Result of FASTA (omim) for
pFN21AB8875
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8875, 166 aa
1>>>pF1KB8875 166 - 166 aa - 166 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7868+/-0.000508; mu= 4.4991+/- 0.031
mean_var=199.1771+/-42.197, 0's: 0 Z-trim(114.7): 613 B-trim: 242 in 1/52
Lambda= 0.090877
statistics sampled from 23810 (24676) to 23810 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.289), width: 16
Scan time: 5.480
The best scores are: opt bits E(85289)
NP_001791 (OMIM: 600927) cyclin-dependent kinase 4 ( 166) 1064 151.7 5e-37
NP_524145 (OMIM: 600927) cyclin-dependent kinase 4 ( 166) 1064 151.7 5e-37
NP_001253 (OMIM: 603369) cyclin-dependent kinase 4 ( 168) 437 69.5 2.8e-12
NP_523240 (OMIM: 603369) cyclin-dependent kinase 4 ( 168) 437 69.5 2.8e-12
NP_004927 (OMIM: 600431) cyclin-dependent kinase 4 ( 138) 342 57.0 1.4e-08
NP_000068 (OMIM: 155601,155755,600160,606719) cycl ( 156) 338 56.5 2.1e-08
NP_001182061 (OMIM: 155601,155755,600160,606719) c ( 167) 332 55.8 3.9e-08
XP_011515978 (OMIM: 155601,155755,600160,606719) P ( 172) 331 55.6 4.3e-08
XP_011515977 (OMIM: 155601,155755,600160,606719) P ( 184) 331 55.7 4.5e-08
XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720) 293 51.9 5.6e-06
XP_016871637 (OMIM: 600465,615493) PREDICTED: anky (1725) 293 51.9 5.6e-06
XP_016871636 (OMIM: 600465,615493) PREDICTED: anky (1735) 293 51.9 5.7e-06
XP_016871635 (OMIM: 600465,615493) PREDICTED: anky (1737) 293 51.9 5.7e-06
XP_016871634 (OMIM: 600465,615493) PREDICTED: anky (1738) 293 51.9 5.7e-06
XP_016871633 (OMIM: 600465,615493) PREDICTED: anky (1741) 293 51.9 5.7e-06
XP_016871632 (OMIM: 600465,615493) PREDICTED: anky (1742) 293 51.9 5.7e-06
XP_016871631 (OMIM: 600465,615493) PREDICTED: anky (1747) 293 51.9 5.7e-06
XP_016871630 (OMIM: 600465,615493) PREDICTED: anky (1751) 293 52.0 5.7e-06
XP_016871629 (OMIM: 600465,615493) PREDICTED: anky (1763) 293 52.0 5.7e-06
XP_016871628 (OMIM: 600465,615493) PREDICTED: anky (1764) 293 52.0 5.7e-06
XP_016871627 (OMIM: 600465,615493) PREDICTED: anky (1785) 293 52.0 5.8e-06
XP_016871626 (OMIM: 600465,615493) PREDICTED: anky (1786) 293 52.0 5.8e-06
XP_016871625 (OMIM: 600465,615493) PREDICTED: anky (1795) 293 52.0 5.8e-06
XP_016871624 (OMIM: 600465,615493) PREDICTED: anky (1838) 293 52.0 5.9e-06
XP_016871623 (OMIM: 600465,615493) PREDICTED: anky (1845) 293 52.0 5.9e-06
XP_016871622 (OMIM: 600465,615493) PREDICTED: anky (1850) 293 52.0 5.9e-06
XP_016871621 (OMIM: 600465,615493) PREDICTED: anky (1855) 293 52.0 5.9e-06
NP_001191332 (OMIM: 600465,615493) ankyrin-3 isofo (1861) 293 52.0 5.9e-06
XP_016871620 (OMIM: 600465,615493) PREDICTED: anky (1862) 293 52.0 5.9e-06
XP_016871619 (OMIM: 600465,615493) PREDICTED: anky (1866) 293 52.0 5.9e-06
NP_001307803 (OMIM: 600465,615493) ankyrin-3 isofo (1867) 293 52.0 5.9e-06
NP_001191333 (OMIM: 600465,615493) ankyrin-3 isofo (1868) 293 52.0 5.9e-06
XP_005269772 (OMIM: 600465,615493) PREDICTED: anky (1885) 293 52.0 6e-06
XP_016871618 (OMIM: 600465,615493) PREDICTED: anky (1888) 293 52.0 6e-06
XP_016871617 (OMIM: 600465,615493) PREDICTED: anky (1889) 293 52.0 6e-06
XP_006717865 (OMIM: 600465,615493) PREDICTED: anky (1898) 293 52.0 6e-06
XP_016871616 (OMIM: 600465,615493) PREDICTED: anky (2603) 293 52.2 7.3e-06
XP_016871615 (OMIM: 600465,615493) PREDICTED: anky (2612) 293 52.2 7.3e-06
XP_016871614 (OMIM: 600465,615493) PREDICTED: anky (2646) 293 52.2 7.3e-06
XP_016871613 (OMIM: 600465,615493) PREDICTED: anky (2647) 293 52.2 7.3e-06
XP_016871612 (OMIM: 600465,615493) PREDICTED: anky (2655) 293 52.2 7.4e-06
XP_011538011 (OMIM: 600465,615493) PREDICTED: anky (2656) 293 52.2 7.4e-06
