Result of FASTA (omim) for
pFN21ASDA1916
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1916, 545 aa
1>>>pF1KSDA1916 545 - 545 aa - 545 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7716+/-0.000538; mu= 15.7434+/- 0.033
mean_var=114.4338+/-24.260, 0's: 0 Z-trim(109.4): 368 B-trim: 191 in 2/52
Lambda= 0.119894
statistics sampled from 17055 (17532) to 17055 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.551), E-opt: 0.2 (0.206), width: 16
Scan time: 9.430
The best scores are: opt bits E(85289)
NP_060646 (OMIM: 608301) leucine-rich repeat LGI f ( 545) 3634 640.9 3.1e-183
NP_005088 (OMIM: 600512,604619) leucine-rich gliom ( 557) 2129 380.5 7.2e-105
NP_644807 (OMIM: 608302) leucine-rich repeat LGI f ( 548) 2006 359.3 1.8e-98
XP_011512152 (OMIM: 608301) PREDICTED: leucine-ric ( 331) 1842 330.7 4.4e-90
XP_016863845 (OMIM: 608301) PREDICTED: leucine-ric ( 287) 1834 329.2 1e-89
NP_001295205 (OMIM: 600512,604619) leucine-rich gl ( 509) 1733 312.0 2.8e-84
NP_644813 (OMIM: 608303) leucine-rich repeat LGI f ( 537) 1494 270.7 8.1e-72
XP_016872400 (OMIM: 600512,604619) PREDICTED: leuc ( 281) 1006 186.0 1.3e-46
NP_001295204 (OMIM: 600512,604619) leucine-rich gl ( 291) 998 184.6 3.6e-46
XP_011524897 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 902 168.1 4.2e-41
XP_016881918 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 902 168.1 4.2e-41
XP_016881919 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 902 168.1 4.2e-41
XP_016881917 (OMIM: 608303) PREDICTED: leucine-ric ( 365) 902 168.1 4.2e-41
XP_016872401 (OMIM: 600512,604619) PREDICTED: leuc ( 243) 602 116.1 1.3e-25
NP_848665 (OMIM: 610462) reticulon-4 receptor-like ( 420) 348 72.4 3.2e-12
NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 353 73.8 4.3e-12
XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 352 73.6 4.7e-12
NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 352 73.6 4.9e-12
XP_011515759 (OMIM: 615904) PREDICTED: peroxidasin (1439) 321 68.2 1.9e-10
XP_005264764 (OMIM: 269400,605158) PREDICTED: pero (1455) 320 68.1 2.2e-10
XP_016874279 (OMIM: 608870) PREDICTED: leucine-ric ( 623) 307 65.4 5.8e-10
XP_016867994 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 305 65.1 7.6e-10
NP_071426 (OMIM: 610486) leucine-rich repeat-conta ( 653) 305 65.1 7.6e-10
XP_011514763 (OMIM: 610486) PREDICTED: leucine-ric ( 653) 305 65.1 7.6e-10
XP_011536195 (OMIM: 608870) PREDICTED: leucine-ric (1041) 307 65.7 8.2e-10
NP_001129523 (OMIM: 608870) leucine-rich repeats a (1059) 307 65.7 8.3e-10
NP_700356 (OMIM: 608870) leucine-rich repeats and (1119) 307 65.7 8.7e-10
XP_011531881 (OMIM: 608868) PREDICTED: leucine-ric ( 833) 305 65.2 9e-10
XP_016861625 (OMIM: 608868) PREDICTED: leucine-ric ( 833) 305 65.2 9e-10
XP_016861624 (OMIM: 608868) PREDICTED: leucine-ric ( 867) 305 65.2 9.2e-10
XP_011531880 (OMIM: 608868) PREDICTED: leucine-ric (1045) 305 65.3 1e-09
XP_016861623 (OMIM: 608868) PREDICTED: leucine-ric (1068) 305 65.3 1.1e-09
NP_056356 (OMIM: 608868) leucine-rich repeats and (1093) 305 65.3 1.1e-09
XP_005248194 (OMIM: 612303) PREDICTED: adhesion G ( 833) 297 63.8 2.3e-09
XP_011515758 (OMIM: 615904) PREDICTED: peroxidasin (1439) 300 64.6 2.4e-09
XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495) 298 64.3 3.1e-09
XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499) 298 64.3 3.1e-09
XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509) 298 64.3 3.1e-09
NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529) 298 64.3 3.2e-09
XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533) 298 64.3 3.2e-09
NP_660333 (OMIM: 612303) adhesion G protein-couple (1321) 297 64.0 3.2e-09
NP_003052 (OMIM: 603742) slit homolog 1 protein pr (1534) 295 63.8 4.5e-09
XP_005271426 (OMIM: 608869,615112) PREDICTED: leuc ( 958) 292 63.0 4.7e-09
NP_001299615 (OMIM: 608869,615112) leucine-rich re ( 962) 292 63.0 4.7e-09
NP_055628 (OMIM: 608869,615112) leucine-rich repea (1065) 292 63.1 5.1e-09
NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521) 291 63.1 7.3e-09
NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525) 291 63.1 7.3e-09
XP_016873565 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 277 60.3 2.1e-08
XP_011518542 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 277 60.3 2.1e-08
XP_016873559 (OMIM: 608817) PREDICTED: leucine-ric ( 640) 277 60.3 2.1e-08
>>NP_060646 (OMIM: 608301) leucine-rich repeat LGI famil (545 aa)
initn: 3634 init1: 3634 opt: 3634 Z-score: 3410.7 bits: 640.9 E(85289): 3.1e-183
Smith-Waterman score: 3634; 99.8% identity (100.0% similar) in 545 aa overlap (1-545:1-545)
10 20 30 40 50 60
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD FYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD LAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD GSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFLFASSFKGKTKIFEHII
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
NP_060 GSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHII
490 500 510 520 530 540
pF1KSD VDLSL
:::::
NP_060 VDLSL
>>NP_005088 (OMIM: 600512,604619) leucine-rich glioma-in (557 aa)
initn: 2272 init1: 1484 opt: 2129 Z-score: 2003.7 bits: 380.5 E(85289): 7.2e-105
Smith-Waterman score: 2129; 56.1% identity (81.1% similar) in 540 aa overlap (11-544:19-556)
10 20 30 40 50
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGS
.. .: ::.: : . .. .:::.:.:::.. .: ..
NP_005 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAK--PKCPAVCTCTKDNALCENA
10 20 30 40 50
60 70 80 90 100 110
pF1KSD SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLE
.:: :: :. :::.: . :.::.. : :::::::..:::: .: :::: :: :::
NP_005 RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD YLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECD
:::::.:.:..:::..::::..: :::::::....::.:.:. :::: ..:::::.:.::
NP_005 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KSD CKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVS
:: ::: :: ::.:: :. : :::::...:.:...: :..: :.:. : :::::.:
NP_005 CKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KSD VDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVV
.:::. :: ::.:::: .:. :::::.: .::.:::::: : : :: :.:. :..:.
NP_005 IDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVI
240 250 260 270 280 290
300 310 320 330 340 350
pF1KSD VAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLST
:::::::::::: : .::.:.::::. .: :::::: :.:... .::.:::::::..:
NP_005 VAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTT
300 310 320 330 340 350
360 370 380 390 400
pF1KSD VYKWNSKGFYSYQSLHEWFRDTDAEFVDIDGKS------HLILSSRSQVPIILQWNKSSK
.::::..::::.:::: :.::::.:...: :::::: :: :.: ::::...
NP_005 IYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQ
360 370 380 390 400 410
410 420 430 440 450 460
pF1KSD KFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMT
:. . :::::::: ::: : ... .:. ::::::::.::.:....: .:: .::::.:.
