Result of FASTA (omim) for
pFN21AA0267
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0267, 669 aa
1>>>pF1KA0267 669 - 669 aa - 669 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5451+/-0.000405; mu= 17.5937+/- 0.025
mean_var=64.3562+/-13.177, 0's: 0 Z-trim(110.6): 73 B-trim: 1085 in 1/52
Lambda= 0.159874
statistics sampled from 18930 (19010) to 18930 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.223), width: 16
Scan time: 7.660
The best scores are: opt bits E(85289)
NP_006350 (OMIM: 300231,300243) sodium/hydrogen ex ( 669) 4408 1026.1 0
NP_001317581 (OMIM: 300231,300243) sodium/hydrogen ( 617) 4040 941.2 0
XP_016884714 (OMIM: 300231,300243) PREDICTED: sodi ( 617) 4040 941.2 0
NP_001171122 (OMIM: 300231,300243) sodium/hydrogen ( 649) 3471 810.0 0
XP_006724789 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 3471 810.0 0
XP_016884712 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 3471 810.0 0
XP_016884713 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 3471 810.0 0
NP_001036002 (OMIM: 300231,300243) sodium/hydrogen ( 701) 3471 810.0 0
XP_016861692 (OMIM: 608396,613410) PREDICTED: sodi ( 528) 2153 505.9 1.5e-142
NP_775924 (OMIM: 608396,613410) sodium/hydrogen ex ( 645) 2150 505.3 2.9e-142
XP_016885395 (OMIM: 300368) PREDICTED: sodium/hydr ( 706) 2064 485.5 2.9e-136
XP_006724627 (OMIM: 300368) PREDICTED: sodium/hydr ( 706) 2064 485.5 2.9e-136
XP_005272738 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 2038 479.5 1.9e-134
XP_005272739 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 2038 479.5 1.9e-134
NP_001244220 (OMIM: 300368) sodium/hydrogen exchan ( 726) 2038 479.5 1.9e-134
XP_011542292 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 2038 479.5 1.9e-134
XP_016885394 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 2038 479.5 1.9e-134
NP_115980 (OMIM: 300368) sodium/hydrogen exchanger ( 725) 2007 472.3 2.7e-132
XP_016861691 (OMIM: 608396,613410) PREDICTED: sodi ( 578) 1906 449.0 2.3e-125
XP_011511005 (OMIM: 608396,613410) PREDICTED: sodi ( 429) 1682 397.3 6.3e-110
XP_011511006 (OMIM: 608396,613410) PREDICTED: sodi ( 369) 973 233.7 9.3e-61
NP_056081 (OMIM: 612730) sodium/hydrogen exchanger ( 581) 889 214.4 9.4e-55
NP_001247420 (OMIM: 612730) sodium/hydrogen exchan ( 597) 758 184.2 1.2e-45
NP_003039 (OMIM: 600530) sodium/hydrogen exchanger ( 812) 682 166.7 3e-40
NP_004165 (OMIM: 182307,616868) sodium/hydrogen ex ( 834) 670 164.0 2.1e-39
NP_001011552 (OMIM: 600531) sodium/hydrogen exchan ( 798) 664 162.6 5.2e-39
NP_001271280 (OMIM: 182307,616868) sodium/hydrogen ( 825) 659 161.4 1.2e-38
XP_016879083 (OMIM: 600477) PREDICTED: sodium/hydr ( 544) 649 159.0 4.1e-38
NP_003038 (OMIM: 107310,616291) sodium/hydrogen ex ( 815) 651 159.6 4.3e-38
NP_001310900 (OMIM: 600477) sodium/hydrogen exchan ( 675) 649 159.1 5e-38
XP_011540323 (OMIM: 107310,616291) PREDICTED: sodi ( 705) 649 159.1 5.2e-38
NP_001310902 (OMIM: 600477) sodium/hydrogen exchan ( 895) 649 159.1 6.4e-38
NP_004585 (OMIM: 600477) sodium/hydrogen exchanger ( 896) 649 159.1 6.4e-38
XP_011527041 (OMIM: 612730) PREDICTED: sodium/hydr ( 589) 613 150.8 1.4e-35
XP_011509460 (OMIM: 600531) PREDICTED: sodium/hydr ( 769) 547 135.6 6.7e-31
XP_011527039 (OMIM: 612730) PREDICTED: sodium/hydr ( 602) 543 134.6 1e-30
XP_011527045 (OMIM: 612730) PREDICTED: sodium/hydr ( 334) 531 131.8 4.2e-30
XP_016883245 (OMIM: 612730) PREDICTED: sodium/hydr ( 334) 531 131.8 4.2e-30
XP_011527044 (OMIM: 612730) PREDICTED: sodium/hydr ( 395) 531 131.8 4.8e-30
XP_016883244 (OMIM: 612730) PREDICTED: sodium/hydr ( 395) 531 131.8 4.8e-30
XP_011527042 (OMIM: 612730) PREDICTED: sodium/hydr ( 564) 531 131.8 6.6e-30
XP_016883243 (OMIM: 612730) PREDICTED: sodium/hydr ( 565) 531 131.8 6.6e-30
XP_006723819 (OMIM: 612730) PREDICTED: sodium/hydr ( 614) 531 131.9 7.1e-30
XP_011527038 (OMIM: 612730) PREDICTED: sodium/hydr ( 630) 531 131.9 7.3e-30
NP_001310901 (OMIM: 600477) sodium/hydrogen exchan ( 795) 502 125.2 9.2e-28
XP_011527046 (OMIM: 612730) PREDICTED: sodium/hydr ( 304) 457 114.7 5.3e-25
XP_011527040 (OMIM: 612730) PREDICTED: sodium/hydr ( 591) 435 109.7 3.2e-23
XP_011527043 (OMIM: 612730) PREDICTED: sodium/hydr ( 558) 244 65.6 5.5e-10
NP_001310903 (OMIM: 600477) sodium/hydrogen exchan ( 600) 233 63.1 3.4e-09
NP_001310904 (OMIM: 600477) sodium/hydrogen exchan ( 601) 233 63.1 3.4e-09
>>NP_006350 (OMIM: 300231,300243) sodium/hydrogen exchan (669 aa)
