Result of FASTA (omim) for
pFN21AA0418
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0418, 940 aa
1>>>pF1KA0418 940 - 940 aa - 940 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.3953+/-0.000392; mu= -6.8560+/- 0.025
mean_var=298.1450+/-61.837, 0's: 0 Z-trim(122.0): 60 B-trim: 346 in 1/57
Lambda= 0.074278
statistics sampled from 39306 (39369) to 39306 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.747), E-opt: 0.2 (0.462), width: 16
Scan time: 13.330
The best scores are: opt bits E(85289)
NP_001295104 (OMIM: 249420,613293) SH3 and PX doma ( 430) 620 80.3 2.2e-14
NP_001017995 (OMIM: 249420,613293) SH3 and PX doma ( 911) 522 70.0 6.2e-11
XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 ( 939) 522 70.0 6.3e-11
NP_000256 (OMIM: 233700,608512) neutrophil cytosol ( 390) 384 55.0 8.5e-07
>>NP_001295104 (OMIM: 249420,613293) SH3 and PX domain-c (430 aa)
initn: 877 init1: 345 opt: 620 Z-score: 379.0 bits: 80.3 E(85289): 2.2e-14
Smith-Waterman score: 817; 48.8% identity (68.4% similar) in 285 aa overlap (1-283:152-396)
10 20 30
pF1KA0 MILEQYVVVSNYKKQENSELSLQAGEVVDV
:.:::::::.::.:::.::.::..:.:::.
NP_001 FETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDI
130 140 150 160 170 180
40 50 60 70 80 90
pF1KA0 IEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKD
:::::::::::::.::::::::: ::.:.:..:. ... :::::... :::....:
NP_001 IEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE---EEEKYTVIYPYTARDQD
190 200 210 220 230
100 110 120 130 140 150
pF1KA0 EIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGN
:...:.:..::::.::::::: ::: ::::::::::::: : . :.
NP_001 EMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK----------NSGEPL-----
240 250 260 270 280
160 170 180 190 200 210
pF1KA0 IMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLA
:: : : .: ..: . .: ::: . .:
NP_001 ------------------PPKPGPG--SPSHPGALDLDGVSRQQN--AVGREKELLSSQR
290 300 310 320
220 230 240 250 260
pF1KA0 QGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPPEPPSVEVEYYTIAEFQS
.: . :. ::..: ::::::. .. :..::::: ::.:: :::::::::.
NP_001 DGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQT
330 340 350 360 370 380
270 280 290 300 310 320
pF1KA0 CISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPK
: :::::..: :.:
NP_001 TIPDGISFQAGLKVEDHKNVHLESPVEVPLRRIKMRTALGKHVAASMEM
390 400 410 420 430
>>NP_001017995 (OMIM: 249420,613293) SH3 and PX domain-c (911 aa)
initn: 1222 init1: 370 opt: 522 Z-score: 317.3 bits: 70.0 E(85289): 6.2e-11
Smith-Waterman score: 1244; 32.1% identity (54.2% similar) in 951 aa overlap (1-939:152-910)
10 20 30
pF1KA0 MILEQYVVVSNYKKQENSELSLQAGEVVDV
:.:::::::.::.:::.::.::..:.:::.
NP_001 FETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDI
130 140 150 160 170 180
40 50 60 70 80 90
pF1KA0 IEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKD
:::::::::::::.::::::::: ::.:.:..:. .. . :::::... :::....:
NP_001 IEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSL---QPEEEEKYTVIYPYTARDQD
190 200 210 220 230
100 110 120 130 140 150
pF1KA0 EIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGN
:...:.:..::::.::::::: ::: ::::::::::::: : . :.
NP_001 EMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK----------NSGEPL-----
240 250 260 270 280
160 170 180 190 200 210
pF1KA0 IMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLA
:: : : .: ..: . .: ::: . .:
NP_001 ------------------PPKPGPG--SPSHPGALDLDGVSRQQN--AVGREKELLSSQR
290 300 310 320
220 230 240 250 260
pF1KA0 QGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPPEPPSVEVEYYTIAEFQS
.: . :. ::..: ::::::. .. :..::::: ::.:: :::::::::.
NP_001 DGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQT
330 340 350 360 370 380
270 280 290 300 310 320
pF1KA0 CISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPK
: :::::..: :.:::.:: .::::.:: .:::::::..::: :: ::. .::.
