Result of FASTA (omim) for
pFN21AB5228
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5228, 473 aa
1>>>pF1KB5228 473 - 473 aa - 473 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.2793+/-0.000406; mu= 1.4354+/- 0.025
mean_var=301.9470+/-61.443, 0's: 0 Z-trim(122.0): 322 B-trim: 33 in 1/57
Lambda= 0.073809
statistics sampled from 39114 (39464) to 39114 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.783), E-opt: 0.2 (0.463), width: 16
Scan time: 11.630
The best scores are: opt bits E(85289)
NP_075380 (OMIM: 181500,605566) reticulon-4 recept ( 473) 3316 366.6 8.5e-101
NP_848665 (OMIM: 610462) reticulon-4 receptor-like ( 420) 1066 126.9 1e-28
NP_848663 (OMIM: 610461) reticulon-4 receptor-like ( 441) 1027 122.8 1.9e-27
NP_055632 (OMIM: 613356) TLR4 interactor with leuc ( 811) 469 63.7 2.2e-09
NP_060960 (OMIM: 606666,615311) leucine-rich repea ( 951) 420 58.5 9.3e-08
NP_001264155 (OMIM: 606667) leucine-rich repeat-co ( 883) 410 57.4 1.8e-07
NP_004961 (OMIM: 601489,615961) insulin-like growt ( 605) 405 56.7 2.1e-07
NP_001139478 (OMIM: 601489,615961) insulin-like gr ( 643) 405 56.7 2.2e-07
XP_016885198 (OMIM: 300278,310500) PREDICTED: nyct ( 481) 392 55.2 4.6e-07
NP_072089 (OMIM: 300278,310500) nyctalopin precurs ( 481) 392 55.2 4.6e-07
NP_003658 (OMIM: 606667) leucine-rich repeat-conta ( 907) 392 55.5 7.1e-07
NP_001278917 (OMIM: 603104) carboxypeptidase N sub ( 545) 385 54.5 8.4e-07
XP_005269337 (OMIM: 603104) PREDICTED: carboxypept ( 545) 385 54.5 8.4e-07
NP_001073982 (OMIM: 603104) carboxypeptidase N sub ( 545) 385 54.5 8.4e-07
NP_001017403 (OMIM: 606653) leucine-rich repeat-co ( 967) 388 55.1 1e-06
NP_006661 (OMIM: 190920) trophoblast glycoprotein ( 420) 367 52.5 2.7e-06
NP_001159864 (OMIM: 190920) trophoblast glycoprote ( 420) 367 52.5 2.7e-06
XP_011534399 (OMIM: 190920) PREDICTED: trophoblast ( 420) 367 52.5 2.7e-06
XP_011518546 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_011518542 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873568 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_011518544 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873567 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873559 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_011518540 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873561 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_011518543 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873560 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
NP_001245348 (OMIM: 608817) leucine-rich repeat-co ( 640) 368 52.8 3.3e-06
NP_065980 (OMIM: 608817) leucine-rich repeat-conta ( 640) 368 52.8 3.3e-06
XP_016873566 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873565 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873563 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873562 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_011518541 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_011518545 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016873564 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 368 52.8 3.3e-06
XP_016867994 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 367 52.7 3.6e-06
XP_011514763 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 367 52.7 3.6e-06
NP_071426 (OMIM: 610486) leucine-rich repeat-conta ( 653) 367 52.7 3.6e-06
XP_005244884 (OMIM: 605492) PREDICTED: leucine-ric ( 713) 364 52.4 4.8e-06
NP_963924 (OMIM: 605492) leucine-rich repeat neuro ( 713) 364 52.4 4.8e-06
NP_006329 (OMIM: 605492) leucine-rich repeat neuro ( 713) 364 52.4 4.8e-06
XP_011507368 (OMIM: 605492) PREDICTED: leucine-ric ( 713) 364 52.4 4.8e-06
XP_016855539 (OMIM: 605492) PREDICTED: leucine-ric ( 713) 364 52.4 4.8e-06
XP_005262400 (OMIM: 300561) PREDICTED: SLIT and NT ( 845) 355 51.5 1e-05
NP_001137478 (OMIM: 300561) SLIT and NTRK-like pro ( 845) 355 51.5 1e-05
NP_001137476 (OMIM: 300561) SLIT and NTRK-like pro ( 845) 355 51.5 1e-05
NP_001137480 (OMIM: 300561) SLIT and NTRK-like pro ( 845) 355 51.5 1e-05
NP_115928 (OMIM: 300561) SLIT and NTRK-like protei ( 845) 355 51.5 1e-05
>>NP_075380 (OMIM: 181500,605566) reticulon-4 receptor p (473 aa)
initn: 3316 init1: 3316 opt: 3316 Z-score: 1930.6 bits: 366.6 E(85289): 8.5e-101
Smith-Waterman score: 3316; 100.0% identity (100.0% similar) in 473 aa overlap (1-473:1-473)
