FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0591, 412 aa 1>>>pF1KE0591 412 - 412 aa - 412 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.0837+/-0.000366; mu= 2.9383+/- 0.023 mean_var=286.1237+/-60.030, 0's: 0 Z-trim(123.0): 328 B-trim: 796 in 1/56 Lambda= 0.075822 statistics sampled from 41621 (41981) to 41621 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.786), E-opt: 0.2 (0.492), width: 16 Scan time: 10.650 The best scores are: opt bits E(85289) NP_003576 (OMIM: 604568) double C2-like domain-con ( 412) 2819 321.3 2.8e-87 XP_016880716 (OMIM: 604568) PREDICTED: double C2-l ( 340) 1770 206.5 8.5e-53 XP_011533665 (OMIM: 604568) PREDICTED: double C2-l ( 387) 1591 186.9 7.3e-47 NP_055769 (OMIM: 612159) rabphilin-3A isoform 2 [H ( 690) 896 111.2 8.3e-24 NP_001137326 (OMIM: 612159) rabphilin-3A isoform 1 ( 694) 896 111.2 8.3e-24 XP_011536350 (OMIM: 612159) PREDICTED: rabphilin-3 ( 694) 896 111.2 8.3e-24 XP_016874523 (OMIM: 612159) PREDICTED: rabphilin-3 ( 346) 831 103.7 7.1e-22 XP_016879267 (OMIM: 604567) PREDICTED: double C2-l ( 282) 801 100.4 6e-21 NP_001268991 (OMIM: 604567) double C2-like domain- ( 400) 803 100.7 6.6e-21 XP_011544277 (OMIM: 604567) PREDICTED: double C2-l ( 400) 803 100.7 6.6e-21 NP_001268997 (OMIM: 604567) double C2-like domain- ( 400) 803 100.7 6.6e-21 NP_003577 (OMIM: 604567) double C2-like domain-con ( 400) 803 100.7 6.6e-21 NP_001268992 (OMIM: 604567) double C2-like domain- ( 400) 803 100.7 6.6e-21 XP_016879266 (OMIM: 604567) PREDICTED: double C2-l ( 400) 803 100.7 6.6e-21 XP_016879265 (OMIM: 604567) PREDICTED: double C2-l ( 400) 803 100.7 6.6e-21 NP_065834 (OMIM: 600103) synaptotagmin-4 [Homo sap ( 425) 558 74.0 8e-13 XP_005245071 (OMIM: 608741) PREDICTED: synaptotagm ( 430) 557 73.9 8.7e-13 NP_995320 (OMIM: 607718) synaptotagmin-6 [Homo sap ( 425) 556 73.8 9.3e-13 NP_001257734 (OMIM: 607718) synaptotagmin-6 [Homo ( 425) 556 73.8 9.3e-13 XP_016855860 (OMIM: 607718) PREDICTED: synaptotagm ( 443) 556 73.8 9.6e-13 NP_689493 (OMIM: 608741) synaptotagmin-11 [Homo sa ( 431) 539 71.9 3.4e-12 XP_016856248 (OMIM: 608741) PREDICTED: synaptotagm ( 434) 539 71.9 3.4e-12 XP_005269170 (OMIM: 185605) PREDICTED: synaptotagm ( 419) 486 66.1 1.9e-10 XP_006719639 (OMIM: 185605) PREDICTED: synaptotagm ( 419) 486 66.1 1.9e-10 NP_001278830 (OMIM: 185605) synaptotagmin-1 isofor ( 419) 486 66.1 1.9e-10 NP_001129277 (OMIM: 185605) synaptotagmin-1 isofor ( 422) 486 66.1 1.9e-10 XP_011537012 (OMIM: 185605) PREDICTED: synaptotagm ( 422) 486 66.1 1.9e-10 NP_001129278 (OMIM: 185605) synaptotagmin-1 isofor ( 422) 486 66.1 1.9e-10 NP_005630 (OMIM: 185605) synaptotagmin-1 isoform 1 ( 422) 486 66.1 1.9e-10 XP_016875398 (OMIM: 185605) PREDICTED: synaptotagm ( 422) 486 66.1 1.9e-10 XP_016855802 (OMIM: 600104,616040) PREDICTED: syna ( 419) 484 65.9 2.2e-10 NP_001129976 (OMIM: 600104,616040) synaptotagmin-2 ( 419) 484 65.9 2.2e-10 NP_796376 (OMIM: 600104,616040) synaptotagmin-2 [H ( 419) 484 65.9 2.2e-10 XP_011507494 (OMIM: 600104,616040) PREDICTED: syna ( 422) 484 65.9 2.2e-10 XP_016855801 (OMIM: 600104,616040) PREDICTED: syna ( 422) 484 65.9 2.2e-10 XP_016855800 (OMIM: 600104,616040) PREDICTED: syna ( 422) 484 65.9 2.2e-10 XP_016855799 (OMIM: 600104,616040) PREDICTED: syna ( 476) 484 65.9 2.4e-10 XP_016855798 (OMIM: 600104,616040) PREDICTED: syna ( 479) 484 65.9 2.4e-10 XP_011525693 (OMIM: 600327) PREDICTED: synaptotagm ( 590) 479 65.5 4e-10 NP_001153800 (OMIM: 600327) synaptotagmin-3 [Homo ( 590) 479 65.5 4e-10 NP_001153801 (OMIM: 600327) synaptotagmin-3 [Homo ( 590) 479 65.5 4e-10 NP_115674 (OMIM: 600327) synaptotagmin-3 [Homo sap ( 590) 479 65.5 4e-10 XP_011525692 (OMIM: 600327) PREDICTED: synaptotagm ( 590) 479 65.5 4e-10 XP_005274447 (OMIM: 604146) PREDICTED: synaptotagm ( 247) 469 64.0 4.7e-10 XP_006718799 (OMIM: 604146) PREDICTED: synaptotagm ( 293) 469 64.1 5.3e-10 NP_004191 (OMIM: 604146) synaptotagmin-7 isoform 2 ( 403) 469 64.2 6.6e-10 XP_011543645 (OMIM: 604146) PREDICTED: synaptotagm ( 409) 469 64.2 6.7e-10 NP_001287702 (OMIM: 604146) synaptotagmin-7 isofor ( 447) 469 64.3 7.1e-10 XP_005274444 (OMIM: 604146) PREDICTED: synaptotagm ( 449) 469 64.3 7.1e-10 XP_011543643 (OMIM: 604146) PREDICTED: synaptotagm ( 453) 469 64.3 7.2e-10 >>NP_003576 (OMIM: 604568) double C2-like domain-contain (412 aa) initn: 2819 init1: 2819 opt: 2819 Z-score: 1688.0 bits: 321.3 E(85289): 2.8e-87 Smith-Waterman score: 2819; 99.8% identity (100.0% similar) in 412 aa overlap (1-412:1-412) 10 20 30 40 50 60 pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 NHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE0 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI 310 320 330 340 350 360 370 380 390 400 410 pF1KE0 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD 370 380 390 400 410 >>XP_016880716 (OMIM: 604568) PREDICTED: double C2-like (340 aa) initn: 1766 init1: 1766 opt: 1770 Z-score: 1068.9 bits: 206.5 E(85289): 8.5e-53 Smith-Waterman score: 1770; 90.5% identity (95.1% similar) in 285 aa overlap (1-282:1-285) 10 20 30 40 50 60 pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 NHTKTFNICLEKQLPVDKTE---DKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMD ::::::.:::::::: . :.. .:.. ...:. ..: XP_016 NHTKTFSICLEKQLPRTQQGPRVDRTRKEHAWNMLDLSACEIRRGDSRVSFPRNGICLNV 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE0 ANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWD XP_016 MSEQICPRPAPAATPSESWSLCPSSLPHPPLSMASPSPGS 310 320 330 340 >>XP_011533665 (OMIM: 604568) PREDICTED: double C2-like (387 aa) initn: 1589 init1: 1589 opt: 1591 Z-score: 962.4 bits: 186.9 E(85289): 7.3e-47 Smith-Waterman score: 2584; 93.7% identity (93.9% similar) in 412 aa overlap (1-412:1-387) 10 20 30 40 50 60 pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL ::::::::::::::::::::::::::::::: :::: XP_011 SDDCTALGTLDFSLLYDQENNALHCTITKAK-------------------------ANKL 130 140 150 190 200 210 220 230 240 pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE0 NHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG ::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE0 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI 280 290 300 310 320 330 370 380 390 400 410 pF1KE0 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSELPGAVLSD 340 350 360 370 380 >>NP_055769 (OMIM: 612159) rabphilin-3A isoform 2 [Homo (690 aa) initn: 1588 init1: 830 opt: 896 Z-score: 548.4 bits: 111.2 E(85289): 8.3e-24 Smith-Waterman score: 1623; 62.2% identity (79.0% similar) in 400 aa overlap (24-404:293-684) 10 20 30 40 50 pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFP-RFPRGLPPDAGPRA :: :: . :: . :. : : : . NP_055 LRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPG--T 270 280 290 300 310 320 60 70 80 90 100 110 pF1KE0 AAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPED .::: .:.: :. ::::: ... : :... . .: :. :: : : :. NP_055 TAPPREERTGGVGG----YPAVGAREDR--MSHPSGPYSQASAAAPQPAAARQPPPPEEE 330 340 350 360 370 120 130 140 150 160 170 pF1KE0 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP : .:..:.::. :.::.:.:::::::.:..:.::: ::::::::: :::::::::::::: NP_055 EEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLP 380 390 400 410 420 430 180 190 200 210 220 230 pF1KE0 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR ::::.::::::::::: :: :::::.:.::::::: :::::::::::::: ::::::::: NP_055 GASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETR 440 450 460 470 480 490 240 250 260 270 pF1KE0 VPLKKLKPNHTKTFNICLEKQLPVDKT-------------EDK-----SLEERGRILISL :::::::. :.::::::. .:. .. :.. ..::::.::.:: NP_055 FSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSL 500 510 520 530 540 550 280 290 300 310 320 330 pF1KE0 KYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFN ::.:. ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .:::::::::: NP_055 MYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFN 560 570 580 590 600 610 340 350 360 370 380 390 pF1KE0 EEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKR ::: :.:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::. NP_055 EEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKK 620 630 640 650 660 670 400 410 pF1KE0 IERWHTLTSELPGAVLSD ::::: : .: NP_055 IERWHQLQNENHVSSD 680 690 >>NP_001137326 (OMIM: 612159) rabphilin-3A isoform 1 [Ho (694 aa) initn: 1588 init1: 830 opt: 896 Z-score: 548.4 bits: 111.2 E(85289): 8.3e-24 Smith-Waterman score: 1623; 62.2% identity (79.0% similar) in 400 aa overlap (24-404:297-688) 10 20 30 40 50 pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFP-RFPRGLPPDAGPRA :: :: . :: . :. : : : . NP_001 LRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPG--T 270 280 290 300 310 320 60 70 80 90 100 110 pF1KE0 AAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPED .::: .:.: :. ::::: ... : :... . .: :. :: : : :. NP_001 TAPPREERTGGVGG----YPAVGAREDR--MSHPSGPYSQASAAAPQPAAARQPPPPEEE 330 340 350 360 370 120 130 140 150 160 170 pF1KE0 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP : .:..:.::. :.::.:.:::::::.:..:.::: ::::::::: :::::::::::::: NP_001 EEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLP 380 390 400 410 420 430 180 190 200 210 220 230 pF1KE0 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR ::::.::::::::::: :: :::::.:.::::::: :::::::::::::: ::::::::: NP_001 GASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETR 440 450 460 470 480 490 240 250 260 270 pF1KE0 VPLKKLKPNHTKTFNICLEKQLPVDKT-------------EDK-----SLEERGRILISL :::::::. :.::::::. .:. .. :.. ..::::.::.:: NP_001 FSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSL 500 510 520 530 540 550 280 290 300 310 320 330 pF1KE0 KYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFN ::.:. ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .:::::::::: NP_001 MYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFN 560 570 580 590 600 610 340 350 360 370 380 390 pF1KE0 EEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKR ::: :.:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::. NP_001 EEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKK 620 630 640 650 660 670 400 410 pF1KE0 IERWHTLTSELPGAVLSD ::::: : .: NP_001 IERWHQLQNENHVSSD 680 690 >>XP_011536350 (OMIM: 612159) PREDICTED: rabphilin-3A is (694 aa) initn: 1588 init1: 830 opt: 896 Z-score: 548.4 bits: 111.2 E(85289): 8.3e-24 Smith-Waterman score: 1623; 62.2% identity (79.0% similar) in 400 aa overlap (24-404:297-688) 10 20 30 40 50 pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFP-RFPRGLPPDAGPRA :: :: . :: . :. : : : . XP_011 LRRANSVQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPG--T 270 280 290 300 310 320 60 70 80 90 100 110 pF1KE0 AAPPDAPARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPED .::: .:.: :. ::::: ... : :... . .: :. :: : : :. XP_011 TAPPREERTGGVGG----YPAVGAREDR--MSHPSGPYSQASAAAPQPAAARQPPPPEEE 330 340 350 360 370 120 130 140 150 160 170 pF1KE0 EPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLP : .:..:.::. :.::.:.:::::::.:..:.::: ::::::::: :::::::::::::: XP_011 EEEANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLP 380 390 400 410 420 430 180 190 200 210 220 230 pF1KE0 GASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR ::::.::::::::::: :: :::::.:.::::::: :::::::::::::: ::::::::: XP_011 GASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETR 440 450 460 470 480 490 240 250 260 270 pF1KE0 VPLKKLKPNHTKTFNICLEKQLPVDKT-------------EDK-----SLEERGRILISL :::::::. :.::::::. .:. .. :.. ..::::.::.:: XP_011 FSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSL 500 510 520 530 540 550 280 290 300 310 320 330 pF1KE0 KYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFN ::.:. ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .:::::::::: XP_011 MYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFN 560 570 580 590 600 610 340 350 360 370 380 390 pF1KE0 EEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKR ::: :.:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::. XP_011 EEFFYDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKK 620 630 640 650 660 670 400 410 pF1KE0 IERWHTLTSELPGAVLSD ::::: : .: XP_011 IERWHQLQNENHVSSD 680 690 >>XP_016874523 (OMIM: 612159) PREDICTED: rabphilin-3A is (346 aa) initn: 1588 init1: 830 opt: 831 Z-score: 513.7 bits: 103.7 E(85289): 7.1e-22 Smith-Waterman score: 1558; 68.1% identity (84.8% similar) in 335 aa overlap (88-404:6-340) 60 70 80 90 100 110 pF1KE0 APARPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDAD : :... . .: :. :: : : :.: .:. XP_016 MSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEAN 10 20 30 120 130 140 150 160 170 pF1KE0 GYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKA .:.::. :.::.:.:::::::.:..:.::: ::::::::: ::::::::::::::::::. XP_016 SYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKS 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE0 NKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKK ::::::::::: :: :::::.:.::::::: :::::::::::::: ::::::::: ::: XP_016 NKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKK 100 110 120 130 140 150 240 250 260 270 pF1KE0 LKPNHTKTFNICLEKQLPVDKT-------------EDK-----SLEERGRILISLKYSSQ ::::. :.::::::. .:. .. :.. ..::::.::.:: ::.: XP_016 LKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYSTQ 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE0 KQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCY . ::.:::.::.:::::::::::::.:: .:.::. ::.:::: .::::::::::::: : XP_016 QGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFY 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE0 EIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWH .:::.:::::::...:::::::::::.::: ::: :::::::::..:::::::.::::: XP_016 DIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERWH 280 290 300 310 320 330 400 410 pF1KE0 TLTSELPGAVLSD : .: XP_016 QLQNENHVSSD 340 >>XP_016879267 (OMIM: 604567) PREDICTED: double C2-like (282 aa) initn: 1305 init1: 777 opt: 801 Z-score: 497.0 bits: 100.4 E(85289): 6e-21 Smith-Waterman score: 1256; 70.2% identity (81.5% similar) in 275 aa overlap (156-408:1-275) 130 140 150 160 170 180 pF1KE0 ALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTL :: :::::::::::::::: :::::.::: XP_016 MDFNGLADPYVKLHLLPGACKANKLKTKTQ 10 20 30 190 200 210 220 230 240 pF1KE0 RNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKT ::::::.::: ::: ::::.:. .:.:::.::::::. ::::::: ::::..:::.. : XP_016 RNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKH 40 50 60 70 80 90 250 260 270 280 pF1KE0 FNICLEKQLPVDKTEDKS----------------------LEERGRILISLKYSSQKQGL ::::::.:.:. . . : ::::::::.::.:::...:: XP_016 FNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGL 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE0 LVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKH ::::.:::::::::.:::::::::::::::::::::::: :::::::::::::: :::. XP_016 LVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIEL 160 170 180 190 200 210 350 360 370 380 390 400 pF1KE0 GDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTS . :: :.:::::::::::::::::::: :: :.:: ::: :::.. : .:::::::: XP_016 STLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTS 220 230 240 250 260 270 410 pF1KE0 ELPGAVLSD ::: : XP_016 ELPPAAGALSSA 280 >>NP_001268991 (OMIM: 604567) double C2-like domain-cont (400 aa) initn: 1723 init1: 777 