Result of FASTA (omim) for
pFN21AB7091
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7091, 184 aa
1>>>pF1KB7091 184 - 184 aa - 184 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2685+/-0.000372; mu= 12.5560+/- 0.023
mean_var=57.7089+/-11.789, 0's: 0 Z-trim(113.1): 19 B-trim: 984 in 1/54
Lambda= 0.168831
statistics sampled from 22243 (22261) to 22243 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.261), width: 16
Scan time: 5.960
The best scores are: opt bits E(85289)
NP_078851 (OMIM: 612112) tumor necrosis factor alp ( 184) 1181 295.7 2.7e-80
XP_016877657 (OMIM: 616438) PREDICTED: tumor necro ( 203) 682 174.2 1.2e-43
NP_001298104 (OMIM: 616438) tumor necrosis factor ( 204) 682 174.2 1.2e-43
XP_011519847 (OMIM: 616438) PREDICTED: tumor necro ( 218) 682 174.2 1.2e-43
NP_997264 (OMIM: 616438) tumor necrosis factor alp ( 292) 682 174.3 1.6e-43
XP_011525982 (OMIM: 615869) PREDICTED: tumor necro ( 186) 678 173.2 2.1e-43
NP_689575 (OMIM: 615869) tumor necrosis factor alp ( 186) 678 173.2 2.1e-43
XP_005259544 (OMIM: 615869) PREDICTED: tumor necro ( 186) 678 173.2 2.1e-43
NP_001161414 (OMIM: 615869) tumor necrosis factor ( 186) 678 173.2 2.1e-43
NP_001071122 (OMIM: 612111) tumor necrosis factor ( 188) 675 172.5 3.5e-43
NP_055165 (OMIM: 612111) tumor necrosis factor alp ( 198) 675 172.5 3.7e-43
NP_001273742 (OMIM: 612111) tumor necrosis factor ( 198) 675 172.5 3.7e-43
XP_016864816 (OMIM: 612111) PREDICTED: tumor necro ( 201) 675 172.5 3.7e-43
NP_001273743 (OMIM: 612111) tumor necrosis factor ( 210) 675 172.5 3.9e-43
NP_001273744 (OMIM: 612111) tumor necrosis factor ( 166) 604 155.2 5.1e-38
XP_016864817 (OMIM: 612111) PREDICTED: tumor necro ( 166) 604 155.2 5.1e-38
NP_001273746 (OMIM: 612111) tumor necrosis factor ( 166) 604 155.2 5.1e-38
XP_016877658 (OMIM: 616438) PREDICTED: tumor necro ( 158) 571 147.1 1.3e-35
>>NP_078851 (OMIM: 612112) tumor necrosis factor alpha-i (184 aa)
initn: 1181 init1: 1181 opt: 1181 Z-score: 1562.4 bits: 295.7 E(85289): 2.7e-80
Smith-Waterman score: 1181; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:1-184)
10 20 30 40 50 60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGPDFTQHLGKICDGLRKLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGPDFTQHLGKICDGLRKLLD
130 140 150 160 170 180
pF1KB7 EGKL
::::
NP_078 EGKL
>>XP_016877657 (OMIM: 616438) PREDICTED: tumor necrosis (203 aa)
initn: 688 init1: 632 opt: 682 Z-score: 904.9 bits: 174.2 E(85289): 1.2e-43
Smith-Waterman score: 682; 55.6% identity (87.2% similar) in 180 aa overlap (4-181:21-200)
10 20 30 40
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELY
::::::::::.::.:::.:...::...::.::::..::::
XP_016 MIHPPVASQVSASVSSGPDVFSSKSLALQAQKKILSKIASKTVANMLIDDTSSEIFDELY
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 RVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALS
.:.::.::.. .:....:::::::::...:.::..:. ::... .::.:: : ::: .:
XP_016 KVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKKLNQTAMTIVS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 FGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYG--
: ::..::. ::..:: ::.:.. :::..::::..:::: :::.::.: .:..::.