10 20 30 40 50 60
pF1KB5 MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 VDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 VDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 LPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 LAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 LAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 GRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 GRVPPGDSPPGNGSGPRHINDSPFGTLPGSAEPPLTAVRPEGSEPPGFPTSGPRRRPGCS
370 380 390 400 410 420
430 440 450 460 470
pF1KB5 RKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 RKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
430 440 450 460 470
>>NP_848665 (OMIM: 610462) reticulon-4 receptor-like 2 p (420 aa)
initn: 973 init1: 895 opt: 1066 Z-score: 636.4 bits: 126.9 E(85289): 1e-28
Smith-Waterman score: 1066; 46.8% identity (68.3% similar) in 385 aa overlap (15-394:18-394)
10 20 30 40 50
pF1KB5 MKRASAGGSRLLAWVLWLQAWQVAAP-CPGACVCYNEPKVTTSCPQQGLQAVPVGIP
.: : : .::: :: :.::. : :.:: .....::...:
NP_848 MLPGLRRLLQAPASACLLLMLLALPLAAPSCPMLCTCYSSPP-TVSCQANNFSSVPLSLP
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 AASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNA
..::.::..: : . ..: . :: ::: :: :. : ..: : ::.:::.::
NP_848 PSTQRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 QLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRD
.:::..: ::.:: ::..::: :: :. : ..::::..:::::::.:.: : :: : :
NP_848 HLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFAD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 LGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFAN
:.::.::::::::. . :..:::: :::::::: ::. :: ::: :.:: :::: :
NP_848 LANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 NLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGR
.:..:: :::: : .:..:::: :::.:::::::::::.:. : :::.: :. : . ::
NP_848 SLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGR
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 DLKRLAANDLQGCAVATGPYHPI--WTGRATDEEPLGLPKCCQPDAADKASVLEPGRPAS
::. : :.:.: :. : .: : ..... :. . : : :.: ::
NP_848 DLRALREADFQACPPAA-PTRPGSRARGNSSSNHLYGVAEAGAPPA--DPSTLYRDLPAE
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 AGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPGSA--EPPLTAVRPEGSEPPGFPTSG
. . .: : .. .: : . .. ::.: ::
NP_848 DSRGRQGGDAPTEDDYWGGYGGE--DQRGEQMCPGAACQAPPDSRGPALSAGLPSPLLCL
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 PRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGP
NP_848 LLLVPHHL
420
>>NP_848663 (OMIM: 610461) reticulon-4 receptor-like 1 p (441 aa)
initn: 1019 init1: 872 opt: 1027 Z-score: 613.7 bits: 122.8 E(85289): 1.9e-27
Smith-Waterman score: 1102; 45.4% identity (64.9% similar) in 416 aa overlap (27-436:25-421)
10 20 30 40 50 60
pF1KB5 MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQ
:: :::: : .:.:: ... :.: :::. :.
NP_848 MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAP-MTVSCQAHNFAAIPEGIPVDSE
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 RIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRS
:.::..:::. . . : .. ::..:: .. : ..: :.. ::.:::.:: :::.
NP_848 RVFLQNNRIGLLQPGHFSPA--MVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRT
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 VDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNL
. : ::.:: .::.:.: .:::. : :.: :: .::::::::: .. : :: : :: ::
NP_848 LAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB5 THLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSA
.:::::::.. :. .:::: .:::::::.:.. :: .::.:: :: ::.:: :.::
NP_848 SHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSE
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB5 LPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKR
: : :::: ::..:::: ::: : :::: :: :::.:::::: ::: : :.:::
NP_848 LQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKL
240 250 260 270 280 290
310 320 330 340 350
pF1KB5 LAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPA-SAGNAL
: :.:...: ::: : : : : . : :. : :.
NP_848 LRAEDFRNC---TGPASPHQIKSHT---------LTTTDRAARKEHHSPHGPTRSKGHPH
300 310 320 330 340
360 370 380 390 400 410
pF1KB5 KGRVPPGDSPPG-NGSGPRHIND-SPFGTLPGSAEPPLTAVRPEGSEPPGF---PTSGPR
: :: :: : ..::. :. : :. :. : : :. .. .: ::. :.