XP_016871611 (OMIM: 600465,615493) PREDICTED: anky (2728) 293 52.2 7.5e-06
XP_006717859 (OMIM: 600465,615493) PREDICTED: anky (2758) 293 52.2 7.5e-06
XP_011538010 (OMIM: 600465,615493) PREDICTED: anky (2759) 293 52.2 7.5e-06
XP_016871610 (OMIM: 600465,615493) PREDICTED: anky (3945) 293 52.4 9.4e-06
XP_016871609 (OMIM: 600465,615493) PREDICTED: anky (3953) 293 52.4 9.4e-06
XP_016871608 (OMIM: 600465,615493) PREDICTED: anky (3954) 293 52.4 9.4e-06
XP_016871607 (OMIM: 600465,615493) PREDICTED: anky (4057) 293 52.4 9.6e-06
NP_066267 (OMIM: 600465,615493) ankyrin-3 isoform (4377) 293 52.5 1e-05
>>NP_001791 (OMIM: 600927) cyclin-dependent kinase 4 inh (166 aa)
initn: 1064 init1: 1064 opt: 1064 Z-score: 785.8 bits: 151.7 E(85289): 5e-37
Smith-Waterman score: 1064; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
70 80 90 100 110 120
130 140 150 160
pF1KB8 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
130 140 150 160
>>NP_524145 (OMIM: 600927) cyclin-dependent kinase 4 inh (166 aa)
initn: 1064 init1: 1064 opt: 1064 Z-score: 785.8 bits: 151.7 E(85289): 5e-37
Smith-Waterman score: 1064; 100.0% identity (100.0% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_524 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_524 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
70 80 90 100 110 120
130 140 150 160
pF1KB8 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
::::::::::::::::::::::::::::::::::::::::::::::
NP_524 AVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
130 140 150 160
>>NP_001253 (OMIM: 603369) cyclin-dependent kinase 4 inh (168 aa)
initn: 465 init1: 330 opt: 437 Z-score: 341.5 bits: 69.5 E(85289): 2.8e-12
Smith-Waterman score: 437; 45.8% identity (77.4% similar) in 155 aa overlap (9-161:6-159)
10 20 30 40 50 60
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
:..:..::::::.... ::. . :. .: : ::.:::::: .:. :: .:
NP_001 MAEPWGNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRL
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
: .::.:...: .: . .:::::.::::::..:.: ::::. :. : ::.:::..:::
NP_001 LLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL
60 70 80 90 100 110
130 140 150 160
pF1KB8 AVVSFLAAE--SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
:: ::. . :.. .:. .: : .:: : ...:...:..
NP_001 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
120 130 140 150 160
>>NP_523240 (OMIM: 603369) cyclin-dependent kinase 4 inh (168 aa)
initn: 465 init1: 330 opt: 437 Z-score: 341.5 bits: 69.5 E(85289): 2.8e-12
Smith-Waterman score: 437; 45.8% identity (77.4% similar) in 155 aa overlap (9-161:6-159)
10 20 30 40 50 60
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALEL
:..:..::::::.... ::. . :. .: : ::.:::::: .:. :: .:
NP_523 MAEPWGNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRL
10 20 30 40 50
70 80 90 100 110 120
pF1KB8 LKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHT
: .::.:...: .: . .:::::.::::::..:.: ::::. :. : ::.:::..:::
NP_523 LLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL
60 70 80 90 100 110
130 140 150 160
pF1KB8 AVVSFLAAE--SDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
:: ::. . :.. .:. .: : .:: : ...:...:..
NP_523 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
120 130 140 150 160
>>NP_004927 (OMIM: 600431) cyclin-dependent kinase 4 inh (138 aa)
initn: 373 init1: 209 opt: 342 Z-score: 275.1 bits: 57.0 E(85289): 1.4e-08
Smith-Waterman score: 342; 51.7% identity (75.0% similar) in 116 aa overlap (12-126:18-132)
10 20 30 40 50
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGST
:..::::: :..::.::. . :...::::. :.::::.::.
