Result of FASTA (omim) for
pFN21AB0457
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB0457, 505 aa
1>>>pF1KB0457 505 - 505 aa - 505 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.5902+/-0.000459; mu= 2.9513+/- 0.028
mean_var=215.3911+/-41.287, 0's: 0 Z-trim(117.3): 146 B-trim: 75 in 1/57
Lambda= 0.087390
statistics sampled from 28930 (29089) to 28930 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.689), E-opt: 0.2 (0.341), width: 16
Scan time: 10.170
The best scores are: opt bits E(85289)
NP_002272 (OMIM: 158000,602153) keratin, type II c ( 505) 3386 440.1 7e-123
NP_002273 (OMIM: 158000,602765) keratin, type II c ( 493) 3130 407.8 3.6e-113
NP_001307127 (OMIM: 158000,601928) keratin, type I ( 486) 2994 390.7 5.1e-108
XP_016874785 (OMIM: 158000,601928) PREDICTED: kera ( 486) 2994 390.7 5.1e-108
XP_005268923 (OMIM: 158000,601928) PREDICTED: kera ( 563) 2994 390.7 5.7e-108
NP_002274 (OMIM: 602032,602767) keratin, type II c ( 507) 2465 324.0 6.3e-88
NP_149034 (OMIM: 602766) keratin, type II cuticula ( 600) 1804 240.7 8.8e-63
XP_011536637 (OMIM: 602766) PREDICTED: keratin, ty ( 600) 1804 240.7 8.8e-63
NP_149022 (OMIM: 601078) keratin, type II cuticula ( 513) 1768 236.1 1.8e-61
NP_000415 (OMIM: 131760,131800,131900,131960,14804 ( 590) 1467 198.2 5.3e-50
NP_005545 (OMIM: 148041,615726) keratin, type II c ( 564) 1434 194.1 9.2e-49
NP_775109 (OMIM: 612315,615735) keratin, type II c ( 564) 1427 193.2 1.7e-48
NP_005546 (OMIM: 148042,615728) keratin, type II c ( 564) 1426 193.1 1.9e-48
NP_004684 (OMIM: 609025,612318) keratin, type II c ( 551) 1411 191.2 6.8e-48
NP_001287739 (OMIM: 602032,602767) keratin, type I ( 295) 1397 189.2 1.4e-47
NP_476429 (OMIM: 122100,148043) keratin, type II c ( 628) 1372 186.3 2.3e-46
NP_006112 (OMIM: 113800,139350,144200,146590,60096 ( 644) 1361 184.9 6e-46
NP_001243222 (OMIM: 148060) keratin, type II cytos ( 483) 1357 184.3 6.9e-46
NP_002264 (OMIM: 148060) keratin, type II cytoskel ( 483) 1357 184.3 6.9e-46
NP_001243211 (OMIM: 148060) keratin, type II cytos ( 511) 1357 184.3 7.2e-46
NP_002263 (OMIM: 123940,193900) keratin, type II c ( 520) 1344 182.7 2.3e-45
NP_005547 (OMIM: 148059) keratin, type II cytoskel ( 469) 1343 182.5 2.3e-45
NP_056932 (OMIM: 616671) keratin, type II cytoskel ( 638) 1341 182.4 3.4e-45
NP_258259 (OMIM: 608245,615896) keratin, type II c ( 523) 1322 179.9 1.6e-44
NP_778238 (OMIM: 608247) keratin, type II cytoskel ( 540) 1315 179.0 2.9e-44
NP_787028 (OMIM: 611160) keratin, type II cytoskel ( 535) 1308 178.2 5.4e-44
NP_000414 (OMIM: 146800,600194) keratin, type II c ( 639) 1305 177.8 8e-44
XP_011536627 (OMIM: 148059) PREDICTED: keratin, ty ( 445) 1297 176.7 1.2e-43
XP_016874238 (OMIM: 608245,615896) PREDICTED: kera ( 441) 1295 176.5 1.4e-43
NP_001139697 (OMIM: 608246) keratin, type II cytos ( 511) 1276 174.1 8.5e-43
NP_542785 (OMIM: 608246) keratin, type II cytoskel ( 511) 1276 174.1 8.5e-43
NP_778223 (OMIM: 194300,608248,613981,614929) kera ( 529) 1251 171.0 7.8e-42
XP_016874323 (OMIM: 608246) PREDICTED: keratin, ty ( 442) 1237 169.1 2.3e-41
XP_016874325 (OMIM: 608246) PREDICTED: keratin, ty ( 419) 1235 168.9 2.6e-41
NP_778253 (OMIM: 611158) keratin, type II cytoskel ( 578) 1190 163.3 1.7e-39
NP_775487 (OMIM: 611159) keratin, type II cytoskel ( 520) 1172 161.0 7.6e-39
XP_016874324 (OMIM: 608246) PREDICTED: keratin, ty ( 439) 1060 146.8 1.2e-34
XP_016874322 (OMIM: 608246) PREDICTED: keratin, ty ( 445) 1060 146.8 1.2e-34
NP_001287743 (OMIM: 611159) keratin, type II cytos ( 410) 950 132.9 1.7e-30
NP_001074961 (OMIM: 611161) keratin, type II cytos ( 422) 936 131.2 5.9e-30
NP_872313 (OMIM: 611161) keratin, type II cytoskel ( 452) 936 131.2 6.2e-30
