Result of FASTA (omim) for
pFN21ASDA1391
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1391, 1191 aa
1>>>pF1KSDA1391 1191 - 1191 aa - 1191 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.0434+/-0.000395; mu= 3.7452+/- 0.024
mean_var=164.1271+/-34.540, 0's: 0 Z-trim(117.1): 301 B-trim: 248 in 1/57
Lambda= 0.100112
statistics sampled from 28526 (28856) to 28526 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.338), width: 16
Scan time: 14.280
The best scores are: opt bits E(85289)
NP_065860 (OMIM: 609568) rho GTPase-activating pro (1191) 7922 1157.2 0
XP_006718956 (OMIM: 609568) PREDICTED: rho GTPase- (1191) 7922 1157.2 0
NP_001245344 (OMIM: 609568) rho GTPase-activating (1168) 7705 1125.9 0
NP_001245345 (OMIM: 609568) rho GTPase-activating (1165) 7699 1125.0 0
NP_001245346 (OMIM: 609568) rho GTPase-activating (1155) 7687 1123.3 0
NP_001245347 (OMIM: 609568) rho GTPase-activating (1155) 7687 1123.3 0
XP_005271685 (OMIM: 609568) PREDICTED: rho GTPase- ( 734) 4873 716.8 1.3e-205
NP_473455 (OMIM: 609667) T-cell activation Rho GTP ( 731) 642 105.7 1.1e-21
NP_001265662 (OMIM: 609667) T-cell activation Rho ( 668) 603 100.1 5.2e-20
NP_620165 (OMIM: 609667) T-cell activation Rho GTP ( 266) 518 87.7 1.1e-16
NP_001657 (OMIM: 300023) rho GTPase-activating pro ( 946) 375 67.2 5.8e-10
XP_016873209 (OMIM: 602732) PREDICTED: rho GTPase- ( 395) 367 65.9 5.8e-10
NP_001158213 (OMIM: 300023) rho GTPase-activating ( 986) 375 67.2 6e-10
NP_004299 (OMIM: 602732) rho GTPase-activating pro ( 439) 367 65.9 6.4e-10
XP_011518397 (OMIM: 602732) PREDICTED: rho GTPase- ( 439) 367 65.9 6.4e-10
NP_851852 (OMIM: 609405) rho GTPase-activating pro ( 433) 328 60.3 3.2e-08
NP_001017526 (OMIM: 609405) rho GTPase-activating ( 464) 328 60.3 3.4e-08
XP_011544179 (OMIM: 608293) PREDICTED: rho GTPase- ( 836) 314 58.3 2.3e-07
XP_011544178 (OMIM: 608293) PREDICTED: rho GTPase- ( 872) 314 58.3 2.4e-07
XP_011544177 (OMIM: 608293) PREDICTED: rho GTPase- ( 885) 314 58.4 2.4e-07
XP_011544176 (OMIM: 608293) PREDICTED: rho GTPase- ( 912) 314 58.4 2.5e-07
XP_011544175 (OMIM: 608293) PREDICTED: rho GTPase- ( 913) 314 58.4 2.5e-07
NP_001006635 (OMIM: 608293) rho GTPase-activating ( 881) 313 58.2 2.7e-07
XP_016863113 (OMIM: 613299) PREDICTED: protein FAM ( 981) 312 58.1 3.3e-07
XP_005262740 (OMIM: 613299) PREDICTED: protein FAM ( 995) 312 58.1 3.3e-07
XP_005262739 (OMIM: 613299) PREDICTED: protein FAM (1003) 312 58.1 3.3e-07
XP_005262738 (OMIM: 613299) PREDICTED: protein FAM (1009) 312 58.1 3.4e-07
XP_011529818 (OMIM: 613299) PREDICTED: protein FAM (1023) 312 58.1 3.4e-07
NP_055698 (OMIM: 613299) protein FAM13A isoform a (1023) 312 58.1 3.4e-07
NP_687034 (OMIM: 609667) T-cell activation Rho GTP ( 553) 302 56.6 5.3e-07
XP_011529819 (OMIM: 613299) PREDICTED: protein FAM ( 995) 305 57.1 6.7e-07
XP_016878879 (OMIM: 608293) PREDICTED: rho GTPase- ( 794) 300 56.3 9e-07
XP_011544180 (OMIM: 608293) PREDICTED: rho GTPase- ( 835) 300 56.3 9.4e-07
NP_060524 (OMIM: 608293) rho GTPase-activating pro ( 803) 299 56.2 1e-06
XP_011519925 (OMIM: 604875) PREDICTED: unconventio (1737) 301 56.6 1.7e-06
XP_016877719 (OMIM: 604875) PREDICTED: unconventio (2547) 301 56.6 2.3e-06
NP_008832 (OMIM: 604875) unconventional myosin-IXa (2548) 301 56.6 2.3e-06
XP_016877718 (OMIM: 604875) PREDICTED: unconventio (2566) 301 56.6 2.4e-06
XP_011519924 (OMIM: 604875) PREDICTED: unconventio (2566) 301 56.6 2.4e-06
XP_011519923 (OMIM: 604875) PREDICTED: unconventio (2598) 301 56.6 2.4e-06
XP_011519922 (OMIM: 604875) PREDICTED: unconventio (2618) 301 56.6 2.4e-06
XP_006720602 (OMIM: 604875) PREDICTED: unconventio (2619) 301 56.6 2.4e-06
XP_011519921 (OMIM: 604875) PREDICTED: unconventio (2619) 301 56.6 2.4e-06
XP_016877717 (OMIM: 604875) PREDICTED: unconventio (2619) 301 56.6 2.4e-06
XP_011519920 (OMIM: 604875) PREDICTED: unconventio (2620) 301 56.6 2.4e-06
XP_011519919 (OMIM: 604875) PREDICTED: unconventio (2637) 301 56.6 2.4e-06
XP_011519916 (OMIM: 604875) PREDICTED: unconventio (2638) 301 56.6 2.4e-06
XP_011519917 (OMIM: 604875) PREDICTED: unconventio (2638) 301 56.6 2.4e-06
XP_011519918 (OMIM: 604875) PREDICTED: unconventio (2638) 301 56.6 2.4e-06
XP_011519915 (OMIM: 604875) PREDICTED: unconventio (2638) 301 56.6 2.4e-06
>>NP_065860 (OMIM: 609568) rho GTPase-activating protein (1191 aa)
initn: 7922 init1: 7922 opt: 7922 Z-score: 6189.2 bits: 1157.2 E(85289): 0
Smith-Waterman score: 7922; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KSD MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD HLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 HLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD QFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPC
