Result of FASTA (omim) for
pFN21AB7405
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7405, 485 aa
1>>>pF1KB7405 485 - 485 aa - 485 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2299+/-0.000352; mu= 19.3760+/- 0.022
mean_var=81.7964+/-16.332, 0's: 0 Z-trim(115.2): 35 B-trim: 440 in 2/53
Lambda= 0.141810
statistics sampled from 25503 (25538) to 25503 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.299), width: 16
Scan time: 9.790
The best scores are: opt bits E(85289)
NP_061183 (OMIM: 611146,613280) zinc transporter 1 ( 485) 3211 666.8 3.8e-191
XP_016857173 (OMIM: 611146,613280) PREDICTED: zinc ( 326) 1829 383.9 3.7e-106
XP_006711500 (OMIM: 611146,613280) PREDICTED: zinc ( 422) 1829 384.0 4.5e-106
NP_067017 (OMIM: 609521) zinc transporter 1 [Homo ( 507) 547 121.8 4.7e-27
NP_001166284 (OMIM: 125853,611145) zinc transporte ( 320) 285 68.0 4.5e-11
NP_001166282 (OMIM: 125853,611145) zinc transporte ( 320) 285 68.0 4.5e-11
NP_001166285 (OMIM: 125853,611145) zinc transporte ( 320) 285 68.0 4.5e-11
NP_001166286 (OMIM: 125853,611145) zinc transporte ( 320) 285 68.0 4.5e-11
NP_776250 (OMIM: 125853,611145) zinc transporter 8 ( 369) 285 68.0 5e-11
XP_016865238 (OMIM: 607819) PREDICTED: zinc transp ( 681) 280 67.2 1.6e-10
XP_006714735 (OMIM: 607819) PREDICTED: zinc transp ( 722) 280 67.3 1.7e-10
XP_005248626 (OMIM: 607819) PREDICTED: zinc transp ( 724) 280 67.3 1.7e-10
NP_075053 (OMIM: 607819) zinc transporter 5 isofor ( 765) 280 67.3 1.8e-10
NP_115902 (OMIM: 608118,609617) zinc transporter 2 ( 323) 273 65.5 2.5e-10
NP_001004434 (OMIM: 608118,609617) zinc transporte ( 372) 273 65.6 2.8e-10
XP_011520299 (OMIM: 602095) PREDICTED: zinc transp ( 429) 214 53.6 1.3e-06
XP_016878049 (OMIM: 602095) PREDICTED: zinc transp ( 429) 214 53.6 1.3e-06
NP_037441 (OMIM: 602095) zinc transporter 4 isofor ( 429) 214 53.6 1.3e-06
XP_011531405 (OMIM: 602878) PREDICTED: zinc transp ( 274) 210 52.6 1.7e-06
XP_011531404 (OMIM: 602878) PREDICTED: zinc transp ( 315) 210 52.6 1.9e-06
NP_001305880 (OMIM: 602878) zinc transporter 3 iso ( 375) 210 52.7 2.1e-06
NP_001305879 (OMIM: 602878) zinc transporter 3 iso ( 375) 210 52.7 2.1e-06
NP_001305878 (OMIM: 602878) zinc transporter 3 iso ( 383) 210 52.7 2.1e-06
NP_003450 (OMIM: 602878) zinc transporter 3 a [Hom ( 388) 210 52.7 2.2e-06
XP_011539081 (OMIM: 611149) PREDICTED: zinc transp ( 306) 196 49.8 1.3e-05
NP_598003 (OMIM: 611149) zinc transporter 7 [Homo ( 376) 196 49.8 1.5e-05
NP_001138356 (OMIM: 611149) zinc transporter 7 [Ho ( 376) 196 49.8 1.5e-05
XP_016855889 (OMIM: 611149) PREDICTED: zinc transp ( 376) 196 49.8 1.5e-05
XP_016878050 (OMIM: 602095) PREDICTED: zinc transp ( 199) 156 41.4 0.0028
NP_001307965 (OMIM: 602095) zinc transporter 4 iso ( 187) 155 41.2 0.0031
XP_016878051 (OMIM: 602095) PREDICTED: zinc transp ( 187) 155 41.2 0.0031
>>NP_061183 (OMIM: 611146,613280) zinc transporter 10 [H (485 aa)
initn: 3211 init1: 3211 opt: 3211 Z-score: 3552.6 bits: 666.8 E(85289): 3.8e-191
Smith-Waterman score: 3211; 100.0% identity (100.0% similar) in 485 aa overlap (1-485:1-485)
10 20 30 40 50 60
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 ARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 ARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 VLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 DPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 DPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 VLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 ETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 ETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 DASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 DASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGAL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 PLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_061 PLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYV
430 440 450 460 470 480
pF1KB7 NRTHF
:::::
NP_061 NRTHF
>>XP_016857173 (OMIM: 611146,613280) PREDICTED: zinc tra (326 aa)
initn: 1829 init1: 1829 opt: 1829 Z-score: 2026.8 bits: 383.9 E(85289): 3.7e-106
Smith-Waterman score: 1829; 100.0% identity (100.0% similar) in 273 aa overlap (213-485:54-326)
190 200 210 220 230 240
pF1KB7 TAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVL
::::::::::::::::::::::::::::::
XP_016 PSHYLLSEFCCSPPLFAHPFVFLGVTGLGAAGDSFNTQNEPEDMMKKEKKSEALNIRGVL
30 40 50 60 70 80
250 260 270 280 290 300
pF1KB7 LHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKET
90 100 110 120 130 140
310 320 330 340 350 360
pF1KB7 AAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDA
150 160 170 180 190 200
370 380 390 400 410 420
pF1KB7 STKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPL
210 220 230 240 250 260
430 440 450 460 470 480
pF1KB7 AHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNR
270 280 290 300 310 320
pF1KB7 THF
:::
XP_016 THF
>>XP_006711500 (OMIM: 611146,613280) PREDICTED: zinc tra (422 aa)
initn: 2225 init1: 1829 opt: 1829 Z-score: 2025.3 bits: 384.0 E(85289): 4.5e-106
Smith-Waterman score: 2117; 70.3% identity (79.4% similar) in 485 aa overlap (1-485:1-422)
10 20 30 40 50 60
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYI
::::::.. ::..: :... .:: ::: .:.:::..: ::.: .:: ..:. .:. :
XP_006 MGRYSGRSFRLILMCVVSILLFVMELVIAYVGNSLSLASDAFAVLSHFVSMIIGFF-GVR
10 20 30 40 50
70 80 90 100 110 120
pF1KB7 ARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVG
: . ..:::. ::.::::..:..: .:: :.:.:::. : :.. ..: ::: .:
XP_006 ASNIKQHKKSTYGFLRADVVGAFGNTIFAVALMFSILVEAIKRYINPQKTEEPILVLSAG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB7 VLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAA
..::. ::.. .:: : :: : : ::: .
XP_006 IIGLFFNVLNYVIFLD------CCY----------------C---AAPKPQGDME-----
120 130 140
190 200 210 220 230 240
pF1KB7 DPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRG
::::::::::::::::::::::::::::
XP_006 --------------------------------AGDSFNTQNEPEDMMKKEKKSEALNIRG
150 160 170
250 260 270 280 290 300
pF1KB7 VLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIK
180 190 200 210 220 230
310 320 330 340 350 360
pF1KB7 ETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQ
240 250 260 270 280 290
370 380 390 400 410 420
pF1KB7 DASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGAL
300 310 320 330 340 350
430 440 450 460 470 480
pF1KB7 PLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYV
360 370 380 390 400 410
pF1KB7 NRTHF
:::::
XP_006 NRTHF
420
>>NP_067017 (OMIM: 609521) zinc transporter 1 [Homo sapi (507 aa)
initn: 924 init1: 401 opt: 547 Z-score: 606.8 bits: 121.8 E(85289): 4.7e-27
Smith-Waterman score: 905; 36.9% identity (64.3% similar) in 498 aa overlap (1-454:1-485)
10 20 30 40 50 60
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYI
:: .. . ::: ::.:: :.: :.: . . .:.:.:::::.::::...: :.: : .
NP_067 MGCWGRNRGRLLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 ARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVG
::: . :.:. ::::.::: ::.:::.:::.:..::. :. .:.....: .:: ::
NP_067 ARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAIERFIEPHEMQQPLVVLGVG
70 80 90 100 110 120
130 140 150 160
pF1KB7 VLGLLVNVVGLLIF-------QDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFG-----
: ::::::.:: .: :: . . .:... : . .. .. ::.
NP_067 VAGLLVNVLGLCLFHHHSGFSQDSGHGHSHGGHGHGHGLPKGPRV-KSTRPGSSDINVAP
130 140 150 160 170
170 180 190 200 210 220
pF1KB7 GPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMK
: :: .. . . . ...... : .. : : .: :: ..: : : ::. :
NP_067 GEQGPDQEETNTLVANTSNSNGLKLDPADPENPR-SGDTVEVQVNG---NLVREPDHMEL
180 190 200 210 220 230
230 240 250 260 270
pF1KB7 KEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLK--SE----------DPCN--
.: .. ::.:::.:::.:::::::.::..:..:: . : :: :::.
