FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE9621, 556 aa
  1>>>pF1KE9621 556 - 556 aa - 556 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.7205+/-0.000472; mu= 10.6851+/- 0.029
 mean_var=77.7632+/-15.625, 0's: 0 Z-trim(109.7): 25  B-trim: 340 in 1/49
 Lambda= 0.145441
 statistics sampled from 17862 (17876) to 17862 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.571), E-opt: 0.2 (0.21), width:  16
 Scan time:  8.880

The best scores are:                                      opt bits E(85289)
NP_006256 (OMIM: 606462,614701) double-strand-brea ( 631)  818 181.8 5.6e-45


>>NP_006256 (OMIM: 606462,614701) double-strand-break re  (631 aa)
 initn: 1379 init1: 676 opt: 818  Z-score: 928.5  bits: 181.8 E(85289): 5.6e-45
Smith-Waterman score: 1232; 40.5% identity (65.8% similar) in 590 aa overlap (1-513:1-588)

               10        20        30        40        50        60
pF1KE9 MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKILSPKVKIALRTSGHLL
       :::.: ..:::::::::::::::.:::::::::::::: ..:.:.:::::.:::::::::
NP_006 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 LGVVRIYNRKAKYLLADCSEAFLKMKMTFCPGLVDLPKENFEASYNAITLPEEFHDFDTQ
       :::::::.::::::::::.:::.:.::.: ::.::::.:: ::.::::::::::::::  
NP_006 LGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQP
               70        80        90       100       110       120

                130       140       150       160           170    
pF1KE9 --NMNAIDVSEHFTQNQSRPEEITLRENFDNDLIFQAESFGE----ESEILRRHSFF-DD
         ... :::...:. :::: ::::.::.  :  :.: ..::.    . ::.:. : : ::
NP_006 LPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD
              130       140       150       160       170       180

             180        190         200          210       220     
pF1KE9 NILLNS--SGPLIE-HSSGSLTGER--SLFYDS---GDGFGDEGAAGEMIDNLLQDDQNI
       ..:...  :. :.: ..: :  .:.   : :..    :.::. . .: . :.:...... 
NP_006 DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGG
              190       200       210       220       230       240

         230         240               250         260       270   
pF1KE9 LLEDMHLNRE--ISLPSEPPNSLAVE--------PDNSECI--CVPENEKMNETILLSTE
       ...:     :  . :: .: ..   :        ::. . .    :     ..: :. .:
NP_006 IFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNE
              250       260       270       280       290       300

           280       290       300       310       320       330   
pF1KE9 EEGFTLDPIDISDIAEKRKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQR
       ::.:.:.::::. . : .  .::.:..: .:::.::.:. ::....: . .:.:::::..
NP_006 EEAFALEPIDIT-VKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKK
              310        320       330       340       350         

           340       350       360          370                    
pF1KE9 LMMWKKRGGVHTLLSTAAQDLIHAELKMLFTKCF---LSSGFKLGRK-------------
       :::::. :::. :.:  :: : . .:  :::.:.   .   ..  ::             
NP_006 LMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKE
     360       370       380       390       400       410         

           380       390       400         410              420    
pF1KE9 ----MIQKESVREEVGNQNIVETSMMQEPNYQQE--LSKPQTWKDVIG-------GSQHS
            . .:. ...  ......  ...::.  ::  .   .:  :  .       : ...
NP_006 FENPEVPREDQQQQHQQRDVIDEPIIEEPSRLQESVMEASRTNIDESAMPPPPPQGVKRK
     420       430       440       450       460       470         

          430       440           450       460            470     
pF1KE9 SHEDTNKNINSEQDIVEM----VSLAAEESSLMNDLFAQEIEYSPV-----ELESLSNEE
       . .   . .   :.. .:    : :  ::   . .:.  :.:  :      : :. ..::
NP_006 AGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIP-ELELLPEKEKEKEKEKEDDEE
     480       490       500       510        520       530        

                    480       490        500       510       520   
pF1KE9 -----------NIETERWNGRILQMLNRL-RESNKMGMQSFSLMKLCRNSDRKQAAAKFY
                  . : .::: :  :::. : :   : : .:.::..::::.          
NP_006 EEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFY
      540       550       560       570       580       590        

           530       540       550      
pF1KE9 SFLVLKKQLAIELSQSAPYADIIATMGPMFYNI
                                        
NP_006 SFLVLKKQQAIELTQEEPYSDIIATPGPRFHII
      600       610       620       630 

>--
 initn: 223 init1: 202 opt: 204  Z-score: 232.3  bits: 53.0 E(85289): 3.4e-06
Smith-Waterman score: 204; 76.7% identity (86.0% similar) in 43 aa overlap (514-556:589-631)

           490       500       510       520       530       540   
pF1KE9 GRILQMLNRLRESNKMGMQSFSLMKLCRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYA
                                     .::::::::::::::::: ::::.:  ::.
NP_006 RTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYS
      560       570       580       590       600       610        

           550      
pF1KE9 DIIATMGPMFYNI
       ::::: :: :. :
NP_006 DIIATPGPRFHII
      620       630 




556 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 18:44:56 2016 done: Mon Nov  7 18:44:57 2016
 Total Scan time:  8.880 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]