Result of FASTA (omim) for
pFN21AA1016
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1016, 728 aa
1>>>pF1KA1016 728 - 728 aa - 728 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9990+/-0.00041; mu= 8.0080+/- 0.026
mean_var=178.1503+/-37.057, 0's: 0 Z-trim(118.0): 183 B-trim: 1374 in 1/54
Lambda= 0.096091
statistics sampled from 30325 (30526) to 30325 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.358), width: 16
Scan time: 12.000
The best scores are: opt bits E(85289)
NP_055931 (OMIM: 610368) leucine-rich repeat and c ( 728) 4862 686.9 7.4e-197
NP_001157685 (OMIM: 610368) leucine-rich repeat an ( 696) 4433 627.4 5.7e-179
NP_001157683 (OMIM: 610368) leucine-rich repeat an ( 763) 3683 523.5 1.2e-147
XP_016875972 (OMIM: 610368) PREDICTED: leucine-ric ( 731) 3672 522.0 3.4e-147
XP_016875973 (OMIM: 610368) PREDICTED: leucine-ric ( 477) 1963 284.9 5.1e-76
NP_036557 (OMIM: 179555) ras suppressor protein 1 ( 277) 355 61.8 4.3e-09
XP_011542154 (OMIM: 605352) PREDICTED: malignant f (1003) 343 60.6 3.6e-08
NP_004216 (OMIM: 605352) malignant fibrous histioc (1052) 343 60.6 3.8e-08
NP_665894 (OMIM: 605247) p53-induced protein with ( 893) 316 56.8 4.5e-07
XP_011518513 (OMIM: 605247) PREDICTED: p53-induced ( 893) 316 56.8 4.5e-07
XP_011518512 (OMIM: 605247) PREDICTED: p53-induced ( 910) 316 56.8 4.5e-07
NP_665893 (OMIM: 605247) p53-induced protein with ( 910) 316 56.8 4.5e-07
XP_011518511 (OMIM: 605247) PREDICTED: p53-induced ( 920) 316 56.8 4.6e-07
XP_005253064 (OMIM: 605247) PREDICTED: p53-induced ( 934) 316 56.8 4.6e-07
XP_005253062 (OMIM: 605247) PREDICTED: p53-induced ( 934) 316 56.8 4.6e-07
XP_005253063 (OMIM: 605247) PREDICTED: p53-induced ( 934) 316 56.8 4.6e-07
XP_016857384 (OMIM: 614453) PREDICTED: leucine-ric (1255) 311 56.2 9.4e-07
XP_016857383 (OMIM: 614453) PREDICTED: leucine-ric (1438) 311 56.3 1e-06
XP_016857382 (OMIM: 614453) PREDICTED: leucine-ric (1472) 311 56.3 1.1e-06
XP_016857381 (OMIM: 614453) PREDICTED: leucine-ric (1490) 311 56.3 1.1e-06
NP_001317564 (OMIM: 614453) leucine-rich repeat-co (1495) 311 56.3 1.1e-06
XP_016857379 (OMIM: 614453) PREDICTED: leucine-ric (1528) 311 56.3 1.1e-06
XP_016857378 (OMIM: 614453) PREDICTED: leucine-ric (1537) 311 56.3 1.1e-06
NP_065845 (OMIM: 614453) leucine-rich repeat-conta (1537) 311 56.3 1.1e-06
XP_016857377 (OMIM: 614453) PREDICTED: leucine-ric (1541) 311 56.3 1.1e-06
XP_016857376 (OMIM: 614453) PREDICTED: leucine-ric (1547) 311 56.3 1.1e-06
XP_016857374 (OMIM: 614453) PREDICTED: leucine-ric (1594) 311 56.3 1.1e-06
XP_016857375 (OMIM: 614453) PREDICTED: leucine-ric (1594) 311 56.3 1.1e-06
XP_005252609 (OMIM: 179555) PREDICTED: ras suppres ( 277) 290 52.8 2.2e-06
NP_001255968 (OMIM: 602775,607721) leucine-rich re ( 536) 295 53.7 2.3e-06
XP_016872192 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 295 53.7 2.4e-06
