Result of FASTA (omim) for
pFN21AB8448
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8448, 445 aa
1>>>pF1KB8448 445 - 445 aa - 445 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.0493+/-0.000278; mu= 15.1607+/- 0.018
mean_var=82.6936+/-16.951, 0's: 0 Z-trim(120.1): 69 B-trim: 1907 in 1/53
Lambda= 0.141039
statistics sampled from 34791 (34860) to 34791 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.409), width: 16
Scan time: 9.720
The best scores are: opt bits E(85289)
NP_690607 (OMIM: 600504) inward rectifier potassiu ( 445) 2987 616.9 3.3e-176
NP_004972 (OMIM: 600504) inward rectifier potassiu ( 445) 2987 616.9 3.3e-176
XP_005256682 (OMIM: 602323) PREDICTED: ATP-sensiti ( 433) 1454 305.0 2.6e-82
NP_066292 (OMIM: 602323) ATP-sensitive inward rect ( 433) 1454 305.0 2.6e-82
XP_011522133 (OMIM: 602323) PREDICTED: ATP-sensiti ( 433) 1454 305.0 2.6e-82
NP_001181887 (OMIM: 613236,613239) inward rectifie ( 433) 1441 302.3 1.6e-81
XP_005276976 (OMIM: 613236,613239) PREDICTED: inwa ( 535) 1441 302.4 1.9e-81
NP_000882 (OMIM: 170390,600681,609622,613980) inwa ( 427) 1388 291.5 2.8e-78
NP_037480 (OMIM: 603953) ATP-sensitive inward rect ( 436) 1304 274.5 4e-73
XP_011541112 (OMIM: 600734,613485,613677) PREDICTE ( 419) 1087 230.3 7.5e-60
XP_011541111 (OMIM: 600734,613485,613677) PREDICTE ( 419) 1087 230.3 7.5e-60
NP_000881 (OMIM: 600734,613485,613677) G protein-a ( 419) 1087 230.3 7.5e-60
NP_004973 (OMIM: 600935) ATP-sensitive inward rect ( 424) 1061 225.0 3e-58
XP_016874773 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1061 225.0 3e-58
XP_005253415 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1061 225.0 3e-58
XP_016874772 (OMIM: 600935) PREDICTED: ATP-sensiti ( 424) 1061 225.0 3e-58
NP_002231 (OMIM: 600877,614098) G protein-activate ( 423) 1046 222.0 2.5e-57
NP_004974 (OMIM: 600932) G protein-activated inwar ( 393) 1024 217.5 5.1e-56
XP_016856736 (OMIM: 600932) PREDICTED: G protein-a ( 450) 1024 217.5 5.8e-56
NP_002230 (OMIM: 601534) G protein-activated inwar ( 501) 951 202.7 1.9e-51
NP_000516 (OMIM: 125853,600937,601820,606176,61058 ( 390) 885 189.2 1.7e-47
NP_001159762 (OMIM: 125853,600937,601820,606176,61 ( 303) 869 185.9 1.3e-46
XP_006718289 (OMIM: 125853,600937,601820,606176,61 ( 303) 869 185.9 1.3e-46
XP_016873169 (OMIM: 125853,600937,601820,606176,61 ( 303) 869 185.9 1.3e-46
NP_722451 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 850 182.0 2.2e-45
NP_722450 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 850 182.0 2.2e-45
NP_722448 (OMIM: 241200,600359) ATP-sensitive inwa ( 372) 850 182.0 2.2e-45
NP_722449 (OMIM: 241200,600359) ATP-sensitive inwa ( 389) 850 182.1 2.3e-45
NP_000211 (OMIM: 241200,600359) ATP-sensitive inwa ( 391) 850 182.1 2.3e-45
NP_001257351 (OMIM: 605722) inward rectifier potas ( 418) 824 176.8 9.7e-44
NP_001278553 (OMIM: 605722) inward rectifier potas ( 418) 824 176.8 9.7e-44
XP_016880102 (OMIM: 605722) PREDICTED: inward rect ( 418) 824 176.8 9.7e-44
XP_011523083 (OMIM: 605722) PREDICTED: inward rect ( 418) 824 176.8 9.7e-44
NP_001278554 (OMIM: 605722) inward rectifier potas ( 418) 824 176.8 9.7e-44
XP_006721950 (OMIM: 605722) PREDICTED: inward rect ( 453) 824 176.8 1e-43