NP_004 MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLE-AGADPNGVNRFGRRAIQVMMMGSA
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 AIALELLKQGASPNVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHL
.: :: .:: :: : . : ::::::: :::::: :: . :: ..: :. : ::. :
NP_004 RVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDL
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 AVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
: ..:: :...:
NP_004 AEERGHRDVAGYLRTATGD
120 130
>>NP_000068 (OMIM: 155601,155755,600160,606719) cyclin-d (156 aa)
initn: 303 init1: 218 opt: 338 Z-score: 271.7 bits: 56.5 E(85289): 2.1e-08
Smith-Waterman score: 338; 44.0% identity (64.7% similar) in 150 aa overlap (8-156:12-156)
10 20 30 40 50
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAI
..: :. ::::: :.::: ::. . :.: : .:. .::::.::. .
NP_000 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARV
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 ALELLKQGASPNVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAV
: :: .:: :: : . : ::::::: :::::: :: . :: ..: :. : ::. ::
NP_000 AELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 QEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
. :: :. .: : . .:: . .. .: .:. :
NP_000 ELGHRDVARYLRAAAG----GTRGSNHARIDAAEGPSDIPD
120 130 140 150
>>NP_001182061 (OMIM: 155601,155755,600160,606719) cycli (167 aa)
initn: 303 init1: 218 opt: 332 Z-score: 267.1 bits: 55.8 E(85289): 3.9e-08
Smith-Waterman score: 332; 43.0% identity (65.1% similar) in 149 aa overlap (8-155:12-155)
10 20 30 40 50
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAI
..: :. ::::: :.::: ::. . :.: : .:. .::::.::. .
NP_001 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARV
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 ALELLKQGASPNVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAV
: :: .:: :: : . : ::::::: :::::: :: . :: ..: :. : ::. ::
NP_001 AELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 QEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
. :: :. .: : . .:: . .. .: ....
NP_001 ELGHRDVARYLRAAAG----GTRGSNHARIDAAEGPSEMIGNHLWVCRSRHA
120 130 140 150 160
>>XP_011515978 (OMIM: 155601,155755,600160,606719) PREDI (172 aa)
initn: 303 init1: 218 opt: 331 Z-score: 266.3 bits: 55.6 E(85289): 4.3e-08
Smith-Waterman score: 331; 50.0% identity (68.9% similar) in 122 aa overlap (8-128:12-132)
10 20 30 40 50
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAI
..: :. ::::: :.::: ::. . :.: : .:. .::::.::. .
XP_011 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARV
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 ALELLKQGASPNVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAV
: :: .:: :: : . : ::::::: :::::: :: . :: ..: :. : ::. ::
XP_011 AELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 QEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
. :: :. .: :
XP_011 ELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSVTASIQVPGGEEGDFGSSYS
120 130 140 150 160 170
>>XP_011515977 (OMIM: 155601,155755,600160,606719) PREDI (184 aa)
initn: 303 init1: 218 opt: 331 Z-score: 265.9 bits: 55.7 E(85289): 4.5e-08
Smith-Waterman score: 331; 50.0% identity (68.9% similar) in 122 aa overlap (8-128:12-132)
10 20 30 40 50
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAI
..: :. ::::: :.::: ::. . :.: : .:. .::::.::. .
XP_011 MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGAL-PNAPNSYGRRPIQVMMMGSARV
10 20 30 40 50
60 70 80 90 100 110
pF1KB8 ALELLKQGASPNVQDTSG-TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAV
: :: .:: :: : . : ::::::: :::::: :: . :: ..: :. : ::. ::
XP_011 AELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE
60 70 80 90 100 110
120 130 140 150 160
pF1KB8 QEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQGHMVAPL
. :: :. .: :
XP_011 ELGHRDVARYLRAAAGGTRGSNHARIDAAEGPSAGWTNLRISKPNCAWHHLEISRSRLFC
120 130 140 150 160 170
>>XP_016871638 (OMIM: 600465,615493) PREDICTED: ankyrin- (1720 aa)
initn: 638 init1: 203 opt: 293 Z-score: 228.3 bits: 51.9 E(85289): 5.6e-06
Smith-Waterman score: 293; 37.5% identity (65.1% similar) in 152 aa overlap (16-163:555-706)
10 20 30 40
pF1KB8 MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTA
::. :: :: .. . ::: .. : :
XP_016 EGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTP
530 540 550 560 570 580
50 60 70 80 90 100
pF1KB8 LQVMM-FGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPD
:.: . . .:: :: :::::.. .: .:.: ::. . .: .:.:.:::.:.
XP_016 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT
590 600 610 620 630 640
110 120 130 140 150 160
pF1KB8 GTGALPIHLAVQEGHTAVVSFLAAES-DLHRRDARGLTPLELALQRGAQDLVDIL--QGH
: .:::.::::. .::.: ... ... . :::::.:: :. .....: ::
XP_016 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA
650 660 670 680 690 700
pF1KB8 MVAPL
:
XP_016 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV
710 720 730 740 750 760
166 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 20:19:40 2016 done: Fri Nov 4 20:19:40 2016
Total Scan time: 5.480 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]