Result of FASTA (omim) for
pFN21AB7407
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7407, 213 aa
1>>>pF1KB7407 213 - 213 aa - 213 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2136+/-0.000249; mu= 14.9676+/- 0.016
mean_var=67.8547+/-13.754, 0's: 0 Z-trim(122.6): 21 B-trim: 915 in 2/59
Lambda= 0.155698
statistics sampled from 40931 (40968) to 40931 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.817), E-opt: 0.2 (0.48), width: 16
Scan time: 4.520
The best scores are: opt bits E(85289)
NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo ( 213) 1527 350.7 1e-96
XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 202) 1208 279.1 3.6e-75
XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 298) 1206 278.7 6.8e-75
XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 201) 710 167.2 1.7e-41
NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo ( 228) 676 159.6 3.8e-39
XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 210) 590 140.2 2.3e-33
NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo ( 238) 561 133.8 2.3e-31
NP_004419 (OMIM: 191164) ephrin-A1 isoform a precu ( 205) 457 110.4 2.2e-24
XP_011541553 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 449 108.5 6e-24
XP_016864694 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 449 108.5 6e-24
NP_872626 (OMIM: 191164) ephrin-A1 isoform b precu ( 183) 438 106.1 3.9e-23
NP_005218 (OMIM: 601380) ephrin-A4 isoform a precu ( 201) 396 96.7 2.9e-20
NP_872632 (OMIM: 601380) ephrin-A4 isoform c precu ( 193) 389 95.1 8.4e-20
NP_872631 (OMIM: 601380) ephrin-A4 isoform b precu ( 207) 384 94.0 1.9e-19
NP_001397 (OMIM: 602297) ephrin-B3 precursor [Homo ( 340) 237 61.1 2.5e-09
NP_004420 (OMIM: 300035,304110) ephrin-B1 precurso ( 346) 197 52.1 1.3e-06
NP_004084 (OMIM: 600527) ephrin-B2 precursor [Homo ( 333) 177 47.6 2.8e-05
XP_016875895 (OMIM: 600527) PREDICTED: ephrin-B2 i ( 335) 177 47.6 2.9e-05
>>NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo sap (213 aa)
initn: 1527 init1: 1527 opt: 1527 Z-score: 1857.4 bits: 350.7 E(85289): 1e-96
Smith-Waterman score: 1527; 100.0% identity (100.0% similar) in 213 aa overlap (1-213:1-213)
10 20 30 40 50 60
pF1KB7 MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEA
130 140 150 160 170 180
190 200 210
pF1KB7 PEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
:::::::::::::::::::::::::::::::::
NP_001 PEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
190 200 210
>>XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (202 aa)
initn: 1222 init1: 1206 opt: 1208 Z-score: 1470.4 bits: 279.1 E(85289): 3.6e-75
Smith-Waterman score: 1208; 87.6% identity (89.1% similar) in 201 aa overlap (18-213:2-202)
10 20 30 40 50
pF1KB7 MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRS----NP-RFHAGAGDD
:: : : ..:: : : .: :::::::::
XP_016 MLPAPLGLRETGVGRARFGTRASGLVRLRIALEPGRFHAGAGDD
10 20 30 40
60 70 80 90 100 110
pF1KB7 GGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECN
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB7 RPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNE
110 120 130 140 150 160
180 190 200 210
pF1KB7 TLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
::::::::::::::::::::::::::::::::::::::
XP_016 TLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
170 180 190 200
>>XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (298 aa)
initn: 1206 init1: 1206 opt: 1206 Z-score: 1465.5 bits: 278.7 E(85289): 6.8e-75
Smith-Waterman score: 1206; 100.0% identity (100.0% similar) in 167 aa overlap (47-213:132-298)
20 30 40 50 60 70
pF1KB7 PLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHY
::::::::::::::::::::::::::::::
XP_016 LGHRETGVGRARFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHY
110 120 130 140 150 160
80 90 100 110 120 130
pF1KB7 GAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPF
170 180 190 200 210 220
140 150 160 170 180 190
pF1KB7 SLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGG
230 240 250 260 270 280
200 210
pF1KB7 CRLFLSTIPVLWTLLGS
:::::::::::::::::
XP_016 CRLFLSTIPVLWTLLGS
290
>>XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (201 aa)
initn: 620 init1: 528 opt: 710 Z-score: 865.9 bits: 167.2 E(85289): 1.7e-41
Smith-Waterman score: 710; 56.0% identity (78.8% similar) in 184 aa overlap (11-194:7-181)
10 20 30 40 50 60
pF1KB7 MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYT
: :..: : :.. . ...: .:::::::: :::::. : :
XP_006 MLHVEMLTLVFLVLWMCVFSQ-DPGSKAVADRYAVYWNSSNPRFQR------GDYH
10 20 30 40
70 80 90 100 110 120
pF1KB7 VEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAP
..: ::::::..:::: .: .. :.::::::: .:...::: ..:::::::::: .:
XP_006 IDVCINDYLDVFCPHYEDSVPE-DKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSP
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB7 GGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEA
.::::::::::::::::::::::::.::.:::.. :. : ::.:::.:::::.:..:.
XP_006 NGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNDTVHES
110 120 130 140 150 160
190 200 210
pF1KB7 PEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
:: ..:. ..:
XP_006 AEPS-RGENAAQTPRIPSRLLAILLFLLAMLLTL
170 180 190 200
>>NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo sap (228 aa)
initn: 671 init1: 475 opt: 676 Z-score: 823.8 bits: 159.6 E(85289): 3.8e-39
Smith-Waterman score: 676; 58.1% identity (78.4% similar) in 167 aa overlap (11-177:7-165)
10 20 30 40 50 60
pF1KB7 MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYT
: :..: : :.. . ...: .:::::::: :::::. : :
NP_001 MLHVEMLTLVFLVLWMCVFSQ-DPGSKAVADRYAVYWNSSNPRFQRG------DYH
10 20 30 40
70 80 90 100 110 120
pF1KB7 VEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAP
..: ::::::..:::: .: .. :.::::::: .:...::: ..:::::::::: .:
NP_001 IDVCINDYLDVFCPHYEDSVPE-DKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSP
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB7 GGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEA
.::::::::::::::::::::::::.::.:::.. :. : ::.:::.::::: .
