Result of FASTA (omim) for
pFN21AA0439
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0439, 834 aa
1>>>pF1KA0439 834 - 834 aa - 834 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7285+/-0.000357; mu= 4.7554+/- 0.022
mean_var=197.6526+/-40.726, 0's: 0 Z-trim(120.4): 325 B-trim: 0 in 0/55
Lambda= 0.091227
statistics sampled from 35142 (35527) to 35142 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.726), E-opt: 0.2 (0.417), width: 16
Scan time: 12.340
The best scores are: opt bits E(85289)
NP_001138442 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 5781 774.0 0
NP_001138443 (OMIM: 606384) E3 ubiquitin-protein l ( 834) 5781 774.0 0
XP_005266720 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 922) 5781 774.0 0
NP_001138441 (OMIM: 606384) E3 ubiquitin-protein l ( 947) 5781 774.0 0
NP_056092 (OMIM: 606384) E3 ubiquitin-protein liga ( 955) 5781 774.0 0
NP_001138436 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 4208 567.0 1.3e-160
NP_001138438 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 4208 567.0 1.3e-160
NP_001138437 (OMIM: 606384) E3 ubiquitin-protein l ( 854) 4208 567.0 1.3e-160
XP_016881168 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 854) 4208 567.0 1.3e-160
XP_005266717 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 942) 4208 567.0 1.4e-160
NP_001138440 (OMIM: 606384) E3 ubiquitin-protein l ( 967) 4208 567.0 1.4e-160
NP_001138439 (OMIM: 606384) E3 ubiquitin-protein l ( 975) 4208 567.0 1.4e-160
NP_001230889 (OMIM: 606384) E3 ubiquitin-protein l ( 911) 3848 519.6 2.5e-146
XP_016881169 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 750) 3600 486.9 1.4e-136
XP_016881166 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 838) 3600 487.0 1.5e-136
XP_016881170 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 684) 3120 423.7 1.4e-117
XP_006722488 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 772) 3120 423.8 1.5e-117
XP_006722484 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 940) 3006 408.8 5.8e-113
XP_016881167 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 973) 3006 408.8 5.9e-113
NP_001316141 (OMIM: 602278) E3 ubiquitin-protein l ( 753) 2827 385.2 6e-106
XP_011519929 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 827) 2827 385.2 6.4e-106
XP_011519927 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 2827 385.2 6.6e-106
XP_011519928 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 849) 2827 385.2 6.6e-106
XP_011519926 (OMIM: 602278) PREDICTED: E3 ubiquiti ( 875) 2827 385.2 6.7e-106
NP_006145 (OMIM: 602278) E3 ubiquitin-protein liga ( 900) 2827 385.2 6.9e-106
NP_940682 (OMIM: 602278) E3 ubiquitin-protein liga (1247) 2827 385.3 8.9e-106
NP_001271269 (OMIM: 602278) E3 ubiquitin-protein l (1302) 2827 385.4 9.2e-106
NP_001271268 (OMIM: 602278) E3 ubiquitin-protein l (1303) 2827 385.4 9.2e-106
NP_001271267 (OMIM: 602278) E3 ubiquitin-protein l (1319) 2827 385.4 9.3e-106
XP_006722487 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 790) 2798 381.4 8.7e-105
XP_016881165 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 856) 2798 381.4 9.3e-105
XP_006722493 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 872) 2798 381.4 9.4e-105
XP_005266715 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 960) 2798 381.4 1e-104
XP_006722491 (OMIM: 606384) PREDICTED: E3 ubiquiti ( 993) 2798 381.5 1e-104
XP_011524189 (OMIM: 606384) PREDICTED: E3 ubiquiti (1011) 2798 381.5 1.1e-104
XP_006722489 (OMIM: 606384) PREDICTED: E3 ubiquiti (1019) 2798 381.5 1.1e-104
XP_005260627 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 1555 217.8 1.4e-55
XP_011527381 (OMIM: 606409,613385) PREDICTED: E3 u ( 692) 1555 217.8 1.4e-55
NP_001244067 (OMIM: 606409,613385) E3 ubiquitin-pr ( 752) 1555 217.8 1.5e-55
XP_016883580 (OMIM: 606409,613385) PREDICTED: E3 u ( 752) 1555 217.8 1.5e-55
NP_113671 (OMIM: 606409,613385) E3 ubiquitin-prote ( 862) 1555 217.8 1.7e-55
NP_001311127 (OMIM: 606409,613385) E3 ubiquitin-pr ( 862) 1555 217.8 1.7e-55
XP_016883579 (OMIM: 606409,613385) PREDICTED: E3 u ( 900) 1555 217.8 1.7e-55
XP_016883578 (OMIM: 606409,613385) PREDICTED: E3 u ( 903) 1555 217.8 1.7e-55
NP_001244066 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 1555 217.8 1.7e-55
NP_001311126 (OMIM: 606409,613385) E3 ubiquitin-pr ( 903) 1555 217.8 1.7e-55
XP_016868484 (OMIM: 602307) PREDICTED: NEDD4-like ( 743) 1501 210.7 2e-53
XP_016868485 (OMIM: 602307) PREDICTED: NEDD4-like ( 743) 1501 210.7 2e-53
XP_016868482 (OMIM: 602307) PREDICTED: NEDD4-like ( 921) 1501 210.7 2.4e-53
XP_005250818 (OMIM: 602307) PREDICTED: NEDD4-like ( 921) 1501 210.7 2.4e-53
>>NP_001138442 (OMIM: 606384) E3 ubiquitin-protein ligas (834 aa)
initn: 5781 init1: 5781 opt: 5781 Z-score: 4123.7 bits: 774.0 E(85289): 0
Smith-Waterman score: 5781; 100.0% identity (100.0% similar) in 834 aa overlap (1-834:1-834)
10 20 30 40 50 60
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
