Result of FASTA (omim) for
pFN21AA1299
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1299, 671 aa
1>>>pF1KA1299 671 - 671 aa - 671 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6761+/-0.000294; mu= 6.6316+/- 0.019
mean_var=222.2984+/-46.746, 0's: 0 Z-trim(124.0): 71 B-trim: 0 in 0/61
Lambda= 0.086021
statistics sampled from 44698 (44791) to 44698 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.804), E-opt: 0.2 (0.525), width: 16
Scan time: 10.180
The best scores are: opt bits E(85289)
NP_001139284 (OMIM: 608937) SH2B adapter protein 1 ( 671) 4610 584.8 3.4e-166
NP_056318 (OMIM: 608937) SH2B adapter protein 1 is ( 671) 4610 584.8 3.4e-166
NP_001139268 (OMIM: 608937) SH2B adapter protein 1 ( 671) 4610 584.8 3.4e-166
NP_001139269 (OMIM: 608937) SH2B adapter protein 1 ( 683) 4327 549.7 1.3e-155
NP_001139267 (OMIM: 608937) SH2B adapter protein 1 ( 756) 4316 548.4 3.6e-155
XP_016878604 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 4316 548.4 3.6e-155
XP_016878603 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 4316 548.4 3.6e-155
NP_001295222 (OMIM: 608937) SH2B adapter protein 1 ( 756) 4316 548.4 3.6e-155
XP_016878605 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 4316 548.4 3.6e-155
XP_016878606 (OMIM: 608937) PREDICTED: SH2B adapte ( 688) 2990 383.8 1.2e-105
NP_001295223 (OMIM: 608937) SH2B adapter protein 1 ( 335) 2320 300.4 7.3e-81
XP_016878607 (OMIM: 608937) PREDICTED: SH2B adapte ( 420) 2026 264.0 8.3e-70
XP_016878608 (OMIM: 608937) PREDICTED: SH2B adapte ( 420) 2026 264.0 8.3e-70
XP_016878609 (OMIM: 608937) PREDICTED: SH2B adapte ( 391) 1740 228.5 3.8e-59
XP_016867169 (OMIM: 605300) PREDICTED: SH2B adapte ( 631) 587 85.5 6.4e-16
XP_016867170 (OMIM: 605300) PREDICTED: SH2B adapte ( 631) 587 85.5 6.4e-16
XP_005277036 (OMIM: 605300) PREDICTED: SH2B adapte ( 632) 587 85.5 6.4e-16
XP_005277034 (OMIM: 605300) PREDICTED: SH2B adapte ( 632) 587 85.5 6.4e-16
XP_011514042 (OMIM: 605300) PREDICTED: SH2B adapte ( 645) 587 85.5 6.5e-16
XP_005277033 (OMIM: 605300) PREDICTED: SH2B adapte ( 673) 587 85.6 6.8e-16
XP_005277032 (OMIM: 605300) PREDICTED: SH2B adapte ( 674) 587 85.6 6.8e-16
NP_066189 (OMIM: 605300) SH2B adapter protein 2 [H ( 675) 587 85.6 6.8e-16
XP_006719243 (OMIM: 133100,187950,254450,605093) P ( 309) 528 78.0 6e-14
NP_001278353 (OMIM: 133100,187950,254450,605093) S ( 373) 528 78.0 7e-14
XP_011536023 (OMIM: 133100,187950,254450,605093) P ( 374) 528 78.0 7e-14
NP_005466 (OMIM: 133100,187950,254450,605093) SH2B ( 575) 528 78.2 9.6e-14
XP_005253876 (OMIM: 133100,187950,254450,605093) P ( 576) 528 78.2 9.6e-14
XP_005253875 (OMIM: 133100,187950,254450,605093) P ( 615) 528 78.2 1e-13
XP_011536022 (OMIM: 133100,187950,254450,605093) P ( 616) 528 78.2 1e-13
XP_011536021 (OMIM: 133100,187950,254450,605093) P ( 616) 528 78.2 1e-13
>>NP_001139284 (OMIM: 608937) SH2B adapter protein 1 iso (671 aa)
initn: 4610 init1: 4610 opt: 4610 Z-score: 3104.7 bits: 584.8 E(85289): 3.4e-166
Smith-Waterman score: 4610; 100.0% identity (100.0% similar) in 671 aa overlap (1-671:1-671)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
610 620 630 640 650 660
670
pF1KA1 GASDCVTDHLP
:::::::::::
NP_001 GASDCVTDHLP
670
>>NP_056318 (OMIM: 608937) SH2B adapter protein 1 isofor (671 aa)
initn: 4610 init1: 4610 opt: 4610 Z-score: 3104.7 bits: 584.8 E(85289): 3.4e-166
Smith-Waterman score: 4610; 100.0% identity (100.0% similar) in 671 aa overlap (1-671:1-671)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
610 620 630 640 650 660
670
pF1KA1 GASDCVTDHLP
:::::::::::
NP_056 GASDCVTDHLP
670
>>NP_001139268 (OMIM: 608937) SH2B adapter protein 1 iso (671 aa)
initn: 4610 init1: 4610 opt: 4610 Z-score: 3104.7 bits: 584.8 E(85289): 3.4e-166
Smith-Waterman score: 4610; 100.0% identity (100.0% similar) in 671 aa overlap (1-671:1-671)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