XP_016 FYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYSLD
130 140 150 160 170 180
170 180
pF1KB7 PDFTQHLGKICDGLRKLLDEGKL
: .: .::.:. :::::
XP_016 GDCRPNLKRICEGINKLLDEKVL
190 200
>>NP_001298104 (OMIM: 616438) tumor necrosis factor alph (204 aa)
initn: 688 init1: 632 opt: 682 Z-score: 904.8 bits: 174.2 E(85289): 1.2e-43
Smith-Waterman score: 682; 55.6% identity (87.2% similar) in 180 aa overlap (4-181:22-201)
10 20 30 40
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDEL
::::::::::.::.:::.:...::...::.::::..:::
NP_001 MDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQKKILSKIASKTVANMLIDDTSSEIFDEL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB7 YRVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTAL
:.:.::.::.. .:....:::::::::...:.::..:. ::... .::.:: : ::: .
NP_001 YKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKKLNQTAMTIV
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB7 SFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYG-
:: ::..::. ::..:: ::.:.. :::..::::..:::: :::.::.: .:..::.
NP_001 SFYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYSL
130 140 150 160 170 180
170 180
pF1KB7 -PDFTQHLGKICDGLRKLLDEGKL
: .: .::.:. :::::
NP_001 DGDCRPNLKRICEGINKLLDEKVL
190 200
>>XP_011519847 (OMIM: 616438) PREDICTED: tumor necrosis (218 aa)
initn: 688 init1: 632 opt: 682 Z-score: 904.4 bits: 174.2 E(85289): 1.2e-43
Smith-Waterman score: 682; 55.6% identity (87.2% similar) in 180 aa overlap (4-181:36-215)
10 20 30
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDE
::::::::::.::.:::.:...::...::.
XP_011 RDPLAVSCLYQRSPLSELPGYKQLKPGPDVFSSKSLALQAQKKILSKIASKTVANMLIDD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB7 TSSEVLDELYRVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQK
::::..::::.:.::.::.. .:....:::::::::...:.::..:. ::... .::.:
XP_011 TSSEIFDELYKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB7 LRQGAMTALSFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDP
: : ::: .:: ::..::. ::..:: ::.:.. :::..::::..:::: :::.::.:
XP_011 LNQTAMTIVSFYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADV
130 140 150 160 170 180
160 170 180
pF1KB7 GLLTALYG--PDFTQHLGKICDGLRKLLDEGKL
.:..::. : .: .::.:. :::::
XP_011 EFLSTLYSLDGDCRPNLKRICEGINKLLDEKVL
190 200 210
>>NP_997264 (OMIM: 616438) tumor necrosis factor alpha-i (292 aa)
initn: 688 init1: 632 opt: 682 Z-score: 902.3 bits: 174.3 E(85289): 1.6e-43
Smith-Waterman score: 682; 55.6% identity (87.2% similar) in 180 aa overlap (4-181:110-289)
10 20 30
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDE
::::::::::.::.:::.:...::...::.
NP_997 VDAQPAARSMDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQKKILSKIASKTVANMLIDD
80 90 100 110 120 130
40 50 60 70 80 90
pF1KB7 TSSEVLDELYRVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQK
::::..::::.:.::.::.. .:....:::::::::...:.::..:. ::... .::.:
NP_997 TSSEIFDELYKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKK
140 150 160 170 180 190
100 110 120 130 140 150
pF1KB7 LRQGAMTALSFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDP
: : ::: .:: ::..::. ::..:: ::.:.. :::..::::..:::: :::.::.:
NP_997 LNQTAMTIVSFYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADV
200 210 220 230 240 250
160 170 180
pF1KB7 GLLTALYG--PDFTQHLGKICDGLRKLLDEGKL
.:..::. : .: .::.:. :::::
NP_997 EFLSTLYSLDGDCRPNLKRICEGINKLLDEKVL
260 270 280 290
>>XP_011525982 (OMIM: 615869) PREDICTED: tumor necrosis (186 aa)
initn: 676 init1: 607 opt: 678 Z-score: 900.2 bits: 173.2 E(85289): 2.1e-43
Smith-Waterman score: 678; 57.0% identity (83.3% similar) in 186 aa overlap (1-184:1-186)
10 20 30 40 50 60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
:..::.:::::::.::::::::...:. ...:.:::::::::::...:.:.:: .::...
