Result of FASTA (ccds) for
pFN21AB5319
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5319, 426 aa
1>>>pF1KB5319 426 - 426 aa - 426 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6353+/-0.000916; mu= 2.2241+/- 0.055
mean_var=170.8892+/-34.510, 0's: 0 Z-trim(112.3): 17 B-trim: 0 in 0/52
Lambda= 0.098111
statistics sampled from 13039 (13055) to 13039 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.754), E-opt: 0.2 (0.401), width: 16
Scan time: 3.290
The best scores are: opt bits E(32554)
CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13 ( 430) 2588 378.2 8.3e-105
CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15 ( 425) 1890 279.4 4.5e-75
CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15 ( 381) 1648 245.1 8.4e-65
CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18 ( 467) 1649 245.3 9.1e-65
CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4 ( 465) 1580 235.6 7.9e-62
CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5 ( 465) 1431 214.5 1.8e-55
CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15 ( 320) 1392 208.9 5.9e-54
CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13 ( 467) 1388 208.4 1.2e-53
CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15 ( 230) 1139 173.0 2.7e-43
CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18 ( 552) 471 78.6 1.6e-14
>>CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13 (430 aa)
initn: 2389 init1: 2389 opt: 2588 Z-score: 1995.1 bits: 378.2 E(32554): 8.3e-105
Smith-Waterman score: 2588; 85.4% identity (94.1% similar) in 426 aa overlap (3-426:7-430)
10 20 30 40 50
pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS
..:::::::::::::::::::::::::::::::.::::::::::::.:::.:::
CCDS93 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 CPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 QKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDS
:::::::::::.:::.::::::::::::::::: ::::.::. . ..:: :: :::.:::
CCDS93 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQMPDVQAVAYEEPKHWCS
:::: .: ::. .. .:: ..: ::::: : :.: ::.: : . : ::::.::::
CCDS93 FQQPPCSALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSDFRPVCYEEPQHWCS
190 200 210 220 230
240 250 260 270 280 290
pF1KB5 IVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKG
..::::::::::.:.::: :::.:::::::::.:::::::::::::::::::::::::::
CCDS93 VAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKG
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 VHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLA
::::::::::::::.::::::::::::::.:::::.::::::::::::.:::: ::::::
CCDS93 VHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 QSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ
:::.::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS93 QSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ
360 370 380 390 400 410
420
pF1KB5 MGSPHNPISSVS
::::::::::::
CCDS93 MGSPHNPISSVS
420 430
>>CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15 (425 aa)
initn: 1042 init1: 913 opt: 1890 Z-score: 1461.2 bits: 279.4 E(32554): 4.5e-75
Smith-Waterman score: 1890; 65.1% identity (82.5% similar) in 435 aa overlap (3-426:1-425)
10 20 30 40 50
pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDALVKKLKKKKGAMEELEKALSC
..:.. :: : ::::::::.:.. :::: :::: .::::::: : ..:::::..
CCDS10 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAITT
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 PGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQ
. ..:.:::::::::::::::::::::::::.::::::.:::::. .: ::: :. :.
CCDS10 QNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 KEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQ
:::.:::::.:::.:::::::::::.: : :.: : . .: :..:: ...
CCDS10 DEVCVNPYHYQRVETPVLPPVLVPRHTEI-P-----AEFPPLDDYSHSIPENTNFPAGIE
120 130 140 150 160 170
180 190 200 210 220
pF1KB5 QPNSHPFPHSPNSSYPNSPGSSSS-TYPHSPTSSDPG-SPFQM-P-----DVQAVAYEEP
:.:. .:..: .: . : .:. . :: ...:. :: : : :.: :.: ::
CCDS10 -PQSN-IPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEP
180 190 200 210 220
230 240 250 260 270 280
pF1KB5 KHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRR
:::: :::::.::::.::::. :. :::::::::.. :::::::::::::...: :::
CCDS10 AFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRR
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB5 HIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEF
:::.::.:::.::::.:::::::.::::: ::: ..:.::.:::::: ::.:::::::::
CCDS10 HIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEF
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB5 AQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLD
: :::::::.:::.::.::.::::::::::::::::.:: :::::::::.::.:::::::
CCDS10 AALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLD
350 360 370 380 390 400
410 420
pF1KB5 KVLTQMGSPHNPISSVS
::::::::: ::::
CCDS10 KVLTQMGSPSIRCSSVS
410 420
>>CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15 (381 aa)
initn: 942 init1: 913 opt: 1648 Z-score: 1276.8 bits: 245.1 E(32554): 8.4e-65
Smith-Waterman score: 1648; 66.9% identity (83.3% similar) in 366 aa overlap (69-426:25-381)
40 50 60 70 80 90
pF1KB5 KKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQ
::::::::::::::::::::::.::::::.
