Result of FASTA (omim) for
pFN21AB9867
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9867, 446 aa
1>>>pF1KB9867 446 - 446 aa - 446 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8135+/-0.000518; mu= 20.6742+/- 0.032
mean_var=96.4953+/-22.864, 0's: 0 Z-trim(109.6): 554 B-trim: 1891 in 2/48
Lambda= 0.130563
statistics sampled from 17053 (17807) to 17053 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.209), width: 16
Scan time: 6.670
The best scores are: opt bits E(85289)
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 2952 567.3 2.8e-161
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 1045 208.1 4e-53
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 677 138.7 2.7e-32
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 651 133.9 8.2e-31
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 651 133.9 8.2e-31
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 651 133.9 8.5e-31
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 651 133.9 8.6e-31
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 651 133.9 8.7e-31
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 651 133.9 8.7e-31
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 651 133.9 8.7e-31
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 651 133.9 8.7e-31
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 640 132.0 4.1e-30
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 636 131.2 6.5e-30
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 597 123.7 9.5e-28
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 597 123.7 9.7e-28
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 597 123.8 1e-27
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 587 121.8 3.4e-27
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 570 118.7 3.4e-26
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 567 117.9 4.1e-26
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 555 115.6 1.8e-25
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 555 115.7 2.1e-25
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 554 115.4 2.1e-25
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 554 115.5 2.2e-25
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 554 115.5 2.4e-25
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 537 112.3 2.2e-24
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 533 111.5 3.4e-24
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 533 111.5 3.4e-24
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 533 111.6 3.8e-24
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 533 111.6 3.9e-24
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 533 111.8 4.7e-24
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 522 109.5 1.5e-23
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 522 109.5 1.5e-23
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 522 109.5 1.6e-23
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 522 109.6 1.7e-23
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 522 109.6 1.7e-23
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 522 109.6 1.7e-23
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 522 109.6 1.7e-23
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 522 109.6 1.7e-23
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 520 109.1 2e-23
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 520 109.1 2e-23
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 520 109.1 2.1e-23
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 520 109.1 2.1e-23
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 520 109.2 2.1e-23
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 520 109.2 2.2e-23
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 507 106.8 1.3e-22
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 491 103.8 1e-21
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 471 100.0 1.3e-20
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 467 99.2 2.3e-20
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 467 99.2 2.3e-20
NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444) 450 96.0 2.1e-19
>>NP_000785 (OMIM: 126449) D(1A) dopamine receptor [Homo (446 aa)
initn: 2952 init1: 2952 opt: 2952 Z-score: 3016.4 bits: 567.3 E(85289): 2.8e-161
Smith-Waterman score: 2952; 100.0% identity (100.0% similar) in 446 aa overlap (1-446:1-446)
10 20 30 40 50 60
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
370 380 390 400 410 420
430 440
pF1KB9 SVILDYDTDVSLEKIQPITQNGQHPT
::::::::::::::::::::::::::
NP_000 SVILDYDTDVSLEKIQPITQNGQHPT
430 440
>>NP_000789 (OMIM: 126453,143465,606798) D(1B) dopamine (477 aa)
initn: 1627 init1: 784 opt: 1045 Z-score: 1074.8 bits: 208.1 E(85289): 4e-53
Smith-Waterman score: 1647; 58.2% identity (79.1% similar) in 450 aa overlap (23-444:40-477)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFR
...:::.:.:::. :::::.:::::..: :
NP_000 AYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 HLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASIL
:::...:: :..:::::::.::.::::::::::.::.::::.::..::::::::::::::
NP_000 HLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASIL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB9 NLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTS--
:::::::::::::: ::::.:::: . :......:::::.:::::::::.::. . .:
NP_000 NLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWG
130 140 150 160 170 180
180 190 200 210
pF1KB9 ----PSD-GNATSLAETI-------DNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIY
:.. .: : : . .::::::.::::::::.::::::::::::::::::
NP_000 GLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIY
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB9 RIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIM
:::: :::::..::::: ::..:..... :. :..:.. :.:.::::::::::::
NP_000 RIAQVQIRRISSLERAAEHAQSCRSSAA------CA-PDTSLRASIKKETKVLKTLSVIM
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB9 GVFVCCWLPFFILNCILPFC-GSGETQP--F-CIDSNTFDVFVWFGWANSSLNPIIYAFN
:::::::::::::::..::: : : : : :.. .:::::::::::::::::.:::::
NP_000 GVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFN
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB9 ADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHA
:::.:.:. :::: ..: : .:::.:.:. ..: ... ....:.:
NP_000 ADFQKVFAQLLGCSHFCSRT--PVETVNISNE---LISYNQDIVFHKEIAAAYIHMMPNA
370 380 390 400 410
400 410 420 430 440
pF1KB9 V--GSSEDLKKEEAAGIARPLE--KLSP-----ALSVI-LDYDTDVSLEKIQPITQNGQH
: :. : . :: . . : .. . :: : :: :: . ..::.:: :.: :: :
NP_000 VTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
420 430 440 450 460 470
pF1KB9 PT
>>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece (408 aa)
initn: 476 init1: 164 opt: 677 Z-score: 700.9 bits: 138.7 E(85289): 2.7e-32
Smith-Waterman score: 677; 33.2% identity (62.9% similar) in 367 aa overlap (25-378:39-395)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHL
:.. .:.: .:.:. :: :: .:. .:
NP_000 SSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 RSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILN
.. .:: :: :::..::....::.: :. ..: ::.:. :..:.. :..: :::: .