NP_001139698 (OMIM: 608246) keratin, type II cytos ( 469) 885 124.8 5.5e-28
XP_016874783 (OMIM: 148059) PREDICTED: keratin, ty ( 292) 846 119.7 1.2e-26
XP_011536590 (OMIM: 611158) PREDICTED: keratin, ty ( 345) 812 115.5 2.6e-25
NP_003371 (OMIM: 116300,193060) vimentin [Homo sap ( 466) 731 105.4 3.8e-22
XP_006717563 (OMIM: 116300,193060) PREDICTED: vime ( 466) 731 105.4 3.8e-22
XP_011536559 (OMIM: 608247) PREDICTED: keratin, ty ( 508) 728 105.0 5.3e-22
XP_016874326 (OMIM: 608246) PREDICTED: keratin, ty ( 271) 714 103.0 1.1e-21
NP_001918 (OMIM: 125660,181400,601419,602067,60476 ( 470) 708 102.5 2.9e-21
NP_001124491 (OMIM: 137780,203450) glial fibrillar ( 431) 702 101.7 4.6e-21
>>NP_002272 (OMIM: 158000,602153) keratin, type II cutic (505 aa)
initn: 3386 init1: 3386 opt: 3386 Z-score: 2327.1 bits: 440.1 E(85289): 7e-123
Smith-Waterman score: 3386; 99.8% identity (99.8% similar) in 505 aa overlap (1-505:1-505)
10 20 30 40 50 60
pF1KB0 MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 RSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 IDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASEL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 NHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSK
::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 CEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 LSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB0 IGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLNTTCGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLNTTCGG
430 440 450 460 470 480
490 500
pF1KB0 GSCGVGSCGISSLGVGSCGSSCRKC
:::::::::::::::::::::::::
NP_002 GSCGVGSCGISSLGVGSCGSSCRKC
490 500
>>NP_002273 (OMIM: 158000,602765) keratin, type II cutic (493 aa)
initn: 3212 init1: 3118 opt: 3130 Z-score: 2152.8 bits: 407.8 E(85289): 3.6e-113
Smith-Waterman score: 3130; 95.5% identity (97.1% similar) in 491 aa overlap (1-486:1-491)
10 20 30 40 50
pF1KB0 MTCG-----SGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFR
:::: :: :::.:::::::.::::::::::::::::::::::::::::::::
NP_002 MTCGFNSIGCGFRPGNFSCVSACGPRPSRCCITAAPYRGISCYRGLTGGFGSHSVCGGFR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB0 AGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNS
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB0 RFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGR
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_002 RFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFAGYIETLRREAECVEADSGR
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB0 LASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQE
:::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
NP_002 LASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB0 IDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAES
:::::::::::::::::::::::::::::::::::::::.::::::::::.:::::::::
NP_002 IDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIVAEIKAQYDDIATRSRAEAES
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB0 WYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQ
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB0 QGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQ
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB0 RLCEGIGAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLN
:::::. ::::::::::::::::::::::::::::::::::::::..:::::: ::::::
NP_002 RLCEGVEAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNLVVSTGLCKPCGQLN
430 440 450 460 470 480
480 490 500
pF1KB0 TTCGGGSCGVGSCGISSLGVGSCGSSCRKC
::::::::: :
NP_002 TTCGGGSCGQGRH
490
>>NP_001307127 (OMIM: 158000,601928) keratin, type II cu (486 aa)
initn: 2987 init1: 2932 opt: 2994 Z-score: 2060.2 bits: 390.7 E(85289): 5.1e-108
