Result of FASTA (omim) for
pFN21AB4188
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4188, 357 aa
1>>>pF1KB4188 357 - 357 aa - 357 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2606+/-0.000381; mu= 17.0577+/- 0.024
mean_var=66.4727+/-13.474, 0's: 0 Z-trim(111.9): 28 B-trim: 1175 in 1/48
Lambda= 0.157309
statistics sampled from 20630 (20649) to 20630 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.242), width: 16
Scan time: 7.640
The best scores are: opt bits E(85289)
NP_001229326 (OMIM: 610932) twinfilin-1 isoform 1 ( 357) 2358 544.1 1.8e-154
NP_002813 (OMIM: 610932) twinfilin-1 isoform 2 [Ho ( 350) 2282 526.8 2.7e-149
NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens ( 349) 1591 370.0 4.4e-102
NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens] ( 166) 152 43.3 0.00048
XP_011534665 (OMIM: 601443,610687) PREDICTED: cofi ( 149) 143 41.2 0.0018
NP_001230574 (OMIM: 601443,610687) cofilin-2 isofo ( 149) 143 41.2 0.0018
NP_619579 (OMIM: 601443,610687) cofilin-2 isoform ( 166) 143 41.2 0.002
NP_068733 (OMIM: 601443,610687) cofilin-2 isoform ( 166) 143 41.2 0.002
>>NP_001229326 (OMIM: 610932) twinfilin-1 isoform 1 [Hom (357 aa)
initn: 2358 init1: 2358 opt: 2358 Z-score: 2894.4 bits: 544.1 E(85289): 1.8e-154
Smith-Waterman score: 2358; 100.0% identity (100.0% similar) in 357 aa overlap (1-357:1-357)
10 20 30 40 50 60
pF1KB4 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
250 260 270 280 290 300
310 320 330 340 350
pF1KB4 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
310 320 330 340 350
>>NP_002813 (OMIM: 610932) twinfilin-1 isoform 2 [Homo s (350 aa)
initn: 1237 init1: 1237 opt: 2282 Z-score: 2801.3 bits: 526.8 E(85289): 2.7e-149
Smith-Waterman score: 2282; 98.0% identity (98.0% similar) in 357 aa overlap (1-357:1-350)
10 20 30 40 50 60
pF1KB4 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_002 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINE-------VQTDVGVDTKHQ
130 140 150 160 170
190 200 210 220 230 240
pF1KB4 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB4 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
240 250 260 270 280 290
310 320 330 340 350
pF1KB4 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
300 310 320 330 340 350
>>NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens] (349 aa)
initn: 1574 init1: 812 opt: 1591 Z-score: 1953.8 bits: 370.0 E(85289): 4.4e-102
Smith-Waterman score: 1591; 64.1% identity (89.2% similar) in 351 aa overlap (1-351:1-344)
10 20 30 40 50 60
pF1KB4 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
:.:::::.:.:..::.::.:: :. ::.:. ::.::::.:. ..: ::.::: ::::
NP_009 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
:. .::::.:.:::::::::.::.:.:::::.: :: ::::::::::.::::::::::::
NP_009 LDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
.:::::.:.:. ::.:.: : ..:::::.::.::.::.::: :.:...:..:::
NP_009 LFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINE-------VKTEISVESKHQ
130 140 150 160 170
190 200 210 220 230 240
pF1KB4 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
::::.:::.. :: .::..:.....::.:...:.. : : :..: :.. .::.:.:.:.
NP_009 TLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB4 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
::::::::::.:::: :::.::::::::: :::.:::::::::::::. ::....... .