NP_001 TIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKK------TSNASRPN
390 400 410 420 430
330 340 350 360 370 380
pF1KA0 VPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEE-----PV
: : . . . : ..: :.. . . .: : : .:: :.. :
NP_001 FLAPLP-HEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDV
440 450 460 470 480 490
390 400 410 420 430 440
pF1KA0 EDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSAR
.::.. . .. .... . .. .:.. : . : : : .:. :
NP_001 LRKASSDMSASAGYEEISDPDMEE-KPSLPPRKESIIKSEGELLERERERQRTEQL---R
500 510 520 530 540 550
450 460 470 480 490 500
pF1KA0 GSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITI
: . :: . :. : . ..: . : .:. .. :: . . ..
NP_001 GPT--PKPPGVILPMMPAKHIPPA---RDSRRPEPKPDKSRLFQL-KNDMGLECGHKVLA
560 570 580 590 600
510 520 530 540 550 560
pF1KA0 NTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSV
. . .. . .::.. :: :. :: ::. : : : :...:
NP_001 KEV----KKPNLRPISKSKTDL-PEEKPDA----TPQ---------NPFLKSRPQVRP--
610 620 630 640
570 580 590 600 610 620
pF1KA0 RPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSR
.: : . :.....:: .:: .::: .::.:. : .:: .
NP_001 KPAPSPKTEPPQGEDQVDICNLRSKLRP----------AKSQDKSL-------LDGEGPQ
650 660 670 680
630 640 650 660 670 680
pF1KA0 RSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESG
... ... . : :::. ..::
NP_001 AVGGQDVAFSRSFLPG------EGPG----------RAQD--------------------
690 700 710
690 700 710 720 730 740
pF1KA0 WWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQAL
: :. .: .:.. .. : :. : : : .:: . :
NP_001 ----RTGKQDGLSPKE---ISCRAPPRPA-KTTDPV--------SKSVPVP--------L
720 730 740
750 760 770 780 790
pF1KA0 NTVNQSKKATPPIPSKPPGGFGKTS-GTPAVK---MRNGVRQVAVRPQSVFVSPPPKDNN
. . :.. ..:: :: ...: : :. .. ..: : ... ::
NP_001 QEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPF
750 760 770 780 790 800
800 810 820 830 840 850
pF1KA0 LSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNS
:: .:: . : :: . ..:.. :. :.::. :
NP_001 LS------NSLGGQDDTRGKGSLGPWGTGK------IGENREKAAAA------------S
810 820 830 840
860 870 880 890 900 910
pF1KA0 IPVSPVRPKPIEKSQFIHNNLKD-VYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYC
.: . ..::: .::..::.:::..:..::::. .:: :.: .:::.:
NP_001 VPNA--------------DGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFC
850 860 870 880
920 930 940
pF1KA0 QILDGVKPFKGWVPSNYLEKKN
:.:.:. ..::.:::::.::
NP_001 QVLSGAPSWEGWIPSNYLRKKP
890 900 910
>>XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 and (939 aa)
initn: 1229 init1: 370 opt: 522 Z-score: 317.1 bits: 70.0 E(85289): 6.3e-11
Smith-Waterman score: 1198; 31.2% identity (53.0% similar) in 976 aa overlap (1-939:152-938)
10 20 30
pF1KA0 MILEQYVVVSNYKKQENSELSLQAGEVVDV
:.:::::::.::.:::.::.::..:.:::.
XP_016 FETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDI
130 140 150 160 170 180
40 50 60
pF1KA0 IEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDD-------------------------S
:::::::::::::.::::::::: ::.:.:..:. .
XP_016 IEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVSWRYWSLPRPVGRRRTLG
190 200 210 220 230 240
70 80 90 100 110 120
pF1KA0 DINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPAS
:. . . .::::... :::....::...:.:..::::.::::::: ::: :::::::::
XP_016 DLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPAS
250 260 270 280 290 300
130 140 150 160 170 180
pF1KA0 YLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEI
:::: : . :. :: : : .: .
XP_016 YLKK----------NSGEPL-----------------------PPKPGPG--SPSHPGAL
310 320
190 200 210 220 230 240
pF1KA0 SLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--
.: . .: ::: . .: .: . :. ::..: ::::::. ..