Smith-Waterman score: 2994; 93.8% identity (97.5% similar) in 485 aa overlap (1-483:1-483)
10 20 30 40 50 60
pF1KB0 MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCG
::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTCGSYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 RSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 IDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASEL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 NHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSK
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 CEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 LSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEG
370 380 390 400 410 420
430 440 450 460 470
pF1KB0 IGAVNVCVSSSRGGVVCGDLCVSGSRPVTGS-VCSAPCNGNVAV-STGLCAPCGQLNTTC
.:.::::::::::::::::::.: . ::... : :.: :.::.: .:. ::: ..... :
NP_001 VGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVSSVPSNSNVVVGTTNACAPSARVGV-C
430 440 450 460 470
480 490 500
pF1KB0 GGGSCGVGSCGISSLGVGSCGSSCRKC
:: ::
NP_001 GG-SCKRC
480
>>XP_016874785 (OMIM: 158000,601928) PREDICTED: keratin, (486 aa)
initn: 2987 init1: 2932 opt: 2994 Z-score: 2060.2 bits: 390.7 E(85289): 5.1e-108
Smith-Waterman score: 2994; 93.8% identity (97.5% similar) in 485 aa overlap (1-483:1-483)
10 20 30 40 50 60
pF1KB0 MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCG
::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTCGSYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB0 RSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB0 IDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASEL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB0 NHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB0 RLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSK
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB0 CEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB0 LSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEG
370 380 390 400 410 420
430 440 450 460 470
pF1KB0 IGAVNVCVSSSRGGVVCGDLCVSGSRPVTGS-VCSAPCNGNVAV-STGLCAPCGQLNTTC
.:.::::::::::::::::::.: . ::... : :.: :.::.: .:. ::: ..... :
XP_016 VGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVSSVPSNSNVVVGTTNACAPSARVGV-C
430 440 450 460 470
480 490 500
pF1KB0 GGGSCGVGSCGISSLGVGSCGSSCRKC
:: ::
XP_016 GG-SCKRC
480
>>XP_005268923 (OMIM: 158000,601928) PREDICTED: keratin, (563 aa)
initn: 2987 init1: 2932 opt: 2994 Z-score: 2059.3 bits: 390.7 E(85289): 5.7e-108
Smith-Waterman score: 2994; 93.8% identity (97.5% similar) in 485 aa overlap (1-483:78-560)
10 20 30
pF1KB0 MTCGSGFGGRAFSCISACGPRPGRCCITAA
::::: :::::::::::::::::::::::
XP_005 ASSERLTPRPLCSPFGRLHPQNLLSSPKSTMTCGSYCGGRAFSCISACGPRPGRCCITAA
50 60 70 80 90 100
40 50 60 70 80 90
pF1KB0 PYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTP
110 120 130 140 150 160
100 110 120 130 140 150
pF1KB0 LNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSN
170 180 190 200 210 220
160 170 180 190 200 210
pF1KB0 LEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVA
230 240 250 260 270 280
220 230 240 250 260 270
pF1KB0 LKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLN
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_005 LKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLN
290 300 310 320 330 340
280 290 300 310 320 330
pF1KB0 MDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQ
350 360 370 380 390 400
340 350 360 370 380 390
pF1KB0 RLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQ
410 420 430 440 450 460
400 410 420 430 440 450
pF1KB0 EVMNSKLGLDIEIATYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVVCGDLCVSGSRPVTG
::::::::::::::::::::::::::::::.:.::::::::::::::::::.: . ::..