XP_016880100 (OMIM: 605722) PREDICTED: inward rect ( 453) 824 176.8 1e-43
NP_061128 (OMIM: 605722) inward rectifier potassiu ( 453) 824 176.8 1e-43
XP_016880101 (OMIM: 605722) PREDICTED: inward rect ( 453) 824 176.8 1e-43
XP_006721949 (OMIM: 605722) PREDICTED: inward rect ( 453) 824 176.8 1e-43
XP_005257394 (OMIM: 605722) PREDICTED: inward rect ( 453) 824 176.8 1e-43
XP_016880098 (OMIM: 605722) PREDICTED: inward rect ( 453) 824 176.8 1e-43
NP_733937 (OMIM: 605722) inward rectifier potassiu ( 453) 824 176.8 1e-43
NP_733938 (OMIM: 605722) inward rectifier potassiu ( 453) 824 176.8 1e-43
XP_016880099 (OMIM: 605722) PREDICTED: inward rect ( 453) 824 176.8 1e-43
XP_006721948 (OMIM: 605722) PREDICTED: inward rect ( 453) 824 176.8 1e-43
NP_001278551 (OMIM: 605722) inward rectifier potas ( 453) 824 176.8 1e-43
NP_001278552 (OMIM: 605722) inward rectifier potas ( 453) 824 176.8 1e-43
NP_001247438 (OMIM: 601534) G protein-activated in ( 308) 735 158.6 2.1e-38
NP_002232 (OMIM: 274600,600791,602208,612780) ATP- ( 379) 716 154.8 3.7e-37
NP_001263367 (OMIM: 602106) ATP-sensitive inward r ( 375) 694 150.3 8.1e-36
>>NP_690607 (OMIM: 600504) inward rectifier potassium ch (445 aa)
initn: 2987 init1: 2987 opt: 2987 Z-score: 3284.5 bits: 616.9 E(85289): 3.3e-176
Smith-Waterman score: 2987; 100.0% identity (100.0% similar) in 445 aa overlap (1-445:1-445)
10 20 30 40 50 60
pF1KB8 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 IFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 IFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 FLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 FLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 RAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 RAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 TQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 TQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 LPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 LPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG
370 380 390 400 410 420
430 440
pF1KB8 SHLDLERMQASLPLDNISYRRESAI
:::::::::::::::::::::::::
NP_690 SHLDLERMQASLPLDNISYRRESAI
430 440
>>NP_004972 (OMIM: 600504) inward rectifier potassium ch (445 aa)
initn: 2987 init1: 2987 opt: 2987 Z-score: 3284.5 bits: 616.9 E(85289): 3.3e-176
Smith-Waterman score: 2987; 100.0% identity (100.0% similar) in 445 aa overlap (1-445:1-445)
10 20 30 40 50 60
pF1KB8 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 IFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 FLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 RAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 TQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 LPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG
370 380 390 400 410 420
430 440
pF1KB8 SHLDLERMQASLPLDNISYRRESAI
:::::::::::::::::::::::::
NP_004 SHLDLERMQASLPLDNISYRRESAI
430 440
>>XP_005256682 (OMIM: 602323) PREDICTED: ATP-sensitive i (433 aa)
initn: 1893 init1: 1359 opt: 1454 Z-score: 1598.8 bits: 305.0 E(85289): 2.6e-82
Smith-Waterman score: 1846; 65.0% identity (82.5% similar) in 440 aa overlap (7-445:33-433)
10 20 30
pF1KB8 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLS
::..:. ::. ::::::::::::. :::..