CCDS45 MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYCRLWRWPDLH
10 20 30 40 50
100 110 120 130 140 150
pF1KB5 SHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRN
:::::. .: ::: :. :. :::.:::::.:::.:::::::::::.: : :.:
CCDS45 SHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEI-P-----AEFPP
60 70 80 90 100
160 170 180 190 200 210
pF1KB5 LGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSS-TYPHSPTSSDPG-SPF
: . .: :..:: ... :.:. .:..: .: . : .:. . :: ...:. ::
CCDS45 LDDYSHSIPENTNFPAGIE-PQSN-IPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPN
110 120 130 140 150 160
220 230 240 250 260 270
pF1KB5 QM-P-----DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRF
: : :.: :.: :: :::: :::::.::::.::::. :. :::::::::.. ::
CCDS45 PMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RF
170 180 190 200 210 220
280 290 300 310 320 330
pF1KB5 CLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPT
:::::::::::...: ::::::.::.:::.::::.:::::::.::::: ::: ..:.::.
CCDS45 CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPA
230 240 250 260 270 280
340 350 360 370 380 390
pF1KB5 TVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDV
:::::: ::.:::::::::: :::::::.:::.::.::.::::::::::::::::.:: :
CCDS45 TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV
290 300 310 320 330 340
400 410 420
pF1KB5 TSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
::::::::.::.:::::::::::::::: ::::
CCDS45 TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
350 360 370 380
>>CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18 (467 aa)
initn: 1739 init1: 908 opt: 1649 Z-score: 1276.3 bits: 245.3 E(32554): 9.1e-65
Smith-Waterman score: 1777; 59.3% identity (75.1% similar) in 469 aa overlap (12-426:10-467)
10 20 30 40
pF1KB5 MNVTSLFSFTSPAVKRLLGWK-------------QGDEEEKWAEKAVDALVKKLKKKKGA
:.:::::::: :. .:::: :::: .::::::: :
CCDS11 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKT-GR
10 20 30 40 50
50 60 70
pF1KB5 MEELEKALSCPGQPSNCVTIP------------------------------RSLDGRLQV
..:::::.. . ..::::: :::::::::
CCDS11 LDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQV
60 70 80 90 100 110
80 90 100 110 120 130
pF1KB5 SHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPP
:::::::::::::.::::::.:::::: .: ::. :. :. :::.:::::.:::.:::::
CCDS11 SHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPP
120 130 140 150 160 170
140 150 160 170 180 190
pF1KB5 VLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPG
::::::.: .:... : . .: :..:: ... :.:. .:..: .: . :
CCDS11 VLVPRHTE------ILTELPPLDDYTHSIPENTNFPAGIE-PQSNYIPETPPPGYISEDG
180 190 200 210 220 230
200 210 220 230 240
pF1KB5 SSSSTYPHSPTSSDPGSPFQM-P----------DVQAVAYEEPKHWCSIVYYELNNRVGE
.:. .. : : ::: .. : :.: :.: :: ::::.:::::.::::
CCDS11 ETSDQQLNQ--SMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGE
240 250 260 270 280
250 260 270 280 290 300
pF1KB5 AFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYA
.::::. :. :::::::::.. :::::::::::::.:.: ::::::.::.:::.::::.:
CCDS11 TFHASQPSLTVDGFTDPSNSE-RFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFA
290 300 310 320 330 340
310 320 330 340 350 360
pF1KB5 ECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYE
::::::.::::: ::: ..:.::.:::::: ::.:::::::::: :::::::.:::.::.
