Result of FASTA (omim) for
pFN21AA1717
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1717, 366 aa
1>>>pF1KA1717 366 - 366 aa - 366 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3080+/-0.000348; mu= 15.9497+/- 0.022
mean_var=64.7329+/-12.741, 0's: 0 Z-trim(113.9): 74 B-trim: 63 in 2/48
Lambda= 0.159409
statistics sampled from 23443 (23519) to 23443 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.276), width: 16
Scan time: 7.240
The best scores are: opt bits E(85289)
NP_085151 (OMIM: 606594) histone-lysine N-methyltr ( 366) 2516 587.5 1.6e-167
NP_001293128 (OMIM: 606594) histone-lysine N-methy ( 362) 2102 492.3 7.4e-139
XP_016864150 (OMIM: 606594) PREDICTED: histone-lys ( 228) 1542 363.4 2.9e-100
NP_001293129 (OMIM: 606594) histone-lysine N-methy ( 135) 881 211.2 1.1e-54
NP_543136 (OMIM: 609314,615481) radial spoke head ( 309) 199 54.6 3.6e-07
XP_011528088 (OMIM: 609314,615481) PREDICTED: radi ( 285) 198 54.3 3.9e-07
NP_001273435 (OMIM: 609314,615481) radial spoke he ( 271) 160 45.6 0.00016
XP_016879841 (OMIM: 601674) PREDICTED: histone-lys ( 410) 139 40.8 0.0065
XP_016879840 (OMIM: 601674) PREDICTED: histone-lys ( 637) 139 40.9 0.0094
XP_016879839 (OMIM: 601674) PREDICTED: histone-lys ( 668) 139 40.9 0.0098
>>NP_085151 (OMIM: 606594) histone-lysine N-methyltransf (366 aa)
initn: 2516 init1: 2516 opt: 2516 Z-score: 3128.4 bits: 587.5 E(85289): 1.6e-167
Smith-Waterman score: 2516; 100.0% identity (100.0% similar) in 366 aa overlap (1-366:1-366)
10 20 30 40 50 60
pF1KA1 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 HFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 HFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 VMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 PNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_085 PNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF
310 320 330 340 350 360
pF1KA1 QATQQK
::::::
NP_085 QATQQK
>>NP_001293128 (OMIM: 606594) histone-lysine N-methyltra (362 aa)
initn: 2182 init1: 2098 opt: 2102 Z-score: 2613.9 bits: 492.3 E(85289): 7.4e-139
Smith-Waterman score: 2102; 96.3% identity (97.8% similar) in 321 aa overlap (1-321:1-319)
10 20 30 40 50 60
pF1KA1 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 HFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 VMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 PNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF
::::::. . ..: : :.
NP_001 PNCIYDIGQKNHLGT--CKRSRFGAPLPKIPHLDQAPWVEHRKAGIPLYSAAQGLMLIMM
310 320 330 340 350
>>XP_016864150 (OMIM: 606594) PREDICTED: histone-lysine (228 aa)
initn: 1542 init1: 1542 opt: 1542 Z-score: 1921.0 bits: 363.4 E(85289): 2.9e-100
Smith-Waterman score: 1542; 100.0% identity (100.0% similar) in 228 aa overlap (139-366:1-228)
110 120 130 140 150 160
pF1KA1 QYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGK
::::::::::::::::::::::::::::::
XP_016 MTGEKIAYVYPDERTALYGKFIDGEMIEGK
10 20 30
170 180 190 200 210 220
pF1KA1 LATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGE
40 50 60 70 80 90
230 240 250 260 270 280
pF1KA1 GLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYC
100 110 120 130 140 150
290 300 310 320 330 340
pF1KA1 ASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPE
160 170 180 190 200 210
350 360
pF1KA1 APEWYQVELKAFQATQQK
::::::::::::::::::
XP_016 APEWYQVELKAFQATQQK
220
>>NP_001293129 (OMIM: 606594) histone-lysine N-methyltra (135 aa)
initn: 881 init1: 881 opt: 881 Z-score: 1102.9 bits: 211.2 E(85289): 1.1e-54
Smith-Waterman score: 881; 100.0% identity (100.0% similar) in 124 aa overlap (1-124:1-124)
10 20 30 40 50 60
pF1KA1 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 IYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRP
::::
NP_001 IYYPVSRVTVHSAGK
130
>>NP_543136 (OMIM: 609314,615481) radial spoke head 1 ho (309 aa)
initn: 162 init1: 162 opt: 199 Z-score: 249.7 bits: 54.6 E(85289): 3.6e-07
Smith-Waterman score: 199; 26.8% identity (56.0% similar) in 168 aa overlap (13-177:21-182)
10 20 30 40 50
pF1KA1 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFF
:: .. : :: . . : .::.. :...:.: .