initn: 4408 init1: 4408 opt: 4408 Z-score: 5489.5 bits: 1026.1 E(85289): 0
Smith-Waterman score: 4408; 100.0% identity (100.0% similar) in 669 aa overlap (1-669:1-669)
10 20 30 40 50 60
pF1KA0 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 HVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSIL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 AYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA0 ELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA0 GSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA0 TQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA0 IFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA0 TTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA0 FDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA0 TYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNL
610 620 630 640 650 660
pF1KA0 LDNTRHGPA
:::::::::
NP_006 LDNTRHGPA
>>NP_001317581 (OMIM: 300231,300243) sodium/hydrogen exc (617 aa)
initn: 4040 init1: 4040 opt: 4040 Z-score: 5031.4 bits: 941.2 E(85289): 0
Smith-Waterman score: 4040; 100.0% identity (100.0% similar) in 617 aa overlap (53-669:1-617)
30 40 50 60 70 80
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
::::::::::::::::::::::::::::::
NP_001 MDEEIVSEKQAEESHRQDSANLLIFILLLT
10 20 30
90 100 110 120 130 140
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA0 LVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCV
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA0 TLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA0 AIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKL
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA0 REFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLF
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA0 ELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRS
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA0 KIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLS
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA0 CLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLP
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA0 ACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMG
520 530 540 550 560 570
630 640 650 660
pF1KA0 NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
580 590 600 610
>>XP_016884714 (OMIM: 300231,300243) PREDICTED: sodium/h (617 aa)
initn: 4040 init1: 4040 opt: 4040 Z-score: 5031.4 bits: 941.2 E(85289): 0
Smith-Waterman score: 4040; 100.0% identity (100.0% similar) in 617 aa overlap (53-669:1-617)
30 40 50 60 70 80
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
::::::::::::::::::::::::::::::
XP_016 MDEEIVSEKQAEESHRQDSANLLIFILLLT
10 20 30
90 100 110 120 130 140
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KA0 LVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCV
100 110 120 130 140 150
210 220 230 240 250 260
pF1KA0 TLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KA0 AIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKL
220 230 240 250 260 270
330 340 350 360 370 380
pF1KA0 REFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLF
280 290 300 310 320 330
390 400 410 420 430 440
pF1KA0 ELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRS
340 350 360 370 380 390
450 460 470 480 490 500
pF1KA0 KIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLS
400 410 420 430 440 450
510 520 530 540 550 560
pF1KA0 CLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLP
460 470 480 490 500 510
570 580 590 600 610 620
pF1KA0 ACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMG
520 530 540 550 560 570
630 640 650 660
pF1KA0 NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
580 590 600 610
>>NP_001171122 (OMIM: 300231,300243) sodium/hydrogen exc (649 aa)
initn: 3470 init1: 3470 opt: 3471 Z-score: 4321.7 bits: 810.0 E(85289): 0
Smith-Waterman score: 3966; 95.1% identity (95.1% similar) in 649 aa overlap (53-669:1-649)
30 40 50 60 70 80
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
::::::::::::::::::::::::::::::
NP_001 MDEEIVSEKQAEESHRQDSANLLIFILLLT
10 20 30
90 100 110 120 130 140
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
40 50 60 70 80 90
150 160 170
pF1KA0 LV--------------------------------TFDPEVFFNILLPPIIFYAGYSLKRR
:: ::::::::::::::::::::::::::
NP_001 LVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR
100 110 120 130 140 150
180 190 200 210 220 230
pF1KA0 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
160 170 180 190 200 210
240 250 260 270 280 290