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD NILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLRE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD FYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD SLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD THRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 THRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLIN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD QSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQI
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD SEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD MEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD PEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KSD EEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 EEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
1150 1160 1170 1180 1190
>>XP_006718956 (OMIM: 609568) PREDICTED: rho GTPase-acti (1191 aa)
initn: 7922 init1: 7922 opt: 7922 Z-score: 6189.2 bits: 1157.2 E(85289): 0
Smith-Waterman score: 7922; 100.0% identity (100.0% similar) in 1191 aa overlap (1-1191:1-1191)
10 20 30 40 50 60
pF1KSD MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD HLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD NVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD QFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPC
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD NILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLRE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD FYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD SLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD THRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 THRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLIN
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD QSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQI
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD SEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KSD MEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGV
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KSD PEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSH
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190
pF1KSD EEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
1150 1160 1170 1180 1190
>>NP_001245344 (OMIM: 609568) rho GTPase-activating prot (1168 aa)
initn: 7705 init1: 7705 opt: 7705 Z-score: 6019.9 bits: 1125.9 E(85289): 0
Smith-Waterman score: 7705; 100.0% identity (100.0% similar) in 1158 aa overlap (34-1191:11-1168)
10 20 30 40 50 60
pF1KSD MSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRPTTR
::::::::::::::::::::::::::::::
NP_001 MSARERQPALKKKMKTLAERRRSAPSLILDKALQKRPTTR
10 20 30 40
70 80 90 100 110 120
pF1KSD DSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNF
50 60 70 80 90 100
130 140 150 160 170 180
pF1KSD KIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRY
110 120 130 140 150 160
190 200 210 220 230 240
pF1KSD INLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQ
170 180 190 200 210 220
250 260 270 280 290 300
pF1KSD LWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KSD QCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLF
290 300 310 320 330 340
370 380 390 400 410 420
pF1KSD GISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLD
350 360 370 380 390 400
430 440 450 460 470 480
pF1KSD CESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVV
410 420 430 440 450 460
490 500 510 520 530 540
pF1KSD LLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFL
470 480 490 500 510 520
550 560 570 580 590 600
pF1KSD IENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDL
530 540 550 560 570 580
610 620 630 640 650 660
pF1KSD VKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNIL
590 600 610 620 630 640
670 680 690 700 710 720
pF1KSD VYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQ
650 660 670 680 690 700
730 740 750 760 770 780
pF1KSD KKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLS
710 720 730 740 750 760
790 800 810 820 830 840
pF1KSD GSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHR
770 780 790 800 810 820
850 860 870 880 890 900
pF1KSD RCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSL
830 840 850 860 870 880
910 920 930 940 950 960
pF1KSD VMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEH
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KSD SVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEW
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KSD HSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEA
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KSD NSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEI
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190
pF1KSD EPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
1130 1140 1150 1160
>>NP_001245345 (OMIM: 609568) rho GTPase-activating prot (1165 aa)
initn: 7699 init1: 7699 opt: 7699 Z-score: 6015.3 bits: 1125.0 E(85289): 0
Smith-Waterman score: 7699; 100.0% identity (100.0% similar) in 1157 aa overlap (35-1191:9-1165)
10 20 30 40 50 60
pF1KSD SPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRPTTRD
::::::::::::::::::::::::::::::
NP_001 MTFWIIINKKMKTLAERRRSAPSLILDKALQKRPTTRD
10 20 30
70 80 90 100 110 120
pF1KSD SPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNFK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD IKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYI
100 110 120 130 140 150
190 200 210 220 230 240
pF1KSD NLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQL
160 170 180 190 200 210
250 260 270 280 290 300
pF1KSD WVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQ
220 230 240 250 260 270
310 320 330 340 350 360
pF1KSD CQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFG
280 290 300 310 320 330
370 380 390 400 410 420
pF1KSD ISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDC
340 350 360 370 380 390
430 440 450 460 470 480
pF1KSD ESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KSD LRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLI
460 470 480 490 500 510
550 560 570 580 590 600
pF1KSD ENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLV
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD KKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILV
580 590 600 610 620 630
670 680 690 700 710 720
pF1KSD YTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQK
640 650 660 670 680 690
730 740 750 760 770 780
pF1KSD KLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSG
700 710 720 730 740 750
790 800 810 820 830 840
pF1KSD SEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRR
760 770 780 790 800 810
850 860 870 880 890 900
pF1KSD CSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLV
820 830 840 850 860 870
910 920 930 940 950 960
pF1KSD MGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHS
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KSD VFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWH
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KSD SQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEAN
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KSD SLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIE
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190
pF1KSD PGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
1120 1130 1140 1150 1160
>>NP_001245346 (OMIM: 609568) rho GTPase-activating prot (1155 aa)
initn: 7687 init1: 7687 opt: 7687 Z-score: 6006.0 bits: 1123.3 E(85289): 0
Smith-Waterman score: 7687; 100.0% identity (100.0% similar) in 1155 aa overlap (37-1191:1-1155)
10 20 30 40 50 60
pF1KSD QQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRPTTRDSP
::::::::::::::::::::::::::::::
NP_001 MKTLAERRRSAPSLILDKALQKRPTTRDSP
10 20 30
70 80 90 100 110 120
pF1KSD SASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNFKIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNFKIK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD NKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYINL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYINL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KSD EKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQLWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQLWV
160 170 180 190 200 210
250 260 270 280 290 300
pF1KSD NSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQCQ
220 230 240 250 260 270
310 320 330 340 350 360
pF1KSD FILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFGIS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KSD LPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCES
340 350 360 370 380 390
430 440 450 460 470 480
pF1KSD IFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLR
400 410 420 430 440 450
490 500 510 520 530 540
pF1KSD YLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIEN
460 470 480 490 500 510
550 560 570 580 590 600
pF1KSD CLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKK
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD LGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILVYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILVYT
580 590 600 610 620 630
670 680 690 700 710 720
pF1KSD KIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKL
640 650 660 670 680 690
730 740 750 760 770 780
pF1KSD RKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSE
700 710 720 730 740 750
790 800 810 820 830 840
pF1KSD GNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCS
760 770 780 790 800 810
850 860 870 880 890 900
pF1KSD EPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLVMG
820 830 840 850 860 870
910 920 930 940 950 960
pF1KSD IEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVF
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KSD TPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWHSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWHSQ
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KSD MHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEANSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEANSL
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KSD QEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIEPG
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190
pF1KSD SQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
1120 1130 1140 1150
>>NP_001245347 (OMIM: 609568) rho GTPase-activating prot (1155 aa)
initn: 7687 init1: 7687 opt: 7687 Z-score: 6006.0 bits: 1123.3 E(85289): 0
Smith-Waterman score: 7687; 100.0% identity (100.0% similar) in 1155 aa overlap (37-1191:1-1155)
10 20 30 40 50 60
pF1KSD QQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRPTTRDSP
::::::::::::::::::::::::::::::
NP_001 MKTLAERRRSAPSLILDKALQKRPTTRDSP
10 20 30
70 80 90 100 110 120
pF1KSD SASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNFKIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNFKIK
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD NKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYINL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYINL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KSD EKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQLWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQLWV
160 170 180 190 200 210
250 260 270 280 290 300
pF1KSD NSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQCQ
220 230 240 250 260 270
310 320 330 340 350 360
pF1KSD FILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFGIS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KSD LPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCES
340 350 360 370 380 390
430 440 450 460 470 480
pF1KSD IFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLR
400 410 420 430 440 450
490 500 510 520 530 540
pF1KSD YLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIEN
460 470 480 490 500 510
550 560 570 580 590 600
pF1KSD CLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKK
520 530 540 550 560 570
610 620 630 640 650 660
pF1KSD LGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILVYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILVYT
580 590 600 610 620 630
670 680 690 700 710 720
pF1KSD KIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKL
640 650 660 670 680 690
730 740 750 760 770 780
pF1KSD RKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSE
700 710 720 730 740 750
790 800 810 820 830 840
pF1KSD GNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCS
760 770 780 790 800 810
850 860 870 880 890 900
pF1KSD EPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLVMG
820 830 840 850 860 870
910 920 930 940 950 960
pF1KSD IEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVF
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KSD TPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWHSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWHSQ
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KSD MHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEANSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEANSL
1000 1010 1020 1030 1040 1050
1090 1100 1110 1120 1130 1140
pF1KSD QEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIEPG
1060 1070 1080 1090 1100 1110
1150 1160 1170 1180 1190
pF1KSD SQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
1120 1130 1140 1150
>>XP_005271685 (OMIM: 609568) PREDICTED: rho GTPase-acti (734 aa)
initn: 4873 init1: 4873 opt: 4873 Z-score: 3812.6 bits: 716.8 E(85289): 1.3e-205
Smith-Waterman score: 4873; 100.0% identity (100.0% similar) in 734 aa overlap (458-1191:1-734)
430 440 450 460 470 480
pF1KSD FVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRY
::::::::::::::::::::::::::::::
XP_005 MDQGNDEEKINTVQRLLDQLPRANVVLLRY
10 20 30
490 500 510 520 530 540
pF1KSD LFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIENC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIENC
40 50 60 70 80 90
550 560 570 580 590 600
pF1KSD LRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKKL
100 110 120 130 140 150
610 620 630 640 650 660
pF1KSD GQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILVYTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILVYTK
160 170 180 190 200 210
670 680 690 700 710 720
pF1KSD IPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKLR
220 230 240 250 260 270
730 740 750 760 770 780
pF1KSD KSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSEG
280 290 300 310 320 330
790 800 810 820 830 840
pF1KSD NHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCSE
340 350 360 370 380 390
850 860 870 880 890 900
pF1KSD PNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLVMGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLVMGI
400 410 420 430 440 450
910 920 930 940 950 960
pF1KSD EVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVFT
460 470 480 490 500 510
970 980 990 1000 1010 1020
pF1KSD PTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWHSQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWHSQM
520 530 540 550 560 570
1030 1040 1050 1060 1070 1080
pF1KSD HSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEANSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEANSLQ
580 590 600 610 620 630
1090 1100 1110 1120 1130 1140
pF1KSD EEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIEPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIEPGS
640 650 660 670 680 690
1150 1160 1170 1180 1190
pF1KSD QSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
700 710 720 730
>>NP_473455 (OMIM: 609667) T-cell activation Rho GTPase- (731 aa)
initn: 590 init1: 459 opt: 642 Z-score: 510.1 bits: 105.7 E(85289): 1.1e-21
Smith-Waterman score: 643; 28.6% identity (61.5% similar) in 538 aa overlap (296-818:18-538)
270 280 290 300 310 320
pF1KSD IKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQCQFILKPSRLAAAQQLSDSGH
:: : : : . .: : :. . ::
NP_473 MKLRSSHNASKTLNANNMETLI-ECQSEGDIKEHPLLASCESEDSIC
10 20 30 40
330 340 350 360 370 380
pF1KSD KTF--KRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFGISLPNIC-ENDNLPKPVLD
. . :.:.....: : . ... .. . . ..:: : :: ..:.::.:. :
NP_473 QLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQD
50 60 70 80 90 100
390 400 410 420 430 440
pF1KSD MLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCESIFVIASVLKDFLRNIP
.: .: ::: :.::::..:: :. .::::.:::: : :. . ..: :.:::::.::
NP_473 ILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIP
110 120 130 140 150 160
450 460 470 480 490 500
pF1KSD GSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSN
...::::...:...... ..:..:...... :.::: :..::..: ::: : ..: :
NP_473 RKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVN
170 180 190 200 210 220
510 520 530 540 550 560
pF1KSD QMTAFNLAVCVAPSILW--PPASSSPELENEFTKKVSLLIQFLIENCLRIFGEEITSLFR
.: . :::.:..:..: : : : ......::. :..:::.::..::::.:
NP_473 RMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEIFGENIPVHSS
230 240 250 260 270 280
570 580 590 600 610
pF1KSD EVSVRCDTRENASDISCFQLNDSSYDS----LENELNEDVDAPCSDLVKKLGQGSRSMDS
.: . ..::.: .: :::.::: .:.. . ...: . .. .. ..::
NP_473 ITSDDSLEHTDSSDVSTLQ-NDSAYDSNDPDVESNSSSGISSPSRQPQVPMATAA-GLDS
290 300 310 320 330 340
620 630 640 650 660 670
pF1KSD VLTLSDYDLD-QPEVEGLL----TLSDFDLAHSKDEDVQMKRPLESKPVNILVYTKIPLR
. . ... .: : . .:.. : .:. . .. :::. .: . .
NP_473 AGPQDAREVSPEPIVSTVARLKSSLAQPDRRYSEPSMPSSQECLESRVTNQTLTKSEGDF
350 360 370 380 390 400
680 690 700 710 720 730
pF1KSD DHARAPSAMCTPSYLSTAAANAAKSLR-RHRRCSEPSIDYLDSKLSYLREFYQKKLRKSS
:. : . . . .. ... . .: . .: : : . : . .::
NP_473 PVPRVGSRLESEEAEDPFPEEVFPAVQGKTKRPVDLKIKNLAPGSVLPRALVLKAFSSSS
410 420 430 440 450 460
740 750 760 770 780 790
pF1KSD CDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSEGNHV
:: :. . . ..: ... .::..: :. :. ... ::.:.: . . :
NP_473 LDA--SSDSSPVASPSSP--KRNFFSRHQSFTTKTE---KGKPSREIKKHSMSFTFAPHK
470 480 490 500 510
800 810 820 830 840 850
pF1KSD KLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCSEPNI
:.. :. .:..: .::: ....
NP_473 KVLTKN----LSAGSG---KSQDFTRDHVPRGVRKESQLAGRIVQENGCETHNQTARGFC
520 530 540 550 560 570
>>NP_001265662 (OMIM: 609667) T-cell activation Rho GTPa (668 aa)
initn: 590 init1: 459 opt: 603 Z-score: 480.3 bits: 100.1 E(85289): 5.2e-20
Smith-Waterman score: 604; 29.4% identity (62.8% similar) in 476 aa overlap (356-818:16-475)
330 340 350 360 370 380
pF1KSD KTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFGISLPNIC-ENDNLPKPVLDML
. . ..:: : :: ..:.::.:. :.:
NP_001 MRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDIL
10 20 30 40
390 400 410 420 430 440
pF1KSD FFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCESIFVIASVLKDFLRNIPGS
.: ::: :.::::..:: :. .::::.:::: : :. . ..: :.:::::.:: .