NP_848 GPR--PGHRKPGKNCTNPRNRNQISKAGA--GKQAPELPDYAPDYQHKFSFDIMPTARPK
350 360 370 380 390
420 430 440 450 460 470
pF1KB5 RRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
:. :.:.. :. . ::.:
NP_848 RKGKCARRTPIRAPSGVQQASSASSLGASLLAWTLGLAVTLR
400 410 420 430 440
>>NP_055632 (OMIM: 613356) TLR4 interactor with leucine (811 aa)
initn: 471 init1: 345 opt: 469 Z-score: 289.3 bits: 63.7 E(85289): 2.2e-09
Smith-Waterman score: 486; 33.4% identity (51.9% similar) in 416 aa overlap (61-439:159-571)
40 50 60 70 80 90
pF1KB5 CVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHS
.. : :: .. .: : : :: : :.:
NP_055 PLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLES
130 140 150 160 170 180
100 110 120 130 140
pF1KB5 NVLARIDAAAFTGLALLEQLDLSDNAQLRSV-DPATFHGLGRLHTLHLDRCGLQELGPGL
: . . ::. :. :. :.:: : :. ::: : : .: :. .::.::: .
NP_055 NRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRI
190 200 210 220 230 240
150 160 170 180 190 200
pF1KB5 FRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLL
:. : : : :. : : : ..: : : .: :.:::.:..: .. ::::. : :
NP_055 FQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDL
250 260 270 280 290 300
210 220 230 240 250 260
pF1KB5 HQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRAR
:... .:: .: :::: : : : :::: . .: :: : :. : :.:::: :
NP_055 SGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLR
310 320 330 340 350 360
270 280 290 300 310 320
pF1KB5 PL--WA--WLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQ-GCAVATGPYHPIWTGR-
: : : .. : . : : : : :. : : ..:: : . .: . . :
NP_055 GLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPSASLTADRR
370 380 390 400 410 420
330 340 350 360
pF1KB5 ------ATDEE---PLGLPKCC--QPDAADK----ASVLEPGRPAS-AGN--ALK-GRVP
:. :: : :: . ::. .. :.: : .:: ::. .:
NP_055 RQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRG
430 440 450 460 470 480
370 380 390 400 410
pF1KB5 PGDSPPG------NGSGPRHIN--DSPFGTLPGSAEPPLTAVRPE---GSEPPGFPTSGP
:: . :. : .:. .. .: : :.: :. : :: : :.. :
NP_055 PGLQQPSPSVAAAAGPAPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAPS--PAGDP
490 500 510 520 530 540
420 430 440 450 460 470
pF1KB5 RRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEGSGALPSLTCSLTPLGLALVLWTVLGPC
.: : . :. . : .:. .:.:
NP_055 WQRATKHRLG-TEHQERAAQSDGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSASVRWA
550 560 570 580 590 600
>>NP_060960 (OMIM: 606666,615311) leucine-rich repeat-co (951 aa)
initn: 507 init1: 256 opt: 420 Z-score: 260.3 bits: 58.5 E(85289): 9.3e-08
Smith-Waterman score: 420; 36.0% identity (61.5% similar) in 239 aa overlap (24-260:24-258)
10 20 30 40 50
pF1KB5 MKRASAGGSRLLAWVLWLQAWQVAAP--CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAA
::: : . : : .. .: .: .:: ::: :. :
NP_060 MPGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRV--DCSGKGLTAVPEGLSAF
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 SQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQL
.: . . : :...: .:. : : : .: :. : :..:: :. : :..: ::
NP_060 TQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNN-QL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 RSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLG
..: ...::. :..:.:: . . :.::. :..:.:.::.: .: . .:
NP_060 KTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 NLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNL
.: : : :.:::.:. :: .: :: : ::.:.. . : : : : :: : :::
NP_060 TLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 SALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDL
. .: .:. : .:. : ...:
NP_060 GEFP-QAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLS
240 250 260 270 280 290
>>NP_001264155 (OMIM: 606667) leucine-rich repeat-contai (883 aa)
initn: 277 init1: 271 opt: 410 Z-score: 254.9 bits: 57.4 E(85289): 1.8e-07
Smith-Waterman score: 410; 35.9% identity (61.6% similar) in 237 aa overlap (27-261:34-268)
10 20 30 40 50
pF1KB5 MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVCYNEPKVT--TSCPQQGLQAVPVG
:: : : . .. ..: . ::. .: .
NP_001 SRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 IPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSD
. . .. . : : ::.. . . : : : : .:.:. : .::::: :. : :..
