001289987 (OMIM: 612038) transmembrane emp24 do ( 186) 1197 267.5 1.1e-71 NP_001289991 (OMIM: 612038) transmembrane emp24 do ( 168) 1126 252.1 4.2e-67 NP_001289990 (OMIM: 612038) transmembrane emp24 do ( 168) 1126 252.1 4.2e-67 NP_001289988 (OMIM: 612038) transmembrane emp24 do ( 178) 880 198.9 4.5e-51 NP_001289989 (OMIM: 612038) transmembrane emp24 do ( 127) 804 182.4 3e-46 NP_006818 (OMIM: 605406) transmembrane emp24 domai ( 219) 319 77.7 1.7e-14 NP_057124 (OMIM: 616876) transmembrane emp24 domai ( 229) 175 46.6 4.2e-05 NP_006849 (OMIM: 605395) transmembrane emp24 domai ( 227) 159 43.1 0.00045 XP_006722694 (OMIM: 605395) PREDICTED: transmembra ( 189) 157 42.7 0.00052 >>NP_872353 (OMIM: 612038) transmembrane emp24 domain-co (227 aa) initn: 1519 init1: 1519 opt: 1519 Z-score: 1782.8 bits: 337.1 E(85289): 1.5e-92 Smith-Waterman score: 1519; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227) 10 20 30 40 50 60 pF1KE0 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYR 130 140 150 160 170 180 190 200 210 220 pF1KE0 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV ::::::::::::::::::::::::::::::::::::::::::::::: NP_872 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV 190 200 210 220 >>NP_001289987 (OMIM: 612038) transmembrane emp24 domain (186 aa) initn: 1197 init1: 1197 opt: 1197 Z-score: 1408.0 bits: 267.5 E(85289): 1.1e-71 Smith-Waterman score: 1197; 100.0% identity (100.0% similar) in 178 aa overlap (1-178:1-178) 10 20 30 40 50 60 pF1KE0 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRAS 130 140 150 160 170 180 190 200 210 220 pF1KE0 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV NP_001 AYLLVI >>NP_001289991 (OMIM: 612038) transmembrane emp24 domain (168 aa) initn: 1126 init1: 1126 opt: 1126 Z-score: 1325.7 bits: 252.1 E(85289): 4.2e-67 Smith-Waterman score: 1126; 100.0% identity (100.0% similar) in 168 aa overlap (60-227:1-168) 30 40 50 60 70 80 pF1KE0 LYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVV :::::::::::::::::::::::::::::: NP_001 MWDKQKEVFLPSTPGLGMHVEVKDPDGKVV 10 20 30 90 100 110 120 130 140 pF1KE0 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT 100 110 120 130 140 150 210 220 pF1KE0 GIWQMRHLKSFFEAKKLV :::::::::::::::::: NP_001 GIWQMRHLKSFFEAKKLV 160 >>NP_001289990 (OMIM: 612038) transmembrane emp24 domain (168 aa) initn: 1126 init1: 1126 opt: 1126 Z-score: 1325.7 bits: 252.1 E(85289): 4.2e-67 Smith-Waterman score: 1126; 100.0% identity (100.0% similar) in 168 aa overlap (60-227:1-168) 30 40 50 60 70 80 pF1KE0 LYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVV :::::::::::::::::::::::::::::: NP_001 MWDKQKEVFLPSTPGLGMHVEVKDPDGKVV 10 20 30 90 100 110 120 130 140 pF1KE0 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT 100 110 120 130 140 150 210 220 pF1KE0 GIWQMRHLKSFFEAKKLV :::::::::::::::::: NP_001 GIWQMRHLKSFFEAKKLV 160 >>NP_001289988 (OMIM: 612038) transmembrane emp24 domain (178 aa) initn: 1188 init1: 880 opt: 880 Z-score: 1038.0 bits: 198.9 E(85289): 4.5e-51 Smith-Waterman score: 1094; 78.4% identity (78.4% similar) in 227 aa overlap (1-227:1-178) 10 20 30 40 50 60 pF1KE0 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 MALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYR ::::::::: :: NP_001 MALFAGGKL-------------------------------------------------YR 130 190 200 210 220 pF1KE0 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV 140 150 160 170 >>NP_001289989 (OMIM: 612038) transmembrane emp24 domain (127 aa) initn: 804 init1: 804 opt: 804 Z-score: 951.4 bits: 182.4 E(85289): 3e-46 Smith-Waterman score: 804; 100.0% identity (100.0% similar) in 119 aa overlap (60-178:1-119) 30 40 50 60 70 80 pF1KE0 LYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVV :::::::::::::::::::::::::::::: NP_001 MWDKQKEVFLPSTPGLGMHVEVKDPDGKVV 10 20 30 90 100 110 120 130 140 pF1KE0 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAA 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE0 KDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILT ::::::::::::::::::::::::::::: NP_001 KDKLTELQLRARQLLDQVEQIQKEQDYQRASAYLLVI 100 110 120 >>NP_006818 (OMIM: 605406) transmembrane emp24 domain-co (219 aa) initn: 319 init1: 242 opt: 319 Z-score: 381.2 bits: 77.7 E(85289): 1.7e-14 Smith-Waterman score: 376; 34.2% identity (64.1% similar) in 231 aa