XP_005 AASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHT-RRRCRNRFVKKNGQCNIEFANMD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 NKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAA
.:::::.::.:::::: ::::::.::: :::.:::.::..:: :: :::::
XP_005 EKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLE--------
70 80 90 100 110
100 110 120 130 140 150
pF1KB8 GGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQ
:: : : . ::.:.:.::..:::::.:::::::::.::::::::.::. ::.:
XP_005 --PAEGRGRT------PCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQ
120 130 140 150 160
160 170 180 190 200 210
pF1KB8 SIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVE
:::::.:::::::.:::::::::::::::::::.::...:::::::::::::::::::::
XP_005 SIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVE
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB8 AHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGK
:::::::::: .:.::::.:::: :..::.: ::::::::::: :.::::: :::.:...
XP_005 AHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISR
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB8 EELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRF
..::..:::::::::::::::::::::::::::.:::::::::::.::::..::.:::.:
XP_005 QDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHF
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB8 HKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAA
:::::: .:: :::..: :.:. . : ..::::::::..:..::. : .. .
XP_005 HKTYEVPSTPRCSAKDLVENKFLL-----PSANSFCYENELAFLSRDEED-EADGDQDGR
350 360 370 380 390
400 410 420 430 440
pF1KB8 VAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLP-LDNISYRRESAI
::. .: : :..:.::. :.. ::::: :
XP_005 SRDGLSPQA---------------RH-DFDRLQAGGGVLEQRPYRRESEI
400 410 420 430
>>NP_066292 (OMIM: 602323) ATP-sensitive inward rectifie (433 aa)
initn: 1893 init1: 1359 opt: 1454 Z-score: 1598.8 bits: 305.0 E(85289): 2.6e-82
Smith-Waterman score: 1846; 65.0% identity (82.5% similar) in 440 aa overlap (7-445:33-433)
10 20 30
pF1KB8 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLS
::..:. ::. ::::::::::::. :::..
NP_066 AASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHT-RRRCRNRFVKKNGQCNIEFANMD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 NKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAA
.:::::.::.:::::: ::::::.::: :::.:::.::..:: :: :::::
NP_066 EKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLE--------
70 80 90 100 110
100 110 120 130 140 150
pF1KB8 GGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQ
:: : : . ::.:.:.::..:::::.:::::::::.::::::::.::. ::.:
NP_066 --PAEGRGRT------PCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQ
120 130 140 150 160
160 170 180 190 200 210
pF1KB8 SIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVE
:::::.:::::::.:::::::::::::::::::.::...:::::::::::::::::::::
NP_066 SIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVE
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB8 AHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGK
:::::::::: .:.::::.:::: :..::.: ::::::::::: :.::::: :::.:...
NP_066 AHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISR
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB8 EELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRF
..::..:::::::::::::::::::::::::::.:::::::::::.::::..::.:::.:
NP_066 QDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHF
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB8 HKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAA
:::::: .:: :::..: :.:. . : ..::::::::..:..::. : .. .
NP_066 HKTYEVPSTPRCSAKDLVENKFLL-----PSANSFCYENELAFLSRDEED-EADGDQDGR
350 360 370 380 390
400 410 420 430 440
pF1KB8 VAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLP-LDNISYRRESAI
::. .: : :..:.::. :.. ::::: :
NP_066 SRDGLSPQA---------------RH-DFDRLQAGGGVLEQRPYRRESEI
400 410 420 430
>>XP_011522133 (OMIM: 602323) PREDICTED: ATP-sensitive i (433 aa)
initn: 1893 init1: 1359 opt: 1454 Z-score: 1598.8 bits: 305.0 E(85289): 2.6e-82
Smith-Waterman score: 1846; 65.0% identity (82.5% similar) in 440 aa overlap (7-445:33-433)
10 20 30
pF1KB8 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLS
::..:. ::. ::::::::::::. :::..
