Result of FASTA (omim) for
pFN21AB0477
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0477, 518 aa
1>>>pF1KB0477 518 - 518 aa - 518 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1242+/-0.000342; mu= 14.6822+/- 0.021
mean_var=89.1123+/-17.974, 0's: 0 Z-trim(115.8): 15 B-trim: 154 in 1/54
Lambda= 0.135864
statistics sampled from 26576 (26588) to 26576 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.672), E-opt: 0.2 (0.312), width: 16
Scan time: 9.860
The best scores are: opt bits E(85289)
NP_060297 (OMIM: 612804,613845) serine--tRNA ligas ( 518) 3480 692.3 9.1e-199
NP_001139373 (OMIM: 612804,613845) serine--tRNA li ( 520) 3275 652.1 1.1e-186
NP_006504 (OMIM: 607529) serine--tRNA ligase, cyto ( 514) 590 125.8 3e-28
NP_001317598 (OMIM: 607529) serine--tRNA ligase, c ( 536) 497 107.6 9.7e-23
>>NP_060297 (OMIM: 612804,613845) serine--tRNA ligase, m (518 aa)
initn: 3480 init1: 3480 opt: 3480 Z-score: 3689.5 bits: 692.3 E(85289): 9.1e-199
Smith-Waterman score: 3480; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518)
10 20 30 40 50 60
pF1KB0 MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
430 440 450 460 470 480
490 500 510
pF1KB0 LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
::::::::::::::::::::::::::::::::::::::
NP_060 LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
490 500 510
>>NP_001139373 (OMIM: 612804,613845) serine--tRNA ligase (520 aa)
initn: 3300 init1: 2452 opt: 3275 Z-score: 3472.3 bits: 652.1 E(85289): 1.1e-186
Smith-Waterman score: 3275; 95.4% identity (96.2% similar) in 521 aa overlap (1-518:1-520)
10 20 30 40 50 60
pF1KB0 MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
70 80 90 100 110 120
130 140 150 160 170
pF1KB0 LANQDSGEVQQ---DPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPD
::::::::::: :: .. . . : ::::::::::::::::::::::
NP_001 LANQDSGEVQQVRLDPGAGSIFGPTFLPFPGQLSLLV-EAQLEEQFYLQALKLPNQTHPD
130 140 150 160 170
180 190 200 210 220 230
pF1KB0 VPVGDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPVGDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB0 LQHGLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQHGLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB0 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVT
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB0 GPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFG
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB0 EVTSASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVTSASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLV
420 430 440 450 460 470
480 490 500 510
pF1KB0 PPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
:::::::::::::::::::::::::::::::::::::::::
NP_001 PPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
480 490 500 510 520
>>NP_006504 (OMIM: 607529) serine--tRNA ligase, cytoplas (514 aa)
initn: 433 init1: 287 opt: 590 Z-score: 628.0 bits: 125.8 E(85289): 3e-28
Smith-Waterman score: 596; 29.5% identity (66.4% similar) in 342 aa overlap (158-485:123-460)
130 140 150 160 170 180
pF1KB0 EVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPVGDESQA-
.:: . . . .. : ::.::.... ..
NP_006 DALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVD
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB0 -RVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNF
.: .. :: : . .:... .: .. .. . :.: :.:.:.:. ..:...:...
NP_006 NKVERIWGDCTVR--KKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQY
160 170 180 190 200 210
250 260 270 280 290
pF1KB0 TFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNI--------DPARFKDLNLA
.. : ::. :. .: ..: :.. .. . . ..:.. : . . :
NP_006 ALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDE-ELYKVIGKGSEKSDDNSYDEKYLI
220 230 240 250 260
300 310 320 330 340 350
pF1KB0 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNT-GQEPRGLYRVHHFTKVEMFGV
.:.: .:. :. . .:::.... :::.: :... :.. ::..:::.: :.:.:
NP_006 ATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVY
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB0 TGPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRF
..: ..: ...::... :. ::. ...... . :. : .:.:.:::.:: : :
NP_006 SSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAF
330 340 350 360 370 380
420 430 440 450 460 470
pF1KB0 GEVTSASNCTDFQSRRLHIMF-QTEA--GELQFAHTVNATACAVPRLLIALLESNQQKDG
:..: :::::.:.:::.: . ::. ...:.: .::: ::. : . :.::. : . :
NP_006 RELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKG
390 400 410 420 430 440
480 490 500 510
pF1KB0 SVLVPPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
. :: :. ..
NP_006 -ITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQN
450 460 470 480 490 500
>>NP_001317598 (OMIM: 607529) serine--tRNA ligase, cytop (536 aa)
initn: 433 init1: 287 opt: 497 Z-score: 529.3 bits: 107.6 E(85289): 9.7e-23
Smith-Waterman score: 554; 28.3% identity (62.9% similar) in 364 aa overlap (158-485:123-482)
130 140 150 160 170 180
pF1KB0 EVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPVGDESQA-
.:: . . . .. : ::.::.... ..
NP_001 DALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVD
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB0 -RVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNF
.: .. :: : . .:... .: .. .. . :.: :.:.:.:. ..:...:...
NP_001 NKVERIWGDCTVR--KKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQY
160 170 180 190 200 210
250 260 270 280 290
pF1KB0 TFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNI--------DPARFKDLNLA
.. : ::. :. .: ..: :.. .. . . ..:.. : . . :
NP_001 ALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDE-ELYKVIGKGSEKSDDNSYDEKYLI
220 230 240 250 260
300 310 320 330 340 350
pF1KB0 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNT-GQEPRGLYRVHHFTKVEMFGV
.:.: .:. :. . .:::.... :::.: :... :.. ::..:::.: :.:.:
NP_001 ATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVY
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB0 TGPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRF
..: ..: ...::... :. ::. ...... . :. : .:.:.:::.:: : :
NP_001 SSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAF
330 340 350 360 370 380
420 430 440 450
pF1KB0 GEVTSASNCTDFQSRRLHIMF-QT-------------------EAG-----ELQFAHTVN
:..: :::::.:.:::.: . :: ::. ...:.: .:
NP_001 RELVSCSNCTDYQARRLRIRYGQTKKMMDKRKNNLHLSTQNKLEASLFSPKKVEFVHMLN
390 400 410 420 430 440
460 470 480 490 500 510
pF1KB0 ATACAVPRLLIALLESNQQKDGSVLVPPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGL
:: ::. : . :.::. : . : . :: :. ..
NP_001 ATMCATTRTICAILENYQTEKG-ITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKK
450 460 470 480 490 500
pF1KB0 PGQPAVS
NP_001 QHEGSKKKAAARDVTLENRLQNMEVTDA
510 520 530
518 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 17:04:56 2016 done: Sat Nov 5 17:04:57 2016
Total Scan time: 9.860 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]