Result of FASTA (omim) for
pFN21AB5574
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5574, 212 aa
1>>>pF1KB5574 212 - 212 aa - 212 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1653+/-0.00036; mu= 14.1273+/- 0.022
mean_var=60.7347+/-13.045, 0's: 0 Z-trim(113.8): 65 B-trim: 2060 in 2/52
Lambda= 0.164572
statistics sampled from 23261 (23349) to 23261 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.274), width: 16
Scan time: 6.270
The best scores are: opt bits E(85289)
NP_115904 (OMIM: 605404) bcl-2-related ovarian kil ( 212) 1399 340.4 1.3e-93
XP_011509998 (OMIM: 605404) PREDICTED: bcl-2-relat ( 212) 1399 340.4 1.3e-93
XP_016860264 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 899 221.6 4.8e-58
XP_016860265 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 899 221.6 4.8e-58
XP_011509999 (OMIM: 605404) PREDICTED: bcl-2-relat ( 117) 740 183.8 9.9e-47
NP_001278357 (OMIM: 600040) apoptosis regulator BA ( 221) 208 57.6 1.8e-08
NP_004315 (OMIM: 600040) apoptosis regulator BAX i ( 218) 205 56.9 2.9e-08
NP_620119 (OMIM: 600040) apoptosis regulator BAX i ( 179) 200 55.7 5.6e-08
NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192) 199 55.5 7e-08
XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173) 187 52.6 4.6e-07
NP_001278358 (OMIM: 600040) apoptosis regulator BA ( 181) 186 52.4 5.7e-07
NP_001309171 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 182 51.5 1.4e-06
NP_001304850 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 182 51.5 1.4e-06
NP_001309168 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 182 51.5 1.4e-06
XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 182 51.5 1.4e-06
NP_001304849 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 182 51.5 1.4e-06
NP_612815 (OMIM: 600039) bcl-2-like protein 1 isof ( 233) 182 51.5 1.4e-06
NP_001309169 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 182 51.5 1.4e-06
XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 182 51.5 1.4e-06
NP_001304848 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 182 51.5 1.4e-06
NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [ ( 193) 175 49.8 3.7e-06
NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Hom ( 193) 175 49.8 3.7e-06
NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211) 170 48.6 9e-06
XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211) 170 48.6 9e-06
XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homol ( 152) 162 46.6 2.5e-05
NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 ( 205) 161 46.5 3.8e-05
NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 ( 239) 160 46.2 5.2e-05
XP_011524437 (OMIM: 151430) PREDICTED: apoptosis r ( 224) 158 45.8 6.8e-05
NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197) 157 45.5 7.2e-05
XP_016881406 (OMIM: 151430) PREDICTED: apoptosis r ( 198) 157 45.5 7.2e-05
NP_001278359 (OMIM: 600040) apoptosis regulator BA ( 140) 155 44.9 7.5e-05
NP_001278360 (OMIM: 600040) apoptosis regulator BA ( 114) 149 43.5 0.00017
NP_620118 (OMIM: 600040) apoptosis regulator BAX i ( 143) 149 43.5 0.0002
NP_068779 (OMIM: 159552) induced myeloid leukemia ( 350) 147 43.2 0.00061
>>NP_115904 (OMIM: 605404) bcl-2-related ovarian killer (212 aa)
initn: 1399 init1: 1399 opt: 1399 Z-score: 1801.6 bits: 340.4 E(85289): 1.3e-93
Smith-Waterman score: 1399; 100.0% identity (100.0% similar) in 212 aa overlap (1-212:1-212)
10 20 30 40 50 60
pF1KB5 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLRAGLSWSAPERAAPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLRAGLSWSAPERAAPVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSAGITW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSAGITW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVLKCVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_115 GKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVLKCVVS
130 140 150 160 170 180
190 200 210
pF1KB5 TDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
::::::::::::::::::::::::::::::::
NP_115 TDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
190 200 210
>>XP_011509998 (OMIM: 605404) PREDICTED: bcl-2-related o (212 aa)
initn: 1399 init1: 1399 opt: 1399 Z-score: 1801.6 bits: 340.4 E(85289): 1.3e-93