XP_011 AASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHT-RRRCRNRFVKKNGQCNIEFANMD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 NKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAA
.:::::.::.:::::: ::::::.::: :::.:::.::..:: :: :::::
XP_011 EKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLE--------
70 80 90 100 110
100 110 120 130 140 150
pF1KB8 GGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQ
:: : : . ::.:.:.::..:::::.:::::::::.::::::::.::. ::.:
XP_011 --PAEGRGRT------PCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQ
120 130 140 150 160
160 170 180 190 200 210
pF1KB8 SIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVE
:::::.:::::::.:::::::::::::::::::.::...:::::::::::::::::::::
XP_011 SIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVE
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB8 AHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGK
:::::::::: .:.::::.:::: :..::.: ::::::::::: :.::::: :::.:...
XP_011 AHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISR
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB8 EELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRF
..::..:::::::::::::::::::::::::::.:::::::::::.::::..::.:::.:
XP_011 QDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHF
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB8 HKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAA
:::::: .:: :::..: :.:. . : ..::::::::..:..::. : .. .
XP_011 HKTYEVPSTPRCSAKDLVENKFLL-----PSANSFCYENELAFLSRDEED-EADGDQDGR
350 360 370 380 390
400 410 420 430 440
pF1KB8 VAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLP-LDNISYRRESAI
::. .: : :..:.::. :.. ::::: :
XP_011 SRDGLSPQA---------------RH-DFDRLQAGGGVLEQRPYRRESEI
400 410 420 430
>>NP_001181887 (OMIM: 613236,613239) inward rectifier po (433 aa)
initn: 1882 init1: 1345 opt: 1441 Z-score: 1584.6 bits: 302.3 E(85289): 1.6e-81
Smith-Waterman score: 1823; 70.8% identity (88.2% similar) in 380 aa overlap (7-386:33-390)
10 20 30
pF1KB8 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLS
::..:. ::. ::::::::::::. :::..
NP_001 AASRANPYSIVSLEEDGLHLVTMSGANGFGNGKVHT-RRRCRNRFVKKNGQCNIAFANMD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 NKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAA
.:::::.::.:::::: ::::::.::: :::.:::.::..:: :: :::::
NP_001 EKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLE--------
70 80 90 100 110
100 110 120 130 140 150
pF1KB8 GGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQ
:: : : . ::.:.:.::..:::::.:::::::::.::::::: .::. ::.:
NP_001 --PAEGHGRT------PCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECLVAVFMVVAQ
120 130 140 150 160
160 170 180 190 200 210
pF1KB8 SIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVE
:::::.:::::::.:::::::::::::::::::.::...:::::::::::::::::::::
NP_001 SIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVE
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB8 AHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGK
:::::::::: .:.::::.:::: :..::.: ::::::::::: :.::::: :::.:...
NP_001 AHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISR
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB8 EELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRF
..::..:::::::::::::::::::::::::::.:::::::::::.::::..::.:::.:
NP_001 QDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHF
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB8 HKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAA
:::::: .:: :::..: :.:. . : ..::::::::..:..::.
NP_001 HKTYEVPSTPRCSAKDLVENKFLL-----PSANSFCYENELAFLSRDEEDEADGDQDGRS
350 360 370 380 390 400
400 410 420 430 440
pF1KB8 VAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
NP_001 RDGLSPQARHDFDRLQAGGGVLEQRPYRRGSEI
410 420 430
>>XP_005276976 (OMIM: 613236,613239) PREDICTED: inward r (535 aa)
initn: 1854 init1: 1345 opt: 1441 Z-score: 1583.1 bits: 302.4 E(85289): 1.9e-81
Smith-Waterman score: 1823; 70.8% identity (88.2% similar) in 380 aa overlap (7-386:135-492)
10 20 30
pF1KB8 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLS
::..:. ::. ::::::::::::. :::..
