Result of FASTA (omim) for
pFN21AB9486
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9486, 1221 aa
1>>>pF1KB9486 1221 - 1221 aa - 1221 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1894+/-0.000451; mu= 18.7151+/- 0.028
mean_var=119.4182+/-23.738, 0's: 0 Z-trim(114.3): 354 B-trim: 123 in 1/51
Lambda= 0.117365
statistics sampled from 23674 (24068) to 23674 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.282), width: 16
Scan time: 14.000
The best scores are: opt bits E(85289)
NP_955387 (OMIM: 607512,615458) A disintegrin and (1221) 8724 1489.7 0
XP_011521225 (OMIM: 607512,615458) PREDICTED: A di (1049) 6986 1195.4 0
NP_001313287 (OMIM: 607512,615458) A disintegrin a (1049) 6986 1195.4 0
XP_016878477 (OMIM: 607512,615458) PREDICTED: A di ( 809) 5951 1020.0 0
XP_016878478 (OMIM: 607512,615458) PREDICTED: A di ( 809) 5951 1020.0 0
XP_011521226 (OMIM: 607512,615458) PREDICTED: A di ( 978) 5868 1006.0 0
NP_620687 (OMIM: 607510) A disintegrin and metallo (1224) 5032 864.6 0
XP_011541423 (OMIM: 605008) PREDICTED: A disintegr ( 863) 2312 403.9 2.4e-111
XP_011541419 (OMIM: 605008) PREDICTED: A disintegr ( 966) 2312 403.9 2.6e-111
XP_011541416 (OMIM: 605008) PREDICTED: A disintegr (1117) 2312 404.0 2.8e-111
NP_922932 (OMIM: 605008) A disintegrin and metallo (1117) 2312 404.0 2.8e-111
XP_011541415 (OMIM: 605008) PREDICTED: A disintegr (1117) 2312 404.0 2.8e-111
NP_112217 (OMIM: 606184) A disintegrin and metallo (1594) 2275 397.9 2.8e-109
NP_055087 (OMIM: 605009) A disintegrin and metallo (1686) 2233 390.8 4.1e-107
XP_005254194 (OMIM: 605009) PREDICTED: A disintegr (1689) 2233 390.8 4.1e-107
XP_016865394 (OMIM: 606184) PREDICTED: A disintegr (1631) 2172 380.4 5.1e-104
XP_011541425 (OMIM: 605008) PREDICTED: A disintegr ( 738) 2162 378.4 9.3e-104
XP_016865395 (OMIM: 606184) PREDICTED: A disintegr (1467) 2162 378.7 1.5e-103
NP_891550 (OMIM: 605421) A disintegrin and metallo (1935) 2108 369.7 1.1e-100
XP_016882827 (OMIM: 277600,608990) PREDICTED: A di (1103) 2096 367.4 2.9e-100
NP_112219 (OMIM: 277600,608990) A disintegrin and (1103) 2096 367.4 2.9e-100
XP_011541426 (OMIM: 605008) PREDICTED: A disintegr ( 673) 1874 329.6 4.2e-89
XP_011537056 (OMIM: 611681) PREDICTED: A disintegr (1911) 1836 323.6 7.7e-87
NP_079279 (OMIM: 611681) A disintegrin and metallo (1910) 1819 320.7 5.6e-86
XP_011541422 (OMIM: 605008) PREDICTED: A disintegr ( 868) 1740 307.0 3.4e-82
XP_011541421 (OMIM: 605008) PREDICTED: A disintegr ( 892) 1740 307.0 3.5e-82
XP_006722980 (OMIM: 277600,608990) PREDICTED: A di ( 784) 1710 301.9 1.1e-80
NP_001305710 (OMIM: 605421) A disintegrin and meta (1907) 1673 296.0 1.6e-78
XP_005254929 (OMIM: 607511,613195) PREDICTED: A di (1122) 1661 293.8 4.3e-78
XP_011541424 (OMIM: 605008) PREDICTED: A disintegr ( 827) 1644 290.8 2.6e-77
XP_016877464 (OMIM: 607511,613195) PREDICTED: A di (1166) 1577 279.6 8.5e-74
XP_016882828 (OMIM: 277600,608990) PREDICTED: A di ( 626) 1549 274.6 1.5e-72
XP_016882829 (OMIM: 277600,608990) PREDICTED: A di ( 624) 1547 274.2 1.8e-72
XP_016875468 (OMIM: 611681) PREDICTED: A disintegr (1506) 1429 254.6 3.6e-66
XP_011530724 (OMIM: 605011) PREDICTED: A disintegr (1177) 1396 248.9 1.4e-64
XP_011530723 (OMIM: 605011) PREDICTED: A disintegr (1186) 1396 248.9 1.5e-64
NP_055058 (OMIM: 605011) A disintegrin and metallo (1205) 1396 248.9 1.5e-64
XP_011541427 (OMIM: 605008) PREDICTED: A disintegr ( 628) 1384 246.6 3.7e-64
XP_011541417 (OMIM: 605008) PREDICTED: A disintegr (1067) 1386 247.2 4.4e-64
XP_011541418 (OMIM: 605008) PREDICTED: A disintegr (1021) 1384 246.8 5.3e-64
NP_001311441 (OMIM: 606184) A disintegrin and meta (1509) 1338 239.2 1.6e-61
XP_016865552 (OMIM: 225410,604539) PREDICTED: A di (1046) 1334 238.4 1.9e-61
NP_055059 (OMIM: 225410,604539) A disintegrin and (1211) 1334 238.4 2.1e-61
XP_011537602 (OMIM: 607506) PREDICTED: A disintegr (1056) 1317 235.5 1.4e-60
NP_631894 (OMIM: 607506) A disintegrin and metallo (1226) 1312 234.7 2.8e-60
XP_011537605 (OMIM: 607506) PREDICTED: A disintegr ( 820) 1302 232.8 6.9e-60
NP_542453 (OMIM: 607506) A disintegrin and metallo (1223) 1300 232.7 1.2e-59
NP_008969 (OMIM: 605007) A disintegrin and metallo ( 930) 1297 232.1 1.4e-59
XP_011537609 (OMIM: 607506) PREDICTED: A disintegr ( 791) 1285 230.0 4.9e-59
XP_011537608 (OMIM: 607506) PREDICTED: A disintegr ( 791) 1285 230.0 4.9e-59
>>NP_955387 (OMIM: 607512,615458) A disintegrin and meta (1221 aa)