CCDS11 ECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQ
350 360 370 380 390 400
370 380 390 400 410 420
pF1KB5 LTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
::.::::::::::::::::.:: :::::::::.::.:::::::::::::::: ::.:
CCDS11 LTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
410 420 430 440 450 460
>>CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4 (465 aa)
initn: 2996 init1: 1569 opt: 1580 Z-score: 1223.5 bits: 235.6 E(32554): 7.9e-62
Smith-Waterman score: 2880; 91.5% identity (91.5% similar) in 458 aa overlap (1-419:1-458)
10 20 30 40 50 60
pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
130 140 150 160 170 180
190 200 210
pF1KB5 SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMP---------------------
:::::::::::::::::::::::::::::::::::::::
CCDS37 SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ
190 200 210 220 230 240
220 230 240 250 260
pF1KB5 ------------------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
::::::::::::::::::::::::::::::::::::::::::
CCDS37 PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB5 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB5 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS37 NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
370 380 390 400 410 420
390 400 410 420
pF1KB5 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
::::::::::::::::::::::::::::::::::::::
CCDS37 GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
430 440 450 460
>>CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5 (465 aa)
initn: 2761 init1: 1399 opt: 1431 Z-score: 1109.5 bits: 214.5 E(32554): 1.8e-55
Smith-Waterman score: 2662; 85.0% identity (88.7% similar) in 460 aa overlap (7-426:8-465)
10 20 30 40 50
pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPG
:::::::::::::::::::::::::::::::::::::::::::::::::: ::
CCDS75 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 QPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKE
:::.:::::::::::::::::::::::::::::::::::::::::::. :::::::::::
CCDS75 QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 VCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQP
::::::::::::::::::::::::.:.:::::::.:::::..:::::: ::::::::.::
CCDS75 VCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQP
130 140 150 160 170 180
180 190 200 210
pF1KB5 NSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMP--------------------
:. ::: :::: :: :: .:::::.::.:: ::::::.:
CCDS75 NNTPFPLSPNSPYPPSP--ASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNS
190 200 210 220 230
220 230 240 250
pF1KB5 --------------------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDG
::: ::::::::::::::::::::::::::::::::::::
CCDS75 QPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDG
240 250 260 270 280 290
260 270 280 290 300 310
pF1KB5 FTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSR
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 FTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSR
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB5 NCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVK
:::.::::::::::::::.::::::::::::::::::::::::.::::::::::::::::
CCDS75 NCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVK
360 370 380 390 400 410
380 390 400 410 420
pF1KB5 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
::::::::::::::::::::::::::::::::::::::: :::::::
CCDS75 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
420 430 440 450 460
>>CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15 (320 aa)
initn: 942 init1: 913 opt: 1392 Z-score: 1082.2 bits: 208.9 E(32554): 5.9e-54
Smith-Waterman score: 1392; 64.4% identity (81.8% similar) in 329 aa overlap (106-426:1-320)
80 90 100 110 120 130
pF1KB5 QVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVL
.: ::: :. :. :::.:::::.:::.:::
CCDS53 MELCEFAFNMKKDEVCVNPYHYQRVETPVL
10 20 30
140 150 160 170 180 190
pF1KB5 PPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNS
::::::::.: : :.: : . .: :..:: ... :.:. .:..: .: .
CCDS53 PPVLVPRHTEI-P-----AEFPPLDDYSHSIPENTNFPAGIE-PQSN-IPETPPPGYLSE
40 50 60 70 80
200 210 220 230 240
pF1KB5 PGSSSS-TYPHSPTSSDPG-SPFQM-P-----DVQAVAYEEPKHWCSIVYYELNNRVGEA
: .:. . :: ...:. :: : : :.: :.: :: :::: :::::.::::.
CCDS53 DGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGET
90 100 110 120 130 140
250 260 270 280 290 300
pF1KB5 FHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAE
::::. :. :::::::::.. :::::::::::::...: ::::::.::.:::.::::.::
CCDS53 FHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAE
150 160 170 180 190 200
310 320 330 340 350 360
pF1KB5 CLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYEL
:::::.::::: ::: ..:.::.:::::: ::.:::::::::: :::::::.:::.::.:
CCDS53 CLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQL
210 220 230 240 250 260
370 380 390 400 410 420
pF1KB5 TKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
:.::::::::::::::::.:: :::::::::.::.:::::::::::::::: ::::
CCDS53 TRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
270 280 290 300 310 320
>>CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13 (467 aa)
initn: 2556 init1: 1344 opt: 1388 Z-score: 1076.6 bits: 208.4 E(32554): 1.2e-53
Smith-Waterman score: 2498; 79.1% identity (87.0% similar) in 460 aa overlap (6-426:10-467)
10 20 30 40 50
pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALS
::::::::::::::::::::::::::::::.::::::::::::.:::.:::
CCDS45 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 CPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 QKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG-QNEPHMPLNATFPDS
:::::::::::.:::.::::::::::::::::: ::::.::. . ..:: :: :::.:::
CCDS45 QKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS
130 140 150 160 170 180
180 190 200 210
pF1KB5 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTS-SDPGSPFQ-------MP--------
:::: .: ::. .. .:: ..: ::::: : :.: ::.: .:
CCDS45 FQQPPCSALPPSPSHAFSQSPCTAS--YPHSPGSPSEPESPYQHSVDTPPLPYHATEASE
190 200 210 220 230
220 230 240 250
pF1KB5 ----------------------DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLV
: . : ::::.::::..::::::::::.:.::: :::.