NP_000 QT-MTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIET
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB9 LCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSD
::...:::: :...:.:: .: . : . ..:..:. .:: :.. .: .. .:
NP_000 LCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVG----AD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB9 GNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI-AALE
..: . : . . :.. :: .:::.:. .:. .:.:.. .: .:.: . . :
NP_000 AEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELG
190 200 210 220 230 240
240 250 260 270 280
pF1KB9 R-AAVHAKNCQTTTGNGKPV-ECSQPES-------SFKMSFKRETKVLKTLSVIMGVFVC
: .. . . :: :. ::. .. :: ..: ::..:::.:.
NP_000 RFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KB9 CWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFST
::::::. : . . : : . . .: .. :.:.:::..::.:: . :::.::
NP_000 CWLPFFLANVLRALGG-----PSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRR
310 320 330 340 350
350 360 370 380 390 400
pF1KB9 LLG-CYRLCPATNNAIETVSINNNGA-AMFSSHHEPRGSISKECNLVYLIPHAVGSSEDL
:: : : : : .. .:. : :: .::
NP_000 LLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
360 370 380 390 400
410 420 430 440
pF1KB9 KKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
>>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa)
initn: 574 init1: 276 opt: 651 Z-score: 674.2 bits: 133.9 E(85289): 8.2e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
..: :: . .:. ::: .::: :: .: :::.:
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
::......:::.:::.. :.:..:. :. :.: :: :::::.: :..: ::::..::.
XP_006 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
::.::: ..: :.:: .: . ... . .:.::..::. :. ..:.. : .: :
XP_006 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
::: :. . :.. :.. :::.:.::..: : :.: .:... : . . ..
XP_006 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
180 190 200 210 220
240 250 260 270 280
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
.: :: . :.: .. . : .. .:.:: :. :::....: :: ::
XP_006 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
::::. ..:. : : : . ..: . :.:. :: .::::: .. .:.:::..
XP_006 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
.: ::
XP_006 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
340 350 360 370 380 390
>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa)
initn: 574 init1: 276 opt: 651 Z-score: 674.2 bits: 133.9 E(85289): 8.2e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
..: :: . .:. ::: .::: :: .: :::.:
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
::......:::.:::.. :.:..:. :. :.: :: :::::.: :..: ::::..::.
NP_150 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
::.::: ..: :.:: .: . ... . .:.::..::. :. ..:.. : .: :
NP_150 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
::: :. . :.. :.. :::.:.::..: : :.: .:... : . . ..
NP_150 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
180 190 200 210 220
240 250 260 270 280
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
.: :: . :.: .. . : .. .:.:: :. :::....: :: ::
NP_150 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
::::. ..:. : : : . ..: . :.:. :: .::::: .. .:.:::..
NP_150 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
.: ::
NP_150 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
340 350 360 370 380 390
>>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa)
initn: 574 init1: 276 opt: 651 Z-score: 673.9 bits: 133.9 E(85289): 8.5e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
..: :: . .:. ::: .::: :: .: :::.:
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
::......:::.:::.. :.:..:. :. :.: :: :::::.: :..: ::::..::.
NP_150 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
::.::: ..: :.:: .: . ... . .:.::..::. :. ..:.. : .: :
NP_150 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
::: :. . :.. :.. :::.:.::..: : :.: .:... : . . ..
NP_150 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
180 190 200 210 220
240 250 260 270 280
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
.: :: . :.: .. . : .. .:.:: :. :::....: :: ::
NP_150 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
::::. ..:. : : : . ..: . :.:. :: .::::: .. .:.:::..