initn: 8724 init1: 8724 opt: 8724 Z-score: 7985.7 bits: 1489.7 E(85289): 0
Smith-Waterman score: 8724; 99.8% identity (99.8% similar) in 1221 aa overlap (1-1221:1-1221)
10 20 30 40 50 60
pF1KB9 MECALLLACAFRAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD
::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB9 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB9 YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB9 CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB9 CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB9 KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB9 ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB9 ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB9 LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB9 LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB9 KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB9 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB9 EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB9 GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_955 GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ
1150 1160 1170 1180 1190 1200
1210 1220
pF1KB9 HGVCNHKFYGKQCCKSCTRKI
:::::::::::::::::::::
NP_955 HGVCNHKFYGKQCCKSCTRKI
1210 1220
>>XP_011521225 (OMIM: 607512,615458) PREDICTED: A disint (1049 aa)
initn: 6986 init1: 6986 opt: 6986 Z-score: 6396.2 bits: 1195.4 E(85289): 0
Smith-Waterman score: 6986; 99.7% identity (99.8% similar) in 965 aa overlap (257-1221:85-1049)
230 240 250 260 270 280
pF1KB9 YSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSA
:. :::::::::::::::::::::::::::
XP_011 PQVTFPMHLRVERQSITIEGCKSSIFVDDARNVYAPKPPTEDTYLRFDEYGSSGRPRRSA
60 70 80 90 100 110
290 300 310 320 330 340
pF1KB9 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
120 130 140 150 160 170
350 360 370 380 390 400
pF1KB9 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
180 190 200 210 220 230
410 420 430 440 450 460
pF1KB9 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
240 250 260 270 280 290
470 480 490 500 510 520
pF1KB9 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
300 310 320 330 340 350
530 540 550 560 570 580
pF1KB9 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
360 370 380 390 400 410
590 600 610 620 630 640
pF1KB9 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
420 430 440 450 460 470
650 660 670 680 690 700
pF1KB9 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
480 490 500 510 520 530
710 720 730 740 750 760
pF1KB9 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
540 550 560 570 580 590
770 780 790 800 810 820
pF1KB9 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
600 610 620 630 640 650
830 840 850 860 870 880
pF1KB9 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
660 670 680 690 700 710
890 900 910 920 930 940
pF1KB9 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
720 730 740 750 760 770
950 960 970 980 990 1000
pF1KB9 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
780 790 800 810 820 830
1010 1020 1030 1040 1050 1060
pF1KB9 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
840 850 860 870 880 890
1070 1080 1090 1100 1110 1120
pF1KB9 TCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
900 910 920 930 940 950
1130 1140 1150 1160 1170 1180
pF1KB9 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
960 970 980 990 1000 1010
1190 1200 1210 1220
pF1KB9 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
:::::::::::::::::::::::::::::::::::
XP_011 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
1020 1030 1040
>>NP_001313287 (OMIM: 607512,615458) A disintegrin and m (1049 aa)
initn: 6986 init1: 6986 opt: 6986 Z-score: 6396.2 bits: 1195.4 E(85289): 0
Smith-Waterman score: 6986; 99.7% identity (99.8% similar) in 965 aa overlap (257-1221:85-1049)
230 240 250 260 270 280
pF1KB9 YSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSA
:. :::::::::::::::::::::::::::
NP_001 PQVTFPMHLRVERQSITIEGCKSSIFVDDARNVYAPKPPTEDTYLRFDEYGSSGRPRRSA
60 70 80 90 100 110
290 300 310 320 330 340
pF1KB9 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
120 130 140 150 160 170
350 360 370 380 390 400
pF1KB9 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
180 190 200 210 220 230
410 420 430 440 450 460
pF1KB9 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
240 250 260 270 280 290
470 480 490 500 510 520
pF1KB9 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
300 310 320 330 340 350