NP_543 MSDLGSEELEEEGENDIGEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 FFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKD
: .:. : :: . .:::.. : ::. .: ... .: . : .. . :..
NP_543 FKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDT-YTGEWFA
70 80 90 100 110
120 130 140 150 160
pF1KA1 NIRHGV-CWIYYPDGGSLVGE-VNEDGEMTGEKIAYVYPDERTALYGKFIDGEMI-EGKL
. ::: ..: :.. :: :: . : :.: .. ..: :::.. . . ::
NP_543 HQRHGQGTYLYAETGSKYVGTWVNGQQEGTAE---LIHLNHR--YQGKFLNKNPVGPGKY
120 130 140 150 160 170
170 180 190 200 210 220
pF1KA1 ATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEG
. .. :.
NP_543 VFDVGCEQHGEYRLTDMERGEEEEEEELVTVVPKWKATQITELALWTPTLPKKPTSTDGP
180 190 200 210 220 230
>>XP_011528088 (OMIM: 609314,615481) PREDICTED: radial s (285 aa)
initn: 162 init1: 162 opt: 198 Z-score: 249.0 bits: 54.3 E(85289): 3.9e-07
Smith-Waterman score: 198; 27.8% identity (56.3% similar) in 151 aa overlap (13-161:21-165)
10 20 30 40 50
pF1KA1 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFF
:: .. : :: . . : .::.. :...:.: .
XP_011 MSDLGSEELEEEGENDIGEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYK
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 FFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKD
: .:. : :: . .:::.. : ::. .: ... .: . : .. . :..
XP_011 FKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYINNDT-YTGEWFA
70 80 90 100 110
120 130 140 150 160 170
pF1KA1 NIRHGV-CWIYYPDGGSLVGE-VNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLA
. ::: ..: :.. :: :: . : :.: .. ..: :::..
XP_011 HQRHGQGTYLYAETGSKYVGTWVNGQQEGTAE---LIHLNHR--YQGKFLNKNERGEEEE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KA1 TLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGL
XP_011 EEELVTVVPKWKATQITELALWTPTLPKKPTSTDGPGQDAPGAESAGEPGEEAQALLEGF
180 190 200 210 220 230
>>NP_001273435 (OMIM: 609314,615481) radial spoke head 1 (271 aa)
initn: 122 init1: 122 opt: 160 Z-score: 202.1 bits: 45.6 E(85289): 0.00016
Smith-Waterman score: 160; 29.2% identity (64.0% similar) in 89 aa overlap (23-110:39-125)
10 20 30 40 50
pF1KA1 MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFF
:: : : . .:.::.... ..:.: ..
NP_001 LEEEGENDIGGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KA1 FFDGSTLEGYYVDDALQGQGVYTY-EDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYK
.....: : . .:::.: : : :. ::.:.:. .: :. . : ..:..
NP_001 YINNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHR--YQGKFL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KA1 DNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLAT
NP_001 NKNPVGPGKYVFDVGCEQHGEYRLTDMERGEEEEEEELVTVVPKWKATQITELALWTPTL
130 140 150 160 170 180
>>XP_016879841 (OMIM: 601674) PREDICTED: histone-lysine (410 aa)
initn: 105 init1: 56 opt: 139 Z-score: 173.3 bits: 40.8 E(85289): 0.0065
Smith-Waterman score: 158; 26.2% identity (51.5% similar) in 206 aa overlap (142-340:208-395)
120 130 140 150 160 170
pF1KA1 DNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLAT
::. :: .. . : . .