Smith-Waterman score: 1399; 100.0% identity (100.0% similar) in 212 aa overlap (1-212:1-212)
10 20 30 40 50 60
pF1KB5 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLRAGLSWSAPERAAPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLRAGLSWSAPERAAPVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSAGITW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSAGITW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 GKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVLKCVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVLKCVVS
130 140 150 160 170 180
190 200 210
pF1KB5 TDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
::::::::::::::::::::::::::::::::
XP_011 TDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
190 200 210
>>XP_016860264 (OMIM: 605404) PREDICTED: bcl-2-related o (134 aa)
initn: 899 init1: 899 opt: 899 Z-score: 1163.1 bits: 221.6 E(85289): 4.8e-58
Smith-Waterman score: 899; 100.0% identity (100.0% similar) in 134 aa overlap (79-212:1-134)
50 60 70 80 90 100
pF1KB5 SWSAPERAAPVPGRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLA
::::::::::::::::::::::::::::::
XP_016 MIRPSVYRNVARQLHISLQSEPVVTDAFLA
10 20 30
110 120 130 140 150 160
pF1KB5 VAGHIFSAGITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAGHIFSAGITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRR
40 50 60 70 80 90
170 180 190 200 210
pF1KB5 GGWTDVLKCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGWTDVLKCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
100 110 120 130
>>XP_016860265 (OMIM: 605404) PREDICTED: bcl-2-related o (134 aa)
initn: 899 init1: 899 opt: 899 Z-score: 1163.1 bits: 221.6 E(85289): 4.8e-58
Smith-Waterman score: 899; 100.0% identity (100.0% similar) in 134 aa overlap (79-212:1-134)
50 60 70 80 90 100
pF1KB5 SWSAPERAAPVPGRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLA
::::::::::::::::::::::::::::::
XP_016 MIRPSVYRNVARQLHISLQSEPVVTDAFLA
10 20 30
110 120 130 140 150 160
pF1KB5 VAGHIFSAGITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAGHIFSAGITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRR
40 50 60 70 80 90
170 180 190 200 210
pF1KB5 GGWTDVLKCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGWTDVLKCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
100 110 120 130
>>XP_011509999 (OMIM: 605404) PREDICTED: bcl-2-related o (117 aa)
initn: 740 init1: 740 opt: 740 Z-score: 959.9 bits: 183.8 E(85289): 9.9e-47
Smith-Waterman score: 740; 100.0% identity (100.0% similar) in 116 aa overlap (1-116:1-116)
10 20 30 40 50 60
pF1KB5 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLRAGLSWSAPERAAPVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLRAGLSWSAPERAAPVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSAGITW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSAD
70 80 90 100 110
130 140 150 160 170 180
pF1KB5 GKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVLKCVVS
>>NP_001278357 (OMIM: 600040) apoptosis regulator BAX is (221 aa)
initn: 153 init1: 118 opt: 208 Z-score: 273.1 bits: 57.6 E(85289): 1.8e-08
Smith-Waterman score: 208; 29.1% identity (57.0% similar) in 172 aa overlap (22-184:13-175)
10 20 30 40 50
pF1KB5 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGRE-YVHARLLRAGLSWSAPERAA-P
::..: . .. :: . ... : : : ::: : :
NP_001 MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMG--GEAPELALDP
10 20 30 40
60 70 80 90 100 110
pF1KB5 VP--GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSA
:: . .. : :.::::. :. : :. . ..:. ::. .::
NP_001 VPQDASTKKLSECLKRIGDELD-------SNMELQRMIAAVDTDSPREVFFRVAADMFSD
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 G-ITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGW----
: ..::.::.:. :. :.. . : ...... .:.:. : :.. .:::
NP_001 GNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWGLPL
110 120 130 140 150 160
180 190 200 210
pF1KB5 TDVLKCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
.. :: ..: .::
NP_001 AESLKRLMSLSPGRPPLLLWDAHVADRDHLCGGSAHRLTHHLEEDGLRPPAALDCVFPP
170 180 190 200 210 220
>>NP_004315 (OMIM: 600040) apoptosis regulator BAX isofo (218 aa)
initn: 146 init1: 128 opt: 205 Z-score: 269.3 bits: 56.9 E(85289): 2.9e-08