530 540 550 560 570 580
pF1KB9 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
360 370 380 390 400 410
590 600 610 620 630 640
pF1KB9 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
420 430 440 450 460 470
650 660 670 680 690 700
pF1KB9 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
480 490 500 510 520 530
710 720 730 740 750 760
pF1KB9 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
540 550 560 570 580 590
770 780 790 800 810 820
pF1KB9 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
600 610 620 630 640 650
830 840 850 860 870 880
pF1KB9 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
660 670 680 690 700 710
890 900 910 920 930 940
pF1KB9 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
720 730 740 750 760 770
950 960 970 980 990 1000
pF1KB9 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
780 790 800 810 820 830
1010 1020 1030 1040 1050 1060
pF1KB9 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
840 850 860 870 880 890
1070 1080 1090 1100 1110 1120
pF1KB9 TCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
900 910 920 930 940 950
1130 1140 1150 1160 1170 1180
pF1KB9 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
960 970 980 990 1000 1010
1190 1200 1210 1220
pF1KB9 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
:::::::::::::::::::::::::::::::::::
NP_001 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
1020 1030 1040
>>XP_016878477 (OMIM: 607512,615458) PREDICTED: A disint (809 aa)
initn: 5951 init1: 5951 opt: 5951 Z-score: 5450.5 bits: 1020.0 E(85289): 0
Smith-Waterman score: 5951; 99.9% identity (99.9% similar) in 809 aa overlap (413-1221:1-809)
390 400 410 420 430 440
pF1KB9 HDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNF
::::::::::::::::::::::::::::::
XP_016 MCSKYRSCTINEDTGLGLAFTIAHESGHNF
10 20 30
450 460 470 480 490 500
pF1KB9 GMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAG
40 50 60 70 80 90
510 520 530 540 550 560
pF1KB9 QYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAE
100 110 120 130 140 150
570 580 590 600 610 620
pF1KB9 GTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
160 170 180 190 200 210
630 640 650 660 670 680
pF1KB9 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
220 230 240 250 260 270
690 700 710 720 730 740
pF1KB9 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK
280 290 300 310 320 330
750 760 770 780 790 800
pF1KB9 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTG
340 350 360 370 380 390
810 820 830 840 850 860
pF1KB9 GWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK
400 410 420 430 440 450
870 880 890 900 910 920
pF1KB9 VMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTE
460 470 480 490 500 510
930 940 950 960 970 980
pF1KB9 PKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ
520 530 540 550 560 570
990 1000 1010 1020 1030 1040
pF1KB9 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG
580 590 600 610 620 630
1050 1060 1070 1080 1090 1100
pF1KB9 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKP
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_016 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP
640 650 660 670 680 690
1110 1120 1130 1140 1150 1160
pF1KB9 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLL
700 710 720 730 740 750
1170 1180 1190 1200 1210 1220
pF1KB9 HQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
760 770 780 790 800
>>XP_016878478 (OMIM: 607512,615458) PREDICTED: A disint (809 aa)
initn: 5951 init1: 5951 opt: 5951 Z-score: 5450.5 bits: 1020.0 E(85289): 0
Smith-Waterman score: 5951; 99.9% identity (99.9% similar) in 809 aa overlap (413-1221:1-809)
390 400 410 420 430 440
pF1KB9 HDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNF
::::::::::::::::::::::::::::::
XP_016 MCSKYRSCTINEDTGLGLAFTIAHESGHNF
10 20 30
450 460 470 480 490 500
pF1KB9 GMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAG
40 50 60 70 80 90
510 520 530 540 550 560
pF1KB9 QYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAE
100 110 120 130 140 150
570 580 590 600 610 620
pF1KB9 GTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ
160 170 180 190 200 210
630 640 650 660 670 680
pF1KB9 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRC
220 230 240 250 260 270
690 700 710 720 730 740
pF1KB9 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK
280 290 300 310 320 330
750 760 770 780 790 800
pF1KB9 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTG
340 350 360 370 380 390
810 820 830 840 850 860
pF1KB9 GWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPK
400 410 420 430 440 450
870 880 890 900 910 920
pF1KB9 VMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTE
460 470 480 490 500 510
930 940 950 960 970 980
pF1KB9 PKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ
520 530 540 550 560 570
990 1000 1010 1020 1030 1040
pF1KB9 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG
580 590 600 610 620 630
1050 1060 1070 1080 1090 1100
pF1KB9 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKP
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_016 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP
640 650 660 670 680 690
1110 1120 1130 1140 1150 1160
pF1KB9 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLL
700 710 720 730 740 750
1170 1180 1190 1200 1210 1220
pF1KB9 HQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
760 770 780 790 800
>>XP_011521226 (OMIM: 607512,615458) PREDICTED: A disint (978 aa)
initn: 6112 init1: 5863 opt: 5868 Z-score: 5373.5 bits: 1006.0 E(85289): 0
Smith-Waterman score: 6314; 92.4% identity (92.5% similar) in 965 aa overlap (257-1221:85-978)
230 240 250 260 270 280
pF1KB9 YSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSA
:. :::::::::::::::::::::::::::
XP_011 PQVTFPMHLRVERQSITIEGCKSSIFVDDARNVYAPKPPTEDTYLRFDEYGSSGRPRRSA
60 70 80 90 100 110
290 300 310 320 330 340
pF1KB9 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLI
120 130 140 150 160 170
350 360 370 380 390 400
pF1KB9 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLG
180 190 200 210 220 230
410 420 430 440 450 460
pF1KB9 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLT
240 250 260 270 280 290
470 480 490 500 510 520
pF1KB9 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFG
300 310 320 330 340 350
530 540 550 560 570 580
pF1KB9 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPR
360 370 380 390 400 410
590 600 610 620 630 640
pF1KB9 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNEN
420 430 440 450 460 470
650 660 670 680 690 700
pF1KB9 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTP
480 490 500 510 520 530
710 720 730 740 750 760
pF1KB9 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYP
540 550 560 570 580 590
770 780 790 800 810 820
pF1KB9 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN
600 610 620 630 640 650
830 840 850 860 870 880
pF1KB9 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECS
660 670 680 690 700 710
890 900 910 920 930 940
pF1KB9 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKA
720 730 740 750 760 770
950 960 970 980 990 1000
pF1KB9 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKT
780 790 800 810 820 830
1010 1020 1030 1040 1050 1060
pF1KB9 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSEC--
840 850 860 870 880 890
1070 1080 1090 1100 1110 1120
pF1KB9 TCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAG
XP_011 ------------------------------------------------------------
1130 1140 1150 1160 1170 1180
pF1KB9 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ---------TVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDP
900 910 920 930 940
1190 1200 1210 1220
pF1KB9 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
:::::::::::::::::::::::::::::::::::
XP_011 SCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
950 960 970
>>NP_620687 (OMIM: 607510) A disintegrin and metalloprot (1224 aa)
initn: 4669 init1: 3042 opt: 5032 Z-score: 4607.2 bits: 864.6 E(85289): 0
Smith-Waterman score: 5032; 56.2% identity (79.6% similar) in 1226 aa overlap (20-1219:9-1221)
10 20 30 40 50
pF1KB9 MECALLLACAFRAAGSGPPRGLAGL----GRVAKALQLCCLCCASVAAALAS----DSSS
::::.: ..::. : . :..: . : .
NP_620 MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPA
10 20 30 40
60 70 80 90 100
pF1KB9 GASGLND--DYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNAR-SSLHYRFSAFGQELH
: . .: .:. ::: :.:.::.:.:. :..:.. .. ::: :... ...:
NP_620 ERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFH
50 60 70 80 90 100
110 120 130 140 150 160
pF1KB9 LELKPSA-ILSSHFIVQVLGKDGASETQK-PEVQQCFYQGFIRNDSSSSVAVSTCAGLSG
..:. :. ... ::::.::: :.. .: : . ::::: .:. .::::.::: ::::
NP_620 MDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSG
110 120 130 140 150 160
170 180 190 200 210 220
pF1KB9 LIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGY
.:::.. .... :::. :. . . .. .. ::::::..: . ..:..
