Result of FASTA (omim) for
pFN21AE9665
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9665, 672 aa
1>>>pF1KE9665 672 - 672 aa - 672 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7196+/-0.000413; mu= 17.0602+/- 0.026
mean_var=71.1551+/-14.259, 0's: 0 Z-trim(110.4): 33 B-trim: 36 in 1/53
Lambda= 0.152045
statistics sampled from 18765 (18782) to 18765 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.22), width: 16
Scan time: 9.420
The best scores are: opt bits E(85289)
NP_079021 (OMIM: 611027) SHC SH2 domain-binding pr ( 672) 4475 991.5 0
NP_001311247 (OMIM: 611027) SHC SH2 domain-binding ( 634) 3865 857.7 0
XP_011521637 (OMIM: 611027) PREDICTED: SHC SH2 dom ( 468) 3004 668.8 1.3e-191
NP_001311248 (OMIM: 611027) SHC SH2 domain-binding ( 594) 2411 538.7 2.3e-152
>>NP_079021 (OMIM: 611027) SHC SH2 domain-binding protei (672 aa)
initn: 4475 init1: 4475 opt: 4475 Z-score: 5302.5 bits: 991.5 E(85289): 0
Smith-Waterman score: 4475; 99.9% identity (100.0% similar) in 672 aa overlap (1-672:1-672)
10 20 30 40 50 60
pF1KE9 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 GYGVVLVKPTIFSDLQESAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
NP_079 GYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK
610 620 630 640 650 660
670
pF1KE9 WNGKGSFGTFLF
::::::::::::
NP_079 WNGKGSFGTFLF
670
>>NP_001311247 (OMIM: 611027) SHC SH2 domain-binding pro (634 aa)
initn: 3864 init1: 3864 opt: 3865 Z-score: 4579.7 bits: 857.7 E(85289): 0
Smith-Waterman score: 4127; 94.0% identity (94.2% similar) in 672 aa overlap (1-672:1-634)
10 20 30 40 50 60
pF1KE9 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM
:::::::::::::::::::: :::::::::::::::::::::::::::::::
NP_001 MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKP--------
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH
::::::::::::::::::::::::::::::
NP_001 ------------------------------ADCKASEVQEFTAEFLEKVLEPSGWRAVWH
60 70 80
130 140 150 160 170 180
pF1KE9 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE9 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE9 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE9 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE9 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE9 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE9 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE
450 460 470 480 490 500
550 560 570 580 590 600
pF1KE9 GYGVVLVKPTIFSDLQESAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
NP_001 GYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE9 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK
570 580 590 600 610 620
670
pF1KE9 WNGKGSFGTFLF
::::::::::::
NP_001 WNGKGSFGTFLF
630
>>XP_011521637 (OMIM: 611027) PREDICTED: SHC SH2 domain- (468 aa)
initn: 2997 init1: 2997 opt: 3004 Z-score: 3561.1 bits: 668.8 E(85289): 1.3e-191
Smith-Waterman score: 3004; 96.8% identity (98.5% similar) in 465 aa overlap (1-465:1-464)
10 20 30 40 50 60
pF1KE9 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_011 MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK
:::::::::::::::::::::::::::: .: ...... .: :
XP_011 DTFVDCTGADIKISGIKFVQHDAVEGIL-THGSRSNFDFQILLFEKYTS
430 440 450 460
490 500 510 520 530 540
pF1KE9 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE
>>NP_001311248 (OMIM: 611027) SHC SH2 domain-binding pro (594 aa)
initn: 2403 init1: 2403 opt: 2411 Z-score: 2856.5 bits: 538.7 E(85289): 2.3e-152
Smith-Waterman score: 3798; 88.1% identity (88.2% similar) in 672 aa overlap (1-672:1-594)
10 20 30 40 50 60
pF1KE9 MADGSLTGGGLEAAAMAPERTGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_001 MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTMECMKELLDLKEHRLPLQELWV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVP
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRL----------
190 200 210 220 230
250 260 270 280 290 300
pF1KE9 SGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLK
NP_001 ------------------------------------------------------------
310 320 330 340 350 360
pF1KE9 LIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --------YVFGYQKNSNIQAKGVRSSGQKITHVVSSTMMAGLLRSLLTDRLCQEPGEEE
240 250 260 270 280
370 380 390 400 410 420
pF1KE9 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKG
290 300 310 320 330 340
430 440 450 460 470 480
pF1KE9 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMK
350 360 370 380 390 400
490 500 510 520 530 540
pF1KE9 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIIHNNE
410 420 430 440 450 460
550 560 570 580 590 600
pF1KE9 GYGVVLVKPTIFSDLQESAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
NP_001 GYGVVLVKPTIFSDLQENAEDGTEENKALKIQTSGEPDVAERVDLEELIECATGKMELCA
470 480 490 500 510 520
610 620 630 640 650 660
pF1KE9 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTDPSEQVEGNCEIVNELIAASTQKGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFK
530 540 550 560 570 580
670
pF1KE9 WNGKGSFGTFLF
::::::::::::
NP_001 WNGKGSFGTFLF
590
672 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:12:50 2016 done: Mon Nov 7 00:12:51 2016
Total Scan time: 9.420 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]