pF1KA0 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KA0 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
280 290 300 310 320 330
360 370 380 390 400 410
pF1KA0 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
340 350 360 370 380 390
420 430 440 450 460 470
pF1KA0 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
400 410 420 430 440 450
480 490 500 510 520 530
pF1KA0 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
460 470 480 490 500 510
540 550 560 570 580 590
pF1KA0 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
520 530 540 550 560 570
600 610 620 630 640 650
pF1KA0 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
580 590 600 610 620 630
660
pF1KA0 MDDSEPPLNLLDNTRHGPA
:::::::::::::::::::
NP_001 MDDSEPPLNLLDNTRHGPA
640
>>XP_006724789 (OMIM: 300231,300243) PREDICTED: sodium/h (649 aa)
initn: 3470 init1: 3470 opt: 3471 Z-score: 4321.7 bits: 810.0 E(85289): 0
Smith-Waterman score: 3966; 95.1% identity (95.1% similar) in 649 aa overlap (53-669:1-649)
30 40 50 60 70 80
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
::::::::::::::::::::::::::::::
XP_006 MDEEIVSEKQAEESHRQDSANLLIFILLLT
10 20 30
90 100 110 120 130 140
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
40 50 60 70 80 90
150 160 170
pF1KA0 LV--------------------------------TFDPEVFFNILLPPIIFYAGYSLKRR
:: ::::::::::::::::::::::::::
XP_006 LVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR
100 110 120 130 140 150
180 190 200 210 220 230
pF1KA0 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
160 170 180 190 200 210
240 250 260 270 280 290
pF1KA0 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KA0 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
280 290 300 310 320 330
360 370 380 390 400 410
pF1KA0 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
340 350 360 370 380 390
420 430 440 450 460 470
pF1KA0 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
400 410 420 430 440 450
480 490 500 510 520 530
pF1KA0 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
460 470 480 490 500 510
540 550 560 570 580 590
pF1KA0 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
520 530 540 550 560 570
600 610 620 630 640 650
pF1KA0 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
580 590 600 610 620 630
660
pF1KA0 MDDSEPPLNLLDNTRHGPA
:::::::::::::::::::
XP_006 MDDSEPPLNLLDNTRHGPA
640
>>XP_016884712 (OMIM: 300231,300243) PREDICTED: sodium/h (649 aa)
initn: 3470 init1: 3470 opt: 3471 Z-score: 4321.7 bits: 810.0 E(85289): 0
Smith-Waterman score: 3966; 95.1% identity (95.1% similar) in 649 aa overlap (53-669:1-649)
30 40 50 60 70 80
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
::::::::::::::::::::::::::::::
XP_016 MDEEIVSEKQAEESHRQDSANLLIFILLLT
10 20 30
90 100 110 120 130 140
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
40 50 60 70 80 90
150 160 170
pF1KA0 LV--------------------------------TFDPEVFFNILLPPIIFYAGYSLKRR
:: ::::::::::::::::::::::::::
XP_016 LVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR
100 110 120 130 140 150
180 190 200 210 220 230
pF1KA0 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
160 170 180 190 200 210
240 250 260 270 280 290
pF1KA0 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KA0 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
280 290 300 310 320 330
360 370 380 390 400 410
pF1KA0 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
340 350 360 370 380 390
420 430 440 450 460 470
pF1KA0 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
400 410 420 430 440 450
480 490 500 510 520 530
pF1KA0 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
460 470 480 490 500 510
540 550 560 570 580 590
pF1KA0 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
520 530 540 550 560 570
600 610 620 630 640 650
pF1KA0 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
580 590 600 610 620 630
660
pF1KA0 MDDSEPPLNLLDNTRHGPA
:::::::::::::::::::
XP_016 MDDSEPPLNLLDNTRHGPA
640
>>XP_016884713 (OMIM: 300231,300243) PREDICTED: sodium/h (649 aa)
initn: 3470 init1: 3470 opt: 3471 Z-score: 4321.7 bits: 810.0 E(85289): 0
Smith-Waterman score: 3966; 95.1% identity (95.1% similar) in 649 aa overlap (53-669:1-649)
30 40 50 60 70 80
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
::::::::::::::::::::::::::::::
XP_016 MDEEIVSEKQAEESHRQDSANLLIFILLLT
10 20 30
90 100 110 120 130 140
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
40 50 60 70 80 90
150 160 170
