Result of FASTA (omim) for
pFN21AB6108
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6108, 617 aa
1>>>pF1KB6108 617 - 617 aa - 617 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.3318+/-0.000427; mu= -8.6543+/- 0.026
mean_var=308.5224+/-63.585, 0's: 0 Z-trim(120.4): 32 B-trim: 1154 in 1/54
Lambda= 0.073018
statistics sampled from 35463 (35506) to 35463 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.416), width: 16
Scan time: 9.980
The best scores are: opt bits E(85289)
NP_689853 (OMIM: 609843) mRNA-decapping enzyme 1B ( 617) 4096 445.4 2.8e-124
XP_011519229 (OMIM: 609843) PREDICTED: mRNA-decapp ( 515) 3400 372.0 2.8e-102
NP_001306221 (OMIM: 609843) mRNA-decapping enzyme ( 153) 695 86.7 6.2e-17
NP_060873 (OMIM: 607010) mRNA-decapping enzyme 1A ( 582) 701 87.7 1.2e-16
NP_001277133 (OMIM: 607010) mRNA-decapping enzyme ( 544) 699 87.5 1.3e-16
>>NP_689853 (OMIM: 609843) mRNA-decapping enzyme 1B isof (617 aa)
initn: 4096 init1: 4096 opt: 4096 Z-score: 2352.2 bits: 445.4 E(85289): 2.8e-124
Smith-Waterman score: 4096; 100.0% identity (100.0% similar) in 617 aa overlap (1-617:1-617)
10 20 30 40 50 60
pF1KB6 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 PKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 QETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 SADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 STPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 STPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 AHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 AQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 RESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 RESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNII
550 560 570 580 590 600
610
pF1KB6 YEAYLFSMTQAAMKKTM
:::::::::::::::::
NP_689 YEAYLFSMTQAAMKKTM
610
>>XP_011519229 (OMIM: 609843) PREDICTED: mRNA-decapping (515 aa)
initn: 3400 init1: 3400 opt: 3400 Z-score: 1957.2 bits: 372.0 E(85289): 2.8e-102
Smith-Waterman score: 3400; 99.6% identity (100.0% similar) in 512 aa overlap (106-617:4-515)
80 90 100 110 120 130
pF1KB6 NRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEECQRIAELMKNLTQYEQ
..::::::::::::::::::::::::::::
XP_011 MQIKVSIYGIWFYDKEECQRIAELMKNLTQYEQ
10 20 30
140 150 160 170 180 190
pF1KB6 LKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSEPKKITSSSAIYDNPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSEPKKITSSSAIYDNPN
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB6 LIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQ
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB6 QQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRP
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB6 CENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQSTPGAANKCDPSTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQSTPGAANKCDPSTPA
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB6 PASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLP
280 290 300 310 320 330
440 450 460 470 480 490
pF1KB6 ISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWIN
340 350 360 370 380 390
500 510 520 530 540 550
pF1KB6 KTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPA
400 410 420 430 440 450
560 570 580 590 600 610
pF1KB6 AATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKK
460 470 480 490 500 510
pF1KB6 TM
::
XP_011 TM
>>NP_001306221 (OMIM: 609843) mRNA-decapping enzyme 1B i (153 aa)
initn: 695 init1: 695 opt: 695 Z-score: 425.0 bits: 86.7 E(85289): 6.2e-17
Smith-Waterman score: 695; 100.0% identity (100.0% similar) in 106 aa overlap (1-106:1-106)
10 20 30 40 50 60
pF1KB6 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARCESFLLQWVVLLLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSE
NP_001 FGQVFKIVQCLPLCLHLVSVAMGGVSILTNVNV
130 140 150
>>NP_060873 (OMIM: 607010) mRNA-decapping enzyme 1A isof (582 aa)
initn: 831 init1: 594 opt: 701 Z-score: 419.8 bits: 87.7 E(85289): 1.2e-16
Smith-Waterman score: 817; 33.3% identity (59.0% similar) in 630 aa overlap (13-610:8-575)
10 20 30 40 50 60
pF1KB6 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
:...:::::..:::::. :.:...::::::: .::.:::::.:::::
NP_060 MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLF
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
:: ::::: :::::.:::.:.: .::..:::.:::..:::::::: ::::.::::::..:
NP_060 VYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDC
60 70 80 90 100 110
130 140 150 160 170
pF1KB6 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNS-GEGKEVDILRMLIKAKDEYTKCK---
.:::.:: .... : ...:.. :: :. .. . .:::.:: .::::: . .
NP_060 HRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 -TCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQ
. : : :.. .: . . . :: .:.. :. .. ::.. ::: .
NP_060 SNISSPGLQPSTQ--LSNLGSTETLEEMPSGSQDKSAPSGHK-------HLTVEELFGTS
180 190 200 210 220
240 250 260 270 280 290
pF1KB6 DKATCQETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSP-PIEKQL--CP
: : .. .. ...:.:: : . : .:: : :.: :: :
NP_060 LPK------EQPAVVGLDS----EEMERLP---G---DASQKEPNSFLPFPFE-QLGGAP
230 240 250 260
300 310 320 330 340
pF1KB6 AIQKLMVRSADLH--------PLSELPENRPCENGSTHSAGEFFTGPV-QPGSPHNIGTS
. : : :: : :. : . : . . . .:: .: : . :.