XP_011 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
:.:.:::.:...: :. ..: :::: :::.. : ::::.:: .:::::. :::. :
XP_011 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
70 80 90 100 110 120
130 140 150 160 170
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLRKL
::::.: . : ::: :::::: ::: :..: .:.::::: . .:: .::.:: ..
XP_011 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
130 140 150 160 170 180
180
pF1KB7 LDEGKL
::::.:
XP_011 LDEGSL
>>NP_689575 (OMIM: 615869) tumor necrosis factor alpha-i (186 aa)
initn: 676 init1: 607 opt: 678 Z-score: 900.2 bits: 173.2 E(85289): 2.1e-43
Smith-Waterman score: 678; 57.0% identity (83.3% similar) in 186 aa overlap (1-184:1-186)
10 20 30 40 50 60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
:..::.:::::::.::::::::...:. ...:.:::::::::::...:.:.:: .::...
NP_689 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
:.:.:::.:...: :. ..: :::: :::.. : ::::.:: .:::::. :::. :
NP_689 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
70 80 90 100 110 120
130 140 150 160 170
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLRKL
::::.: . : ::: :::::: ::: :..: .:.::::: . .:: .::.:: ..
NP_689 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
130 140 150 160 170 180
180
pF1KB7 LDEGKL
::::.:
NP_689 LDEGSL
>>XP_005259544 (OMIM: 615869) PREDICTED: tumor necrosis (186 aa)
initn: 676 init1: 607 opt: 678 Z-score: 900.2 bits: 173.2 E(85289): 2.1e-43
Smith-Waterman score: 678; 57.0% identity (83.3% similar) in 186 aa overlap (1-184:1-186)
10 20 30 40 50 60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
:..::.:::::::.::::::::...:. ...:.:::::::::::...:.:.:: .::...
XP_005 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
:.:.:::.:...: :. ..: :::: :::.. : ::::.:: .:::::. :::. :
XP_005 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
70 80 90 100 110 120
130 140 150 160 170
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLRKL
::::.: . : ::: :::::: ::: :..: .:.::::: . .:: .::.:: ..
XP_005 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
130 140 150 160 170 180
180
pF1KB7 LDEGKL
::::.:
XP_005 LDEGSL
>>NP_001161414 (OMIM: 615869) tumor necrosis factor alph (186 aa)
initn: 676 init1: 607 opt: 678 Z-score: 900.2 bits: 173.2 E(85289): 2.1e-43
Smith-Waterman score: 678; 57.0% identity (83.3% similar) in 186 aa overlap (1-184:1-186)
10 20 30 40 50 60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
:..::.:::::::.::::::::...:. ...:.:::::::::::...:.:.:: .::...
NP_001 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
:.:.:::.:...: :. ..: :::: :::.. : ::::.:: .:::::. :::. :
NP_001 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
70 80 90 100 110 120
130 140 150 160 170
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLRKL
::::.: . : ::: :::::: ::: :..: .:.::::: . .:: .::.:: ..
NP_001 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
130 140 150 160 170 180
180
pF1KB7 LDEGKL
::::.:
NP_001 LDEGSL
>>NP_001071122 (OMIM: 612111) tumor necrosis factor alph (188 aa)
initn: 687 init1: 593 opt: 675 Z-score: 896.2 bits: 172.5 E(85289): 3.5e-43
Smith-Waterman score: 675; 55.0% identity (87.8% similar) in 180 aa overlap (4-181:6-185)
10 20 30 40 50
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQR
:.::.::.::.::.:.::...:.: .::.::::::::::::..:::... .:..
NP_001 MATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 VIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAG
.::.:::..::.:.:.::..:. .:::: .:..:..: :::..:: .::.::. ::.
NP_001 IIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 LLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLR
::.:::..: .....::: :::::. .::::::: .:.:::.: .: :: :.:::.
NP_001 LLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGIN
130 140 150 160 170 180
180
pF1KB7 KLLDEGKL
:.:::
NP_001 KMLDEENI
184 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 04:38:24 2016 done: Fri Nov 4 04:38:25 2016
Total Scan time: 5.960 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]