NP_620 MIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWE--
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB9 SPSHIP-HASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSA
.: : :.:. : :::::::::::: :.:: :: .. ::: : : .::
NP_620 -LAHQPLHSSDLRLGLP-----QKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSL
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 GKSQKG--LNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVS
.:... ::::::::.::::...::. :.:::.::..::::.::::::::..::...:.
NP_620 LRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVG
290 300 310 320 330 340
350 360 370 380 390 400
pF1KB9 LILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDT
:::::.: ::.:.::::..:.:::::::.:.::.: ::::::::::.::::::::::::
NP_620 LILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDT
350 360 370 380 390 400
410 420 430 440 450 460
pF1KB9 LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPT
::::::::::::::::::::::::::::::::::::::::::::::: :.:.::::::::
NP_620 LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPT
410 420 430 440 450 460
470 480 490 500 510 520
pF1KB9 LTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQ
:.: ::::::: ::::::.::::: :: ::.:.:: . .::::.::::..:::.::::::
NP_620 LAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQ
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB9 FGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELG
:: ::::: : : :::::.:::::.:..::::::::::::.:: .:::: :::::.:. :
NP_620 FGEKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEG
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB9 PRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCN
:.: ::.:: ::.:: :::::::::. . : :.::::..:: :: ::.: .::: . :
NP_620 PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCP
590 600 610 620 630 640
650 660 670 680 690 700
pF1KB9 ENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDG
..:.:::: ::::.::. ::: :.:::::.::..: ::::: ::.:.:::..:.:::::
NP_620 RDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDG
650 660 670 680 690 700
710 720 730 740 750 760
pF1KB9 TPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEY
:::: .. .:::::.:: ::::. ::: :: :.::::.:.::.: ...::: ..:..:.:
NP_620 TPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQY
710 720 730 740 750 760
770 780 790 800 810 820
pF1KB9 YPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRS
: .: ::.:::::.: :..::.::..::. ..:::.: :..::::.. :.::::.:.::
NP_620 YHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRS
770 780 790 800 810 820
830 840 850 860 870 880
pF1KB9 FNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKV-MNGTPPATKRPAYTWSIVQS
.:.:: : : :::::::. :.:.::.:::.::.:..:.. . ::: .:.:::.::.:
NP_620 YNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPA--QPSYTWAIVRS
830 840 850 860 870
890 900 910 920 930 940
pF1KB9 ECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTC
::::::::: ..:. : :: . ::: :::. ::.::: :.. .:: : :.::.:
NP_620 ECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSAC
880 890 900 910 920 930
950 960 970 980 990 1000
pF1KB9 SKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQC
:..:.:: ::: .::... ...: : :::: .:.. :::::..::: :: :::..:
NP_620 SRTCGGGAQSRPVQCTRRVHYDSEP-VPASLCPQPAPSSRQACNSQSCPPAWSAGPWAEC
940 950 960 970 980 990
1010 1020 1030 1040 1050
pF1KB9 SKTCGRGVRKRELLCKGSA----AETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVAS
:.:::.: ::: . ::.. :. ::.. ::: :.:...:.:.: :: : ..:::..:
NP_620 SHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVS
1000 1010 1020 1030 1040 1050
1060 1070 1080 1090 1100 1110
pF1KB9 SWSECSATCGLGVRKREMKCREKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHP
.::.::.:: :..:: .:: :: .:: . ..: .. ::.:.::..: :: ::
NP_620 AWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHP
1060 1070 1080 1090 1100 1110
1120 1130 1140 1150 1160 1170
pF1KB9 VYNMVAG-----WYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNT
. .:: :.. ::.:::..::::::::::.:. :::.:.::::::: . ::::
NP_620 PFA-AAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNT
1120 1130 1140 1150 1160 1170
1180 1190 1200 1210 1220
pF1KB9 NFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI
.::: ::. : : :.:.::.::::::.:.::::::::::.:..
NP_620 HFCPIAEKK-DAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSKSNL
1180 1190 1200 1210 1220
>>XP_011541423 (OMIM: 605008) PREDICTED: A disintegrin a (863 aa)
initn: 2090 init1: 896 opt: 2312 Z-score: 2120.1 bits: 403.9 E(85289): 2.4e-111
Smith-Waterman score: 2486; 40.9% identity (67.4% similar) in 860 aa overlap (313-1141:16-862)
290 300 310 320 330 340
pF1KB9 RRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVV
.. : : :. :..:...:. .:..:
XP_011 MATLMLFTKSLPFNNDICMITLIVGFRVAKLYRDSSLGNVVNIIV
10 20 30 40
350 360 370 380 390
pF1KB9 VSLILLEQEPGGLLINHHADQSLNSFCQWQSAL---------IGKNG-KRHDHAILLTGF
. ::.: .. .: ::::::.::.:::.::... : .:: .::.:.:.: .