CCDS45 TQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLI
240 250 260 270 280 290
260 270 280 290 300 310
pF1KB5 DGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQ
:::::::::.:::::::::::::::::::::::::::::::::::::::::.::::::::
CCDS45 DGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQ
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB5 SRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSF
::::::.:::::.::::::::::::.:::: :::::::::.::::.::::::::::::::
CCDS45 SRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSF
360 370 380 390 400 410
380 390 400 410 420
pF1KB5 VKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
:::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 VKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
420 430 440 450 460
>>CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15 (230 aa)
initn: 942 init1: 913 opt: 1139 Z-score: 890.8 bits: 173.0 E(32554): 2.7e-43
Smith-Waterman score: 1139; 74.9% identity (88.8% similar) in 223 aa overlap (206-426:9-230)
180 190 200 210 220 230
pF1KB5 FQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPT-SSDPGSPFQMP-DVQAVAYEEPKHWC
::. : .: :: . :.: :.: :: ::
CCDS53 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWC
10 20 30
240 250 260 270 280 290
pF1KB5 SIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGK
:: :::::.::::.::::. :. :::::::::.. :::::::::::::...: ::::::.
CCDS53 SISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGR
40 50 60 70 80 90
300 310 320 330 340 350
pF1KB5 GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLL
::.:::.::::.:::::::.::::: ::: ..:.::.:::::: ::.:::::::::: ::
CCDS53 GVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALL
100 110 120 130 140 150
360 370 380 390 400 410
pF1KB5 AQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLT
:::::.:::.::.::.::::::::::::::::.:: :::::::::.::.:::::::::::
CCDS53 AQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLT
160 170 180 190 200 210
420
pF1KB5 QMGSPHNPISSVS
::::: ::::
CCDS53 QMGSPSIRCSSVS
220 230
>>CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18 (552 aa)
initn: 696 init1: 225 opt: 471 Z-score: 374.0 bits: 78.6 E(32554): 1.6e-14
Smith-Waterman score: 712; 34.6% identity (58.4% similar) in 433 aa overlap (14-355:20-449)
10 20 30 40 50
pF1KB5 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKA
:. :. .:: : : .:..:...::::::.:: .. : :
CCDS11 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 LSCPG-QPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPF
.. : .::.:::: :.:::::::. :::.::::: :.::::::... ::: .. :.. :
CCDS11 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQYAF
70 80 90 100 110
120 130 140 150
pF1KB5 GSKQKEVCINPYHYKRVESPVL-----------PPVLVPRHS---EYNPQHSLLAQFRNL
: ::.:::::.:: :: . : .. . ... : :: .. ...
CCDS11 DLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSI
120 130 140 150 160 170
160 170 180 190
pF1KB5 GQNEPHMPLNATFPDSFQQP-----------NSHPFPHSP--NSSYPNS-----------
:. : : : . .... : .. ::. : ..: : :
CCDS11 -QTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLL
180 190 200 210 220 230
200 210 220
pF1KB5 -------PGSSSS-------TYPHSPTSSDPGS---PF--QMPDVQA-------------
::.... :: :. :.. :: :. ..: :
CCDS11 QIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHP
240 250 260 270 280 290
230 240 250 260
pF1KB5 ---------VAYEEP-------KHWCSIVYYELNNRVGEAFHASSTS--VLVDGFTDPSN
.:.. : ..::::.:.:.. .:::.:.. :. : :::..:::.
CCDS11 GHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSG
300 310 320 330 340 350
270 280 290 300 310 320
pF1KB5 NKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSSIFVQSRNCNYH
. .::::: ::::.:. .:: .: ::::::.: : :.:...:::: ..:::: . .
CCDS11 G-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDRE
360 370 380 390 400 410
330 340 350 360 370 380
pF1KB5 HGFHP-TTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGA
: : .: :: . .:.:. .. . . :
CCDS11 AGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGG
420 430 440 450 460 470
390 400 410 420
pF1KB5 EYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
CCDS11 IAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLD
480 490 500 510 520 530
426 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 03:36:42 2016 done: Fri Nov 4 03:36:43 2016
Total Scan time: 3.290 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]