Result of FASTA (omim) for
pFN21AB8369
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8369, 198 aa
1>>>pF1KB8369 198 - 198 aa - 198 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9283+/-0.000265; mu= 8.2077+/- 0.017
mean_var=133.9706+/-26.723, 0's: 0 Z-trim(123.2): 11 B-trim: 0 in 0/56
Lambda= 0.110808
statistics sampled from 42670 (42682) to 42670 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.5), width: 16
Scan time: 6.090
The best scores are: opt bits E(85289)
NP_004055 (OMIM: 600778,610755) cyclin-dependent k ( 198) 1367 228.5 5.7e-60
NP_000067 (OMIM: 130650,600856,614732) cyclin-depe ( 316) 258 51.3 1.9e-06
XP_016872577 (OMIM: 130650,600856,614732) PREDICTE ( 316) 258 51.3 1.9e-06
NP_001116102 (OMIM: 130650,600856,614732) cyclin-d ( 305) 251 50.2 4e-06
NP_001116103 (OMIM: 130650,600856,614732) cyclin-d ( 305) 251 50.2 4e-06
XP_005252789 (OMIM: 130650,600856,614732) PREDICTE ( 175) 247 49.4 4.1e-06
NP_001278478 (OMIM: 116899) cyclin-dependent kinas ( 198) 239 48.1 1.1e-05
NP_001207707 (OMIM: 116899) cyclin-dependent kinas ( 164) 236 47.6 1.3e-05
NP_001207706 (OMIM: 116899) cyclin-dependent kinas ( 164) 236 47.6 1.3e-05
NP_000380 (OMIM: 116899) cyclin-dependent kinase i ( 164) 236 47.6 1.3e-05
NP_510867 (OMIM: 116899) cyclin-dependent kinase i ( 164) 236 47.6 1.3e-05
>>NP_004055 (OMIM: 600778,610755) cyclin-dependent kinas (198 aa)
initn: 1367 init1: 1367 opt: 1367 Z-score: 1197.7 bits: 228.5 E(85289): 5.7e-60
Smith-Waterman score: 1367; 99.5% identity (99.5% similar) in 198 aa overlap (1-198:1-198)
10 20 30 40 50 60
pF1KB8 MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 NFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDGSGSRPAAPLIG
:::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_004 NFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 APANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 APANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPN
130 140 150 160 170 180
190
pF1KB8 AGSVEQTPKKPGLRRRQT
::::::::::::::::::
NP_004 AGSVEQTPKKPGLRRRQT
190
>>NP_000067 (OMIM: 130650,600856,614732) cyclin-dependen (316 aa)
initn: 298 init1: 198 opt: 258 Z-score: 236.8 bits: 51.3 E(85289): 1.9e-06
Smith-Waterman score: 277; 37.2% identity (58.6% similar) in 145 aa overlap (1-123:1-143)
10 20 30 40 50
pF1KB8 MSNVRVSNGSPSLERMDARQAEHP---KPSACRNLFGPVDHEELTRDLEKHCRDMEEASQ
::.. . . : ..::. :: . : . ::::.::::::::::.:.:. . ... .:
NP_000 MSDASLRSTS-TMERLVAR-GTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQ
10 20 30 40 50
60 70 80 90 100
pF1KB8 RKWNFDFQNHKPLEG--KYEWQEVEKGSLPEFYYRP-----------PRPPKGACKV---
.:..:::. ::.: . .: ::.. :.: :: . ::: : :
NP_000 NRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPP
60 70 80 90 100 110
110 120 130 140 150
pF1KB8 --PAQESQDGSGSRPAA-PLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATD
:: :: :: : : . .::
NP_000 LEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVL
120 130 140 150 160 170
>>XP_016872577 (OMIM: 130650,600856,614732) PREDICTED: c (316 aa)
initn: 298 init1: 198 opt: 258 Z-score: 236.8 bits: 51.3 E(85289): 1.9e-06
Smith-Waterman score: 277; 37.2% identity (58.6% similar) in 145 aa overlap (1-123:1-143)
10 20 30 40 50
pF1KB8 MSNVRVSNGSPSLERMDARQAEHP---KPSACRNLFGPVDHEELTRDLEKHCRDMEEASQ
::.. . . : ..::. :: . : . ::::.::::::::::.:.:. . ... .:
XP_016 MSDASLRSTS-TMERLVAR-GTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQ
10 20 30 40 50
60 70 80 90 100
pF1KB8 RKWNFDFQNHKPLEG--KYEWQEVEKGSLPEFYYRP-----------PRPPKGACKV---
.:..:::. ::.: . .: ::.. :.: :: . ::: : :
XP_016 NRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPP
60 70 80 90 100 110
110 120 130 140 150
pF1KB8 --PAQESQDGSGSRPAA-PLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATD
:: :: :: : : . .::
XP_016 LEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVL
120 130 140 150 160 170
>>NP_001116102 (OMIM: 130650,600856,614732) cyclin-depen (305 aa)
initn: 298 init1: 198 opt: 251 Z-score: 230.9 bits: 50.2 E(85289): 4e-06