pF1KA0 LV--------------------------------TFDPEVFFNILLPPIIFYAGYSLKRR
:: ::::::::::::::::::::::::::
XP_016 LVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR
100 110 120 130 140 150
180 190 200 210 220 230
pF1KA0 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
160 170 180 190 200 210
240 250 260 270 280 290
pF1KA0 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KA0 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
280 290 300 310 320 330
360 370 380 390 400 410
pF1KA0 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
340 350 360 370 380 390
420 430 440 450 460 470
pF1KA0 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
400 410 420 430 440 450
480 490 500 510 520 530
pF1KA0 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
460 470 480 490 500 510
540 550 560 570 580 590
pF1KA0 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
520 530 540 550 560 570
600 610 620 630 640 650
pF1KA0 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
580 590 600 610 620 630
660
pF1KA0 MDDSEPPLNLLDNTRHGPA
:::::::::::::::::::
XP_016 MDDSEPPLNLLDNTRHGPA
640
>>NP_001036002 (OMIM: 300231,300243) sodium/hydrogen exc (701 aa)
initn: 3470 init1: 3470 opt: 3471 Z-score: 4321.2 bits: 810.0 E(85289): 0
Smith-Waterman score: 4334; 95.4% identity (95.4% similar) in 701 aa overlap (1-669:1-701)
10 20 30 40 50 60
pF1KA0 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
70 80 90 100 110 120
130 140
pF1KA0 HVPSDVNNVTLSCEVQSSPTTLLV--------------------------------TFDP
:::::::::::::::::::::::: ::::
NP_001 HVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDP
130 140 150 160 170 180
150 160 170 180 190 200
pF1KA0 EVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVT
190 200 210 220 230 240
210 220 230 240 250 260
pF1KA0 GQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSS
250 260 270 280 290 300
270 280 290 300 310 320
pF1KA0 SIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KA0 ETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFL
370 380 390 400 410 420
390 400 410 420 430 440
pF1KA0 AENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNF
430 440 450 460 470 480
450 460 470 480 490 500
pF1KA0 QHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRV
490 500 510 520 530 540
510 520 530 540 550 560
pF1KA0 GVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPI
550 560 570 580 590 600
570 580 590 600 610 620
pF1KA0 ARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDA
610 620 630 640 650 660
630 640 650 660
pF1KA0 LDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
:::::::::::::::::::::::::::::::::::::::::
NP_001 LDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
670 680 690 700
>>XP_016861692 (OMIM: 608396,613410) PREDICTED: sodium/h (528 aa)
initn: 2076 init1: 1464 opt: 2153 Z-score: 2680.2 bits: 505.9 E(85289): 1.5e-142
Smith-Waterman score: 2166; 65.1% identity (84.5% similar) in 516 aa overlap (143-645:9-521)
120 130 140 150 160 170
pF1KA0 GLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHF
..:::::.:::.:::::::.::::::.:::
XP_016 MKLEEQWCMMTFDPEIFFNVLLPPIIFHAGYSLKKRHF
10 20 30
180 190 200 210 220 230
pF1KA0 FRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLA-GDFYFTDCLLFGAIVSATD
:.::::::.::::::::::.::: :::: : : .::: :::.:::::.::...::::
XP_016 FQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTDCLFFGSLMSATD
40 50 60 70 80 90
240 250 260 270 280 290
pF1KA0 PVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKS
:::::::::::.:: .::.::::::::::::::::. :: :.: .: ..::..:.:.:
XP_016 PVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK-ENPNAFDAAAFFQS
100 110 120 130 140 150
300 310 320 330 340 350
pF1KA0 IGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTG
.: :::::.::::::.: ...:::.:::::: :: .::::::::.:::.:: ::: :.::
XP_016 VGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTG
160 170 180 190 200 210
360 370 380 390 400 410
pF1KA0 VVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP
.:::::::.:::::::::::..:. :::::::..:::::: :: ::::.:::::::.::
XP_016 IVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA
220 230 240 250 260 270
420 430 440 450 460 470
pF1KA0 TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTA
:..:::.:::..:: ::::::.::::::..:: ::::::::.:::::.:::::::.:
XP_016 LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTE
280 290 300 310 320 330
480 490 500 510 520
pF1KA0 TYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQ--------EHLGVPENE
. .::::.::::.::::::::::::: ::. :.:::::: :. .: . . .