opt: 803 Z-score: 496.3 bits: 100.7 E(85289): 6.6e-21 Smith-Waterman score: 1624; 61.3% identity (74.9% similar) in 426 aa overlap (5-408:4-393) 10 20 30 40 50 60 pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA :::.. ::.:::::::.:::::::::.:::::::: : ::.... NP_001 MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGP-------GPEGGG------ 10 20 30 40 70 80 90 100 110 120 pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE :.: ..:. .: . :. : : ::: ..:.:. NP_001 -----GGGGEAPA-----------HLVPLALAPPAALLG-------ATTPEDGAEVDSYD 50 60 70 80 130 140 150 160 170 180 pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL ::: ::::::.:.::::. . .:::.: .:::::::: :::::::::::::::: ::::: NP_001 SDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKL 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP .::: ::::::.::: ::: ::::.:. .:.:::.::::::. ::::::: ::::..::: NP_001 KTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKP 150 160 170 180 190 200 250 260 270 pF1KE0 NHTKTFNICLEKQLPVDKTEDKS----------------------LEERGRILISLKYSS .. : ::::::.:.:. . . : ::::::::.::.::: NP_001 SQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSS 210 220 230 240 250 260 280 290 300 310 320 330 pF1KE0 QKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFC ...::::::.:::::::::.:::::::::::::::::::::::: :::::::::::::: NP_001 RRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFF 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE0 YEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERW :::. . :: :.:::::::::::::::::::: :: :.:: ::: :::.. : .::: NP_001 YEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERW 330 340 350 360 370 380 400 410 pF1KE0 HTLTSELPGAVLSD :::::::: : NP_001 HTLTSELPPAAGALSSA 390 400 >>XP_011544277 (OMIM: 604567) PREDICTED: double C2-like (400 aa) initn: 1723 init1: 777 opt: 803 Z-score: 496.3 bits: 100.7 E(85289): 6.6e-21 Smith-Waterman score: 1624; 61.3% identity (74.9% similar) in 426 aa overlap (5-408:4-393) 10 20 30 40 50 60 pF1KE0 MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPA :::.. ::.:::::::.:::::::::.:::::::: : ::.... XP_011 MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGP-------GPEGGG------ 10 20 30 40 70 80 90 100 110 120 pF1KE0 RPAVAGAGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYE :.: ..:. .: . :. : : ::: ..:.:. XP_011 -----GGGGEAPA-----------HLVPLALAPPAALLG-------ATTPEDGAEVDSYD 50 60 70 80 130 140 150 160 170 180 pF1KE0 SDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKL ::: ::::::.:.::::. . .:::.: .:::::::: :::::::::::::::: ::::: XP_011 SDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKL 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE0 RTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKP .::: ::::::.::: ::: ::::.:. .:.:::.::::::. ::::::: ::::..::: XP_011 KTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKP 150 160 170 180 190 200 250 260 270 pF1KE0 NHTKTFNICLEKQLPVDKTEDKS----------------------LEERGRILISLKYSS .. : ::::::.:.:. . . : ::::::::.::.::: XP_011 SQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSS 210 220 230 240 250 260 280 290 300 310 320 330 pF1KE0 QKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFC ...::::::.:::::::::.:::::::::::::::::::::::: :::::::::::::: XP_011 RRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFF 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE0 YEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERW :::. . :: :.:::::::::::::::::::: :: :.:: ::: :::.. : .::: XP_011 YEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERW 330 340 350 360 370 380 400 410 pF1KE0 HTLTSELPGAVLSD :::::::: : XP_011 HTLTSELPPAAGALSSA 390 400 412 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 04:42:08 2016 done: Mon Nov 7 04:42:10 2016 Total Scan time: 10.650 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]