NP_031399 (OMIM: 602775,607721) leucine-rich repea ( 582) 295 53.7 2.4e-06
NP_001311265 (OMIM: 602775,607721) leucine-rich re ( 582) 295 53.7 2.4e-06
NP_001311266 (OMIM: 602775,607721) leucine-rich re ( 582) 295 53.7 2.4e-06
XP_016872193 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 295 53.7 2.4e-06
XP_016872191 (OMIM: 602775,607721) PREDICTED: leuc ( 582) 295 53.7 2.4e-06
XP_006717379 (OMIM: 610933,614436) PREDICTED: E3 u ( 690) 296 53.9 2.5e-06
XP_006714723 (OMIM: 606944) PREDICTED: protein LAP (1246) 299 54.5 2.9e-06
XP_016865126 (OMIM: 606944) PREDICTED: protein LAP (1298) 299 54.6 3e-06
NP_001006600 (OMIM: 606944) erbin isoform 7 [Homo (1302) 299 54.6 3.1e-06
NP_001240627 (OMIM: 606944) erbin isoform 4 [Homo (1346) 299 54.6 3.1e-06
NP_001240630 (OMIM: 606944) erbin isoform 9 [Homo (1367) 299 54.6 3.2e-06
NP_061165 (OMIM: 606944) erbin isoform 2 [Homo sap (1371) 299 54.6 3.2e-06
NP_001240626 (OMIM: 606944) erbin isoform 1 [Homo (1412) 299 54.6 3.2e-06
XP_016865125 (OMIM: 606944) PREDICTED: protein LAP (1415) 299 54.6 3.3e-06
NP_001240628 (OMIM: 606944) erbin isoform 8 [Homo (1419) 299 54.6 3.3e-06
XP_005248612 (OMIM: 606944) PREDICTED: protein LAP (1456) 299 54.6 3.3e-06
XP_005248611 (OMIM: 606944) PREDICTED: protein LAP (1460) 299 54.6 3.3e-06
XP_016865124 (OMIM: 606944) PREDICTED: protein LAP (1460) 299 54.6 3.3e-06
XP_016866486 (OMIM: 608195) PREDICTED: leucine-ric ( 331) 285 52.2 4.1e-06
>>NP_055931 (OMIM: 610368) leucine-rich repeat and calpo (728 aa)
initn: 4862 init1: 4862 opt: 4862 Z-score: 3655.2 bits: 686.9 E(85289): 7.4e-197
Smith-Waterman score: 4862; 100.0% identity (100.0% similar) in 728 aa overlap (1-728:1-728)
10 20 30 40 50 60
pF1KA1 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 STAPFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 STAPFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 DLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 ADLCSPCDILQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ADLCSPCDILQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYIT
670 680 690 700 710 720
pF1KA1 YHWNALSA
::::::::
NP_055 YHWNALSA
>>NP_001157685 (OMIM: 610368) leucine-rich repeat and ca (696 aa)
initn: 4836 init1: 4433 opt: 4433 Z-score: 3334.1 bits: 627.4 E(85289): 5.7e-179
Smith-Waterman score: 4433; 99.1% identity (99.3% similar) in 671 aa overlap (1-671:1-671)
10 20 30 40 50 60
pF1KA1 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 STAPFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STAPFGLKPRSVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 DLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLGAALMDGVVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 ADLCSPCDILQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYIT
:: : ::.