XP_005 EVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVS
470 480 490 500 510 520
460 470 480 490 500
pF1KB0 S-VCSAPCNGNVAV-STGLCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC
. : :.: :.::.: .:. ::: ..... ::: ::
XP_005 TRVSSVPSNSNVVVGTTNACAPSARVGV-CGG-SCKRC
530 540 550 560
>>NP_002274 (OMIM: 602032,602767) keratin, type II cutic (507 aa)
initn: 2567 init1: 2390 opt: 2465 Z-score: 1699.5 bits: 324.0 E(85289): 6.3e-88
Smith-Waterman score: 2608; 81.0% identity (89.3% similar) in 504 aa overlap (1-484:1-499)
10 20 30 40 50
pF1KB0 MTC-----GSGFG-GRAFSCISACGPRPG-RCCITAAPYRGISCYRGLTGGFGSHSVC--
:.: .:: : : :: :: .:. : ::::.::::::.:::::::: :::.:.:
NP_002 MSCRSYRISSGCGVTRNFSSCSAVAPKTGNRCCISAAPYRGVSCYRGLTG-FGSRSLCNL
10 20 30 40 50
60 70 80 90 100
pF1KB0 ---------GGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCV
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GSCGPRIAVGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCV
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB0 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL
::::::::::::::::::::::::::::::::::: :::::..::.::::::: ::::::
NP_002 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFSGYIETL
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB0 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK
::::::::::::::::::::::::::::::::::::.::::::::::.::::::::::::
NP_002 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCAYLRK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB0 SDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY
::::::::::..: .:::::::::::.::.:::::::.::.:::::::::::::::::::
NP_002 SDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDCIIAEIKAQY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB0 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ
::...::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_002 DDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEIENAKCQ
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB0 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE
.:::::::..::::::::::::::::::::::::::::::::..:::::::::::::::
NP_002 RAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDMACLLKEYQEVMNSKLGLDIE
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB0 IATYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVVCGDLCVSGS--RPVTGSVCSAPCNGN
::::::::::::.:::::.:.:::::::::::: :: : : . : .: : :: ..
NP_002 IATYRRLLEGEEHRLCEGVGSVNVCVSSSRGGVSCGGLSYSTTPGRQIT-SGPSAIGGSI
420 430 440 450 460 470
470 480 490 500
pF1KB0 VAVSTGLCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC
..:. :::: ... :::
NP_002 TVVAPDSCAPCQPRSSSF---SCGSSRSVRFA
480 490 500
>>NP_149034 (OMIM: 602766) keratin, type II cuticular Hb (600 aa)
initn: 1781 init1: 1752 opt: 1804 Z-score: 1248.1 bits: 240.7 E(85289): 8.8e-63
Smith-Waterman score: 1812; 60.5% identity (80.6% similar) in 496 aa overlap (15-500:65-555)
10 20 30 40
pF1KB0 MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGG
:.: : :: .: . . :.. : :
NP_149 SVSCWSGPGFRGLGSFGSRSVITFGSYSPRIAAVGSRPIHCGVRFGAGCGMGFGDGRGVG
40 50 60 70 80 90
50 60 70 80 90
pF1KB0 FG--SHSVCG-GFRAGSC------GRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEI
.: . : : :: ::: : .:::: ::: :. : ::.:.::.::::::::::
NP_149 LGPRADSCVGLGFGAGSGIGYGFGGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEI
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB0 DPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLF
::::: ::..::::::.::..::.:::::::::::::::::: .: :...: .:::::::
NP_149 DPNAQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLF
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB0 EGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDV
:.:: .:::. : . .:..:: .: ::.:.::::.:::::::: ::.::::::::::::
NP_149 ESYITNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDV
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB0 DCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCII
: :.. ::::::::..: ::::::. :: :::..::::::.:::.::.:::::::.: ::
NP_149 DAAFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGII
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB0 AEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAE
::.::::.... ::::.::.::..: :::..:. .: ..:: ..:::::.:.:::: ::
NP_149 AEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAE
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB0 VENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNS
.:.:: : .:::::::..::::::.::::.::::.:: :::.:::::: . ::::.::.
NP_149 IEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNA
400 410 420 430 440 450
400 410 420 430 440 450
pF1KB0 KLGLDIEIATYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVVCG-DLCVSGSRPVTGSVCS
:::::::::::::::::::.:::::.: ::. :::::::.::: . :.:: :.: .