XP_011 ARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRY
50 60 70 80 90 100
400 410 420 430 440 450
pF1KB9 DICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNP
:::..::.:: :::.: ..::: :::.:::: ::: ::::::: :::::: ::: ::
XP_011 DICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNS
110 120 130 140 150 160
460 470 480 490 500
pF1KB9 CR---KAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDK
: . ...:. .:.:.. ::::.:::.:. .::.. .. :: .:: . .. ::
XP_011 CGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKR-DFLYPAV
170 180 190 200 210 220
510 520 530 540 550 560
pF1KB9 LPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLS
:::.:::: ::..:.:: .. :. : ..:. ::: ..:: :. .::::::.: .
XP_011 APGQVYDADEQCRFQYGATSRQCKYG---EVCRELWCLSKSNRCVTNSIPAAEGTLCQTG
230 240 250 260 270 280
570 580 590 600 610 620
pF1KB9 M----WCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGG
:: ::.:: :: :. : : :. :: :.::::::::::. . :::..: :. ::
XP_011 NIEKGWCYQGDCVPFGTW-PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGG
290 300 310 320 330 340
630 640 650 660 670 680
pF1KB9 LFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLY
.: : . :. :: .:: .: ::: .:::.... :::: .:.::::: . : :
XP_011 KYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKP-CALN
350 360 370 380 390
690 700 710 720 730 740
pF1KB9 CKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDN
: ::...:. . : ::: :. .. :.::.: :. ::::. ::: : : : :: ::.
XP_011 CLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDG
400 410 420 430 440 450
750 760 770 780 790 800
pF1KB9 STCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWS
::: .:.. .. . :. :: :: :. ::..:. .:..:.:..: .. ::..:.:.
XP_011 STCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWT
460 470 480 490 500 510
810 820 830 840 850 860
pF1KB9 IDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMN
:::: .: :::.:.:.: ..:: : : :::.:.:. .:.: .: :: .:. .: . .
XP_011 IDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRT
520 530 540 550 560 570
870 880 890 900 910 920
pF1KB9 GTPPATKRPAYTWS-IVQSECSVSCGGGYINVKAICLR-DQNTQVNSSFCSAKTKPVTEP
:. . .. ..::. ::::..:.:: ...: : :.:. :....:. .:: .
XP_011 GS--GDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQ
580 590 600 610 620 630
930 940 950 960 970 980
pF1KB9 KICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQV
. ::. :: :. :.: :::.: ::...: . :..: ..::.. .: : . :..
XP_011 RACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEK
640 650 660 670 680 690
990 1000 1010 1020 1030 1040
pF1KB9 QACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSA-AETLPESQCTSLPRPELQEG
. ::...::::: ::.:. :: : ..: .:::.: ..:.: .:: .: ..
XP_011 EPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIR
700 710 720 730 740 750
1050 1060 1070 1080 1090
pF1KB9 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCREKGFQG-----KLITFP-----
: ::::: .::...:..::: :::: . : ..: :. . . :
XP_011 CSLGRCPPP---RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQC
760 770 780 790 800 810
1100 1110 1120 1130 1140 1150
pF1KB9 ERRCRNIKKPNLDLEETCNRRA-CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV
: .: . : . . :. : :: ... . : :.: :: :
XP_011 ESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAYF--RQMCCKTCQGH
820 830 840 850 860
1160 1170 1180 1190 1200 1210
pF1KB9 QQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGK
>>XP_011541419 (OMIM: 605008) PREDICTED: A disintegrin a (966 aa)
initn: 2264 init1: 896 opt: 2312 Z-score: 2119.5 bits: 403.9 E(85289): 2.6e-111
Smith-Waterman score: 2651; 39.4% identity (65.3% similar) in 1006 aa overlap (167-1141:5-965)
140 150 160 170 180 190
pF1KB9 KPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAG
:.: :. .:..: :: . . ...: :
XP_011 MKTHGVIATEDEEYFIEPLKNTTEDSKHFSYENG
10 20 30
200 210 220 230 240 250
pF1KB9 HHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGR
: :::.::..: .:. . : : . .. : : .. : . ... :. :
XP_011 H-PHVIYKKSA---LQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHR
40 50 60 70 80 90
260 270 280 290 300 310
pF1KB9 RKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTT
.:. . . :: ::::::::: :: ::. ..
XP_011 QKRSV-------SIERF---------------------VETLVVADKMMVGYHGRKDIEH
100 110 120
320 330 340 350 360 370
pF1KB9 YILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSAL-
:::.:::.:. :..:...:. .:..:. ::.: .. .: ::::::.::.:::.::...