NP_001 EKLCLPHHILEEKGLVKVGITIQALLDITVTKALFT
670 680 690
>>NP_001157683 (OMIM: 610368) leucine-rich repeat and ca (763 aa)
initn: 3683 init1: 3683 opt: 3683 Z-score: 2771.6 bits: 523.5 E(85289): 1.2e-147
Smith-Waterman score: 4767; 95.4% identity (95.4% similar) in 760 aa overlap (1-725:1-760)
10 20 30 40 50 60
pF1KA1 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
490 500 510 520 530 540
550 560
pF1KA1 STAPFGLKPRS-----------------------------------VFLRPQRNLESIDP
::::::::::: ::::::::::::::
NP_001 STAPFGLKPRSDPALILPPISFNTLTQAQTWDSSSYSVPSEGDSDNVFLRPQRNLESIDP
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA1 QFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVA
610 620 630 640 650 660
630 640 650 660 670 680
pF1KA1 SIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDILQLDFRHIRKTVDTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDILQLDFRHIRKTVDTLL
670 680 690 700 710 720
690 700 710 720
pF1KA1 ALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYITYHWNALSA
::::::::::::::::::::::::::::::::::::::::
NP_001 ALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYITYHWNALSA
730 740 750 760
>>XP_016875972 (OMIM: 610368) PREDICTED: leucine-rich re (731 aa)
initn: 4408 init1: 3672 opt: 3672 Z-score: 2763.6 bits: 522.0 E(85289): 3.4e-147
Smith-Waterman score: 4342; 94.1% identity (94.2% similar) in 706 aa overlap (1-671:1-706)
10 20 30 40 50 60
pF1KA1 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATPGSEPQPFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGLERALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVLIASNNKLGSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_016 PEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLSLVKFDF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRADGLHSEFMNYKARAED
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQDPNGLSTDITERSVLNL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYSPNEIRENSPAVSPTTN
490 500 510 520 530 540
550 560
pF1KA1 STAPFGLKPRS-----------------------------------VFLRPQRNLESIDP
::::::::::: ::::::::::::::
XP_016 STAPFGLKPRSDPALILPPISFNTLTQAQTWDSSSYSVPSEGDSDNVFLRPQRNLESIDP
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA1 QFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVA
610 620 630 640 650 660
630 640 650 660 670 680
pF1KA1 SIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDILQLDFRHIRKTVDTLL
::::::::::::::::::::::::::::::::::: :: : ::.
XP_016 SIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEEKLCLPHHILEEKGLVKVGITIQAL
670 680 690 700 710 720
690 700 710 720
pF1KA1 ALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYITYHWNALSA
XP_016 LDITVTKALFT
730
>>XP_016875973 (OMIM: 610368) PREDICTED: leucine-rich re (477 aa)
initn: 2699 init1: 1963 opt: 1963 Z-score: 1485.8 bits: 284.9 E(85289): 5.1e-76
Smith-Waterman score: 2633; 90.9% identity (91.2% similar) in 452 aa overlap (255-671:1-452)
230 240 250 260 270 280
pF1KA1 VLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIF
::::::::::::::::::::::::::::::
XP_016 MKQLQVLLLENNPLQSPPAQICTKGKVHIF
10 20 30
290 300 310 320 330 340
pF1KA1 KYLSIQACQIKTADSLYLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYLSIQACQIKTADSLYLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDT
40 50 60 70 80 90
350 360 370 380 390 400
pF1KA1 VSLNVPMSNIMEEEQIIKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSLNVPMSNIMEEEQIIKEDSCHRLSPVKGEFHQEFQPEPSLLGDSTNSGEERDQFTDRA
100 110 120 130 140 150
410 420 430 440 450 460
pF1KA1 DGLHSEFMNYKARAEDCEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGLHSEFMNYKARAEDCEELLRIEEDVHWQTEGIISSSKDQDMDIAMIEQLREAVDLLQD
160 170 180 190 200 210
470 480 490 500 510 520
pF1KA1 PNGLSTDITERSVLNLYPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNGLSTDITERSVLNLYPMGSAEALELQDSALNGQIQLETSPVCEVQSDLTLQSNGSQYS
220 230 240 250 260 270
530 540 550
pF1KA1 PNEIRENSPAVSPTTNSTAPFGLKPRS---------------------------------
:::::::::::::::::::::::::::
XP_016 PNEIRENSPAVSPTTNSTAPFGLKPRSDPALILPPISFNTLTQAQTWDSSSYSVPSEGDS
280 290 300 310 320 330
560 570 580 590 600
pF1KA1 --VFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNVFLRPQRNLESIDPQFTIRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDG
340 350 360 370 380 390
610 620 630 640 650 660
pF1KA1 VVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDI
::::::::::::::::::::::::::::::::::::::::::::::::::: :: : :
XP_016 VVLCHLVNHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLEACRKLGVPEEKLCLPHHI
400 410 420 430 440 450
670 680 690 700 710 720
pF1KA1 LQLDFRHIRKTVDTLLALGEKAPPPTSALRSRDLIGFCLVHILFIVLVYITYHWNALSA
:.