XP_016 STQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPC
180 190 200 210 220 230
180 190 200 210 220 230
pF1KA1 LMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLF
....: : . : : : :.: .. :: : . . ... .: : . :: : :
XP_016 YLAVRECDPDLCLTCGAS-EHWDCKVVSC--KNCSIQRGLK-KHLLLAPSDV--AGWGTF
240 250 260 270 280 290
240 250 260 270 280
pF1KA1 SKVAVGPNTVMSFYNGVRITHQEVDSR----DWALNGNTLSLDEETVIDVPEPYNHVSKY
: .: : .: : : :...:.: : : ... ..:... :.:. . :.. ..
XP_016 IKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKI-RF
300 310 320 330 340 350
290 300 310 320 330 340
pF1KA1 CASLGHKANHSFTPNCIYDMFV---HPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGK
:::: .::: . . :.: : . ::..: ::: : :...
XP_016 -------ANHSVNPNCYAKVVMVNGDHRIG----IFAKRAIQAGEELFFDYRYSQADALK
360 370 380 390
350 360
pF1KA1 SGPEAPEWYQVELKAFQATQQK
XP_016 YVGIERETDVL
400 410
>>XP_016879840 (OMIM: 601674) PREDICTED: histone-lysine (637 aa)
initn: 56 init1: 56 opt: 139 Z-score: 170.4 bits: 40.9 E(85289): 0.0094
Smith-Waterman score: 158; 26.2% identity (51.5% similar) in 206 aa overlap (142-340:435-622)
120 130 140 150 160 170
pF1KA1 DNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLAT
::. :: .. . : . .
XP_016 STQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPC
410 420 430 440 450 460
180 190 200 210 220 230
pF1KA1 LMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLF
....: : . : : : :.: .. :: : . . ... .: : . :: : :
XP_016 YLAVRECDPDLCLTCGAS-EHWDCKVVSC--KNCSIQRGLK-KHLLLAPSDV--AGWGTF
470 480 490 500 510
240 250 260 270 280
pF1KA1 SKVAVGPNTVMSFYNGVRITHQEVDSR----DWALNGNTLSLDEETVIDVPEPYNHVSKY
: .: : .: : : :...:.: : : ... ..:... :.:. . :.. ..
XP_016 IKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKI-RF
520 530 540 550 560 570
290 300 310 320 330 340
pF1KA1 CASLGHKANHSFTPNCIYDMFV---HPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGK
:::: .::: . . :.: : . ::..: ::: : :...
XP_016 -------ANHSVNPNCYAKVVMVNGDHRIG----IFAKRAIQAGEELFFDYRYSQADALK
580 590 600 610 620
350 360
pF1KA1 SGPEAPEWYQVELKAFQATQQK
XP_016 YVGIERETDVL
630
>>XP_016879839 (OMIM: 601674) PREDICTED: histone-lysine (668 aa)
initn: 56 init1: 56 opt: 139 Z-score: 170.1 bits: 40.9 E(85289): 0.0098
Smith-Waterman score: 158; 26.2% identity (51.5% similar) in 206 aa overlap (142-340:466-653)
120 130 140 150 160 170
pF1KA1 DNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLAT
::. :: .. . : . .
XP_016 STQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPC
440 450 460 470 480 490
180 190 200 210 220 230
pF1KA1 LMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLF
....: : . : : : :.: .. :: : . . ... .: : . :: : :
XP_016 YLAVRECDPDLCLTCGAS-EHWDCKVVSC--KNCSIQRGLK-KHLLLAPSDV--AGWGTF
500 510 520 530 540
240 250 260 270 280
pF1KA1 SKVAVGPNTVMSFYNGVRITHQEVDSR----DWALNGNTLSLDEETVIDVPEPYNHVSKY
: .: : .: : : :...:.: : : ... ..:... :.:. . :.. ..
XP_016 IKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKI-RF
550 560 570 580 590 600
290 300 310 320 330 340
pF1KA1 CASLGHKANHSFTPNCIYDMFV---HPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGK
:::: .::: . . :.: : . ::..: ::: : :...
XP_016 -------ANHSVNPNCYAKVVMVNGDHRIG----IFAKRAIQAGEELFFDYRYSQADALK
610 620 630 640 650
350 360
pF1KA1 SGPEAPEWYQVELKAFQATQQK
XP_016 YVGIERETDVL
660
366 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 21:54:12 2016 done: Wed Nov 2 21:54:13 2016
Total Scan time: 7.240 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]