XP_016 SQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQEANNLD
340 350 360 370 380 390
530 540 550 560 570 580
pF1KA0 RRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQ
. :::::: ::::::.:::.::::.::::::::::::: ::::.: ::::::: ::
XP_016 KNMTKAESARLFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQAY--GEQ
400 410 420 430 440 450
590 600 610 620 630
pF1KA0 LKDDDSDLILNDGDISLTYGD--STVNTEPATSSAPRRFMGNS--SEDALDRELAFGDHE
::.:: . :.:. .....: . :. . :: . .. .. .:. . .:..: .:
XP_016 LKEDDVECIVNQDELAINYQEQASSPCSPPARLGLDQKASPQTPGKENIYEGDLGLGGYE
460 470 480 490 500 510
640 650 660
pF1KA0 LVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
: .. :
XP_016 LKLEQTLGQSQLN
520
>>NP_775924 (OMIM: 608396,613410) sodium/hydrogen exchan (645 aa)
initn: 2340 init1: 1464 opt: 2150 Z-score: 2675.1 bits: 505.3 E(85289): 2.9e-142
Smith-Waterman score: 2372; 60.2% identity (80.0% similar) in 636 aa overlap (57-645:7-638)
30 40 50 60 70 80
pF1KA0 PLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTIL
..:::. . ..: ...::.: .:: ::::
NP_775 MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTIL
10 20 30
90 100 110 120 130 140
pF1KA0 TIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTL-SC-EVQSSPTTLLV
::::::..: ::::::: ::.:::..::.:::. .:.:... :. .: .. ::.::::
NP_775 TIWLFKNHRFRFLHETGGAMVYGLIMGLILRYAT-APTDIESGTVYDCVKLTFSPSTLLV
40 50 60 70 80 90
150 160 170
pF1KA0 --------------------------------TFDPEVFFNILLPPIIFYAGYSLKRRHF
:::::.:::.:::::::.::::::.:::
NP_775 NITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHF
100 110 120 130 140 150
180 190 200 210 220 230
pF1KA0 FRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLA-GDFYFTDCLLFGAIVSATD
:.::::::.::::::::::.::: :::: : : .::: :::.:::::.::...::::
NP_775 FQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTDCLFFGSLMSATD
160 170 180 190 200 210
240 250 260 270 280 290
pF1KA0 PVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKS
:::::::::::.:: .::.::::::::::::::::. :: :.: .: ..::..:.:.:
NP_775 PVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK-ENPNAFDAAAFFQS
220 230 240 250 260 270
300 310 320 330 340 350
pF1KA0 IGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTG
.: :::::.::::::.: ...:::.:::::: :: .::::::::.:::.:: ::: :.::
NP_775 VGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTG
280 290 300 310 320 330
360 370 380 390 400 410
pF1KA0 VVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP
.:::::::.:::::::::::..:. :::::::..:::::: :: ::::.:::::::.::
NP_775 IVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA
340 350 360 370 380 390
420 430 440 450 460 470
pF1KA0 TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTA
:..:::.:::..:: ::::::.::::::..:: ::::::::.:::::.:::::::.:
NP_775 LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTE
400 410 420 430 440 450
480 490 500 510 520
pF1KA0 TYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQ--------EHLGVPENE
. .::::.::::.::::::::::::: ::. :.:::::: :. .: . . .
NP_775 SQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQEANNLD
460 470 480 490 500 510
530 540 550 560 570 580
pF1KA0 RRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQ
. :::::: ::::::.:::.::::.::::::::::::: ::::.: ::::::: ::
NP_775 KNMTKAESARLFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQAY--GEQ
520 530 540 550 560 570
590 600 610 620 630
pF1KA0 LKDDDSDLILNDGDISLTYGD--STVNTEPATSSAPRRFMGNS--SEDALDRELAFGDHE
::.:: . :.:. .....: . :. . :: . .. .. .:. . .:..: .:
NP_775 LKEDDVECIVNQDELAINYQEQASSPCSPPARLGLDQKASPQTPGKENIYEGDLGLGGYE
580 590 600 610 620 630
640 650 660
pF1KA0 LVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
: .. :
NP_775 LKLEQTLGQSQLN
640
669 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 18:27:57 2016 done: Wed Nov 2 18:27:58 2016
Total Scan time: 7.660 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]