XP_016 LEEKGLVKVGITIQALLDITVTKALFT
460 470
>>NP_036557 (OMIM: 179555) ras suppressor protein 1 isof (277 aa)
initn: 528 init1: 165 opt: 355 Z-score: 284.3 bits: 61.8 E(85289): 4.3e-09
Smith-Waterman score: 355; 31.9% identity (61.9% similar) in 273 aa overlap (59-322:1-262)
30 40 50 60 70 80
pF1KA1 HHHHHQHHGGTGAPGGAGGGGGGSGGFNLPLNRGLERALEEA--ANSGGLNLSARKLKEF
....:.. .::. :. ...: : ....
NP_036 MSKSLKKLVEESREKNQPEVDMSDRGISNM
10 20 30
90 100 110 120 130 140
pF1KA1 PRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLT
. . :: .: ::.:.:. :: .. .. .::.::...: :. .: : .:: :
NP_036 LDVNGL-FTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLK
40 50 60 70 80
150 160 170 180 190 200
pF1KA1 YLNLSRNQLSALPACLCGLP-LKVLIASNNKLG--SLPEEIGQLKQLMELDVSCNEITAL
.:::. :.:..:: . .:: :.:: . :.:. ::: .. : : : .: :.. :
NP_036 HLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEIL
90 100 110 120 130 140
210 220 230 240 250
pF1KA1 PQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVK-FDFSCNKVLVIPICFREMK---QLQ
: .::.: .:. :..: : : ::.:. .: .: . .. :.. :.: . .. : :
NP_036 PPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQ
150 160 170 180 190 200
260 270 280 290 300 310
pF1KA1 VLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHVEDGKK
:. :::: .: :. : :.:.: :.. ::. :.. . : ::
NP_036 VFKAENNPWVTPIADQFQLGVSHVFEY-------IRSETYKYLYGR---HMQANPEPPKK
210 220 230 240 250
320 330 340 350 360 370
pF1KA1 DSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQIIKEDSCHRLSPVKGEFHQE
..:
NP_036 NNDKSKKISRKPLAAKNR
260 270
>>XP_011542154 (OMIM: 605352) PREDICTED: malignant fibro (1003 aa)
initn: 368 init1: 160 opt: 343 Z-score: 267.6 bits: 60.6 E(85289): 3.6e-08
Smith-Waterman score: 343; 33.4% identity (59.5% similar) in 296 aa overlap (40-326:38-319)
10 20 30 40 50 60
pF1KA1 PFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGG---GGSGGFNLPLNRGLERA
:: :::. . .: . :: : : .:
XP_011 NLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVP---MELCHFVSLE
: ::. :.: :. : :.. : .::....: :: : :
XP_011 L---------NLGNNGLEEVPEGL--GSALGSLRVLVLRRNRFARLPPAVAELGHH--LT
70 80 90 100 110
130 140 150 160 170 180
pF1KA1 ILNLYHNCIRVIPEAIVN-LQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLP
:.. :: . .. .:. :. : ::::.::: :::: : .: :. : .: :.:. ::
XP_011 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KA1 EEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF-
. .. :..: :::. :..::.:.:. :: .:.::.: : :. ::... : .:. .
XP_011 DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KA1 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
: .. ..: : :. .:. :.:.:: ::. :::. ...... :: . . : :
XP_011 SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLN-LSSNLFEEFPAALL
240 250 260 270 280 290
310 320 330 340 350 360
pF1KA1 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
: .:. .: .. . . ::.:
XP_011 PLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ
300 310 320 330 340 350
>>NP_004216 (OMIM: 605352) malignant fibrous histiocytom (1052 aa)
initn: 368 init1: 160 opt: 343 Z-score: 267.3 bits: 60.6 E(85289): 3.8e-08
Smith-Waterman score: 343; 33.4% identity (59.5% similar) in 296 aa overlap (40-326:38-319)
10 20 30 40 50 60
pF1KA1 PFVPALSVATLHPLHHPHHHHHHHQHHGGTGAPGGAGGGG---GGSGGFNLPLNRGLERA
:: :::. . .: . :: : : .:
NP_004 NLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 LEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVP---MELCHFVSLE
: ::. :.: :. : :.. : .::....: :: : :
NP_004 L---------NLGNNGLEEVPEGL--GSALGSLRVLVLRRNRFARLPPAVAELGHH--LT
70 80 90 100 110
130 140 150 160 170 180
pF1KA1 ILNLYHNCIRVIPEAIVN-LQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLP
:.. :: . .. .:. :. : ::::.::: :::: : .: :. : .: :.:. ::
NP_004 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP
120 130 140 150 160 170
190 200 210 220 230 240
pF1KA1 EEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDF-
. .. :..: :::. :..::.:.:. :: .:.::.: : :. ::... : .:. .