NP_001 LSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 NAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTF
: ::: : ....: :..:.:: .. . :. : :: .:..:.:.:::: .: ..:
NP_001 N-QLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 RDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLF
:.:. : . : :.: .:. :: .: :: : ::.::. . . : : : :: :
NP_001 RSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLN
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 ANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLA
:::. .:: :. : :. :.. :::
NP_001 YNNLDEFPT-AIRTLSNLKELHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLT
250 260 270 280 290 300
>>NP_004961 (OMIM: 601489,615961) insulin-like growth fa (605 aa)
initn: 1010 init1: 325 opt: 405 Z-score: 254.0 bits: 56.7 E(85289): 2.1e-07
Smith-Waterman score: 412; 32.5% identity (57.0% similar) in 286 aa overlap (64-309:321-605)
40 50 60 70 80 90
pF1KB5 YNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVL
: ::: .. ::.. .: .: : : :
NP_004 GLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL
300 310 320 330 340 350
100 110 120 130 140 150
pF1KB5 ARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGL
.. :.:: ::. . ..:: : ::.. .:.:::.::.:::. : .. : : ::
NP_004 QEVKAGAFLGLTNVAVMNLSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL
360 370 380 390 400
160 170 180 190 200 210
pF1KB5 AALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNR
..:. :.:.::.: .. .... :..: .: : .:... .:.: :.:: .:. ::: .::
NP_004 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR
410 420 430 440 450 460
220 230 240 250 260
pF1KB5 VAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN-------------
.:.. :. : : . : . : : :::. :::: :.:: : .:
NP_004 LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLE
470 480 490 500 510 520
270 280 290
pF1KB5 -------PWVCDCRARPLWAW-LQ------KF-----RGSSSEVP--------CSLPQRL
:: : : . : . :: .: .:.. . : :. : ..
NP_004 RLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEV
530 540 550 560 570 580
300 310 320 330 340 350
pF1KB5 AGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPA
.: ::. :. . :
NP_004 VGLDLRDLSEAHFAPC
590 600
>--
initn: 515 init1: 281 opt: 334 Z-score: 213.2 bits: 49.2 E(85289): 3.9e-05
Smith-Waterman score: 449; 37.6% identity (64.6% similar) in 237 aa overlap (27-260:41-276)
10 20 30 40 50
pF1KB5 MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVC-YNEP--KVTTSCPQQGLQAVPV
::.:::: :.. .... : ...: .:
NP_004 ALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPD
20 30 40 50 60 70
60 70 80 90 100 110
pF1KB5 GIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLS
:.:...: ..: :: .: :: :.:. .: .: :... :. .. :. :: : .: :
NP_004 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE
80 90 100 110 120 130
120 130 140 150 160 170
pF1KB5 DNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDT
: ::::. .:: : .: :. :..: :::.::..: : : :.: .::: .
NP_004 RN-QLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAA
140 150 160 170 180
180 190 200 210 220 230
pF1KB5 FRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYL
:: ::.: .: : :::.. . : :: : .: : .: . .. ..: .: ::. :::
NP_004 FRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYL
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 FANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRL
: ..:. :. :.::..: :. :
NP_004 DRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRT
250 260 270 280 290 300
>>NP_001139478 (OMIM: 601489,615961) insulin-like growth (643 aa)
initn: 1010 init1: 325 opt: 405 Z-score: 253.7 bits: 56.7 E(85289): 2.2e-07
Smith-Waterman score: 412; 32.5% identity (57.0% similar) in 286 aa overlap (64-309:359-643)
40 50 60 70 80 90
pF1KB5 YNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVL
: ::: .. ::.. .: .: : : :
NP_001 GLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL
330 340 350 360 370 380
100 110 120 130 140 150
pF1KB5 ARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGL
.. :.:: ::. . ..:: : ::.. .:.:::.::.:::. : .. : : ::
NP_001 QEVKAGAFLGLTNVAVMNLSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL
390 400 410 420 430 440
160 170 180 190 200 210
pF1KB5 AALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNR
..:. :.:.::.: .. .... :..: .: : .:... .:.: :.:: .:. ::: .::
NP_001 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR
450 460 470 480 490 500
220 230 240 250 260
pF1KB5 VAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN-------------
.:.. :. : : . : . : : :::. :::: :.:: : .:
NP_001 LAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLE
510 520 530 540 550 560
270 280 290
pF1KB5 -------PWVCDCRARPLWAW-LQ------KF-----RGSSSEVP--------CSLPQRL
:: : : . : . :: .: .:.. . : :. : ..
