Result of FASTA (omim) for
pFN21AA1376
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1376, 414 aa
1>>>pF1KA1376 414 - 414 aa - 414 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5338+/-0.000334; mu= 16.3396+/- 0.021
mean_var=71.0128+/-14.151, 0's: 0 Z-trim(115.9): 20 B-trim: 492 in 1/48
Lambda= 0.152197
statistics sampled from 26644 (26663) to 26644 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.689), E-opt: 0.2 (0.313), width: 16
Scan time: 8.170
The best scores are: opt bits E(85289)
NP_065852 (OMIM: 612464) arrestin domain-containin ( 414) 2792 622.0 8.2e-178
NP_001316599 (OMIM: 612464) arrestin domain-contai ( 194) 1309 296.2 4.6e-80
NP_001316601 (OMIM: 612464) arrestin domain-contai ( 194) 1309 296.2 4.6e-80
NP_001316600 (OMIM: 612464) arrestin domain-contai ( 194) 1309 296.2 4.6e-80
NP_006463 (OMIM: 606599) thioredoxin-interacting p ( 391) 946 216.7 8.1e-56
XP_016855574 (OMIM: 606599) PREDICTED: thioredoxin ( 395) 928 212.7 1.3e-54
NP_001300901 (OMIM: 606599) thioredoxin-interactin ( 336) 926 212.3 1.5e-54
>>NP_065852 (OMIM: 612464) arrestin domain-containing pr (414 aa)
initn: 2792 init1: 2792 opt: 2792 Z-score: 3313.3 bits: 622.0 E(85289): 8.2e-178
Smith-Waterman score: 2792; 100.0% identity (100.0% similar) in 414 aa overlap (1-414:1-414)
10 20 30 40 50 60
pF1KA1 MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 ESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 TPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 LCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 KEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 LFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRN
310 320 330 340 350 360
370 380 390 400 410
pF1KA1 NLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
370 380 390 400 410
>>NP_001316599 (OMIM: 612464) arrestin domain-containing (194 aa)
initn: 1309 init1: 1309 opt: 1309 Z-score: 1558.4 bits: 296.2 E(85289): 4.6e-80
Smith-Waterman score: 1309; 100.0% identity (100.0% similar) in 194 aa overlap (221-414:1-194)
200 210 220 230 240 250
pF1KA1 ISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANL
::::::::::::::::::::::::::::::
NP_001 MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
10 20 30
260 270 280 290 300 310
pF1KA1 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
40 50 60 70 80 90
320 330 340 350 360 370
pF1KA1 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
100 110 120 130 140 150
380 390 400 410
pF1KA1 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
160 170 180 190
>>NP_001316601 (OMIM: 612464) arrestin domain-containing (194 aa)
initn: 1309 init1: 1309 opt: 1309 Z-score: 1558.4 bits: 296.2 E(85289): 4.6e-80
Smith-Waterman score: 1309; 100.0% identity (100.0% similar) in 194 aa overlap (221-414:1-194)
200 210 220 230 240 250
pF1KA1 ISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANL
::::::::::::::::::::::::::::::
NP_001 MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
10 20 30
260 270 280 290 300 310
pF1KA1 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
40 50 60 70 80 90
320 330 340 350 360 370
pF1KA1 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
100 110 120 130 140 150
380 390 400 410
pF1KA1 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
160 170 180 190
>>NP_001316600 (OMIM: 612464) arrestin domain-containing (194 aa)
initn: 1309 init1: 1309 opt: 1309 Z-score: 1558.4 bits: 296.2 E(85289): 4.6e-80
Smith-Waterman score: 1309; 100.0% identity (100.0% similar) in 194 aa overlap (221-414:1-194)
200 210 220 230 240 250
pF1KA1 ISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANL
::::::::::::::::::::::::::::::
NP_001 MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
10 20 30
260 270 280 290 300 310
pF1KA1 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
40 50 60 70 80 90
320 330 340 350 360 370
pF1KA1 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
100 110 120 130 140 150
380 390 400 410
pF1KA1 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
160 170 180 190
>>NP_006463 (OMIM: 606599) thioredoxin-interacting prote (391 aa)
initn: 1038 init1: 672 opt: 946 Z-score: 1123.1 bits: 216.7 E(85289): 8.1e-56
Smith-Waterman score: 1049; 42.1% identity (70.8% similar) in 401 aa overlap (1-399:2-383)
10 20 30 40 50
pF1KA1 MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRW
... :.::. . : :: . ::.::. :.::: .:: :::...: : : ::: :
NP_006 MVMFKKIKSFEVVF---NDPE-KVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW
10 20 30 40 50
60 70 80 90 100 110
pF1KA1 TESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSG-RHEYAFSFEL
. :: :. . ::. ..: :. .:. ..:. . .. : ..:: :.:::
NP_006 MQ----GS-----QQCKQTSEYLRYEDTLL--LEDQPTGENEMVIMRPGNKYEYKFGFEL
60 70 80 90 100
120 130 140 150 160 170
pF1KA1 PQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKE
:: ::.:::.:..: : ::::: : :: . ::.: : . .:.:::.:..: .. ::
NP_006 PQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKE
110 120 130 140 150 160
180 190 200 210 220 230
pF1KA1 KTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKG
: . : : .: .:.::.:.:::. :. :.: :..:: ::.::::::: ... :.:
NP_006 KKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANG
170 180 190 200 210 220
240 250 260 270 280 290
pF1KA1 KMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGA
. : . : ....::. . :: .: :: :.. . :::: :.:.::::::..::..::.