Smith-Waterman score: 270; 38.3% identity (57.9% similar) in 133 aa overlap (13-123:1-132)
10 20 30 40 50
pF1KB8 MSNVRVSNGSPSLERMDARQAEHP---KPSACRNLFGPVDHEELTRDLEKHCRDMEEASQ
.::. :: . : . ::::.::::::::::.:.:. . ... .:
NP_001 MERLVAR-GTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQ
10 20 30 40
60 70 80 90 100
pF1KB8 RKWNFDFQNHKPLEG--KYEWQEVEKGSLPEFYYRP-----------PRPPKGACKV---
.:..:::. ::.: . .: ::.. :.: :: . ::: : :
NP_001 NRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPP
50 60 70 80 90 100
110 120 130 140 150
pF1KB8 --PAQESQDGSGSRPAA-PLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATD
:: :: :: : : . .::
NP_001 LEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVL
110 120 130 140 150 160
>>NP_001116103 (OMIM: 130650,600856,614732) cyclin-depen (305 aa)
initn: 298 init1: 198 opt: 251 Z-score: 230.9 bits: 50.2 E(85289): 4e-06
Smith-Waterman score: 270; 38.3% identity (57.9% similar) in 133 aa overlap (13-123:1-132)
10 20 30 40 50
pF1KB8 MSNVRVSNGSPSLERMDARQAEHP---KPSACRNLFGPVDHEELTRDLEKHCRDMEEASQ
.::. :: . : . ::::.::::::::::.:.:. . ... .:
NP_001 MERLVAR-GTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQ
10 20 30 40
60 70 80 90 100
pF1KB8 RKWNFDFQNHKPLEG--KYEWQEVEKGSLPEFYYRP-----------PRPPKGACKV---
.:..:::. ::.: . .: ::.. :.: :: . ::: : :
NP_001 NRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPP
50 60 70 80 90 100
110 120 130 140 150
pF1KB8 --PAQESQDGSGSRPAA-PLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATD
:: :: :: : : . .::
NP_001 LEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVL
110 120 130 140 150 160
>>XP_005252789 (OMIM: 130650,600856,614732) PREDICTED: c (175 aa)
initn: 212 init1: 198 opt: 247 Z-score: 230.8 bits: 49.4 E(85289): 4.1e-06
Smith-Waterman score: 247; 44.4% identity (72.8% similar) in 81 aa overlap (13-88:1-80)
10 20 30 40 50
pF1KB8 MSNVRVSNGSPSLERMDARQAEHP---KPSACRNLFGPVDHEELTRDLEKHCRDMEEASQ
.::. :: . : . ::::.::::::::::.:.:. . ... .:
XP_005 MERLVAR-GTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQ
10 20 30 40
60 70 80 90 100 110
pF1KB8 RKWNFDFQNHKPLEG--KYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDGSGSRPA
.:..:::. ::.: . .: ::.. :.: ::
XP_005 NRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQISSPSARDQRLRSRRAMSPRRV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB8 APLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVS
XP_005 PLQAPPLAWARWSRPRARGCGEPKPKEPRGNLPGQRTLEGRWASAGTVHVAATGGGCRRA
110 120 130 140 150 160
>>NP_001278478 (OMIM: 116899) cyclin-dependent kinase in (198 aa)
initn: 226 init1: 202 opt: 239 Z-score: 223.1 bits: 48.1 E(85289): 1.1e-05
Smith-Waterman score: 239; 32.6% identity (58.1% similar) in 172 aa overlap (8-166:32-189)
10 20 30
pF1KB8 MSNVRVSNGSPSLERMDARQAEHPKPS-ACRNLFGPV
.:. : :.:: .: : ::: :::::
NP_001 WGVFRRQTTHSSNPPLPGQQSCCNHRDFFCSGAMSEPAGDVRQ--NPCGSKACRRLFGPV
10 20 30 40 50
40 50 60 70 80 90
pF1KB8 DHEELTRD---LEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPR
: :.:.:: : : ..:: .: ::::: .. :::: . :..:. .::..: :
NP_001 DSEQLSRDCDALMAGC--IQEARER-WNFDFVTETPLEGDFAWERVRGLGLPKLYL-PTG
60 70 80 90 100 110
100 110 120 130 140
pF1KB8 PPKGACKVPAQESQDGSGSRPAAPLIGAPANSEDTHLVD--------PKT-DPSDSQTGL
: .: ... :.: ::.. ...:. : :: :.. . .... :
NP_001 PRRG-------RDELGGGRRPGTSPALLQGTAEEDH-VDLSLSCTLVPRSGEQAEGSPGG
120 130 140 150 160
150 160 170 180 190
pF1KB8 AEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
. : ..: .. . ..::
NP_001 PGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP
170 180 190
>>NP_001207707 (OMIM: 116899) cyclin-dependent kinase in (164 aa)
initn: 226 init1: 202 opt: 236 Z-score: 221.7 bits: 47.6 E(85289): 1.3e-05
Smith-Waterman score: 236; 33.1% identity (58.9% similar) in 163 aa overlap (17-166:7-155)
10 20 30 40 50
pF1KB8 MSNVRVSNGSPSLERMDARQAEHPKPS-ACRNLFGPVDHEELTRD---LEKHCRDMEEAS
:.:: .: : ::: :::::: :.:.:: : : ..::
NP_001 MSEPAGDVRQ--NPCGSKACRRLFGPVDSEQLSRDCDALMAGC--IQEAR
10 20 30 40
60 70 80 90 100 110
pF1KB8 QRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDGSGSRPAA
.: ::::: .. :::: . :..:. .::..: : : .: ... :.: ::..