XP_011 YILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSIL
130 140 150 160 170 180
380 390 400 410 420
pF1KB9 --------IGKNG-KRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDT
: .:: .::.:.:.: .:::..::.:: :::.: ..::: :::.::::
XP_011 SHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDI
190 200 210 220 230 240
430 440 450 460 470 480
pF1KB9 GLGLAFTIAHESGHNFGMIHDGEGNPCR---KAEGNIMSPTLTGNNGVFSWSSCSRQYLK
::: ::::::: :::::: ::: :: : . ...:. .:.:.. ::::.:::.:.
XP_011 GLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYIT
250 260 270 280 290 300
490 500 510 520 530 540
pF1KB9 KFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKS
.::.. .. :: .:: . .. :: :::.:::: ::..:.:: .. :. : ..:.
XP_011 SFLDSGRGTCLDNEPPKR-DFLYPAVAPGQVYDADEQCRFQYGATSRQCKYG---EVCRE
310 320 330 340 350
550 560 570 580 590
pF1KB9 LWCHRVGHRCETKFMPAAEGTVCGLSM----WCRQGQCVKFGELGPRPIHGQWSAWSKWS
::: ..:: :. .::::::.: . :: ::.:: :: :. : : :. :: :.
XP_011 LWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW-PQSIDGGWGPWSLWG
360 370 380 390 400 410
600 610 620 630 640 650
pF1KB9 ECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYN
::::::::::. . :::..: :. :: .: : . :. :: .:: .: ::: .:::...
XP_011 ECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFD
420 430 440 450 460 470
660 670 680 690 700 710
pF1KB9 SKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGV
. :::: .:.::::: . : : : ::...:. . : ::: :. .. :.::.:
XP_011 NMPFRGKYYNWKPYTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGE
480 490 500 510 520 530
720 730 740 750 760 770
pF1KB9 CELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEI
:. ::::. ::: : : : :: ::.::: .:.. .. . :. :: :: :. ::.
XP_011 CKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEV
540 550 560 570 580 590
780 790 800 810 820 830
pF1KB9 QELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNE
.:. .:..:.:..: .. ::..:.:.:::: .: :::.:.:.: ..:: : : :::.:
XP_011 REVAMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSE
600 610 620 630 640 650
840 850 860 870 880 890
pF1KB9 TLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWS-IVQSECSVSCGGGYINVKA
.:. .:.: .: :: .:. .: . .:. . .. ..::. ::::..:.:: ..
XP_011 NLIVMVLLQEQNLGIRYKFNVPITRTGS--GDNEVGFTWNHQPWSECSATCAGGVQRQEV
660 670 680 690 700 710
900 910 920 930 940 950
pF1KB9 ICLR-DQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQ
.: : :.:. :....:. .:: . . ::. :: :. :.: :::.: ::...: .
XP_011 VCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVL
720 730 740 750 760 770
960 970 980 990 1000 1010
pF1KB9 CVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELL
:..: ..::.. .: : . :.. . ::...::::: ::.:. :: : ..: .:
XP_011 CIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVL
780 790 800 810 820 830
1020 1030 1040 1050 1060 1070
pF1KB9 CKGSA-AETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKRE
::.: ..:.: .:: .: .. : ::::: .::...:..::: :::: . :
XP_011 CKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP---RWVTGDWGQCSAQCGLGQQMRT
840 850 860 870 880 890
1080 1090 1100 1110 1120
pF1KB9 MKCREKGFQG-----KLITFP-----ERRCRNIKKPNLDLEETCNRRA-CPAHPVYNMVA
..: :. . . : : .: . : . . :. : :: ... .
XP_011 VQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCS
900 910 920 930 940 950
1130 1140 1150 1160 1170 1180
pF1KB9 GWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKRED
: :.: :: :
XP_011 RAYF--RQMCCKTCQGH
960
>>XP_011541416 (OMIM: 605008) PREDICTED: A disintegrin a (1117 aa)
initn: 2264 init1: 896 opt: 2312 Z-score: 2118.7 bits: 404.0 E(85289): 2.8e-111
Smith-Waterman score: 2867; 38.6% identity (66.0% similar) in 1123 aa overlap (59-1141:40-1116)
30 40 50 60 70 80
pF1KB9 AKALQLCCLCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDILHN--GRK
. : .. :..::. :...: . .. .:.
XP_011 WILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRR
10 20 30 40 50 60
90 100 110 120 130 140
pF1KB9 KRSA-----QNARSSLHYRFSAFGQELHLELK-PSAILSSHFIVQVLGKDGASETQKPEV
.:: :.: :.: ...::.:...::.: . ..:.:: :. :::: . .. .