NP_060 QSETLGVPSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTA
270 280 290 300 310 320
350 360 370 380 390
pF1KB6 RGVQNASRTQNLFEKLQSTPGAANKCDP--STPAPA-SSAAL--NRS--RAPTSVTPVAP
. . :...... ...:: . .: . :.: : :.: :.: ::: .:: .:
NP_060 QVPPSLPRNSTMMQAVKTTP---RQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTA-
330 340 350 360 370 380
400 410 420 430 440 450
pF1KB6 GKGLAQPPQAYFNG-SLPPQTVGHQAHGREQSTLPRQTLPISGSQTGSSGVISPQELLKK
: . : .. : :: : . : : : . .: . ..: .. :
NP_060 --GTSLPSVDLLQKLRLTPQ------HDQIQ-TQPLGKGAMVASFSPAAGQLATPE----
390 400 410 420 430
460 470 480 490 500 510
pF1KB6 LQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWI-NKTPNTEQQTPLFQVISP-Q
.... .. :. : : .:.. .. . ::.: :. :.. : ... :
NP_060 -SFIEPPSKT-AAARVAASASLSNMVLA-----PLQSMQQNQDPEVFVQPKVLSSAIPVA
440 450 460 470 480
520 530 540 550 560
pF1KB6 RIP-----ATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPAAATSLLLPIQSPE
: .::. :.:..: :: : .. : : : ... : .. : .. .
NP_060 GAPLVTATTTAVSSVLLAPSVFQQTVT-----RSSDLERKASSPSP---LTIGTPESQRK
490 500 510 520 530
570 580 590 600 610
pF1KB6 PSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKKTM
::.: :.: :::..:..::.::..::. ..:.:: .:.
NP_060 PSII----LSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
540 550 560 570 580
>>NP_001277133 (OMIM: 607010) mRNA-decapping enzyme 1A i (544 aa)
initn: 831 init1: 594 opt: 699 Z-score: 419.1 bits: 87.5 E(85289): 1.3e-16
Smith-Waterman score: 814; 31.5% identity (58.6% similar) in 616 aa overlap (13-610:8-537)
10 20 30 40 50 60
pF1KB6 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
:...:::::..:::::. :.:...::::::: .::.:::::.:::::
NP_001 MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLF
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
:: ::::: :::::.:::.:.: .::..:::.:::..:::::::: ::::.::::::..:
NP_001 VYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDC
60 70 80 90 100 110
130 140 150 160 170
pF1KB6 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNS-GEGKEVDILRMLIKAKDEYTKCKTCS
.:::.:: .... : ...:.. :: :. .. . .:::.:: .::::: . .
NP_001 HRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERSAPSG
120 130 140 150 160 170
180 190 200 210 220
pF1KB6 EP----KKITSSSAIYDNPNLI----KPIPVKPSENQQQR----IPQPNQTLDPEPQHLS
. ... ..: ..: .. . . :.. .:.. .: : . : :: .
NP_001 HKHLTVEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSET
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 L----TALFGKQDKATCQETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHS
: .: . : . : . : . :..... .:. . .: : : .
NP_001 LGVPSAAHHSVQPEITTPVLITPASI--TQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQV
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB6 PPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTS
:: . .: . . . :: :.: . : :.. .: . .: :. ..
NP_001 PPSLPRNSTMMQAVKTTPRQRSPL----LNQPVPELS-HASLIANQSPFR--APLNVTNT
300 310 320 330 340
350 360 370 380 390 400
pF1KB6 RGVQNASRTQNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQP
:.. : .:..::. :: . : : ...:. :. .:. :
NP_001 AGTSLPSV--DLLQKLRLTP----QHDQIQTQPLGKGAM--------VASFSPAAGQLAT
350 360 370 380 390
410 420 430 440 450 460
pF1KB6 PQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQ
:..... ::. . : .: ...: . :. :..: :: .::.:
NP_001 PESFIE---PPS---KTAAAR-----------VAASASLSNMVLAP------LQSMQQNQ
400 410 420
470 480 490 500 510 520
pF1KB6 QLHASNRP-ALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPS
. .. .: .:.. .:: .: :: .. : .::. :
NP_001 DPEVFVQPKVLSSAIPV------AGAPL---VTAT-------------------TTAVSS
430 440 450 460
530 540 550 560 570 580
pF1KB6 LLMSPMVFAQPTSVPPKERESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQL
.:..: :: : .. : : : ... : .. : .. .::.: :.: ::
NP_001 VLLAPSVFQQTVT-----RSSDLERKASSPSP---LTIGTPESQRKPSII----LSKSQL
470 480 490 500
590 600 610
pF1KB6 QEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKKTM
:..:..::.::..::. ..:.:: .:.
NP_001 QDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
510 520 530 540
617 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:46:31 2016 done: Fri Nov 4 21:46:32 2016
Total Scan time: 9.980 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]