Result of FASTA (omim) for
pFN21AB8104
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8104, 461 aa
1>>>pF1KB8104 461 - 461 aa - 461 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.5643+/-0.000314; mu= 4.4893+/- 0.020
mean_var=196.6873+/-39.269, 0's: 0 Z-trim(122.5): 5 B-trim: 0 in 0/60
Lambda= 0.091451
statistics sampled from 40778 (40783) to 40778 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.478), width: 16
Scan time: 8.370
The best scores are: opt bits E(85289)
NP_002211 (OMIM: 147521) inositol-trisphosphate 3- ( 461) 3126 424.5 3e-118
XP_011519824 (OMIM: 147521) PREDICTED: inositol-tr ( 289) 1961 270.7 3.8e-72
NP_002212 (OMIM: 147522) inositol-trisphosphate 3- ( 946) 1448 203.3 2.3e-51
NP_079470 (OMIM: 606476,611775) inositol-trisphosp ( 683) 1291 182.5 3e-45
XP_016882813 (OMIM: 606476,611775) PREDICTED: inos ( 422) 1178 167.5 6.4e-41
>>NP_002211 (OMIM: 147521) inositol-trisphosphate 3-kina (461 aa)
initn: 3126 init1: 3126 opt: 3126 Z-score: 2244.0 bits: 424.5 E(85289): 3e-118
Smith-Waterman score: 3126; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461)
10 20 30 40 50 60
pF1KB8 MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 RRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 STSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 STSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVIS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 PFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 DGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 TEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 EFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKT
370 380 390 400 410 420
430 440 450 460
pF1KB8 TPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
:::::::::::::::::::::::::::::::::::::::::
NP_002 TPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
430 440 450 460
>>XP_011519824 (OMIM: 147521) PREDICTED: inositol-trisph (289 aa)
initn: 1961 init1: 1961 opt: 1961 Z-score: 1416.2 bits: 270.7 E(85289): 3.8e-72
Smith-Waterman score: 1961; 100.0% identity (100.0% similar) in 289 aa overlap (173-461:1-289)
150 160 170 180 190 200
pF1KB8 SDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAG
::::::::::::::::::::::::::::::
XP_011 MVNLPVISPFKKRYAWVQLAGHTGSFKAAG
10 20 30
210 220 230 240 250 260
pF1KB8 TSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLD
40 50 60 70 80 90
270 280 290 300 310 320
pF1KB8 CKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGI
100 110 120 130 140 150
330 340 350 360 370 380
pF1KB8 SSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRD
160 170 180 190 200 210
390 400 410 420 430 440
pF1KB8 TLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNRED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNRED
220 230 240 250 260 270
450 460
pF1KB8 GYLLGLDNLIGILASLAER
:::::::::::::::::::
XP_011 GYLLGLDNLIGILASLAER
280
>>NP_002212 (OMIM: 147522) inositol-trisphosphate 3-kina (946 aa)
initn: 1400 init1: 1189 opt: 1448 Z-score: 1043.2 bits: 203.3 E(85289): 2.3e-51
Smith-Waterman score: 1448; 57.2% identity (76.5% similar) in 400 aa overlap (67-460:545-941)
40 50 60 70 80 90
pF1KB8 LFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSP
:. ::. : : . . .. : : :.
NP_002 KAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDM
520 530 540 550 560 570
100 110 120 130 140 150
pF1KB8 GPPERERDCLPAAGSSHLQQP-RRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQL
: : . . :: . . : :.::.::.:::: :: ::::.:. :: : : .
NP_002 GTQE-DGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAF
580 590 600 610 620 630
160 170 180 190 200 210
pF1KB8 EAGEDVGQK----NHWQKIRTMVNL-PVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKR
: :: . :.::..::. : . :::.: :.:::::.::::::. .: :::.
NP_002 LHTLD-QQKPRVSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAA-NGRILKK
640 650 660 670 680 690
220 230 240 250 260 270
pF1KB8 CSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTY
: :. :: :::.:.:: :::.:: : .::: : :..::: ::.:::.:::::.:::
NP_002 HCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTY
700 710 720 730 740 750
280 290 300 310 320 330
pF1KB8 LEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGF
:::::::::..:.::::::.::. ::::::::::.::::::::::::::: :::..::::
NP_002 LEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGF
760 770 780 790 800 810
340 350 360 370 380 390
pF1KB8 RIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFF
::::::: ::. . ::: :..:::: ..:.::..:....: : .::. :: ::::: ::
NP_002 RIEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFF
820 830 840 850 860 870
400 410 420 430 440 450
pF1KB8 RRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDN
. ::::::::::.::. ..: ::.::::::::::.:: :.: ::.::::::::: ::.:
NP_002 KCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYLSGLNN
880 890 900 910 920 930
460
pF1KB8 LIGILASLAER
:. ::. ...