NP_067 EEDRAGQLNMRGVFLHVLGDALGSVIVVVNALVFY-FSWKGCSEGDFCVNPCFPDPCKAF
240 250 260 270 280 290
280 290 300 310
pF1KB7 -----------------WQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNME
: :.::.: :.:: :.: ...::.::.: :::: ::: ....
NP_067 VEIINSTHASVYEAGPCWVLYLDPTLCVVMVCILLYTTYPLLKESALILLQTVPKQIDIR
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB7 ELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHN
.:...: : :. :::.:.:.:....:::: ::: .:.... :...::. :::
NP_067 NLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKCEDPTSYMEVAKTIKDVFHNHGIHA
360 370 380 390 400 410
380 390 400 410 420 430
pF1KB7 VTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSL
.::: : ... .:. .. :. : .. :: . :: :.:: : . ::.. . :.
NP_067 TTIQPEFASVG----SKSSVVPCELACRTQ-CALKQCC--GTLPQAPSGKDAEKTPAVSI
420 430 440 450 460
440 450 460 470 480
pF1KB7 DTYG-SDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF
. :..: .. : :
NP_067 SCLELSNNLEKKPRRTKAENIPAVVIEIKNMPNKQPESSL
470 480 490 500
>>NP_001166284 (OMIM: 125853,611145) zinc transporter 8 (320 aa)
initn: 227 init1: 169 opt: 285 Z-score: 319.7 bits: 68.0 E(85289): 4.5e-11
Smith-Waterman score: 299; 24.6% identity (53.4% similar) in 386 aa overlap (21-404:35-319)
10 20 30 40 50
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLIS
:..::.:.:....:.:...:. ..: :: :
NP_001 HSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 LCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERI
. ..: . ... .: :.:. :::..::: :. ::. . . ... :: ::.
NP_001 FLLSLFSLWLSSKPPSK-RLTFGWHRAEILGAL-----LSILCIWVVTGVLVYLAC-ERL
70 80 90 100 110
120 130 140 150 160 170
pF1KB7 DDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGP
:. . . :. .: ..::.
NP_001 LYPDYQIQATVM---------IIVSSCAV-------------------------------
120 130
180 190 200 210 220 230
pF1KB7 QGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKE
::. ..: : : ..: : . .::
NP_001 --------AAN---------IVL--TVVLHQRCLGHN--------------------HKE
140 150
240 250 260 270 280
pF1KB7 KKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLP-LKSEDPCNWQCYIDPSLTVLMVI
...: ..:....:..:: . :. :.:.:.:.: : : :: : : .. :
NP_001 VQANA-SVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPI---C------TFIFSI
160 170 180 190 200
290 300 310 320 330 340
pF1KB7 IILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATL
..:.:.. ..:. . .:.. :::..:. . . :: :. ::: .::: :. ...: .
NP_001 LVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSA
210 220 230 240 250 260
350 360 370 380 390 400
pF1KB7 HIKYPKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKG
:. .: : . .: . . .. .:..:::.:. :..: :.:..::
NP_001 HVATAASRDSQVVRREIAKALSKSFTMHSLTIQMES-----PVDQDPDCLFCEDPCD
270 280 290 300 310 320
410 420 430 440 450 460
pF1KB7 CAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQ
>>NP_001166282 (OMIM: 125853,611145) zinc transporter 8 (320 aa)
initn: 227 init1: 169 opt: 285 Z-score: 319.7 bits: 68.0 E(85289): 4.5e-11
Smith-Waterman score: 299; 24.6% identity (53.4% similar) in 386 aa overlap (21-404:35-319)
10 20 30 40 50
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLIS
:..::.:.:....:.:...:. ..: :: :
NP_001 HSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 LCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERI
. ..: . ... .: :.:. :::..::: :. ::. . . ... :: ::.
NP_001 FLLSLFSLWLSSKPPSK-RLTFGWHRAEILGAL-----LSILCIWVVTGVLVYLAC-ERL
70 80 90 100 110
120 130 140 150 160 170
pF1KB7 DDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGP
:. . . :. .: ..::.