NP_005 LFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMV
420 430 440 450 460 470
470 480 490 500 510 520
pF1KSD LQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFLFA
.::..... .: :::::.:.:.:.:: :: : ::.:. :::::::: :: ..:.::::
NP_005 FQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFA
480 490 500 510 520 530
530 540
pF1KSD SSFKGKTKIFEHIIVDLSL
:::::.:.:..:.:::::
NP_005 SSFKGNTQIYKHVIVDLSA
540 550
>>NP_644807 (OMIM: 608302) leucine-rich repeat LGI famil (548 aa)
initn: 1980 init1: 1980 opt: 2006 Z-score: 1888.8 bits: 359.3 E(85289): 1.8e-98
Smith-Waterman score: 2006; 51.7% identity (80.4% similar) in 542 aa overlap (5-544:7-547)
10 20 30 40 50
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVR--RLARCPATCSCTKESIICVGSSWVP
::: : ::: : . ::. . . : . :: .::::... .:: :. ::
NP_644 MAGLRARGGPGP-GLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVP
10 20 30 40 50
60 70 80 90 100 110
pF1KSD RIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFI
: .:... ::.:::..::::.: ::::: ::.::::::.::.: :.::.:: ::.::::
NP_644 RNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD EGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAK
:.: : ..:. .::::..:::::::::....::::.: :: : .::::::...::::.:
NP_644 ENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KSD WLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTF
:: :: ::.::. . : .::..::.:..:. ...: :::::..::: . .::.. :
NP_644 WLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPF
180 190 200 210 220 230
240 250 260 270 280 290
pF1KSD NSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQL
..:.:.:.:::.. : .:.::..: ..:.:: : . : : :: ...:.:..::::::
NP_644 LYSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KSD FGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKW
::::.::..: . :.:...:::. .:. ::::.: :.:: . .:..::::::: ...:.:
NP_644 FGGSYIYHWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRW
300 310 320 330 340 350
360 370 380 390 400 410
pF1KSD NSKGFYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPN
...::::.:.:: : :::: :::: .:: .::.:: ::.:.: ::....:.:: .:.. .
NP_644 HQNGFYSHQALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQ
360 370 380 390 400 410
420 430 440 450 460 470
pF1KSD MEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNH
. :. ::: :: :: :.:.::::...::.. .: :.:::::::...:::: .
NP_644 VPDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRR
420 430 440 450 460 470
480 490 500 510 520 530
pF1KSD YLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFLFASSFKGKTKIF
:::::::..:.::::::. .: : .:.:. :::::.: . . ..:.: ::::.: ..
NP_644 YLALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVY
480 490 500 510 520 530
540
pF1KSD EHIIVDLSL
.::.::::
NP_644 RHIVVDLSA
540
>>XP_011512152 (OMIM: 608301) PREDICTED: leucine-rich re (331 aa)
initn: 1842 init1: 1842 opt: 1842 Z-score: 1738.2 bits: 330.7 E(85289): 4.4e-90
Smith-Waterman score: 1842; 100.0% identity (100.0% similar) in 274 aa overlap (1-274:1-274)
10 20 30 40 50 60
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS
::::::::::::::::::::::::::::::::::
XP_011 DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGLVTMLPKGWLQLSMCTRGERETHGHV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG
XP_011 HPEVHFPLFSLRLILAFSILVYFVRLLISAG
310 320 330
>>XP_016863845 (OMIM: 608301) PREDICTED: leucine-rich re (287 aa)
initn: 1834 init1: 1834 opt: 1834 Z-score: 1731.5 bits: 329.2 E(85289): 1e-89
Smith-Waterman score: 1834; 100.0% identity (100.0% similar) in 273 aa overlap (1-273:1-273)
10 20 30 40 50 60
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS
:::::::::::::::::::::::::::::::::
XP_016 DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITVEDDEHGTTLESAA
250 260 270 280
310 320 330 340 350 360
pF1KSD HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG
>>NP_001295205 (OMIM: 600512,604619) leucine-rich glioma (509 aa)
initn: 1976 init1: 1092 opt: 1733 Z-score: 1634.0 bits: 312.0 E(85289): 2.8e-84
Smith-Waterman score: 1812; 50.2% identity (73.1% similar) in 540 aa overlap (11-544:19-508)
10 20 30 40 50
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGS
.. .: ::.: : . .. .:::.:.:::.. .: ..