730 740 750 760 770 780
790 800 810 820 830
pF1KA0 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
790 800 810 820 830
>>NP_001138443 (OMIM: 606384) E3 ubiquitin-protein ligas (834 aa)
initn: 5781 init1: 5781 opt: 5781 Z-score: 4123.7 bits: 774.0 E(85289): 0
Smith-Waterman score: 5781; 100.0% identity (100.0% similar) in 834 aa overlap (1-834:1-834)
10 20 30 40 50 60
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSVAYV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA0 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA0 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNG
730 740 750 760 770 780
790 800 810 820 830
pF1KA0 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
790 800 810 820 830
>>XP_005266720 (OMIM: 606384) PREDICTED: E3 ubiquitin-pr (922 aa)
initn: 5781 init1: 5781 opt: 5781 Z-score: 4123.1 bits: 774.0 E(85289): 0
Smith-Waterman score: 5781; 100.0% identity (100.0% similar) in 834 aa overlap (1-834:89-922)
10 20 30
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMA
::::::::::::::::::::::::::::::
XP_005 VSTGADTTTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMA
60 70 80 90 100 110
40 50 60 70 80 90
pF1KA0 YMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
120 130 140 150 160 170
100 110 120 130 140 150
pF1KA0 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPE
180 190 200 210 220 230
160 170 180 190 200 210
pF1KA0 PWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQ
240 250 260 270 280 290
220 230 240 250 260 270
pF1KA0 REPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
300 310 320 330 340 350
280 290 300 310 320 330
pF1KA0 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK
360 370 380 390 400 410
340 350 360 370 380 390
pF1KA0 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK
420 430 440 450 460 470
400 410 420 430 440 450
pF1KA0 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV
480 490 500 510 520 530
460 470 480 490 500 510
pF1KA0 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE
540 550 560 570 580 590
520 530 540 550 560 570
pF1KA0 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT
600 610 620 630 640 650
580 590 600 610 620 630
pF1KA0 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL
660 670 680 690 700 710
640 650 660 670 680 690
pF1KA0 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF
720 730 740 750 760 770
700 710 720 730 740 750
pF1KA0 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD
780 790 800 810 820 830
760 770 780 790 800 810
pF1KA0 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY
840 850 860 870 880 890
820 830
pF1KA0 ETFEDLREKLLMAVENAQGFEGVD
::::::::::::::::::::::::
XP_005 ETFEDLREKLLMAVENAQGFEGVD
900 910 920
>>NP_001138441 (OMIM: 606384) E3 ubiquitin-protein ligas (947 aa)
initn: 5781 init1: 5781 opt: 5781 Z-score: 4122.9 bits: 774.0 E(85289): 0
Smith-Waterman score: 5781; 100.0% identity (100.0% similar) in 834 aa overlap (1-834:114-947)
10 20 30
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMA
::::::::::::::::::::::::::::::
NP_001 EVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMA
90 100 110 120 130 140
40 50 60 70 80 90
pF1KA0 YMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
150 160 170 180 190 200
100 110 120 130 140 150
pF1KA0 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPE
210 220 230 240 250 260
160 170 180 190 200 210
pF1KA0 PWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQ
270 280 290 300 310 320
220 230 240 250 260 270
pF1KA0 REPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
330 340 350 360 370 380
280 290 300 310 320 330
pF1KA0 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK
390 400 410 420 430 440
340 350 360 370 380 390
pF1KA0 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK
450 460 470 480 490 500
400 410 420 430 440 450
pF1KA0 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV
510 520 530 540 550 560
460 470 480 490 500 510
pF1KA0 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE
570 580 590 600 610 620
520 530 540 550 560 570
pF1KA0 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT
630 640 650 660 670 680
580 590 600 610 620 630
pF1KA0 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL
690 700 710 720 730 740
640 650 660 670 680 690
pF1KA0 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF
750 760 770 780 790 800
700 710 720 730 740 750
pF1KA0 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD
810 820 830 840 850 860
760 770 780 790 800 810
pF1KA0 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY
870 880 890 900 910 920
820 830
pF1KA0 ETFEDLREKLLMAVENAQGFEGVD
::::::::::::::::::::::::
NP_001 ETFEDLREKLLMAVENAQGFEGVD
930 940
>>NP_056092 (OMIM: 606384) E3 ubiquitin-protein ligase N (955 aa)
initn: 5781 init1: 5781 opt: 5781 Z-score: 4122.8 bits: 774.0 E(85289): 0
Smith-Waterman score: 5781; 100.0% identity (100.0% similar) in 834 aa overlap (1-834:122-955)
10 20 30