XP_005 AASRANPYSIVSLEEDGLHLVTMSGANGFGNGKVHT-RRRCRNRFVKKNGQCNIAFANMD
110 120 130 140 150 160
40 50 60 70 80 90
pF1KB8 NKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAA
.:::::.::.:::::: ::::::.::: :::.:::.::..:: :: :::::
XP_005 EKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLE--------
170 180 190 200 210
100 110 120 130 140 150
pF1KB8 GGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQ
:: : : . ::.:.:.::..:::::.:::::::::.::::::: .::. ::.:
XP_005 --PAEGHGRT------PCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECLVAVFMVVAQ
220 230 240 250 260
160 170 180 190 200 210
pF1KB8 SIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVE
:::::.:::::::.:::::::::::::::::::.::...:::::::::::::::::::::
XP_005 SIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVE
270 280 290 300 310 320
220 230 240 250 260 270
pF1KB8 AHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGK
:::::::::: .:.::::.:::: :..::.: ::::::::::: :.::::: :::.:...
XP_005 AHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISR
330 340 350 360 370 380
280 290 300 310 320 330
pF1KB8 EELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRF
..::..:::::::::::::::::::::::::::.:::::::::::.::::..::.:::.:
XP_005 QDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHF
390 400 410 420 430 440
340 350 360 370 380 390
pF1KB8 HKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAA
:::::: .:: :::..: :.:. . : ..::::::::..:..::.
XP_005 HKTYEVPSTPRCSAKDLVENKFLL-----PSANSFCYENELAFLSRDEEDEADGDQDGRS
450 460 470 480 490 500
400 410 420 430 440
pF1KB8 VAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
XP_005 RDGLSPQARHDFDRLQAGGGVLEQRPYRRGSEI
510 520 530
>>NP_000882 (OMIM: 170390,600681,609622,613980) inward r (427 aa)
initn: 1763 init1: 1283 opt: 1388 Z-score: 1526.4 bits: 291.5 E(85289): 2.8e-78
Smith-Waterman score: 1716; 60.9% identity (79.1% similar) in 440 aa overlap (7-445:32-427)
10 20 30
pF1KB8 MHGHSRNGQAHVPRRKR-RNRFVKKNGQCNVYFANL
::...: :.. :.:::::.:.::: : :.
NP_000 GSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINV
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB8 SNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPA
..:.:::.::::::::: :::.::.:: ::..:::::: .:: ::..::::.::
NP_000 GEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASK----
70 80 90 100 110
100 110 120 130 140 150
pF1KB8 AGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVV
: : :. .::.: .:::::.::::::::::::::.:::.::. ::
NP_000 -----EG---------KACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVF
120 130 140 150 160
160 170 180 190 200 210
pF1KB8 QSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIV
::::::.::.:.::..:::::.:::: .::.:::.:::..::::::::::::::::::.:
NP_000 QSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLV
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB8 EAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMG
::::::::.: .:.::::.:::: :.:::.: :.::::::::: :::::::::::: ..
NP_000 EAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLS
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB8 KEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSR
:..... :::::::::::::::::::: ::::::.:::::::.:::.:::: .:::::::
NP_000 KQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSR
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB8 FHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAA
::::::: .:: ::::.: :.: . : ..::::::.:: :.::.. :.