NP_001 RLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEV
570 580 590 600 610 620
300 310 320 330 340 350
pF1KB5 AGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPA
.: ::. :. . :
NP_001 VGLDLRDLSEAHFAPC
630 640
>--
initn: 515 init1: 281 opt: 336 Z-score: 214.0 bits: 49.4 E(85289): 3.5e-05
Smith-Waterman score: 449; 37.6% identity (64.6% similar) in 237 aa overlap (27-260:79-314)
10 20 30 40 50
pF1KB5 MKRASAGGSRLLAWVLWLQAWQVAAPCPGACVC-YNEP--KVTTSCPQQGLQAVPV
::.:::: :.. .... : ...: .:
NP_001 ALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPD
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB5 GIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLS
:.:...: ..: :: .: :: :.:. .: .: :... :. .. :. :: : .: :
NP_001 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB5 DNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDT
: ::::. .:: : .: :. :..: :::.::..: : : :.: .::: .
NP_001 RN-QLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAA
170 180 190 200 210 220
180 190 200 210 220 230
pF1KB5 FRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYL
:: ::.: .: : :::.. . : :: : .: : .: . .. ..: .: ::. :::
NP_001 FRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYL
230 240 250 260 270 280
240 250 260 270 280 290
pF1KB5 FANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRL
: ..:. :. :.::..: :. :
NP_001 DRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRT
290 300 310 320 330 340
>>XP_016885198 (OMIM: 300278,310500) PREDICTED: nyctalop (481 aa)
initn: 382 init1: 309 opt: 392 Z-score: 247.8 bits: 55.2 E(85289): 4.6e-07
Smith-Waterman score: 392; 33.9% identity (59.1% similar) in 242 aa overlap (60-301:138-376)
30 40 50 60 70 80
pF1KB5 ACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLH
.:. : . :. :: . : :
XP_016 GLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAF
110 120 130 140 150 160
90 100 110 120 130 140
pF1KB5 SNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGL
.:.. :. .: . ::: : . : . .....: ....:: ::..: :. .. . :
XP_016 DNLFRRVPGA-LRGLANLTHAHL-ERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGA
170 180 190 200 210 220
150 160 170 180 190 200
pF1KB5 FRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLL
: ..:..: :.:: : :: :.:: : : : : :: .. : . : : :. : :
XP_016 FGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYL
230 240 250 260 270 280
210 220 230 240 250 260
pF1KB5 HQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRAR
.: .: :. ::..:. :..:.: .: :..: :. : : : : ::: :::: .
XP_016 DRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLE
290 300 310 320 330 340
270 280 290 300 310 320
pF1KB5 PLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEP
: :.. : ..:::. : .:: ::...
XP_016 WLRDWMEG-SGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPE
350 360 370 380 390 400
330 340 350 360 370 380
pF1KB5 LGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPG
XP_016 PAATTVSRFSSLLSKLLAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLAS
410 420 430 440 450 460
>>NP_072089 (OMIM: 300278,310500) nyctalopin precursor [ (481 aa)
initn: 382 init1: 309 opt: 392 Z-score: 247.8 bits: 55.2 E(85289): 4.6e-07
Smith-Waterman score: 392; 33.9% identity (59.1% similar) in 242 aa overlap (60-301:138-376)
30 40 50 60 70 80
pF1KB5 ACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLH
.:. : . :. :: . : :
NP_072 GLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAF
110 120 130 140 150 160
90 100 110 120 130 140
pF1KB5 SNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGL
.:.. :. .: . ::: : . : . .....: ....:: ::..: :. .. . :
NP_072 DNLFRRVPGA-LRGLANLTHAHL-ERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGA
170 180 190 200 210 220
150 160 170 180 190 200
pF1KB5 FRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLL
: ..:..: :.:: : :: :.:: : : : : :: .. : . : : :. : :
NP_072 FGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYL
230 240 250 260 270 280
210 220 230 240 250 260
pF1KB5 HQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRAR
.: .: :. ::..:. :..:.: .: :..: :. : : : : ::: :::: .
NP_072 DRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLE
290 300 310 320 330 340
270 280 290 300 310 320
pF1KB5 PLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEP
: :.. : ..:::. : .:: ::...
NP_072 WLRDWMEG-SGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPE
350 360 370 380 390 400
330 340 350 360 370 380
pF1KB5 LGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGTLPG
NP_072 PAATTVSRFSSLLSKLLAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLAS
410 420 430 440 450 460
473 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 03:29:35 2016 done: Fri Nov 4 03:29:37 2016
Total Scan time: 11.630 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]