NP_001 ER-WNFDFVTETPLEGDFAWERVRGLGLPKLYL-PTGPRRG-------RDELGGGRRPGT
50 60 70 80 90
120 130 140 150 160
pF1KB8 PLIGAPANSEDTHLVD--------PKT-DPSDSQTGLAEQCAGIRKRPATDDSSTQNKRA
...:. : :: :.. . .... : . : ..: .. . ..::
NP_001 SPALLQGTAEEDH-VDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRR
100 110 120 130 140 150
170 180 190
pF1KB8 NRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
NP_001 LIFSKRKP
160
>>NP_001207706 (OMIM: 116899) cyclin-dependent kinase in (164 aa)
initn: 226 init1: 202 opt: 236 Z-score: 221.7 bits: 47.6 E(85289): 1.3e-05
Smith-Waterman score: 236; 33.1% identity (58.9% similar) in 163 aa overlap (17-166:7-155)
10 20 30 40 50
pF1KB8 MSNVRVSNGSPSLERMDARQAEHPKPS-ACRNLFGPVDHEELTRD---LEKHCRDMEEAS
:.:: .: : ::: :::::: :.:.:: : : ..::
NP_001 MSEPAGDVRQ--NPCGSKACRRLFGPVDSEQLSRDCDALMAGC--IQEAR
10 20 30 40
60 70 80 90 100 110
pF1KB8 QRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDGSGSRPAA
.: ::::: .. :::: . :..:. .::..: : : .: ... :.: ::..
NP_001 ER-WNFDFVTETPLEGDFAWERVRGLGLPKLYL-PTGPRRG-------RDELGGGRRPGT
50 60 70 80 90
120 130 140 150 160
pF1KB8 PLIGAPANSEDTHLVD--------PKT-DPSDSQTGLAEQCAGIRKRPATDDSSTQNKRA
...:. : :: :.. . .... : . : ..: .. . ..::
NP_001 SPALLQGTAEEDH-VDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRR
100 110 120 130 140 150
170 180 190
pF1KB8 NRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
NP_001 LIFSKRKP
160
>>NP_000380 (OMIM: 116899) cyclin-dependent kinase inhib (164 aa)
initn: 226 init1: 202 opt: 236 Z-score: 221.7 bits: 47.6 E(85289): 1.3e-05
Smith-Waterman score: 236; 33.1% identity (58.9% similar) in 163 aa overlap (17-166:7-155)
10 20 30 40 50
pF1KB8 MSNVRVSNGSPSLERMDARQAEHPKPS-ACRNLFGPVDHEELTRD---LEKHCRDMEEAS
:.:: .: : ::: :::::: :.:.:: : : ..::
NP_000 MSEPAGDVRQ--NPCGSKACRRLFGPVDSEQLSRDCDALMAGC--IQEAR
10 20 30 40
60 70 80 90 100 110
pF1KB8 QRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDGSGSRPAA
.: ::::: .. :::: . :..:. .::..: : : .: ... :.: ::..
NP_000 ER-WNFDFVTETPLEGDFAWERVRGLGLPKLYL-PTGPRRG-------RDELGGGRRPGT
50 60 70 80 90
120 130 140 150 160
pF1KB8 PLIGAPANSEDTHLVD--------PKT-DPSDSQTGLAEQCAGIRKRPATDDSSTQNKRA
...:. : :: :.. . .... : . : ..: .. . ..::
NP_000 SPALLQGTAEEDH-VDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRR
100 110 120 130 140 150
170 180 190
pF1KB8 NRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
NP_000 LIFSKRKP
160
198 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 12:19:04 2016 done: Fri Nov 4 12:19:05 2016
Total Scan time: 6.090 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]