NP_149 KLGLDIEIATYRRLLEGEESRLCEGVGPVNISVSSSRGGLVCGPEPLVAGSTLSRGGV-T
460 470 480 490 500 510
460 470 480 490 500
pF1KB0 APCNGNVAVSTGLCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC
...: ...:. : :: . ::. . .. . : :. : ::
NP_149 FSGSSSVCATSGVLASCGP---SLGGARVAPATGDLLSTGTRS-GSMLISEACVPSVPCP
520 530 540 550 560
NP_149 LPTQGGFSSCSGGRSSSVRFVSTTTSCRTKY
570 580 590 600
>>XP_011536637 (OMIM: 602766) PREDICTED: keratin, type I (600 aa)
initn: 1781 init1: 1752 opt: 1804 Z-score: 1248.1 bits: 240.7 E(85289): 8.8e-63
Smith-Waterman score: 1812; 60.5% identity (80.6% similar) in 496 aa overlap (15-500:65-555)
10 20 30 40
pF1KB0 MTCGSGFGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGG
:.: : :: .: . . :.. : :
XP_011 SVSCWSGPGFRGLGSFGSRSVITFGSYSPRIAAVGSRPIHCGVRFGAGCGMGFGDGRGVG
40 50 60 70 80 90
50 60 70 80 90
pF1KB0 FG--SHSVCG-GFRAGSC------GRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEI
.: . : : :: ::: : .:::: ::: :. : ::.:.::.::::::::::
XP_011 LGPRADSCVGLGFGAGSGIGYGFGGPGFGYRVGGVGVPAAPSITAVTVNKSLLTPLNLEI
100 110 120 130 140 150
100 110 120 130 140 150
pF1KB0 DPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLF
::::: ::..::::::.::..::.:::::::::::::::::: .: :...: .:::::::
XP_011 DPNAQRVKKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLF
160 170 180 190 200 210
160 170 180 190 200 210
pF1KB0 EGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDV
:.:: .:::. : . .:..:: .: ::.:.::::.:::::::: ::.::::::::::::
XP_011 ESYITNLRRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDV
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB0 DCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCII
: :.. ::::::::..: ::::::. :: :::..::::::.:::.::.:::::::.: ::
XP_011 DAAFMNKSDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGII
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB0 AEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAE
::.::::.... ::::.::.::..: :::..:. .: ..:: ..:::::.:.:::: ::
XP_011 AEVKAQYEEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAE
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB0 VENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNS
.:.:: : .:::::::..::::::.::::.::::.:: :::.:::::: . ::::.::.
XP_011 IEHAKAQRAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNA
400 410 420 430 440 450
400 410 420 430 440 450
pF1KB0 KLGLDIEIATYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVVCG-DLCVSGSRPVTGSVCS
:::::::::::::::::::.:::::.: ::. :::::::.::: . :.:: :.: .
XP_011 KLGLDIEIATYRRLLEGEESRLCEGVGPVNISVSSSRGGLVCGPEPLVAGSTLSRGGV-T
460 470 480 490 500 510
460 470 480 490 500
pF1KB0 APCNGNVAVSTGLCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC
...: ...:. : :: . ::. . .. . : :. : ::
XP_011 FSGSSSVCATSGVLASCGP---SLGGARVAPATGDLLSTGTRS-GSMLISEACVPSVPCP
520 530 540 550 560
XP_011 LPTQGGFSSCSGGRSSSVRFVSTTTSCRTKY
570 580 590 600
>>NP_149022 (OMIM: 601078) keratin, type II cuticular Hb (513 aa)
initn: 1748 init1: 1626 opt: 1768 Z-score: 1224.5 bits: 236.1 E(85289): 1.8e-61
Smith-Waterman score: 1799; 59.6% identity (78.6% similar) in 513 aa overlap (4-501:9-508)
10 20 30 40 50
pF1KB0 MTCGSGFGGRAFSCISACGPRP-GRCCITAAPYRGISCYRGLT--GGFGSHSVCG
:: :...:: :: :: . .. .: : . ::: : .::.:.:.
NP_149 MSYHSFQPGSRCGSQSFSSYSAVMPRMVTHYAVSKGPCRP-GGGRGLRALGCLGSRSLCN
10 20 30 40 50
60 70 80 90 100
pF1KB0 -GF---RAGS-CGRS---FGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQ
:: :..: :: . :::: :..:::: ::: :..:::::.:: :::::..: ::.