NP_001 LYPDYQIQATVM---------IIVSSCAV-------------------------------
120 130
180 190 200 210 220 230
pF1KB7 QGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKE
::. ..: : : ..: : . .::
NP_001 --------AAN---------IVL--TVVLHQRCLGHN--------------------HKE
140 150
240 250 260 270 280
pF1KB7 KKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLP-LKSEDPCNWQCYIDPSLTVLMVI
...: ..:....:..:: . :. :.:.:.:.: : : :: : : .. :
NP_001 VQANA-SVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPI---C------TFIFSI
160 170 180 190 200
290 300 310 320 330 340
pF1KB7 IILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATL
..:.:.. ..:. . .:.. :::..:. . . :: :. ::: .::: :. ...: .
NP_001 LVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSA
210 220 230 240 250 260
350 360 370 380 390 400
pF1KB7 HIKYPKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKG
:. .: : . .: . . .. .:..:::.:. :..: :.:..::
NP_001 HVATAASRDSQVVRREIAKALSKSFTMHSLTIQMES-----PVDQDPDCLFCEDPCD
270 280 290 300 310 320
410 420 430 440 450 460
pF1KB7 CAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQ
>>NP_001166285 (OMIM: 125853,611145) zinc transporter 8 (320 aa)
initn: 227 init1: 169 opt: 285 Z-score: 319.7 bits: 68.0 E(85289): 4.5e-11
Smith-Waterman score: 299; 24.6% identity (53.4% similar) in 386 aa overlap (21-404:35-319)
10 20 30 40 50
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLIS
:..::.:.:....:.:...:. ..: :: :
NP_001 HSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 LCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERI
. ..: . ... .: :.:. :::..::: :. ::. . . ... :: ::.
NP_001 FLLSLFSLWLSSKPPSK-RLTFGWHRAEILGAL-----LSILCIWVVTGVLVYLAC-ERL
70 80 90 100 110
120 130 140 150 160 170
pF1KB7 DDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGP
:. . . :. .: ..::.
NP_001 LYPDYQIQATVM---------IIVSSCAV-------------------------------
120 130
180 190 200 210 220 230
pF1KB7 QGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKE
::. ..: : : ..: : . .::
NP_001 --------AAN---------IVL--TVVLHQRCLGHN--------------------HKE
140 150
240 250 260 270 280
pF1KB7 KKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLP-LKSEDPCNWQCYIDPSLTVLMVI
...: ..:....:..:: . :. :.:.:.:.: : : :: : : .. :
NP_001 VQANA-SVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPI---C------TFIFSI
160 170 180 190 200
290 300 310 320 330 340
pF1KB7 IILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATL
..:.:.. ..:. . .:.. :::..:. . . :: :. ::: .::: :. ...: .
NP_001 LVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSA
210 220 230 240 250 260
350 360 370 380 390 400
pF1KB7 HIKYPKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKG
:. .: : . .: . . .. .:..:::.:. :..: :.:..::
NP_001 HVATAASRDSQVVRREIAKALSKSFTMHSLTIQMES-----PVDQDPDCLFCEDPCD
270 280 290 300 310 320
410 420 430 440 450 460
pF1KB7 CAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQ
>>NP_001166286 (OMIM: 125853,611145) zinc transporter 8 (320 aa)
initn: 227 init1: 169 opt: 285 Z-score: 319.7 bits: 68.0 E(85289): 4.5e-11
Smith-Waterman score: 299; 24.6% identity (53.4% similar) in 386 aa overlap (21-404:35-319)
10 20 30 40 50
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLIS
:..::.:.:....:.:...:. ..: :: :
NP_001 HSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 LCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERI
. ..: . ... .: :.:. :::..::: :. ::. . . ... :: ::.
NP_001 FLLSLFSLWLSSKPPSK-RLTFGWHRAEILGAL-----LSILCIWVVTGVLVYLAC-ERL
70 80 90 100 110
120 130 140 150 160 170
pF1KB7 DDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGP
:. . . :. .: ..::.
NP_001 LYPDYQIQATVM---------IIVSSCAV-------------------------------
120 130
180 190 200 210 220 230
pF1KB7 QGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKE
::. ..: : : ..: : . .::
NP_001 --------AAN---------IVL--TVVLHQRCLGHN--------------------HKE
140 150
240 250 260 270 280
pF1KB7 KKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLP-LKSEDPCNWQCYIDPSLTVLMVI
...: ..:....:..:: . :. :.:.:.:.: : : :: : : .. :
NP_001 VQANA-SVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPI---C------TFIFSI
160 170 180 190 200
290 300 310 320 330 340
pF1KB7 IILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATL
..:.:.. ..:. . .:.. :::..:. . . :: :. ::: .::: :. ...: .