NP_150 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
.: ::
NP_150 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
340 350 360 370 380 390
>>NP_000671 (OMIM: 104221) alpha-1A adrenergic receptor (466 aa)
initn: 493 init1: 276 opt: 651 Z-score: 673.8 bits: 133.9 E(85289): 8.6e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
..: :: . .:. ::: .::: :: .: :::.:
NP_000 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
::......:::.:::.. :.:..:. :. :.: :: :::::.: :..: ::::..::.
NP_000 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
::.::: ..: :.:: .: . ... . .:.::..::. :. ..:.. : .: :
NP_000 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
::: :. . :.. :.. :::.:.::..: : :.: .:... : . . ..
NP_000 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
180 190 200 210 220
240 250 260 270 280
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
.: :: . :.: .. . : .. .:.:: :. :::....: :: ::
NP_000 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
::::. ..:. : : : . ..: . :.:. :: .::::: .. .:.:::..
NP_000 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
.: ::
NP_000 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
340 350 360 370 380 390
>>XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 576 init1: 276 opt: 651 Z-score: 673.7 bits: 133.9 E(85289): 8.7e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
..: :: . .:. ::: .::: :: .: :::.:
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
::......:::.:::.. :.:..:. :. :.: :: :::::.: :..: ::::..::.
XP_016 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
::.::: ..: :.:: .: . ... . .:.::..::. :. ..:.. : .: :
XP_016 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
::: :. . :.. :.. :::.:.::..: : :.: .:... : . . ..
XP_016 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
180 190 200 210 220
240 250 260 270 280
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
.: :: . :.: .. . : .. .:.:: :. :::....: :: ::
XP_016 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
::::. ..:. : : : . ..: . :.:. :: .::::: .. .:.:::..
XP_016 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
.: ::
XP_016 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
340 350 360 370 380 390
>>XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 576 init1: 276 opt: 651 Z-score: 673.7 bits: 133.9 E(85289): 8.7e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
..: :: . .:. ::: .::: :: .: :::.:
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
::......:::.:::.. :.:..:. :. :.: :: :::::.: :..: ::::..::.
XP_016 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
::.::: ..: :.:: .: . ... . .:.::..::. :. ..:.. : .: :
XP_016 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
::: :. . :.. :.. :::.:.::..: : :.: .:... : . . ..
XP_016 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
180 190 200 210 220
240 250 260 270 280
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
.: :: . :.: .. . : .. .:.:: :. :::....: :: ::
XP_016 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
::::. ..:. : : : . ..: . :.:. :: .::::: .. .:.:::..
XP_016 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
.: ::
XP_016 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
340 350 360 370 380 390
>>NP_150646 (OMIM: 104221) alpha-1A adrenergic receptor (475 aa)
initn: 576 init1: 276 opt: 651 Z-score: 673.7 bits: 133.9 E(85289): 8.7e-31
Smith-Waterman score: 717; 36.9% identity (66.3% similar) in 347 aa overlap (19-351:22-347)
10 20 30 40 50
pF1KB9 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSK
..: :: . .:. ::: .::: :: .: :::.:
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHS-
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCV
::......:::.:::.. :.:..:. :. :.: :: :::::.: :..: ::::..::.
NP_150 VTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 ISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNA
::.::: ..: :.:: .: . ... . .:.::..::. :. ..:.. : .: :
NP_150 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQ--P-APED---
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 TSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAA-
::: :. . :.. :.. :::.:.::..: : :.: .:... : . . ..
NP_150 ----ETI--CQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDK
180 190 200 210 220
240 250 260 270 280
pF1KB9 ---------VHAKNCQTTTGNGKPVECSQPESSFKM-SFKRETKVLKTLSVIMGVFVCCW
.: :: . :.: .. . : .. .:.:: :. :::....: :: ::
NP_150 SDSEQVTLRIHRKNAPAG-GSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB9 LPFFILNCILPFCGSGETQP-FCIDSNTFDVFVWFGWANSSLNPIIYAFNA-DFRKAFST
::::. ..:. : : : . ..: . :.:. :: .::::: .. .:.:::..
NP_150 LPFFL---VMPI---GSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQN
290 300 310 320 330
350 360 370 380 390 400
pF1KB9 LLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKK
.: ::
NP_150 VLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKF
340 350 360 370 380 390
446 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 09:19:28 2016 done: Sat Nov 5 09:19:29 2016
Total Scan time: 6.670 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]