FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8523, 937 aa 1>>>pF1KB8523 937 - 937 aa - 937 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1982+/-0.000676; mu= 7.0048+/- 0.041 mean_var=230.4898+/-46.485, 0's: 0 Z-trim(110.5): 589 B-trim: 76 in 1/53 Lambda= 0.084479 statistics sampled from 18220 (18911) to 18220 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.549), E-opt: 0.2 (0.222), width: 16 Scan time: 11.500 The best scores are: opt bits E(85289) NP_085072 (OMIM: 602108) matrilin-2 isoform b prec ( 937) 6497 806.9 0 NP_002371 (OMIM: 602108) matrilin-2 isoform a prec ( 956) 5990 745.1 3.8e-214 XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2 ( 799) 4622 578.3 5.2e-164 XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2 ( 818) 4622 578.3 5.3e-164 XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2 ( 896) 4325 542.2 4.5e-153 NP_001304677 (OMIM: 602108) matrilin-2 isoform c p ( 915) 3818 480.4 1.8e-134 NP_002372 (OMIM: 140600,602109,607078,608728) matr ( 486) 1239 165.8 4.9e-40 XP_016883602 (OMIM: 603897) PREDICTED: matrilin-4 ( 575) 1194 160.4 2.4e-38 XP_005260654 (OMIM: 603897) PREDICTED: matrilin-4 ( 581) 1194 160.4 2.5e-38 NP_003824 (OMIM: 603897) matrilin-4 isoform 1 prec ( 581) 1194 160.4 2.5e-38 NP_766638 (OMIM: 611746) signal peptide, CUB and E ( 988) 1046 142.6 9.6e-33 NP_001290065 (OMIM: 614708) signal peptide, CUB an ( 992) 1042 142.1 1.3e-32 XP_016883603 (OMIM: 603897) PREDICTED: matrilin-4 ( 534) 1012 138.1 1.1e-31 NP_085080 (OMIM: 603897) matrilin-4 isoform 2 prec ( 540) 1012 138.2 1.1e-31 NP_689966 (OMIM: 614708) signal peptide, CUB and E ( 993) 984 135.0 1.8e-30 XP_016859597 (OMIM: 150390) PREDICTED: latent-tran (1681) 929 128.5 2.7e-28 XP_011531158 (OMIM: 150390) PREDICTED: latent-tran (1682) 929 128.5 2.7e-28 XP_016883604 (OMIM: 603897) PREDICTED: matrilin-4 ( 493) 890 123.2 3.1e-27 NP_085095 (OMIM: 603897) matrilin-4 isoform 3 prec ( 499) 890 123.3 3.2e-27 XP_011539190 (OMIM: 604266) PREDICTED: multiple ep (1364) 898 124.7 3.2e-27 NP_001400 (OMIM: 604266) multiple epidermal growth (1541) 898 124.7 3.5e-27 XP_011539188 (OMIM: 604266) PREDICTED: multiple ep (1560) 898 124.7 3.5e-27 XP_011539187 (OMIM: 604266) PREDICTED: multiple ep (1603) 898 124.7 3.6e-27 XP_006710469 (OMIM: 604266) PREDICTED: multiple ep (1436) 893 124.1 5.1e-27 XP_016856022 (OMIM: 604266) PREDICTED: multiple ep (1559) 890 123.8 6.9e-27 XP_016859599 (OMIM: 150390) PREDICTED: latent-tran (1639) 853 119.3 1.6e-25 NP_002370 (OMIM: 115437) cartilage matrix protein ( 496) 805 112.9 4.1e-24 XP_011531160 (OMIM: 150390) PREDICTED: latent-tran (1680) 801 112.9 1.3e-23 NP_001159737 (OMIM: 150390) latent-transforming gr (1342) 799 112.6 1.4e-23 NP_000618 (OMIM: 150390) latent-transforming growt (1395) 799 112.6 1.4e-23 XP_011531162 (OMIM: 150390) PREDICTED: latent-tran (1666) 799 112.7 1.6e-23 XP_005264374 (OMIM: 150390) PREDICTED: latent-tran (1668) 799 112.7 1.6e-23 XP_011531161 (OMIM: 150390) PREDICTED: latent-tran (1669) 799 112.7 1.6e-23 XP_011531157 (OMIM: 150390) PREDICTED: latent-tran (1720) 799 112.7 1.6e-23 NP_996826 (OMIM: 150390) latent-transforming growt (1721) 799 112.7 1.6e-23 XP_011531155 (OMIM: 150390) PREDICTED: latent-tran (1722) 799 112.7 1.6e-23 XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554) 763 108.3 3.2e-22 XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395) 759 107.7 4.1e-22 XP_016882867 (OMIM: 608529) PREDICTED: fibrillin-3 (1595) 747 106.3 1.2e-21 XP_016882866 (OMIM: 608529) PREDICTED: fibrillin-3 (1948) 747 106.4 1.4e-21 XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421) 742 105.7 1.8e-21 XP_016882865 (OMIM: 608529) PREDICTED: fibrillin-3 (2766) 747 106.6 1.8e-21 XP_016882864 (OMIM: 608529) PREDICTED: fibrillin-3 (2768) 747 106.6 1.8e-21 XP_016882863 (OMIM: 608529) PREDICTED: fibrillin-3 (2777) 747 106.6 1.8e-21 XP_016882862 (OMIM: 608529) PREDICTED: fibrillin-3 (2789) 747 106.6 1.8e-21 XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522) 742 105.7 1.8e-21 XP_016882861 (OMIM: 608529) PREDICTED: fibrillin-3 (2809) 747 106.6 1.8e-21 NP_001308360 (OMIM: 608529) fibrillin-3 precursor (2809) 747 106.6 1.8e-21 NP_115823 (OMIM: 608529) fibrillin-3 precursor [Ho (2809) 747 106.6 1.8e-21 XP_016882868 (OMIM: 608529) PREDICTED: fibrillin-3 (2851) 747 106.6 1.9e-21 >>NP_085072 (OMIM: 602108) matrilin-2 isoform b precurso (937 aa) initn: 6497 init1: 6497 opt: 6497 Z-score: 4299.6 bits: 806.9 E(85289): 0 Smith-Waterman score: 6497; 99.9% identity (100.0% similar) in 937 aa overlap (1-937:1-937) 10 20 30 40 50 60 pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_085 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB8 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_085 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 850 860 870 880 890 900 910 920 930 pF1KB8 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR ::::::::::::::::::::::::::::::::::::: NP_085 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 910 920 930 >>NP_002371 (OMIM: 602108) matrilin-2 isoform a precurso (956 aa) initn: 6483 init1: 5990 opt: 5990 Z-score: 3965.6 bits: 745.1 E(85289): 3.8e-214 Smith-Waterman score: 6449; 97.9% identity (98.0% similar) in 956 aa overlap (1-937:1-956) 10 20 30 40 50 60 pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_002 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 790 800 810 820 830 840 850 860 870 880 pF1KB8 SDGRQDSPAGELPKTVQQPT-------------------VQHRYLFEEDNLLRSTQKLSH :::::::::::::::::::: ::::::::::::::::::::: NP_002 SDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSH 850 860 870 880 890 900 890 900 910 920 930 pF1KB8 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 910 920 930 940 950 >>XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2 isof (799 aa) initn: 7659 init1: 4618 opt: 4622 Z-score: 3065.5 bits: 578.3 E(85289): 5.2e-164 Smith-Waterman score: 5314; 85.1% identity (85.3% similar) in 937 aa overlap (1-937:1-799) 10 20 30 40 50 60 pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_016 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI :::::::::::::::::::::::::::::::::::::::::::::::. XP_016 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKS------------ 610 620 630 640 670 680 690 700 710 720 pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK XP_016 ------------------------------------------------------------ 730 740 750 760 770 780 pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS XP_016 ------------------------------------------------------------ 790 800 810 820 830 840 pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ------ITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 650 660 670 680 690 700 850 860 870 880 890 900 pF1KB8 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 710 720 730 740 750 760 910 920 930 pF1KB8 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR ::::::::::::::::::::::::::::::::::::: XP_016 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 770 780 790 >>XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2 isof (818 aa) initn: 5111 init1: 4618 opt: 4622 Z-score: 3065.3 bits: 578.3 E(85289): 5.3e-164 Smith-Waterman score: 5266; 83.4% identity (83.6% similar) in 956 aa overlap (1-937:1-818) 10 20 30 40 50 60 pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_005 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI :::::::::::::::::::::::::::::::::::::::::::::::. XP_005 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKS------------ 610 620 630 640 670 680 690 700 710 720 pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK XP_005 ------------------------------------------------------------ 730 740 750 760 770 780 pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS XP_005 ------------------------------------------------------------ 790 800 810 820 830 840 pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ------ITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 650 660 670 680 690 700 850 860 870 880 pF1KB8 SDGRQDSPAGELPKTVQQPT-------------------VQHRYLFEEDNLLRSTQKLSH :::::::::::::::::::: ::::::::::::::::::::: XP_005 SDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSH 710 720 730 740 750 760 890 900 910 920 930 pF1KB8 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 770 780 790 800 810 >>XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2 isof (896 aa) initn: 4325 init1: 4325 opt: 4325 Z-score: 2869.2 bits: 542.2 E(85289): 4.5e-153 Smith-Waterman score: 6090; 95.5% identity (95.6% similar) in 937 aa overlap (1-937:1-896) 10 20 30 40 50 60 pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_016 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM ::::::::::::::::::: XP_016 -----------------------------------------RINYCALNKPGCEHECVNM 370 430 440 450 460 470 480 pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 380 390 400 410 420 430 490 500 510 520 530 540 pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 440 450 460 470 480 490 550 560 570 580 590 600 pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 500 510 520 530 540 550 610 620 630 640 650 660 pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 560 570 580 590 600 610 670 680 690 700 710 720 pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 620 630 640 650 660 670 730 740 750 760 770 780 pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 680 690 700 710 720 730 790 800 810 820 830 840 pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 740 750 760 770 780 790 850 860 870 880 890 900 pF1KB8 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDGRQDSPAGELPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCE 800 810 820 830 840 850 910 920 930 pF1KB8 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR ::::::::::::::::::::::::::::::::::::: XP_016 NLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 860 870 880 890 >>NP_001304677 (OMIM: 602108) matrilin-2 isoform c precu (915 aa) initn: 4311 init1: 3818 opt: 3818 Z-score: 2535.1 bits: 480.4 E(85289): 1.8e-134 Smith-Waterman score: 6042; 93.6% identity (93.7% similar) in 956 aa overlap (1-937:1-915) 10 20 30 40 50 60 pF1KB8 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB8 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCT :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_001 FVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB8 KIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNM ::::::::::::::::::: NP_001 -----------------------------------------RINYCALNKPGCEHECVNM 370 430 440 450 460 470 480 pF1KB8 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLK 380 390 400 410 420 430 490 500 510 520 530 540 pF1KB8 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSC 440 450 460 470 480 490 550 560 570 580 590 600 pF1KB8 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 500 510 520 530 540 550 610 620 630 640 650 660 pF1KB8 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVI 560 570 580 590 600 610 670 680 690 700 710 720 pF1KB8 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKK 620 630 640 650 660 670 730 740 750 760 770 780 pF1KB8 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWAS 680 690 700 710 720 730 790 800 810 820 830 840 pF1KB8 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALED 740 750 760 770 780 790 850 860 870 880 pF1KB8 SDGRQDSPAGELPKTVQQPT-------------------VQHRYLFEEDNLLRSTQKLSH :::::::::::::::::::: ::::::::::::::::::::: NP_001 SDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSH 800 810 820 830 840 850 890 900 910 920 930 pF1KB8 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR 860 870 880 890 900 910 >>NP_002372 (OMIM: 140600,602109,607078,608728) matrilin (486 aa) initn: 984 init1: 649 opt: 1239 Z-score: 839.8 bits: 165.8 E(85289): 4.9e-40 Smith-Waterman score: 1249; 45.5% identity (67.3% similar) in 444 aa overlap (3-414:8-449) 10 20 30 pF1KB8 MEKMLAGCFLLILGQIVLLPAEA----------RERSRGRSISRGRH-------- . : : .::.: ..:::. : : ..:: . : ::. NP_002 MPRPAPARRLPG-LLLLLWPLLLLPSAAPDPVARPGFRRLETRGPGGSPGRRPSPAAPDG 10 20 30 40 50 40 50 60 70 80 90 pF1KB8 ----ARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDV . ..: : . :... :::::::::::: ...::: :. :.. ::::: NP_002 APASGTSEPGRARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPAD 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB8 TRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEG :::....:.:::: ::.:... :. ...:: :. ::::::.::::: :.. ::. : NP_002 TRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB8 ARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHE :: :.:.: .:::::::::.: ::::.:. .:: ..:.:: ..:. .:: ..::: : NP_002 AREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLE 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB8 DHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCI-NIPGSYVCRCKQGYILNS .::: : ... :: :.: ::. .:. : :.: : :: . :.. :.:.::: ::. NP_002 EHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB8 DQTTCRIQDLCAMEDHNCEQLCVN-VPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGC :. :: : ::.. :.::..::: ::. :.:: ::.: :: : : : : :: .::: NP_002 DKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGC 300 310 320 330 340 350 340 350 360 370 380 pF1KB8 EHECVNA-DGSYLCQCHEGFALNPDEKTCTKIDYCASSNHGCQHECVNTDD-SYSCHCLK .: ::: ::. :.:.::..:: :.:::. : :: ..::::: ::. :: : : NP_002 QHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYP 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB8 GFTLNPDKKTC------RRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSR :.::: ::::: ::. . . ::: NP_002 GYTLNEDKKTCSATEEARRL-VSTEDACGCEATLAFQDKVSSYLQRLNTKLDDILEKLKI 420 430 440 450 460 470 450 460 470 480 490 500 pF1KB8 VDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMD NP_002 NEYGQIHR 480 >>XP_016883602 (OMIM: 603897) PREDICTED: matrilin-4 isof (575 aa) initn: 2431 init1: 1182 opt: 1194 Z-score: 809.3 bits: 160.4 E(85289): 2.4e-38 Smith-Waterman score: 1344; 34.3% identity (51.9% similar) in 807 aa overlap (43-848:20-539) 20 30 40 50 60 70 pF1KB8 LGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHD : : :.. ::::.::::::: . XP_016 MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFE 10 20 30 40 80 90 100 110 120 130 pF1KB8 YAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLST . ...:.. .:. :..::..::::..::.: :.. : :..:.:. ..:::.. . :. XP_016 FETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQ 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB8 GTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIF :::::::::::.:.::: :::::: .: :::: .::::::::: ::::::.:: :: :. XP_016 GTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIY 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB8 AIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHF :.:: ..: ..:....: : ..::::: .:. :. . ::..:: XP_016 AVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLC--------------- 170 180 190 200 210 260 270 280 290 300 310 pF1KB8 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA XP_016 ------------------------------------------------------------ 320 330 340 350 360 370 pF1KB8 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASSNHGC :.: :: .:::::.:::. :::.:.:. ::.:. :...: ::::. .::.: XP_016 -------AIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSC 220 230 240 250 260 380 390 400 410 420 430 pF1KB8 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY :::::.: :: ::: XP_016 QHECVST-------------------------------PGGP------------RCH--- 270 280 440 450 460 470 480 490 pF1KB8 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD XP_016 ------------------------------------------------------------ 500 510 520 530 540 550 pF1KB8 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF : ::: : XP_016 -----------------CREGH----D--------------------------------- 560 570 580 590 600 610 pF1KB8 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK :. ::..:. .:.:...::::: :. XP_016 ----LQPDGRSCQVRDLCNGVDHGCE-----------------FQ--------------- 290 300 310 620 630 640 650 660 670 pF1KB8 STHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFE ::..: :: : : :: : ::. :..: :: .:::...:::::. .::: XP_016 ---------CVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFE 320 330 340 350 360 680 690 700 710 720 730 pF1KB8 VVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGS .::.::. :.: : .::...::::.:.:..:.::: : ...: ..:.:: ..:: .:. XP_016 LVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGT 370 380 390 400 410 420 740 750 760 770 780 790 pF1KB8 MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAV ::::::.:: :.::....:::: . :::...::::::.:::.: ::..:: .::.:::: XP_016 MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAV 430 440 450 460 470 480 800 810 820 830 840 850 pF1KB8 GVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQ-DSPAGE :::::.: ::.::::::.. :. :: ::.:: .. :.:. .:: : : . :: XP_016 GVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTELRSPCEC 490 500 510 520 530 540 860 870 880 890 900 910 pF1KB8 LPKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANE XP_016 ESLVEFQGRTLGALESLTLNHILWGWWRGLEGK 550 560 570 >>XP_005260654 (OMIM: 603897) PREDICTED: matrilin-4 isof (581 aa) initn: 1182 init1: 1182 opt: 1194 Z-score: 809.2 bits: 160.4 E(85289): 2.5e-38 Smith-Waterman score: 1350; 33.1% identity (50.3% similar) in 892 aa overlap (43-934:20-577) 20 30 40 50 60 70 pF1KB8 LGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHD : : :.. ::::.::::::: . XP_005 MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFE 10 20 30 40 80 90 100 110 120 130 pF1KB8 YAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLST . ...:.. .:. :..::..::::..::.: :.. : :..:.:. ..:::.. . :. XP_005 FETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQ 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB8 GTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIF :::::::::::.:.::: :::::: .: :::: .::::::::: ::::::.:: :: :. XP_005 GTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIY 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB8 AIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHF :.:: ..: ..:....: : ..::::: .:. :. . ::..:: XP_005 AVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLC--------------- 170 180 190 200 210 260 270 280 290 300 310 pF1KB8 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA XP_005 ------------------------------------------------------------ 320 330 340 350 360 370 pF1KB8 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASSNHGC :.: :: .:::::.:::. :::.:.:. ::.:. :...: ::::. .::.: XP_005 -------AIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSC 220 230 240 250 260 380 390 400 410 420 430 pF1KB8 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY :::::.: :: ::: XP_005 QHECVST-------------------------------PGGP------------RCH--- 270 280 440 450 460 470 480 490 pF1KB8 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD XP_005 ------------------------------------------------------------ 500 510 520 530 540 550 pF1KB8 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF : ::: : XP_005 -----------------CREGH------------------------------D------- 560 570 580 590 600 610 pF1KB8 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK :. ::..:. .:.:...::::: :. XP_005 ----LQPDGRSCQVRDLCNGVDHGCE-----------------FQ--------------- 290 300 310 620 630 640 650 660 670 pF1KB8 STHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFE ::..: :: : : :: : ::. :..: :: .:::...:::::. .::: XP_005 ---------CVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFE 320 330 340 350 360 680 690 700 710 720 730 pF1KB8 VVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGS .::.::. :.: : .::...::::.:.:..:.::: : ...: ..:.:: ..:: .:. XP_005 LVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGT 370 380 390 400 410 420 740 750 760 770 780 790 pF1KB8 MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAV ::::::.:: :.::....:::: . :::...::::::.:::.: ::..:: .::.:::: XP_005 MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAV 430 440 450 460 470 480 800 810 820 830 840 850 pF1KB8 GVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGEL :::::.: ::.::::::.. :. :: ::.:: .. :.:. .:: : : . XP_005 GVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTE------- 490 500 510 520 530 860 870 880 890 900 910 pF1KB8 PKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEE ::: : :.::.:. ::. . XP_005 --------------------LRS---------P-----------CECESLVEFQGRTLGA 540 550 920 930 pF1KB8 VRKLTQRLEEMTQRMEALENRLRYR ...:: : ..: :.: :::.: XP_005 LESLTLNLAQLTARLEDLENQLANQK 560 570 580 >>NP_003824 (OMIM: 603897) matrilin-4 isoform 1 precurso (581 aa) initn: 1182 init1: 1182 opt: 1194 Z-score: 809.2 bits: 160.4 E(85289): 2.5e-38 Smith-Waterman score: 1350; 33.1% identity (50.3% similar) in 892 aa overlap (43-934:20-577) 20 30 40 50 60 70 pF1KB8 LGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHD : : :.. ::::.::::::: . NP_003 MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFE 10 20 30 40 80 90 100 110 120 130 pF1KB8 YAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLST . ...:.. .:. :..::..::::..::.: :.. : :..:.:. ..:::.. . :. NP_003 FETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQ 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB8 GTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIF :::::::::::.:.::: :::::: .: :::: .::::::::: ::::::.:: :: :. NP_003 GTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIY 110 120 130 140 150 160 200 210 220 230 240 250 pF1KB8 AIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHF :.:: ..: ..:....: : ..::::: .:. :. . ::..:: NP_003 AVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLC--------------- 170 180 190 200 210 260 270 280 290 300 310 pF1KB8 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA NP_003 ------------------------------------------------------------ 320 330 340 350 360 370 pF1KB8 EDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDEKTCTKIDYCASSNHGC :.: :: .:::::.:::. :::.:.:. ::.:. :...: ::::. .::.: NP_003 -------AIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSC 220 230 240 250 260 380 390 400 410 420 430 pF1KB8 QHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGY :::::.: :: ::: NP_003 QHECVST-------------------------------PGGP------------RCH--- 270 280 440 450 460 470 480 490 pF1KB8 TLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSD NP_003 ------------------------------------------------------------ 500 510 520 530 540 550 pF1KB8 HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCF : ::: : NP_003 -----------------CREGH------------------------------D------- 560 570 580 590 600 610 pF1KB8 EGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCK :. ::..:. .:.:...::::: :. NP_003 ----LQPDGRSCQVRDLCNGVDHGCE-----------------FQ--------------- 290 300 310 620 630 640 650 660 670 pF1KB8 STHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFE ::..: :: : : :: : ::. :..: :: .:::...:::::. .::: NP_003 ---------CVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFE 320 330 340 350 360 680 690 700 710 720 730 pF1KB8 VVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGS .::.::. :.: : .::...::::.:.:..:.::: : ...: ..:.:: ..:: .:. NP_003 LVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGT 370 380 390 400 410 420 740 750 760 770 780 790 pF1KB8 MTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAV ::::::.:: :.::....:::: . :::...::::::.:::.: ::..:: .::.:::: NP_003 MTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAV 430 440 450 460 470 480 800 810 820 830 840 850 pF1KB8 GVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGEL :::::.: ::.::::::.. :. :: ::.:: .. :.:. .:: : : . NP_003 GVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTE------- 490 500 510 520 530 860 870 880 890 900 910 pF1KB8 PKTVQQPTVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEE ::: : :.::.:. ::. . NP_003 --------------------LRS---------P-----------CECESLVEFQGRTLGA 540 550 920 930 pF1KB8 VRKLTQRLEEMTQRMEALENRLRYR ...:: : ..: :.: :::.: NP_003 LESLTLNLAQLTARLEDLENQLANQK 560 570 580 937 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 16:34:04 2016 done: Sat Nov 5 16:34:05 2016 Total Scan time: 11.500 Total Display time: 0.310 Function used was FASTA [36.3.4 Apr, 2011]