NP_001 NGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTI
110 120 130 140 150 160
190 200 210
pF1KB7 PEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
NP_001 GVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
170 180 190 200 210 220
>>XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (210 aa)
initn: 579 init1: 475 opt: 590 Z-score: 719.9 bits: 140.2 E(85289): 2.3e-33
Smith-Waterman score: 590; 64.5% identity (84.3% similar) in 121 aa overlap (57-177:28-147)
30 40 50 60 70 80
pF1KB7 EDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERM
: : ..: ::::::..:::: .: ..
XP_011 MQTLEPACFRFSLHTNTNKQCTLGFQRGDYHIDVCINDYLDVFCPHYEDSVPE-DKT
10 20 30 40 50
90 100 110 120 130 140
pF1KB7 EHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGH
:.::::::: .:...::: ..:::::::::: .:.::::::::::::::::::::::::.
XP_011 ERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGR
60 70 80 90 100 110
150 160 170 180 190 200
pF1KB7 EYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPV
::.:::.. :. : ::.:::.::::: .
XP_011 EYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHE
120 130 140 150 160 170
210
pF1KB7 LWTLLGS
XP_011 SAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
180 190 200 210
>>NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo sap (238 aa)
initn: 593 init1: 266 opt: 561 Z-score: 684.0 bits: 133.8 E(85289): 2.3e-31
Smith-Waterman score: 561; 53.4% identity (71.3% similar) in 174 aa overlap (4-170:2-165)
10 20 30 40 50 60
pF1KB7 MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYT
: ::: :::::.:.: :. :. . : ..:.::::: :: ... :::
NP_004 MAAAPLL-LLLLLVPVPLLPLL-AQGPGGALGNRHAVYWNSSNQHLRRE------GYT
10 20 30 40 50
70 80 90 100 110
pF1KB7 VEVSINDYLDIYCPHY-------GAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWE
:.:..::::::::::: :: :. :.::::::. .:. .:. : ::::::
NP_004 VQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQ-GFKRWE
60 70 80 90 100
120 130 140 150 160 170
pF1KB7 CNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPT
:::: :: .:.::::::: .. ::::.::. :::::::: :: . . :::.::.:
NP_004 CNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYIS-TPTHNLHWKCLRMKVFVCCA
110 120 130 140 150 160
180 190 200 210
pF1KB7 NETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
NP_004 STSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGI
170 180 190 200 210 220
>>NP_004419 (OMIM: 191164) ephrin-A1 isoform a precursor (205 aa)
initn: 470 init1: 362 opt: 457 Z-score: 558.6 bits: 110.4 E(85289): 2.2e-24
Smith-Waterman score: 462; 42.7% identity (62.0% similar) in 192 aa overlap (32-211:16-195)
10 20 30 40 50 60
pF1KB7 APAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTV
: .::..:.:: :::.:. ..: ::.
NP_004 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFR---NED---YTI
10 20 30
70 80 90 100 110 120
pF1KB7 EVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPG
.:..:::.:: :::: ::.:.::.:. : . :. ... ::.::::.:
NP_004 HVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKH
40 50 60 70 80 90
130 140 150 160 170
pF1KB7 GPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVR----------
:: :.::::: ::::.:: ::. :: ::::: . :: :::::: :
NP_004 GPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAH
100 110 120 130 140 150
180 190 200 210
pF1KB7 --PTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
: .. : : .: .: . .. ::: :. ::.:
NP_004 DNPQEKRL-AADDPEVRVLHSIGHSAAPRLF----PLAWTVLLLPLLLLQTP
160 170 180 190 200
>>XP_011541553 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (148 aa)
initn: 449 init1: 449 opt: 449 Z-score: 551.0 bits: 108.5 E(85289): 6e-24
Smith-Waterman score: 449; 69.4% identity (88.2% similar) in 85 aa overlap (93-177:1-85)
70 80 90 100 110 120
pF1KB7 VSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGG
::: .:...::: ..:::::::::: .:.:
XP_011 MVNFDGYSACDHTSKGFKRWECNRPHSPNG
10 20 30
130 140 150 160 170 180
pF1KB7 PLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPE
:::::::::::::::::::::::.::.:::.. :. : ::.:::.::::: .
XP_011 PLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGV
40 50 60 70 80 90
190 200 210
pF1KB7 PIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
XP_011 HDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
100 110 120 130 140
>>XP_016864694 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (148 aa)
initn: 449 init1: 449 opt: 449 Z-score: 551.0 bits: 108.5 E(85289): 6e-24
Smith-Waterman score: 449; 69.4% identity (88.2% similar) in 85 aa overlap (93-177:1-85)
70 80 90 100 110 120
pF1KB7 VSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGG
::: .:...::: ..:::::::::: .:.:
XP_016 MVNFDGYSACDHTSKGFKRWECNRPHSPNG
10 20 30
130 140 150 160 170 180
pF1KB7 PLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPE
:::::::::::::::::::::::.::.:::.. :. : ::.:::.::::: .
XP_016 PLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGV
40 50 60 70 80 90
190 200 210
pF1KB7 PIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
XP_016 HDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
100 110 120 130 140
213 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 07:29:50 2016 done: Fri Nov 4 07:29:50 2016
Total Scan time: 4.520 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]