overlap (1-227:1-218) 10 20 30 40 50 pF1KE0 MAGVGAGPLRAMGRQALLLLALCATGAQ---GLYFHIGETEKRCFIEEIPDETMVIGNYR :.:... : : : : :: : : . .. ::. . ..:. ::: . .: : : NP_006 MSGLSGPPARR-GPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLVTGAY- 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 TQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSN .. :.. .. :: :... : :... :.. ...:.:.::.. ..:..:. NP_006 -EISDQSG-----GAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 ST-RMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDY .: :. .: : ::.. : .:.:: ::: .:: :... :.: : :.: .. : NP_006 GTGRIP----DQL-VILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAY 120 130 140 150 160 180 190 200 210 220 pF1KE0 QRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV .. :::..: :.:::: :::..:: . :: . ::. .:. ::.::::. NP_006 MKKREEEMRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE 170 180 190 200 210 >>NP_057124 (OMIM: 616876) transmembrane emp24 domain-co (229 aa) initn: 137 init1: 94 opt: 175 Z-score: 212.7 bits: 46.6 E(85289): 4.2e-05 Smith-Waterman score: 175; 23.9% identity (59.5% similar) in 205 aa overlap (32-225:38-225) 10 20 30 40 50 60 pF1KE0 AGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMW : . .:.:: . .: .. . .: :. NP_057 PFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPMPLKASLEIEY--QVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 DKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRM : :: . .. .:.::... .: :.: : ... ::...:. .. . . NP_057 DGA---------GLDIDFHLASPEGKTLVFEQRKSDGVHTVETEV-GDYMFCFDNTFSTI 70 80 90 100 110 130 140 150 160 170 pF1KE0 A---LFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTE-LQLRARQLLDQVEQIQKE---- . .: ... :: ..::.:.. . :. :... ...:.....:... NP_057 SEKVIF----FELILD-NMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKS 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 ---QDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV : : : : : .::. .:: .::... :...... :. :::.:: :. NP_057 GHIQTLLRAFEARDRNIQESNFDRVNFWSMVNLVVMVVVSAIQVYMLKSLFEDKRKSRT 180 190 200 210 220 >>NP_006849 (OMIM: 605395) transmembrane emp24 domain-co (227 aa) initn: 118 init1: 84 opt: 159 Z-score: 194.0 bits: 43.1 E(85289): 0.00045 Smith-Waterman score: 159; 21.4% identity (52.7% similar) in 201 aa overlap (32-227:36-225) 10 20 30 40 50 60 pF1KE0 AGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMW : . .:.:: . : .. . .:. NP_006 AALALALWLLMPPVEVGGAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQ---- 10 20 30 40 50 60 70 80 90 100 110 pF1KE0 DKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSN---- . . :: . ...:.: ...:.. ..: : ::...:. .. NP_006 -------VIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTI 70 80 90 100 110 120 130 140 150 160 170 pF1KE0 STRMALFAGGKLRVHLDIQV-GEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDY : ....: .. : .: : :: :. ... . . ..:. . NP_006 SEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTL 120 130 140 150 160 170 180 190 200 210 220 pF1KE0 QRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV : : : : .:.. .:: .:: .....:.:... :. :: ::. :. : NP_006 LRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT 180 190 200 210 220 >>XP_006722694 (OMIM: 605395) PREDICTED: transmembrane e (189 aa) initn: 99 init1: 84 opt: 157 Z-score: 192.9 bits: 42.7 E(85289): 0.00052 Smith-Waterman score: 157; 23.3% identity (56.0% similar) in 159 aa overlap (74-227:29-187) 50 60 70 80 90 100 pF1KE0 EEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFT :: . ...:.: ...:.. ..: : XP_006 MRVEARGAATGTGWGGCGCAAVQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVE 10 20 30 40 50 110 120 130 140 150 pF1KE0 SHTPGDHQICLHSN----STRMALFAGGKLRVHLDIQV-GEHANNYPEIAAKDKLTELQL ::...:. .. : ....: .. : .: : :: :. ... XP_006 PTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKE 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE0 RARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLK . . ..:. . : : : : .:.. .:: .:: .....:.:... :. :: XP_006 SIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLK 120 130 140 150 160 170 220 pF1KE0 SFFEAKKLV ::. :. : XP_006 RFFQDKRPVPT 180 227 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 04:06:39 2016 done: Mon Nov 7 04:06:40 2016 Total Scan time: 6.340 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]