NP_001 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAK--PKCPAVCTCTKDNALCENA
10 20 30 40 50
60 70 80 90 100 110
pF1KSD SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLE
.:: :: :. :::.: . :.::.. : ::::::
NP_001 RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL----------------------
60 70 80 90
120 130 140 150 160 170
pF1KSD YLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECD
:::::....::.:.:. :::: ..:::::.:.::
NP_001 --------------------------SLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD
100 110 120 130
180 190 200 210 220 230
pF1KSD CKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVS
:: ::: :: ::.:: :. : :::::...:.:...: :..: :.:. : :::::.:
NP_001 CKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLS
140 150 160 170 180 190
240 250 260 270 280 290
pF1KSD VDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVV
.:::. :: ::.:::: .:. :::::.: .::.:::::: : : :: :.:. :..:.
NP_001 IDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVI
200 210 220 230 240 250
300 310 320 330 340 350
pF1KSD VAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLST
:::::::::::: : .::.:.::::. .: :::::: :.:... .::.:::::::..:
NP_001 VAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTT
260 270 280 290 300 310
360 370 380 390 400
pF1KSD VYKWNSKGFYSYQSLHEWFRDTDAEFVDIDGKS------HLILSSRSQVPIILQWNKSSK
.::::..::::.:::: :.::::.:...: :::::: :: :.: ::::...
NP_001 IYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQ
320 330 340 350 360 370
410 420 430 440 450 460
pF1KSD KFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMT
:. . :::::::: ::: : ... .:. ::::::::.::.:....: .:: .::::.:.
NP_001 LFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMV
380 390 400 410 420 430
470 480 490 500 510 520
pF1KSD LQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFLFA
.::..... .: :::::.:.:.:.:: :: : ::.:. :::::::: :: ..:.::::
NP_001 FQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFA
440 450 460 470 480 490
530 540
pF1KSD SSFKGKTKIFEHIIVDLSL
:::::.:.:..:.:::::
NP_001 SSFKGNTQIYKHVIVDLSA
500
>>NP_644813 (OMIM: 608303) leucine-rich repeat LGI famil (537 aa)
initn: 1507 init1: 1099 opt: 1494 Z-score: 1410.3 bits: 270.7 E(85289): 8.1e-72
Smith-Waterman score: 1494; 41.2% identity (71.1% similar) in 539 aa overlap (9-544:2-536)
10 20 30 40 50 60
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
:. :.:::::..: .. : ..:: :::.:.: .: :: .:
NP_644 MGGAGILLLLLAGAGVV--VAWRPPKGKCPLRCSCSKDSALCEGSPDLPVSFS
10 20 30 40 50
70 80 90 100 110 120
pF1KSD GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
. ::::: ...: : ..:::.:::..::::..:.::::::: ::.::::: :.
NP_644 PTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KSD IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
: .::.::.::::.::::::::::...::: .: ::.: ..::::: :.:::.. ::
NP_644 IGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQ
120 130 140 150 160 170
190 200 210 220 230 240
pF1KSD WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
:. .:..:. : :: .. .:. . ..: . .. ::. ...::. :. ..
NP_644 WMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS
. ....::: :..: ::. . :: ... . :.:.:: ... ..::..:.:.:::
NP_644 EPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG
... ... : . :. .::: ::. .. . ::.::.:::: .:. .. :
NP_644 QLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPG
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD FYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDV
:: .:::: : :::::: ...::. ::.:.: :: :....: .. .: . :::. :::
NP_644 FYPHQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHW--TGGRFERRTDIPEAEDV
360 370 380 390 400
430 440 450 460 470 480
pF1KSD LAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLAL
:.. :. . ..: :::.:::: ::::....: .: :::::: ..::. . .. :
NP_644 YATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAIL
410 420 430 440 450 460
490 500 510 520 530
pF1KSD GSDYTFSQIYQWDKEKQLFKKFKEI---YVQAPRSFTAVSTDRRDFLFASSFKGKTKIFE
:::..:::. . . .: :.. ..:. . :::.:. .. : ::::. ::: :.:..
NP_644 GSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQ
470 480 490 500 510 520
540
pF1KSD HIIVDLSL
: .:::
NP_644 HHEIDLSA
530
>>XP_016872400 (OMIM: 600512,604619) PREDICTED: leucine- (281 aa)
initn: 1004 init1: 1004 opt: 1006 Z-score: 957.6 bits: 186.0 E(85289): 1.3e-46
Smith-Waterman score: 1006; 54.2% identity (79.2% similar) in 264 aa overlap (11-274:19-280)
10 20 30 40 50
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGS
.. .: ::.: : . .. .:::.:.:::.. .: ..