XP_016 DLDGVSRQQN--AVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPR
330 340 350 360 370 380
250 260 270 280 290 300
pF1KA0 GFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGW
:..::::: ::.:: :::::::::. : :::::..: :.:::.:: .::::.:: .::::
XP_016 GLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGW
390 400 410 420 430 440
310 320 330 340 350 360
pF1KA0 APASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEP
:::..::: :: ::. .::. : : . . . : ..: :.. . . .:
XP_016 APATFIDKYKK------TSNASRPNFLAPLP-HEVTQLRLGEAAALENNTGSEATGPSRP
450 460 470 480 490
370 380 390 400 410
pF1KA0 EYDIPAFGFDSEPELSEE-----PVEDRASGERRPAQPHRPSPASSLQRARFKVGESSED
: : .:: :.. : .::.. . .. .... . .. .:.
XP_016 LPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEE-KPSLPPRKES
500 510 520 530 540 550
420 430 440 450 460 470
pF1KA0 VALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKL
. : . : : : .:. :: . :: . :. : . ..: .
XP_016 IIKSEGELLERERERQRTEQL---RGPT--PKPPGVILPMMPAKHIPPA---RDSRRPEP
560 570 580 590 600
480 490 500 510 520 530
pF1KA0 KAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGT
: .:. .. :: . . .. . . .. . .::.. :: :. :: :
XP_016 KPDKSRLFQL-KNDMGLECGHKVLAKEV----KKPNLRPISKSKTDL-PEEKPDA----T
610 620 630 640 650
540 550 560 570 580 590
pF1KA0 PKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGG
:. : : : :...: .: : . :.....:: .:: .:::
XP_016 PQ---------NPFLKSRPQVRP--KPAPSPKTEPPQGEDQVDICNLRSKLRP-------
660 670 680 690 700
600 610 620 630 640 650
pF1KA0 LKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAY
.::.:. : .:: . ... ... . : :::.
XP_016 ---AKSQDKSL-------LDGEGPQAVGGQDVAFSRSFLPG------EGPG---------
710 720 730
660 670 680 690 700 710
pF1KA0 QKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDT
..:: : :. .: .:.. .. : :. : :
XP_016 -RAQD------------------------RTGKQDGLSPKE---ISCRAPPRPA-KTTDP
740 750 760
720 730 740 750 760 770
pF1KA0 VPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTS-GTPAVK---
: .:: . :. . :.. ..:: :: ...: : :.
XP_016 V--------SKSVPVP--------LQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQ
770 780 790 800 810
780 790 800 810 820 830
pF1KA0 MRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAE
.. ..: : ... :: :: .:: . : :: . ..:..
XP_016 CEGHESRAAPTPGRALLVPPKAKPFLS------NSLGGQDDTRGKGSLGPWGTGK-----
820 830 840 850
840 850 860 870 880 890
pF1KA0 AKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKD-VYVSIADYEGD
:. :.::. :.: . ..::: .::..::.:::
XP_016 -IGENREKAAAA------------SVPNA--------------DGLKDSLYVAVADFEGD
860 870 880 890
900 910 920 930 940
pF1KA0 EETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN
..:..::::. .:: :.: .:::.::.:.:. ..::.:::::.::
XP_016 KDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
900 910 920 930
>>NP_000256 (OMIM: 233700,608512) neutrophil cytosol fac (390 aa)
initn: 385 init1: 235 opt: 384 Z-score: 243.0 bits: 55.0 E(85289): 8.5e-07
Smith-Waterman score: 384; 38.3% identity (73.0% similar) in 141 aa overlap (1-141:156-294)
10 20 30
pF1KA0 MILEQYVVVSNYKKQENSELSLQAGEVVDV
.::. : ...::.: .::..:..:.::.:
NP_000 KLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEV
130 140 150 160 170 180
40 50 60 70 80 90
pF1KA0 IEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKD
.::.:::::: . . ..::.::..:: .. . : . . .:: ::... ::. :
NP_000 VEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGE--PYVAIKAYTAVEGD
190 200 210 220 230 240
100 110 120 130 140 150
pF1KA0 EIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGN
:... .: .::::.: :.::: :: :. :. ::.:. .:. ....
NP_000 EVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRS
250 260 270 280 290 300
160 170 180 190 200 210
pF1KA0 IMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLA
NP_000 SIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQP
310 320 330 340 350 360
940 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 18:52:48 2016 done: Wed Nov 2 18:52:49 2016
Total Scan time: 13.330 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]