NP_001 TILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRK
50 60 70 80 90 100
450 460 470 480 490 500
pF1KSD IFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSNQM
..::::...:...... ..:..:...... :.::: :..::..: ::: : ..: :.:
NP_001 LLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRM
110 120 130 140 150 160
510 520 530 540 550 560
pF1KSD TAFNLAVCVAPSILW--PPASSSPELENEFTKKVSLLIQFLIENCLRIFGEEITSLFREV
. :::.:..:..: : : : ......::. :..:::.::..::::.: .
NP_001 DSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEIFGENIPVHSSIT
170 180 190 200 210 220
570 580 590 600 610
pF1KSD SVRCDTRENASDISCFQLNDSSYDS----LENELNEDVDAPCSDLVKKLGQGSRSMDSVL
: . ..::.: .: :::.::: .:.. . ...: . .. .. ..::.
NP_001 SDDSLEHTDSSDVSTLQ-NDSAYDSNDPDVESNSSSGISSPSRQPQVPMATAA-GLDSAG
230 240 250 260 270 280
620 630 640 650 660 670
pF1KSD TLSDYDLD-QPEVEGLL----TLSDFDLAHSKDEDVQMKRPLESKPVNILVYTKIPLRDH
. ... .: : . .:.. : .:. . .. :::. .: . .
NP_001 PQDAREVSPEPIVSTVARLKSSLAQPDRRYSEPSMPSSQECLESRVTNQTLTKSEGDFPV
290 300 310 320 330 340
680 690 700 710 720 730
pF1KSD ARAPSAMCTPSYLSTAAANAAKSLR-RHRRCSEPSIDYLDSKLSYLREFYQKKLRKSSCD
:. : . . . .. ... . .: . .: : : . : . .:: :
NP_001 PRVGSRLESEEAEDPFPEEVFPAVQGKTKRPVDLKIKNLAPGSVLPRALVLKAFSSSSLD
350 360 370 380 390 400
740 750 760 770 780 790
pF1KSD AILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSEGNHVKL
: :. . . ..: ... .::..: :. :. ... ::.:.: . . : :.
NP_001 A--SSDSSPVASPSSP--KRNFFSRHQSFTTKTE---KGKPSREIKKHSMSFTFAPHKKV
410 420 430 440 450
800 810 820 830 840 850
pF1KSD FPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCSEPNIED
. :. .:..: . ::: ....
NP_001 LTKN----LSAGSGK---SQDFTRDHVPRGVRKESQLAGRIVQENGCETHNQTARGFCLR
460 470 480 490 500
>>NP_620165 (OMIM: 609667) T-cell activation Rho GTPase- (266 aa)
initn: 488 init1: 448 opt: 518 Z-score: 420.4 bits: 87.7 E(85289): 1.1e-16
Smith-Waterman score: 518; 36.2% identity (69.9% similar) in 246 aa overlap (296-536:18-262)
270 280 290 300 310 320
pF1KSD IKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQCQFILKPSRLAAAQQLSDSGH
:: : : : . .: : :. . ::
NP_620 MKLRSSHNASKTLNANNMETLI-ECQSEGDIKEHPLLASCESEDSIC
10 20 30 40
330 340 350 360 370 380
pF1KSD KTF--KRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFGISLPNIC-ENDNLPKPVLD
. . :.:.....: : . ... .. . . ..:: : :: ..:.::.:. :
NP_620 QLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQD
50 60 70 80 90 100
390 400 410 420 430 440
pF1KSD MLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCESIFVIASVLKDFLRNIP
.: .: ::: :.::::..:: :. .::::.:::: : :. . ..: :.:::::.::
NP_620 ILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIP
110 120 130 140 150 160
450 460 470 480 490 500
pF1KSD GSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSN
...::::...:...... ..:..:...... :.::: :..::..: ::: : ..: :
NP_620 RKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVN
170 180 190 200 210 220
510 520 530 540 550 560
pF1KSD QMTAFNLAVCVAPSILW--PPASSSPELENEFTKKVSLLIQFLIENCLRIFGEEITSLFR
.: . :::.:..:..: : : : ......::
NP_620 RMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVCSAY
230 240 250 260
570 580 590 600 610 620
pF1KSD EVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKKLGQGSRSMDSVLTL
1191 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 06:05:48 2016 done: Thu Nov 3 06:05:50 2016
Total Scan time: 14.280 Total Display time: 0.410
Function used was FASTA [36.3.4 Apr, 2011]