NP_009 ARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAK
240 250 260 270 280 290
310 320 330 340 350
pF1KB4 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
:::: .: ::::.:::.:::::::: ::.:::::::.:::: .::::::.:
NP_009 KIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS
300 310 320 330 340
>>NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens] (166 aa)
initn: 94 init1: 94 opt: 152 Z-score: 193.6 bits: 43.3 E(85289): 0.00048
Smith-Waterman score: 152; 28.3% identity (67.7% similar) in 99 aa overlap (33-129:51-143)
10 20 30 40 50 60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLE
:......:. .: . : : .:: .:
NP_005 RKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQ---TVDDPYATFV-KMLP
30 40 50 60 70
70 80 90 100 110 120
pF1KB4 DKQPCYILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
::. : :. ...... . .:: :.:. . ...::.::... ..::.. : :: :
NP_005 DKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTG--IKHE
80 90 100 110 120 130
130 140 150 160 170 180
pF1KB4 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
. .. :.:
NP_005 LQANCYEEVKDRCTLAEKLGGSAVISLEGKPL
140 150 160
>>XP_011534665 (OMIM: 601443,610687) PREDICTED: cofilin- (149 aa)
initn: 101 init1: 101 opt: 143 Z-score: 183.2 bits: 41.2 E(85289): 0.0018
Smith-Waterman score: 143; 31.2% identity (64.5% similar) in 93 aa overlap (33-120:34-117)
10 20 30 40 50 60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFV--LPL
: .:...:. . :. . : ::: :::
XP_011 RKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIG---DTVEDPYTSFVKLLPL
10 20 30 40 50 60
70 80 90 100 110
pF1KB4 LEDKQPC-YILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI
. : : :. ...... . .:: :.:. . ...::.::... ..::.: : :
XP_011 ----NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTG--I
70 80 90 100 110
120 130 140 150 160 170
pF1KB4 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDT
: :
XP_011 KHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
120 130 140
>>NP_001230574 (OMIM: 601443,610687) cofilin-2 isoform 2 (149 aa)
initn: 101 init1: 101 opt: 143 Z-score: 183.2 bits: 41.2 E(85289): 0.0018
Smith-Waterman score: 143; 31.2% identity (64.5% similar) in 93 aa overlap (33-120:34-117)
10 20 30 40 50 60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFV--LPL
: .:...:. . :. . : ::: :::
NP_001 RKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIG---DTVEDPYTSFVKLLPL
10 20 30 40 50 60
70 80 90 100 110
pF1KB4 LEDKQPC-YILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI
. : : :. ...... . .:: :.:. . ...::.::... ..::.: : :
NP_001 ----NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTG--I
70 80 90 100 110
120 130 140 150 160 170
pF1KB4 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDT
: :
NP_001 KHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
120 130 140
>>NP_619579 (OMIM: 601443,610687) cofilin-2 isoform 1 [H (166 aa)
initn: 101 init1: 101 opt: 143 Z-score: 182.5 bits: 41.2 E(85289): 0.002
Smith-Waterman score: 143; 31.2% identity (64.5% similar) in 93 aa overlap (33-120:51-134)
10 20 30 40 50 60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFV--LPL
: .:...:. . :. . : ::: :::
NP_619 RKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIG---DTVEDPYTSFVKLLPL
30 40 50 60 70
70 80 90 100 110
pF1KB4 LEDKQPC-YILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI
. : : :. ...... . .:: :.:. . ...::.::... ..::.: : :
NP_619 ----NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTG--I
80 90 100 110 120 130
120 130 140 150 160 170
pF1KB4 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDT
: :
NP_619 KHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
140 150 160
>>NP_068733 (OMIM: 601443,610687) cofilin-2 isoform 1 [H (166 aa)
initn: 101 init1: 101 opt: 143 Z-score: 182.5 bits: 41.2 E(85289): 0.002
Smith-Waterman score: 143; 31.2% identity (64.5% similar) in 93 aa overlap (33-120:51-134)
10 20 30 40 50 60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFV--LPL
: .:...:. . :. . : ::: :::
NP_068 RKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIG---DTVEDPYTSFVKLLPL
30 40 50 60 70
70 80 90 100 110
pF1KB4 LEDKQPC-YILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI
. : : :. ...... . .:: :.:. . ...::.::... ..::.: : :
NP_068 ----NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTG--I
80 90 100 110 120 130
120 130 140 150 160 170
pF1KB4 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDT
: :
NP_068 KHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL
140 150 160
357 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:35:48 2016 done: Thu Nov 3 14:35:50 2016
Total Scan time: 7.640 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]