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMA
::::::::::::::::::::::::::::::
NP_056 EVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMA
100 110 120 130 140 150
40 50 60 70 80 90
pF1KA0 YMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
160 170 180 190 200 210
100 110 120 130 140 150
pF1KA0 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPE
220 230 240 250 260 270
160 170 180 190 200 210
pF1KA0 PWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQ
280 290 300 310 320 330
220 230 240 250 260 270
pF1KA0 REPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 REPSSRLRSCSVTDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT
340 350 360 370 380 390
280 290 300 310 320 330
pF1KA0 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVK
400 410 420 430 440 450
340 350 360 370 380 390
pF1KA0 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLK
460 470 480 490 500 510
400 410 420 430 440 450
pF1KA0 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAV
520 530 540 550 560 570
460 470 480 490 500 510
pF1KA0 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIE
580 590 600 610 620 630
520 530 540 550 560 570
pF1KA0 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFT
640 650 660 670 680 690
580 590 600 610 620 630
pF1KA0 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 FIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTEL
700 710 720 730 740 750
640 650 660 670 680 690
pF1KA0 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGF
760 770 780 790 800 810
700 710 720 730 740 750
pF1KA0 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD
820 830 840 850 860 870
760 770 780 790 800 810
pF1KA0 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPY
880 890 900 910 920 930
820 830
pF1KA0 ETFEDLREKLLMAVENAQGFEGVD
::::::::::::::::::::::::
NP_056 ETFEDLREKLLMAVENAQGFEGVD
940 950
>>NP_001138436 (OMIM: 606384) E3 ubiquitin-protein ligas (854 aa)
initn: 4175 init1: 4175 opt: 4208 Z-score: 3004.7 bits: 567.0 E(85289): 1.3e-160
Smith-Waterman score: 5731; 97.7% identity (97.7% similar) in 854 aa overlap (1-834:1-854)
10 20 30 40 50 60
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
190 200 210 220 230 240
240 250 260 270 280
pF1KA0 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KA0 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
310 320 330 340 350 360
350 360 370 380 390 400
pF1KA0 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
370 380 390 400 410 420
410 420 430 440 450 460
pF1KA0 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
430 440 450 460 470 480
470 480 490 500 510 520
pF1KA0 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KA0 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
550 560 570 580 590 600
590 600 610 620 630 640
pF1KA0 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KA0 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KA0 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
730 740 750 760 770 780
770 780 790 800 810 820
pF1KA0 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
790 800 810 820 830 840
830
pF1KA0 LMAVENAQGFEGVD
::::::::::::::
NP_001 LMAVENAQGFEGVD
850
>>NP_001138438 (OMIM: 606384) E3 ubiquitin-protein ligas (854 aa)
initn: 4175 init1: 4175 opt: 4208 Z-score: 3004.7 bits: 567.0 E(85289): 1.3e-160
Smith-Waterman score: 5731; 97.7% identity (97.7% similar) in 854 aa overlap (1-834:1-854)
10 20 30 40 50 60
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
190 200 210 220 230 240
240 250 260 270 280
pF1KA0 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KA0 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
310 320 330 340 350 360
350 360 370 380 390 400
pF1KA0 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
370 380 390 400 410 420
410 420 430 440 450 460
pF1KA0 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
430 440 450 460 470 480
470 480 490 500 510 520
pF1KA0 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KA0 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
550 560 570 580 590 600
590 600 610 620 630 640
pF1KA0 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KA0 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KA0 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
730 740 750 760 770 780
770 780 790 800 810 820
pF1KA0 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
790 800 810 820 830 840
830
pF1KA0 LMAVENAQGFEGVD
::::::::::::::
NP_001 LMAVENAQGFEGVD
850
>>NP_001138437 (OMIM: 606384) E3 ubiquitin-protein ligas (854 aa)
initn: 4175 init1: 4175 opt: 4208 Z-score: 3004.7 bits: 567.0 E(85289): 1.3e-160
Smith-Waterman score: 5731; 97.7% identity (97.7% similar) in 854 aa overlap (1-834:1-854)
10 20 30 40 50 60
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
190 200 210 220 230 240
240 250 260 270 280
pF1KA0 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KA0 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
310 320 330 340 350 360
350 360 370 380 390 400