NP_001 LVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSA
210 220 230 240 250 260
350 360 370 380 390 400
pF1KB7 HIKYPKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKG
:. .: : . .: . . .. .:..:::.:. :..: :.:..::
NP_001 HVATAASRDSQVVRREIAKALSKSFTMHSLTIQMES-----PVDQDPDCLFCEDPCD
270 280 290 300 310 320
410 420 430 440 450 460
pF1KB7 CAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQ
>>NP_776250 (OMIM: 125853,611145) zinc transporter 8 iso (369 aa)
initn: 227 init1: 169 opt: 285 Z-score: 318.9 bits: 68.0 E(85289): 5e-11
Smith-Waterman score: 299; 24.6% identity (53.4% similar) in 386 aa overlap (21-404:84-368)
10 20 30 40 50
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLIS
:..::.:.:....:.:...:. ..: :: :
NP_776 HSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTS
60 70 80 90 100 110
60 70 80 90 100 110
pF1KB7 LCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERI
. ..: . ... .: :.:. :::..::: :. ::. . . ... :: ::.
NP_776 FLLSLFSLWLSSKPPSK-RLTFGWHRAEILGAL-----LSILCIWVVTGVLVYLAC-ERL
120 130 140 150 160
120 130 140 150 160 170
pF1KB7 DDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGP
:. . . :. .: ..::.
NP_776 LYPDYQIQATVM---------IIVSSCAV-------------------------------
170 180
180 190 200 210 220 230
pF1KB7 QGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKE
::. ..: : : ..: : . .::
NP_776 --------AAN---------IVL--TVVLHQRCLGHN--------------------HKE
190 200
240 250 260 270 280
pF1KB7 KKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLP-LKSEDPCNWQCYIDPSLTVLMVI
...: ..:....:..:: . :. :.:.:.:.: : : :: : : .. :
NP_776 VQANA-SVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPI---C------TFIFSI
210 220 230 240 250
290 300 310 320 330 340
pF1KB7 IILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATL
..:.:.. ..:. . .:.. :::..:. . . :: :. ::: .::: :. ...: .
NP_776 LVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSA
260 270 280 290 300 310
350 360 370 380 390 400
pF1KB7 HIKYPKDRGYQDASTKIREIFHHA-GIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKG
:. .: : . .: . . .. .:..:::.:. :..: :.:..::
NP_776 HVATAASRDSQVVRREIAKALSKSFTMHSLTIQMES-----PVDQDPDCLFCEDPCD
320 330 340 350 360
410 420 430 440 450 460
pF1KB7 CAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQ
>>XP_016865238 (OMIM: 607819) PREDICTED: zinc transporte (681 aa)
initn: 381 init1: 124 opt: 280 Z-score: 309.8 bits: 67.2 E(85289): 1.6e-10
Smith-Waterman score: 333; 29.0% identity (57.3% similar) in 321 aa overlap (10-329:377-629)
10 20 30
pF1KB7 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLS
.....: :.. : .:: : : ::..:.:
XP_016 MGDAFQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLIS
350 360 370 380 390 400
40 50 60 70 80 90
pF1KB7 DSFNMLSDLISLCVGLSAGYIAR-RPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFV
:.:.:: : .: .:: :. ..: . :: :: :::.: :..... :..:: .. : .:.
XP_016 DGFHMLFDCSALVMGLFAALMSRWKATRIFS--YGYGRIEILSGFINGLFLIVIAFFVFM
410 420 430 440 450 460
100 110 120 130 140 150
pF1KB7 EAVLRLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQL
:.: :: : ..: ... :.: ::.::..:. :: :. ...:.
XP_016 ESVARLIDPPELDT-HMLTPVSVGGLIVNLIGI-----CA--FS---HAHSH--------
470 480 490 500
160 170 180 190 200 210
pF1KB7 AEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFN
: :. :: . .:: . .. .. . ..: . :: ..:
XP_016 -------AHGASQG----------SCHSSDHS---HSHHMHGHSDHGHGHSHGSAGGGMN
510 520 530 540
220 230 240 250 260 270
pF1KB7 TQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCY
. :.:::.:::..:.:::. :....... . .:
XP_016 A-----------------NMRGVFLHVLADTLGSIGVIVSTVLI--------EQFGW-FI
550 560 570
280 290 300 310 320 330
pF1KB7 IDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIW
:: .....:.:. :. ::::.. .:: .: . .:: : : ::
XP_016 ADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYE-KELHIALEKVTGILKDAGVNNL
580 590 600 610 620 630
340 350 360 370 380 390
pF1KB7 ELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLL
XP_016 TIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM
640 650 660 670 680
485 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 07:28:47 2016 done: Fri Nov 4 07:28:48 2016
Total Scan time: 9.790 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]