NP_004 DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KA1 SCNKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSL
: .. ..: : :. .:. :.:.:: ::. :::. ...... :: . . : :
NP_004 SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLN-LSSNLFEEFPAALL
240 250 260 270 280 290
310 320 330 340 350 360
pF1KA1 YLHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQI
: .:. .: .. . . ::.:
NP_004 PLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ
300 310 320 330 340 350
>>NP_665894 (OMIM: 605247) p53-induced protein with a de (893 aa)
initn: 260 init1: 165 opt: 316 Z-score: 248.0 bits: 56.8 E(85289): 4.5e-07
Smith-Waterman score: 316; 36.3% identity (64.8% similar) in 182 aa overlap (96-273:124-302)
70 80 90 100 110 120
pF1KA1 ALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEIL
:. .. ::: : : .: . .. .: :
NP_665 SLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGAL
100 110 120 130 140 150
130 140 150 160 170 180
pF1KA1 NLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEI
: :::. .:::. : ::.:....:.:..:: : .: :. : :.: : .:: ::
NP_665 LLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI
160 170 180 190 200 210
190 200 210 220 230 240
pF1KA1 GQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLV-KFDFSCN
: : .:.::... :.. .:: ... :.::: : .. : : .: .:. :::. ..:. :
NP_665 GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN
220 230 240 250 260 270
250 260 270 280 290 300
pF1KA1 KVLVIPICFREMKQLQVLLLENNPL--QSPPAQICTKGKVHIFKYLSIQACQIKTADSLY
.. .: :. . . :..::: :: :
NP_665 QLRDLPP---ELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSFPVTP
280 290 300 310 320 330
310 320 330 340 350 360
pF1KA1 LHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQII
NP_665 QGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAF
340 350 360 370 380 390
>>XP_011518513 (OMIM: 605247) PREDICTED: p53-induced dea (893 aa)
initn: 260 init1: 165 opt: 316 Z-score: 248.0 bits: 56.8 E(85289): 4.5e-07
Smith-Waterman score: 316; 36.3% identity (64.8% similar) in 182 aa overlap (96-273:124-302)
70 80 90 100 110 120
pF1KA1 ALEEAANSGGLNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEIL
:. .. ::: : : .: . .. .: :
XP_011 SLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGAL
100 110 120 130 140 150
130 140 150 160 170 180
pF1KA1 NLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP-LKVLIASNNKLGSLPEEI
: :::. .:::. : ::.:....:.:..:: : .: :. : :.: : .:: ::
XP_011 LLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEI
160 170 180 190 200 210
190 200 210 220 230 240
pF1KA1 GQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLV-KFDFSCN
: : .:.::... :.. .:: ... :.::: : .. : : .: .:. :::. ..:. :
XP_011 GGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDN
220 230 240 250 260 270
250 260 270 280 290 300
pF1KA1 KVLVIPICFREMKQLQVLLLENNPL--QSPPAQICTKGKVHIFKYLSIQACQIKTADSLY
.. .: :. . . :..::: :: :
XP_011 QLRDLPP---ELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPRLFLTSDLDSFPVTP
280 290 300 310 320 330
310 320 330 340 350 360
pF1KA1 LHTMERPHLHQHVEDGKKDSDSGVGSDNGDKRLSATEPSDEDTVSLNVPMSNIMEEEQII
XP_011 QGCSVTLACGVRLQFPAGATATPITIRYRLLLPEPGLVPLGPHDALLSHVLELQPHGVAF
340 350 360 370 380 390
728 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 20:16:17 2016 done: Wed Nov 2 20:16:19 2016
Total Scan time: 12.000 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]