Result of FASTA (omim) for
pFN21AA0116
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA0116, 291 aa
1>>>pF1KA0116 291 - 291 aa - 291 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3318+/-0.000373; mu= 14.5236+/- 0.023
mean_var=59.1456+/-11.930, 0's: 0 Z-trim(111.2): 27 B-trim: 151 in 2/55
Lambda= 0.166768
statistics sampled from 19766 (19779) to 19766 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.603), E-opt: 0.2 (0.232), width: 16
Scan time: 6.650
The best scores are: opt bits E(85289)
NP_055819 (OMIM: 606488) exosome complex component ( 291) 1904 466.6 2.4e-131
XP_016861419 (OMIM: 606488) PREDICTED: exosome com ( 210) 1345 332.1 5.6e-91
NP_852480 (OMIM: 606019,616081) exosome complex co ( 276) 374 98.5 1.5e-20
XP_011530337 (OMIM: 606180) PREDICTED: exosome com ( 392) 375 98.8 1.8e-20
NP_005024 (OMIM: 606180) exosome complex component ( 439) 375 98.8 1.9e-20
XP_006719826 (OMIM: 606019,616081) PREDICTED: exos ( 313) 373 98.3 2e-20
NP_001029366 (OMIM: 606180) exosome complex compon ( 456) 375 98.8 2e-20
>>NP_055819 (OMIM: 606488) exosome complex component RRP (291 aa)
initn: 1904 init1: 1904 opt: 1904 Z-score: 2478.9 bits: 466.6 E(85289): 2.4e-131
Smith-Waterman score: 1904; 99.7% identity (100.0% similar) in 291 aa overlap (1-291:1-291)
10 20 30 40 50 60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA0 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA0 ELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMR
190 200 210 220 230 240
250 260 270 280 290
pF1KA0 KVGKGSLDPESIFEMMETGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
:::::::::::::::::::::::::::::::::.:::::::::::::::::
NP_055 KVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
250 260 270 280 290
>>XP_016861419 (OMIM: 606488) PREDICTED: exosome complex (210 aa)
initn: 1345 init1: 1345 opt: 1345 Z-score: 1754.3 bits: 332.1 E(85289): 5.6e-91
Smith-Waterman score: 1345; 99.5% identity (100.0% similar) in 206 aa overlap (86-291:5-210)
60 70 80 90 100 110
pF1KA0 TDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNN
::::::::::::::::::::::::::::::
XP_016 MASSSASATPEFEGRGGDDLGTEIANTLYRIFNN
10 20 30
120 130 140 150 160 170
pF1KA0 KSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEE
40 50 60 70 80 90
180 190 200 210 220 230
pF1KA0 GSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGV
100 110 120 130 140 150
240 250 260 270 280 290
pF1KA0 VTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_016 VTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
160 170 180 190 200 210
>>NP_852480 (OMIM: 606019,616081) exosome complex compon (276 aa)
initn: 391 init1: 316 opt: 374 Z-score: 489.9 bits: 98.5 E(85289): 1.5e-20
Smith-Waterman score: 374; 28.9% identity (62.8% similar) in 266 aa overlap (18-276:18-276)
10 20 30 40 50 60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
..:. : ::: ..: . :. .:...::: ::::.: ..
NP_852 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC
10 20 30 40 50 60
70 80 90 100 110
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFE-GRGGDDLGTEIANTLYR-IFNNKSS
:::::...:. . :..::. :: . .:. : :.. ...:. . ...:..
NP_852 GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEE--AQVASQFIADVIENSQI
70 80 90 100 110
120 130 140 150 160 170
pF1KA0 VDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSK
.. . ::::: . :::: :.. :. ::..:: ..:. ::: :...:.: . : : .
NP_852 IQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINE-ETALA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KA0 DIELSDDPYDCIRLSVENVPCIVTLCKIGYRH-VVDATLQEEACSLASLLVSVTSKGVVT
...:. : :.... : ... . .:: : .:: . ..: . . .: .
NP_852 EVNLKKKSY----LNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLC
180 190 200 210 220 230
240 250 260 270 280 290
pF1KA0 CMRKVGKGSLDPESIFEMMETG----KRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
:..: : ..: .. . : . :.: :.. ..:. :
NP_852 CLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
240 250 260 270
>>XP_011530337 (OMIM: 606180) PREDICTED: exosome complex (392 aa)
initn: 355 init1: 262 opt: 375 Z-score: 488.7 bits: 98.8 E(85289): 1.8e-20
Smith-Waterman score: 375; 28.9% identity (60.2% similar) in 294 aa overlap (1-289:1-284)
10 20 30 40 50 60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
: . ::. :. .......: :.::: ::: ... .. : :.::.: .:
XP_011 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRIS---FGTDYGCCIVELGKTRVLG
10 20 30 40 50
70 80 90 100 110 120
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
:. :. .:::.. .:: : : .. : :.: :: .:: ... . : . :.. .:
XP_011 QVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCID
60 70 80 90 100 110
130 140 150 160 170 180
pF1KA0 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
..::. :. : . ::. ::. ::..:: :::. .:: . : : : : :: .