XP_016 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAK--PKCPAVCTCTKDNALCENA
10 20 30 40 50
60 70 80 90 100 110
pF1KSD SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLE
.:: :: :. :::.: . :.::.. : :::::::..:::: .: :::: :: :::
XP_016 RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD YLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECD
:::::.:.:..:::..::::..: :::::::....::.:.:. :::: ..:::::.:.::
XP_016 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KSD CKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVS
:: ::: :: ::.:: :. : :::::...:.:...: :..: :.:. : :::::.:
XP_016 CKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KSD VDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVV
.:::. :: ::.:::: .:. :::::.: .::.::::::
XP_016 IDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGS
240 250 260 270 280
300 310 320 330 340 350
pF1KSD VAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLST
>>NP_001295204 (OMIM: 600512,604619) leucine-rich glioma (291 aa)
initn: 996 init1: 996 opt: 998 Z-score: 949.9 bits: 184.6 E(85289): 3.6e-46
Smith-Waterman score: 998; 54.0% identity (79.1% similar) in 263 aa overlap (11-273:19-279)
10 20 30 40 50
pF1KSD MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGS
.. .: ::.: : . .. .:::.:.:::.. .: ..
NP_001 MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAK--PKCPAVCTCTKDNALCENA
10 20 30 40 50
60 70 80 90 100 110
pF1KSD SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLE
.:: :: :. :::.: . :.::.. : :::::::..:::: .: :::: :: :::
NP_001 RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD YLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECD
:::::.:.:..:::..::::..: :::::::....::.:.:. :::: ..:::::.:.::
NP_001 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KSD CKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVS
:: ::: :: ::.:: :. : :::::...:.:...: :..: :.:. : :::::.:
NP_001 CKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KSD VDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVV
.:::. :: ::.:::: .:. :::::.: .::.:::::
NP_001 IDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITVLREIHRFTNMS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KSD VAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLST
>>XP_011524897 (OMIM: 608303) PREDICTED: leucine-rich re (365 aa)
initn: 896 init1: 522 opt: 902 Z-score: 859.0 bits: 168.1 E(85289): 4.2e-41
Smith-Waterman score: 902; 35.8% identity (68.9% similar) in 366 aa overlap (182-544:1-364)
160 170 180 190 200 210
pF1KSD VFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSF
. .:..:. : :: .. .:. .
XP_011 MPTVNASVGTGACAGPASLSHMQLHHLDPK
10 20 30
220 230 240 250 260 270
pF1KSD DYECTTTDFVVHQTLPYQSVSVDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDN
..: . .. ::. ...::. :. ... ....::: :..: ::. . :: ..
XP_011 TFKCRAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEE
40 50 60 70 80 90
280 290 300 310 320 330
pF1KSD ITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIEL
. . :.:.:: ... ..::..:.:.:::... ... : . :. .::: ::
XP_011 LPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAEL
100 110 120 130 140 150
340 350 360 370 380 390
pF1KSD FQIDDETFFVIADSSKAGLSTVYKWNSKGFYSYQSLHEWFRDTDAEFVDIDGKSHLILSS
. .. . ::.::.:::: .:. .. ::: .:::: : :::::: ...::. ::.:.:
XP_011 LWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLAS
160 170 180 190 200 210
400 410 420 430 440 450
pF1KSD RSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSK
:: :....: .. .: . :::. ::: :.. :. . ..: :::.:::: ::::...
XP_011 ASQRPVLFHW--TGGRFERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGS
220 230 240 250 260
460 470 480 490 500
pF1KSD QFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEI---YVQ
.: .: :::::: ..::. . .. ::::..:::. . . .: :.. ..:. .
XP_011 MFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPALV
270 280 290 300 310 320
510 520 530 540
pF1KSD APRSFTAVSTDRRDFLFASSFKGKTKIFEHIIVDLSL
:::.:. .. : ::::. ::: :.:..: .:::
XP_011 APRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA
330 340 350 360
545 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 07:43:51 2016 done: Thu Nov 3 07:43:53 2016
Total Scan time: 9.430 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]