pF1KA0 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
370 380 390 400 410 420
410 420 430 440 450 460
pF1KA0 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
430 440 450 460 470 480
470 480 490 500 510 520
pF1KA0 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KA0 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
550 560 570 580 590 600
590 600 610 620 630 640
pF1KA0 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KA0 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KA0 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
730 740 750 760 770 780
770 780 790 800 810 820
pF1KA0 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
790 800 810 820 830 840
830
pF1KA0 LMAVENAQGFEGVD
::::::::::::::
NP_001 LMAVENAQGFEGVD
850
>>XP_016881168 (OMIM: 606384) PREDICTED: E3 ubiquitin-pr (854 aa)
initn: 4175 init1: 4175 opt: 4208 Z-score: 3004.7 bits: 567.0 E(85289): 1.3e-160
Smith-Waterman score: 5731; 97.7% identity (97.7% similar) in 854 aa overlap (1-834:1-854)
10 20 30 40 50 60
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSND
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQIN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSR
130 140 150 160 170 180
190 200 210 220 230
pF1KA0 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPS----
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAG
190 200 210 220 230 240
240 250 260 270 280
pF1KA0 ----------------VAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
::::::::::::::::::::::::::::::::::::::::::::
XP_016 RARSSTVTGGEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLA
250 260 270 280 290 300
290 300 310 320 330 340
pF1KA0 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQ
310 320 330 340 350 360
350 360 370 380 390 400
pF1KA0 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTS
370 380 390 400 410 420
410 420 430 440 450 460
pF1KA0 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKY
430 440 450 460 470 480
470 480 490 500 510 520
pF1KA0 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYG
490 500 510 520 530 540
530 540 550 560 570 580
pF1KA0 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAV
550 560 570 580 590 600
590 600 610 620 630 640
pF1KA0 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEEN
610 620 630 640 650 660
650 660 670 680 690 700
pF1KA0 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KA0 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQF
730 740 750 760 770 780
770 780 790 800 810 820
pF1KA0 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKL
790 800 810 820 830 840
830
pF1KA0 LMAVENAQGFEGVD
::::::::::::::
XP_016 LMAVENAQGFEGVD
850
>>XP_005266717 (OMIM: 606384) PREDICTED: E3 ubiquitin-pr (942 aa)
initn: 4175 init1: 4175 opt: 4208 Z-score: 3004.1 bits: 567.0 E(85289): 1.4e-160
Smith-Waterman score: 5731; 97.7% identity (97.7% similar) in 854 aa overlap (1-834:89-942)
10 20 30
pF1KA0 MERPYTFKDFLLRPRSHKSRVKGFLRLKMA
::::::::::::::::::::::::::::::
XP_005 VSTGADTTTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMA
60 70 80 90 100 110
40 50 60 70 80 90
pF1KA0 YMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYY
120 130 140 150 160 170
100 110 120 130 140 150
pF1KA0 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPE
180 190 200 210 220 230
160 170 180 190 200 210
pF1KA0 PWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPDSNGEQFSSLIQ
240 250 260 270 280 290
220 230 240 250
pF1KA0 REPSSRLRSCSVTDAVAEQGHLPPPS--------------------VAYVHTTPGLPSGW
:::::::::::::::::::::::::: ::::::::::::::
XP_005 REPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGW
300 310 320 330 340 350
260 270 280 290 300 310
pF1KA0 EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPT
360 370 380 390 400 410
320 330 340 350 360 370
pF1KA0 VTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNG
420 430 440 450 460 470
380 390 400 410 420 430
pF1KA0 RPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHNS
480 490 500 510 520 530
440 450 460 470 480 490
pF1KA0 KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES
540 550 560 570 580 590
500 510 520 530 540 550
pF1KA0 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNY
600 610 620 630 640 650
560 570 580 590 600 610
pF1KA0 TLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMES
660 670 680 690 700 710
620 630 640 650 660 670
pF1KA0 VDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLV
720 730 740 750 760 770
680 690 700 710 720 730
pF1KA0 IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKN
780 790 800 810 820 830
740 750 760 770 780 790
pF1KA0 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWG
840 850 860 870 880 890
800 810 820 830
pF1KA0 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD
900 910 920 930 940
834 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 18:56:26 2016 done: Wed Nov 2 18:56:27 2016
Total Scan time: 12.340 Total Display time: 0.290
Function used was FASTA [36.3.4 Apr, 2011]