NP_149 VGFGRPRVASRCGGTLPGFGYRLGATCGPSA-CITPVTINESLLVPLALEIDPTVQRVKR
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB0 EEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRR
.:::::: ::.:::.::.:::::::.::::::: .:.:...:::.:.::.::::: .:::
NP_149 DEKEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQRCCQTNIEPIFEGYISALRR
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB0 EAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSD
. .:: .: :: ::: .: .:::::::::::.::: .:::::::::::: :.: :.:
NP_149 QLDCVSGDRVRLESELCSLQAALEGYKKKYEEELSLRPCVENEFVALKKDVDTAFLMKAD
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB0 LEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDD
::.:.:::.::::::. :::::: .:::.::.:::.::.::::.:..: :::::::::::
NP_149 LETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMDNSRELDVDGIIAEIKAQYDD
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB0 IVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNS
:..::.::::.::. . ::...:. : ..:: :.:: :.:..:::: :.::.: :
NP_149 IASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILEMNKLIQRLQQETENVKAQRC
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB0 KLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIA
:::.:.:..::::::::.::.:::: :: ::::::::::::..:::::::::::::::::
NP_149 KLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIA
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB0 TYRRLLEGEEQRLCEGIGAVNVCVSSSRGGVV---CGDLCVSGSRPVTGSVCSAPCNGNV
::::::::::.::::::: ::. ::::.:. . :: : :: .. .:
NP_149 TYRRLLEGEEHRLCEGIGPVNISVSSSKGAFLYEPCGV-----STPVLSTGVLRSNGGCS
420 430 440 450 460 470
470 480 490 500
pF1KB0 AVSTG-LCAPCGQLNTTCGGGSCGVGSCGISSLGVGSCGSSCRKC
:.:: : .:: : ::: : ::. .:. :::
NP_149 IVGTGELYVPC----EPQGLLSCGSGR--KSSMTLGAGGSSPSHKH
480 490 500 510
>>NP_000415 (OMIM: 131760,131800,131900,131960,148040,17 (590 aa)
initn: 1423 init1: 1083 opt: 1467 Z-score: 1018.6 bits: 198.2 E(85289): 5.3e-50
Smith-Waterman score: 1478; 49.2% identity (73.6% similar) in 535 aa overlap (3-504:55-586)
10 20 30
pF1KB0 MTCG-SGFGGRAFSCISACGPRPGRCCITAAP
:: .:.:.:.. .. : . ...
NP_000 PSVSRTSFTSVSRSGGGGGGGFGRVSLAGACGVGGYGSRSLYNLG--GSKRISISTSGGS
30 40 50 60 70 80
40 50 60 70 80
pF1KB0 YR-----GISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYR-SGGVCGPS-PPC----ITT
.: : . :. :: :: :: .:. : . : .:: ::. : : :
NP_000 FRNRFGAGAGGGYGFGGGAGSGFGFGGGAGGGFGLGGGAGFGGGFGGPGFPVCPPGGIQE
90 100 110 120 130 140
90 100 110 120 130 140
pF1KB0 VSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQF
:.::.::::::::.:::. : :. ::.::::.::..::.:::::::::::::.:.:: .
NP_000 VTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTL
150 160 170 180 190 200
150 160 170 180 190
pF1KB0 YQNR--ECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEV
:.. . ..::::::: ::..:::. . . .. ::: ::: ..:...: .:.:::.:.
NP_000 LQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEI
210 220 230 240 250 260
200 210 220 230 240 250
pF1KB0 SLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTS
. :.::::::: :::::: ::. : .:::.:.::..::.:.. ... :. .:.:.::::
NP_000 NKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTS
270 280 290 300 310 320
260 270 280 290 300 310
pF1KB0 VVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRT
::...::.:.:..: ::::.::::..:..:::.::::::..: ::.. :. :::. :: :
NP_000 VVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNT
330 340 350 360 370 380
320 330 340 350 360 370
pF1KB0 KEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKA
:.::.:.::::::: ::..:.: : ..:. :.:..::.:: ::.::: :::::: :::::
NP_000 KHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKA
390 400 410 420 430 440
380 390 400 410 420 430
pF1KB0 KQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLC-EGIGAVNVCVSSSR-----
::::: :.:::::.::.::.::.::::::.:::::: :: ::.: ::. : .:
NP_000 KQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSSGY
450 460 470 480 490 500
440 450 460 470 480
pF1KB0 ----------GGVVCGDLCVSGSRPVTGSVCSAPCNGNVAVSTGLCAPCGQLNTTCGGG-
:: . : : . . .:: :. .:.:... :: . . .... : :
NP_000 GSGSGYGGGLGGGLGGGLGGGLAGGSSGSYYSSS-SGGVGLGGGLSVGGSGFSASSGRGL
510 520 530 540 550 560
490 500
pF1KB0 SCGVGSCGISSLGVG--SCGSSCRKC
. : :: : :: .: : :: ::
NP_000 GVGFGSGGGSSSSVKFVSTTSSSRKSFKS
570 580 590
505 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:54:06 2016 done: Sat Nov 5 11:54:07 2016
Total Scan time: 10.170 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]