Smith-Waterman score: 205; 29.4% identity (57.5% similar) in 160 aa overlap (22-176:13-163)
10 20 30 40 50
pF1KB5 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGRE-YVHARLLRAGLSWSAPERAA-P
::..: . .. :: . ... : : : ::: : :
NP_004 MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMG--GEAPELALDP
10 20 30 40
60 70 80 90 100 110
pF1KB5 VP--GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSA
:: . .. : :.::::. :. : :. . ..:. ::. .::
NP_004 VPQDASTKKLSECLKRIGDELD-------SNMELQRMIAAVDTDSPREVFFRVAADMFSD
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 G-ITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVL
: ..::.::.:. :. :.. . : ...... .:.:. : :.. .:::. .:
NP_004 GNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWVRLL
110 120 130 140 150 160
180 190 200 210
pF1KB5 KCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
:
NP_004 KPPHPHHRALTTAPAPPSLPPATPLGPWAFWSRSQWCPLPIFRSSDVVYNAFSLRV
170 180 190 200 210
>>NP_620119 (OMIM: 600040) apoptosis regulator BAX isofo (179 aa)
initn: 156 init1: 123 opt: 200 Z-score: 264.2 bits: 55.7 E(85289): 5.6e-08
Smith-Waterman score: 200; 29.5% identity (57.1% similar) in 156 aa overlap (22-172:13-159)
10 20 30 40 50
pF1KB5 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGRE-YVHARLLRAGLSWSAPERAA-P
::..: . .. :: . ... : : : ::: : :
NP_620 MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMG--GEAPELALDP
10 20 30 40
60 70 80 90 100 110
pF1KB5 VP--GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSA
:: . .. : :.::::. :. : :. . ..:. ::. .::
NP_620 VPQDASTKKLSECLKRIGDELD-------SNMELQRMIAAVDTDSPREVFFRVAADMFSD
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 G-ITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVL
: ..::.::.:. :. :.. . : ...... .:.:. : :.. .::::
NP_620 GNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWTVTI
110 120 130 140 150 160
180 190 200 210
pF1KB5 KCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
NP_620 FVAGVLTASLTIWKKMG
170
>>NP_620116 (OMIM: 600040) apoptosis regulator BAX isofo (192 aa)
initn: 155 init1: 122 opt: 199 Z-score: 262.5 bits: 55.5 E(85289): 7e-08
Smith-Waterman score: 199; 28.9% identity (56.6% similar) in 159 aa overlap (22-175:13-162)
10 20 30 40 50
pF1KB5 MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGRE-YVHARLLRAGLSWSAPERAA-P
::..: . .. :: . ... : : : ::: : :
NP_620 MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMG--GEAPELALDP
10 20 30 40
60 70 80 90 100 110
pF1KB5 VP--GRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSA
:: . .. : :.::::. :. : :. . ..:. ::. .::
NP_620 VPQDASTKKLSECLKRIGDELD-------SNMELQRMIAAVDTDSPREVFFRVAADMFSD
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB5 G-ITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVL
: ..::.::.:. :. :.. . : ...... .:.:. : :.. .::: .:
NP_620 GNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLL
110 120 130 140 150 160
180 190 200 210
pF1KB5 KCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
NP_620 SYFGTPTWQTVTIFVAGVLTASLTIWKKMG
170 180 190
>>XP_016882566 (OMIM: 600040) PREDICTED: apoptosis regul (173 aa)
initn: 151 init1: 122 opt: 187 Z-score: 247.8 bits: 52.6 E(85289): 4.6e-07
Smith-Waterman score: 187; 30.1% identity (57.4% similar) in 136 aa overlap (45-175:15-143)
20 30 40 50 60 70
pF1KB5 MDAFDRSPTDKELVAQAKALGREYVHARLLRAG-LSWSAPERAA-PVP--GRLAEVCAVL
::: .. ::: : ::: . .. :
XP_016 MKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECL
10 20 30 40
80 90 100 110 120
pF1KB5 LRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSAG-ITWGKVVSLYAV
:.::::. :. : :. . ..:. ::. .:: : ..::.::.:.
XP_016 KRIGDELD-------SNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYF
50 60 70 80 90
130 140 150 160 170 180
pF1KB5 AAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVLKCVVSTDPGLRSHW
:. :.. . : ...... .:.:. : :.. .::: .:
XP_016 ASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIF
100 110 120 130 140 150
190 200 210
pF1KB5 LVAALCSFGRFLKAAFFVLLPER
XP_016 VAGVLTASLTIWKKMG
160 170
212 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 03:55:52 2016 done: Fri Nov 4 03:55:53 2016
Total Scan time: 6.270 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]