610 620 630 640 650 660
670
pF1KA1 GASDCVTDHLP
:::::::::::
NP_001 GASDCVTDHLP
670
>>NP_001139269 (OMIM: 608937) SH2B adapter protein 1 iso (683 aa)
initn: 4451 init1: 4322 opt: 4327 Z-score: 2914.7 bits: 549.7 E(85289): 1.3e-155
Smith-Waterman score: 4337; 94.3% identity (95.9% similar) in 684 aa overlap (1-670:1-681)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG
::::::::::::::::::::::::::::::::: : .:::. :. .:
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMRG
610 620 630 640 650 660
650 660 670
pF1KA1 DGCHPDASCTLMPFGASDCVTDHLP
: . . : :: : .: ....
NP_001 --CAREMDATPMP-PAPSCPSERVTV
670 680
>>NP_001139267 (OMIM: 608937) SH2B adapter protein 1 iso (756 aa)
initn: 4312 init1: 4312 opt: 4316 Z-score: 2906.8 bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
:::::::::::::::::::::::::::::::: : . ::
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
610 620 630 640 650
670
pF1KA1 GASDCVTDHLP
NP_001 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
660 670 680 690 700 710
>>XP_016878604 (OMIM: 608937) PREDICTED: SH2B adapter pr (756 aa)
initn: 4312 init1: 4312 opt: 4316 Z-score: 2906.8 bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
:::::::::::::::::::::::::::::::: : . ::
XP_016 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
610 620 630 640 650
670
pF1KA1 GASDCVTDHLP
XP_016 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
660 670 680 690 700 710
>>XP_016878603 (OMIM: 608937) PREDICTED: SH2B adapter pr (756 aa)
initn: 4312 init1: 4312 opt: 4316 Z-score: 2906.8 bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
:::::::::::::::::::::::::::::::: : . ::
XP_016 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
610 620 630 640 650
670
pF1KA1 GASDCVTDHLP
XP_016 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
660 670 680 690 700 710
>>NP_001295222 (OMIM: 608937) SH2B adapter protein 1 iso (756 aa)
initn: 4312 init1: 4312 opt: 4316 Z-score: 2906.8 bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
:::::::::::::::::::::::::::::::: : . ::
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
610 620 630 640 650
670
pF1KA1 GASDCVTDHLP
NP_001 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
660 670 680 690 700 710
>>XP_016878605 (OMIM: 608937) PREDICTED: SH2B adapter pr (756 aa)
initn: 4312 init1: 4312 opt: 4316 Z-score: 2906.8 bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
:::::::::::::::::::::::::::::::: : . ::
XP_016 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
610 620 630 640 650
670
pF1KA1 GASDCVTDHLP
XP_016 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
660 670 680 690 700 710
>>XP_016878606 (OMIM: 608937) PREDICTED: SH2B adapter pr (688 aa)
initn: 3015 init1: 2982 opt: 2990 Z-score: 2018.0 bits: 383.8 E(85289): 1.2e-105
Smith-Waterman score: 3706; 88.6% identity (88.8% similar) in 640 aa overlap (1-640:1-570)
10 20 30 40 50 60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
:::::::::::::::::
XP_016 QDLLLGPSESNDRLSQG-------------------------------------------
430
490 500 510 520 530 540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
:::::::::::::::::::::::::::::::::::
XP_016 -------------------------SFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
440 450 460 470
550 560 570 580 590 600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
480 490 500 510 520 530
610 620 630 640 650 660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
:::::::::::::::::::::::::::::::: : . ::
XP_016 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
540 550 560 570 580 590
670
pF1KA1 GASDCVTDHLP
XP_016 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
600 610 620 630 640 650
671 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 10:53:45 2016 done: Thu Nov 3 10:53:46 2016
Total Scan time: 10.180 Total Display time: 0.130
Function used was FASTA [36.3.4 Apr, 2011]