XP_011 RRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGP-QWKHDFL
70 80 90 100 110 120
150 160 170 180 190
pF1KB9 QQCFYQGFIRND-SSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHP
..: : :..... :...::.:.:.:: :.: :. .:..: :: . . ...: :: :
XP_011 DNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGH-P
130 140 150 160 170 180
200 210 220 230 240 250
pF1KB9 HVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKK
::.::..: .:. . : : . .. : : .. : . ... :. :.:.
XP_011 HVIYKKSA---LQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKR
190 200 210 220 230 240
260 270 280 290 300 310
pF1KB9 YAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYIL
. . :: ::::::::: :: ::. .. :::
XP_011 SV-------SIERF---------------------VETLVVADKMMVGYHGRKDIEHYIL
250 260 270
320 330 340 350 360 370
pF1KB9 TVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSAL----
.:::.:. :..:...:. .:..:. ::.: .. .: ::::::.::.:::.::...
XP_011 SVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQ
280 290 300 310 320 330
380 390 400 410 420
pF1KB9 -----IGKNG-KRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLG
: .:: .::.:.:.: .:::..::.:: :::.: ..::: :::.:::: :::
XP_011 SDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLG
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB9 LAFTIAHESGHNFGMIHDGEGNPCR---KAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFL
::::::: :::::: ::: :: : . ...:. .:.:.. ::::.:::.:. .::
XP_011 SAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB9 STPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWC
.. .. :: .:: . .. :: :::.:::: ::..:.:: .. :. : ..:. :::
XP_011 DSGRGTCLDNEPPKR-DFLYPAVAPGQVYDADEQCRFQYGATSRQCKYG---EVCRELWC
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB9 HRVGHRCETKFMPAAEGTVCGLSM----WCRQGQCVKFGELGPRPIHGQWSAWSKWSECS
..:: :. .::::::.: . :: ::.:: :: :. : : :. :: :.:::
XP_011 LSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW-PQSIDGGWGPWSLWGECS
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB9 RTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKP
:::::::. . :::..: :. :: .: : . :. :: .:: .: ::: .:::.... :
XP_011 RTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMP
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB9 FRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCEL
::: .:.::::: . : : : ::...:. . : ::: :. .. :.::.: :.
XP_011 FRGKYYNWKPYTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKH
640 650 660 670 680 690
730 740 750 760 770 780
pF1KB9 VGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQEL
::::. ::: : : : :: ::.::: .:.. .. . :. :: :: :. ::..:.
XP_011 VGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREV
700 710 720 730 740 750
790 800 810 820 830 840
pF1KB9 QVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLV
.:..:.:..: .. ::..:.:.:::: .: :::.:.:.: ..:: : : :::.:.:.
XP_011 AMSKNYIALKSEGDDYYINGAWTIDWPRKFDVAGTAFHYKRPTDEPESLEALGPTSENLI
760 770 780 790 800 810
850 860 870 880 890 900
pF1KB9 FEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWS-IVQSECSVSCGGGYINVKAICL
.:.: .: :: .:. .: . .:. . .. ..::. ::::..:.:: ...:
XP_011 VMVLLQEQNLGIRYKFNVPITRTGS--GDNEVGFTWNHQPWSECSATCAGGVQRQEVVCK
820 830 840 850 860
910 920 930 940 950 960
pF1KB9 R-DQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
: :.:. :....:. .:: . . ::. :: :. :.: :::.: ::...: . :..
XP_011 RLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIR
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KB9 KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
: ..::.. .: : . :.. . ::...::::: ::.:. :: : ..: .:::.
XP_011 KIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKS
930 940 950 960 970 980
1030 1040 1050 1060 1070
pF1KB9 SA-AETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKC
: ..:.: .:: .: .. : ::::: .::...:..::: :::: . : ..:
XP_011 SDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP---RWVTGDWGQCSAQCGLGQQMRTVQC
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120
pF1KB9 REKGFQG-----KLITFP-----ERRCRNIKKPNLDLEETCNRRA-CPAHPVYNMVAGWY
:. . . : : .: . : . . :. : :: ... . :
XP_011 LSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECKDVNKVAYCPLVLKFKFCSRAY
1050 1060 1070 1080 1090 1100
1130 1140 1150 1160 1170 1180
pF1KB9 SLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSC
:.: :: :
XP_011 FR--QMCCKTCQGH
1110
1221 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 23:52:03 2016 done: Thu Nov 3 23:52:05 2016
Total Scan time: 14.000 Total Display time: 0.460
Function used was FASTA [36.3.4 Apr, 2011]