NP_002 LVDILTEMSQDAPLA
940
>>NP_079470 (OMIM: 606476,611775) inositol-trisphosphate (683 aa)
initn: 1253 init1: 1145 opt: 1291 Z-score: 933.2 bits: 182.5 E(85289): 3e-45
Smith-Waterman score: 1311; 53.1% identity (75.4% similar) in 390 aa overlap (73-460:322-682)
50 60 70 80 90 100
pF1KB8 AAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSP-GPPER
.: :: :.: .: : :. : ..: ::: :
NP_079 DCLLGEPEDGPLEEPEPGELLTHLYSHLKCSPLCPV-PRLIITPETPE-PEAQPVGPPSR
300 310 320 330 340
110 120 130 140 150 160
pF1KB8 ERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDV
. .::. . ::.:: ...::::... . . : ::
NP_079 VE-----GGSGGF--------SSASS------FDESEDDVVAGGGGASD-------PEDR
350 360 370 380
170 180 190 200 210 220
pF1KB8 GQKNHWQKIRTMVNL-PVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLA
. .. :.:..:... : . :.:.: ::::.::.:.:.: : .: :::: . :. :
NP_079 SGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQA-GEDGRILKRFCQCEQRSLE
390 400 410 420 430 440
230 240 250 260 270 280
pF1KB8 RLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARE
.:: : :: :::..:.: .::... :..::: :.:: ..::::: ::::::::.::::
NP_079 QLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARE
450 460 470 480 490 500
290 300 310 320 330 340
pF1KB8 RPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADG
::. :::::.::.:::: ::: ::::: :::::::::::: .::..::::::::::::::
NP_079 RPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADG
510 520 530 540 550 560
350 360 370 380 390 400
pF1KB8 SCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSL
.:.:.:: :.. ::: .:.:.::.::. .:..:. :...:..::.: ::. :::.::::
NP_079 TCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSL
570 580 590 600 610 620
410 420 430 440 450 460
pF1KB8 LFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAE
:::::: : ::.::::::. ::: : :.:: :: ::::::::: ::::.: .: .::.
NP_079 LFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMICLLQGLAQ
630 640 650 660 670 680
pF1KB8 R
NP_079 S
>>XP_016882813 (OMIM: 606476,611775) PREDICTED: inositol (422 aa)
initn: 1229 init1: 1145 opt: 1178 Z-score: 855.6 bits: 167.5 E(85289): 6.4e-41
Smith-Waterman score: 1261; 50.5% identity (71.4% similar) in 412 aa overlap (73-460:39-421)
50 60 70 80 90 100
pF1KB8 AAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSP-GPPER
.: :: :.: .: : :. : ..: ::: :
XP_016 LKQPGNSLALVVSKYNRILMAPGHNLALTCSPLCPV-PRLIITPETPE-PEAQPVGPPSR
10 20 30 40 50 60
110 120 130 140 150 160
pF1KB8 ERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDV
. .::. . ::.:: ...::::... . . : ::
XP_016 VE-----GGSGGF--------SSASS------FDESEDDVVAGGGGASD-------PEDR
70 80 90 100
170 180 190
pF1KB8 GQKNHWQKIRTMVNL-PVISPFKKRYAWVQLAGHTGS----------------------F
. .. :.:..:... : . :.:.: ::::.::.:: :
XP_016 SGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGSCGEVLFLIQFLILSFILPPLGNF
110 120 130 140 150 160
200 210 220 230 240 250
pF1KB8 KAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGP
.: : .: :::: . :. : .:: : :: :::..:.: .::... :..::: :.::
XP_016 QA-GEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGP
170 180 190 200 210
260 270 280 290 300 310
pF1KB8 CVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQW
..::::: ::::::::.::::::. :::::.::.:::: ::: ::::: ::::::::::
XP_016 SIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQW
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB8 REGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQ
:: .::..::::::::::::::.:.:.:: :.. ::: .:.:.::.::. .:..:. :.
XP_016 RETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLE
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB8 QIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEG
..:..::.: ::. :::.:::::::::: : ::.::::::. ::: : :.:: :: ::
XP_016 ELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEG
340 350 360 370 380 390
440 450 460
pF1KB8 NREDGYLLGLDNLIGILASLAER
::::::: ::::.: .: .::.
XP_016 NREDGYLWGLDNMICLLQGLAQS
400 410 420
461 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 09:30:09 2016 done: Fri Nov 4 09:30:10 2016
Total Scan time: 8.370 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]