XP_011 TESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-----V
120 130 140 150 160 170
190 200 210 220 230
pF1KA0 EL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVT
: . . : . ::....: :. .. . : .:: . .:: . .::: . .:
XP_011 TLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERV-MDGLLVIAMNKHREI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KA0 C-MRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
: ... : : ..... . .: .:... . :.. :...... . : ::
XP_011 CTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKA-LENDQKVRKEGGKFGFAESIAN
240 250 260 270 280 290
XP_011 QRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDL
300 310 320 330 340 350
>>NP_005024 (OMIM: 606180) exosome complex component RRP (439 aa)
initn: 355 init1: 262 opt: 375 Z-score: 487.9 bits: 98.8 E(85289): 1.9e-20
Smith-Waterman score: 375; 28.9% identity (60.2% similar) in 294 aa overlap (1-289:1-284)
10 20 30 40 50 60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
: . ::. :. .......: :.::: ::: ... .. : :.::.: .:
NP_005 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRIS---FGTDYGCCIVELGKTRVLG
10 20 30 40 50
70 80 90 100 110 120
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
:. :. .:::.. .:: : : .. : :.: :: .:: ... . : . :.. .:
NP_005 QVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCID
60 70 80 90 100 110
130 140 150 160 170 180
pF1KA0 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
..::. :. : . ::. ::. ::..:: :::. .:: . : : : : :: .
NP_005 TESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-----V
120 130 140 150 160 170
190 200 210 220 230
pF1KA0 EL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVT
: . . : . ::....: :. .. . : .:: . .:: . .::: . .:
NP_005 TLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERV-MDGLLVIAMNKHREI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KA0 C-MRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
: ... : : ..... . .: .:... . :.. :...... . : ::
NP_005 CTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKA-LENDQKVRKEGGKFGFAESIAN
240 250 260 270 280 290
NP_005 QRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDL
300 310 320 330 340 350
>>XP_006719826 (OMIM: 606019,616081) PREDICTED: exosome (313 aa)
initn: 378 init1: 303 opt: 373 Z-score: 487.7 bits: 98.3 E(85289): 2e-20
Smith-Waterman score: 373; 28.7% identity (63.0% similar) in 265 aa overlap (19-276:56-313)
10 20 30 40
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGS
.:. : ::: ..: . :. .:...::
XP_006 RVESAAAEQARRRGAAQAQTRGREDGGWVQKENCRPDGRELGEFRTTTVNIGSISTADGS
30 40 50 60 70 80
50 60 70 80 90 100
pF1KA0 ARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFE-GRGGDDLGTEIAN
: ::::.: .. :::::...:. . :..::. :: . .:. : :.. ...:.
XP_006 ALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEE--AQVAS
90 100 110 120 130 140
110 120 130 140 150 160
pF1KA0 TLYR-IFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIP
. ...:.. .. . ::::: . :::: :.. :. ::..:: ..:. ::: :...:
XP_006 QFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLP
150 160 170 180 190 200
170 180 190 200 210 220
pF1KA0 RVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRH-VVDATLQEEACSLAS
.: . ..: . ...:. : :.... : ... . .:: : .:: . ..
XP_006 EVTI-NEETALAEVNLKKKSY----LNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGT
210 220 230 240 250
230 240 250 260 270 280
pF1KA0 LLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETG----KRVGKVLHASLQSVLHKEESLG
: . . .: . :..: : ..: .. . : . :.: :.. ..:. :
XP_006 LTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK
260 270 280 290 300 310
290
pF1KA0 PKRQKVGFLG
>>NP_001029366 (OMIM: 606180) exosome complex component (456 aa)
initn: 355 init1: 262 opt: 375 Z-score: 487.7 bits: 98.8 E(85289): 2e-20
Smith-Waterman score: 375; 28.9% identity (60.2% similar) in 294 aa overlap (1-289:1-284)
10 20 30 40 50 60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
: . ::. :. .......: :.::: ::: ... .. : :.::.: .:
NP_001 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRIS---FGTDYGCCIVELGKTRVLG
10 20 30 40 50
70 80 90 100 110 120
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
:. :. .:::.. .:: : : .. : :.: :: .:: ... . : . :.. .:
NP_001 QVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCID
60 70 80 90 100 110
130 140 150 160 170 180
pF1KA0 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
..::. :. : . ::. ::. ::..:: :::. .:: . : : : : :: .
NP_001 TESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-----V
120 130 140 150 160 170
190 200 210 220 230
pF1KA0 EL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVT
: . . : . ::....: :. .. . : .:: . .:: . .::: . .:
NP_001 TLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERV-MDGLLVIAMNKHREI
180 190 200 210 220 230
240 250 260 270 280 290
pF1KA0 C-MRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
: ... : : ..... . .: .:... . :.. :...... . : ::
NP_001 CTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKA-LENDQKVRKEGGKFGFAESIAN
240 250 260 270 280 290
NP_001 QRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDL
300 310 320 330 340 350
291 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 18:08:56 2016 done: Wed Nov 2 18:08:57 2016
Total Scan time: 6.650 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]