NP_000 FHKTYEVPNTPLCSARDLAEKKYILSNA-----NSFCYENEVALTSKEEDDSEN------
350 360 370 380 390
400 410 420 430 440
pF1KB8 AVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
:. ... .. .::. :::.::. :::: :
NP_000 ------GVPESTSTDTP--------PDIDLHN-QASVPLEPRPLRRESEI
400 410 420
>>NP_037480 (OMIM: 603953) ATP-sensitive inward rectifie (436 aa)
initn: 1283 init1: 1209 opt: 1304 Z-score: 1433.8 bits: 274.5 E(85289): 4e-73
Smith-Waterman score: 1599; 59.1% identity (79.7% similar) in 403 aa overlap (3-397:30-414)
10 20
pF1KB8 MHGHSRNGQAHVPRR----KRRNRFVKKNGQCN
: ::: : .: . .::.:::::.:.::
NP_037 MGLARALRRLSGALDSGDSRAGDEEEAGPGLCRNGWAPAPVQSPVGRRRGRFVKKDGHCN
10 20 30 40 50 60
30 40 50 60 70 80
pF1KB8 VYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEA
: :.::.... ::..:.::::::.:::.: ..:: .::.:::.::: :: :: .::::
NP_037 VRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDL--
70 80 90 100 110
90 100 110 120 130 140
pF1KB8 SPGVPAAGGPAAGGGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLA
::: : ::. :: .::.::::..::::.:::: : :::::: :
NP_037 ----------------AAPPPPAPCFSHVASFLAAFLFALETQTSIGYGVRSVTEECPAA
120 130 140 150 160
150 160 170 180 190 200
pF1KB8 VIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNL
: :::.: :.:::.:.:..:..:::::.:::: .::.::..::...:: .::::::::::
NP_037 VAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRVGNL
170 180 190 200 210 220
210 220 230 240 250 260
pF1KB8 RKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDS
:.::.:::::::::..: .: ::::.:::..:..::.: : ::::::::: :::::: :
NP_037 RRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSAS
230 240 250 260 270 280
270 280 290 300 310 320
pF1KB8 PLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHY
::: .:. :: :::.:::::::::::::::: ::::: .:.:::::::::.:.. :.:
NP_037 PLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQY
290 300 310 320 330 340
330 340 350 360 370 380
pF1KB8 KVDYSRFHKTYEVAGTPCCSARELQE----SKITVLPAPPPPPSAFCYENELALMSQEEE
.::: .::.:::: ::: :::.::.: .. .. . : .:::::::::: .::
NP_037 EVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSLKSSFPGSLTAFCYENELALSCCQEE
350 360 370 380 390 400
390 400 410 420 430 440
pF1KB8 EMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
. ..:. . .:
NP_037 DEDDETEEGNGVETEDGAASPRVLTPTLALTLPP
410 420 430
>>XP_011541112 (OMIM: 600734,613485,613677) PREDICTED: G (419 aa)
initn: 1248 init1: 1027 opt: 1087 Z-score: 1195.5 bits: 230.3 E(85289): 7.5e-60
Smith-Waterman score: 1305; 49.1% identity (76.0% similar) in 405 aa overlap (15-414:47-419)
10 20 30 40
pF1KB8 MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMA
.: :.:...:.:.:::. .:.. .. ::..
XP_011 VTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKCNVHHGNVQ-ETYRYLS
20 30 40 50 60 70
50 60 70 80 90 100
pF1KB8 DIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGG
:.::: :: .::. :..:. .. :.:::::...: ::...:::. :
XP_011 DLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDHV-------------G
80 90 100 110 120
110 120 130 140 150 160
pF1KB8 GAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVID
. ::. ...::..:::::.::.:::::::: .::.:: ..: ..::.:.: ...
XP_011 DQEWI---PCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVN
130 140 150 160 170
170 180 190 200 210 220
pF1KB8 SFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLI
.::.: ...:...:::::.::.::..::::.:: :::::.:::.::.:::::: .::.::
XP_011 AFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLI
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB8 KPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDF
: .:.:::..::.: :.:::.: : ::.:::::.:: :::.. ::.. :.. .:..:.:
XP_011 KSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEF
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB8 EIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAG
:.:::::::::::.:: ::::::. .:.:::::: ::. ::. :.:::. :: :::. .
XP_011 EVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYET-N
300 310 320 330 340 350
350 360 370 380 390
pF1KB8 TPCCSARELQESK-----ITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAA
:: : :.:: : : . ::.:: . : : : .. : :. ::.
XP_011 TPSCCAKELAEMKREGRLLQYLPSPPLLGG--CAE---AGLDAEAEQNEEDEPK------
360 370 380 390 400
400 410 420 430 440
pF1KB8 GLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI
::: ::.: : .
XP_011 GLG---GSREARGSV
410
445 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 12:58:45 2016 done: Fri Nov 4 12:58:47 2016
Total Scan time: 9.720 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]