NP_006 QTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGS
230 240 250 260 270 280
300 310 320 330 340 350
pF1KA1 MDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQR
..:.::::::. ..:::::..:. : .:.:..:..:. ::::: : .:. :..:
NP_006 KKVILDLPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHR
290 300 310 320 330 340
360 370 380 390 400 410
pF1KA1 RNNLAPVSAC-DDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
.. :.. ::.. . ..:.: : ::.:.::: :.:.::
NP_006 LES--PTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
350 360 370 380 390
>>XP_016855574 (OMIM: 606599) PREDICTED: thioredoxin-int (395 aa)
initn: 1020 init1: 672 opt: 928 Z-score: 1101.6 bits: 212.7 E(85289): 1.3e-54
Smith-Waterman score: 1031; 41.9% identity (70.7% similar) in 399 aa overlap (1-397:2-381)
10 20 30 40 50
pF1KA1 MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRW
... :.::. . : :: . ::.::. :.::: .:: :::...: : : ::: :
XP_016 MVMFKKIKSFEVVF---NDPE-KVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW
10 20 30 40 50
60 70 80 90 100 110
pF1KA1 TESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSG-RHEYAFSFEL
. :: :. . ::. ..: :. .:. ..:. . .. : ..:: :.:::
XP_016 MQ----GS-----QQCKQTSEYLRYEDTLL--LEDQPTGENEMVIMRPGNKYEYKFGFEL
60 70 80 90 100
120 130 140 150 160 170
pF1KA1 PQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKE
:: ::.:::.:..: : ::::: : :: . ::.: : . .:.:::.:..: .. ::
XP_016 PQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKE
110 120 130 140 150 160
180 190 200 210 220 230
pF1KA1 KTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKG
: . : : .: .:.::.:.:::. :. :.: :..:: ::.::::::: ... :.:
XP_016 KKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANG
170 180 190 200 210 220
240 250 260 270 280 290
pF1KA1 KMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGA
. : . : ....::. . :: .: :: :.. . :::: :.:.::::::..::..::.
XP_016 QTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGS
230 240 250 260 270 280
300 310 320 330 340 350
pF1KA1 MDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQR
..:.::::::. ..:::::..:. : .:.:..:..:. ::::: : .:. :..:
XP_016 KKVILDLPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHR
290 300 310 320 330 340
360 370 380 390 400 410
pF1KA1 RNNLAPVSAC-DDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
. .:.. ::.. . ..:.: : ::.:.::: :.:.
XP_016 LE--SPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVRIVIFTVKFVLSFL
350 360 370 380 390
>>NP_001300901 (OMIM: 606599) thioredoxin-interacting pr (336 aa)
initn: 932 init1: 672 opt: 926 Z-score: 1100.3 bits: 212.3 E(85289): 1.5e-54
Smith-Waterman score: 926; 45.5% identity (75.0% similar) in 292 aa overlap (109-399:41-328)
80 90 100 110 120 130
pF1KA1 VEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWV
..:: :.::::: ::.:::.:..: : :::
NP_001 CILSVTASLMATRFSFPSGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWV
20 30 40 50 60 70
140 150 160 170 180 190
pF1KA1 KAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIE
:: : :: . ::.: : . .:.:::.:..: .. ::: . : : .: .:.::.:.
NP_001 KAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARID
80 90 100 110 120 130
200 210 220 230 240 250
pF1KA1 RKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSG
:::. :. :.: :..:: ::.::::::: ... :.:. : . : ....::. . ::
NP_001 RKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISG
140 150 160 170 180 190
260 270 280 290 300 310
pF1KA1 KTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIPLHPFG
.: :: :.. . :::: :.:.::::::..::..::. ..:.::::::. ..
NP_001 TCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGS--RSGLS
200 210 220 230 240
320 330 340 350 360 370
pF1KA1 SRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSAC-DDFERALQG
:::::..:. : .:.:..:..:. ::::: : .:. :..: . .:.. ::.. . ..
NP_001 SRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLE--SPTTPLLDDMDGSQDS
250 260 270 280 290 300
380 390 400 410
pF1KA1 PLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
:.: : ::.:.::: :.:.::
NP_001 PIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
310 320 330
414 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 21:05:35 2016 done: Wed Nov 2 21:05:36 2016
Total Scan time: 8.170 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]