Result of FASTA (omim) for
pFN21AE9571
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9571, 408 aa
1>>>pF1KE9571 408 - 408 aa - 408 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7749+/-0.000306; mu= 18.4572+/- 0.020
mean_var=159.0444+/-36.780, 0's: 0 Z-trim(121.5): 509 B-trim: 1998 in 1/56
Lambda= 0.101699
statistics sampled from 37451 (38137) to 37451 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.764), E-opt: 0.2 (0.447), width: 16
Scan time: 8.430
The best scores are: opt bits E(85289)
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 2812 424.1 3e-118
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 886 141.6 3.9e-33
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 732 118.9 2.2e-26
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 677 110.9 6.3e-24
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 654 107.6 7.2e-23
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 645 106.4 1.9e-22
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 562 94.1 7.8e-19
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 542 91.1 5.9e-18
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 542 91.1 5.9e-18
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 529 89.1 1.9e-17
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 525 88.5 3e-17
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 525 88.6 3.1e-17
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 525 88.7 3.7e-17
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 519 87.6 5e-17
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 519 87.6 5e-17
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 477 81.4 3.8e-15
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 477 81.5 3.8e-15
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 477 81.5 4e-15
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 472 80.8 7.1e-15
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 471 80.6 7.2e-15
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 464 79.6 1.6e-14
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 464 79.7 1.7e-14
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 459 78.9 2.5e-14
XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 458 78.8 3e-14
NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 458 78.8 3e-14
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 448 77.3 8.4e-14
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 443 76.6 1.4e-13
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 440 76.0 1.6e-13
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 440 76.0 1.7e-13
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 440 76.1 1.7e-13
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 440 76.1 1.7e-13
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 440 76.1 1.8e-13
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 440 76.1 1.8e-13
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 422 73.5 1.2e-12
NP_009163 (OMIM: 604525) histamine H3 receptor [Ho ( 445) 409 71.6 4.3e-12
XP_005260323 (OMIM: 604525) PREDICTED: histamine H ( 453) 409 71.6 4.4e-12
NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 403 70.6 7.3e-12
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 399 69.9 9.7e-12
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 399 69.9 9.8e-12
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 399 69.9 9.9e-12
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 399 70.0 1e-11
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 399 70.0 1.1e-11
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 399 70.0 1.1e-11
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 399 70.1 1.2e-11
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 399 70.1 1.2e-11
>>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece (408 aa)
initn: 2812 init1: 2812 opt: 2812 Z-score: 2243.9 bits: 424.1 E(85289): 3e-118
Smith-Waterman score: 2812; 100.0% identity (100.0% similar) in 408 aa overlap (1-408:1-408)
10 20 30 40 50 60
pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
310 320 330 340 350 360
370 380 390 400
pF1KE9 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
370 380 390 400
>>NP_000675 (OMIM: 109630,607276) beta-1 adrenergic rece (477 aa)
initn: 829 init1: 625 opt: 886 Z-score: 715.9 bits: 141.6 E(85289): 3.9e-33
Smith-Waterman score: 1283; 52.5% identity (69.6% similar) in 425 aa overlap (2-394:10-424)
10 20 30
pF1KE9 MAPWPHENSSLAPWPDLPT-----LAPNTANTSGLPGV---P------WEAA
: : . :: :: :: . :.: . .: :: . : : :.
NP_000 MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE9 LAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLA
. : :.:: :: :.::.::::::: ::::::.::.:. :::.::::::::::: .::..
NP_000 M-GLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIV
70 80 90 100 110
100 110 120 130 140 150
pF1KE9 LTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAV
. :.: :. ::::::::::::::::::::..:.:::::.:.:.:: .:.:. :: :
NP_000 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE9 VLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLL
::..:: ::: ::. .:::. .: ::.::...:.:: :..: :.. :: ::::.::
NP_000 CTVWAISALVSFLPILMHWWRAESD-EARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE9 VMLFVYARVFVVATRQLRLLRGELGRF-PPEESPPAPSRSLAPAPVGTCAPPEGVP----
.: ::: ::: : .:.. . . :: ::.:: : .::: ::: : :
NP_000 IMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAP----APPPGPPRPAA
240 250 260 270 280 290
280 290 300 310 320
pF1KE9 -------ACGR----RPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSL
: :: ::.::. :::..:: :::.:::.:::::::::::::..:. :
NP_000 AAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRE-L
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE9 VPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAA--RPALF
:: :. .::::::::::::.:::::::::.::. ::: :.:: . :. ::
NP_000 VPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLC-CARRAARRRHATHGDRPR--
360 370 380 390 400 410
390 400
pF1KE9 PSGVPAARSSPAQPRLCQRLDGASWGVS
:: : . : .:
NP_000 ASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPG
420 430 440 450 460 470
>>NP_000015 (OMIM: 109690,600807,601665) beta-2 adrenerg (413 aa)
initn: 1068 init1: 533 opt: 732 Z-score: 594.5 bits: 118.9 E(85289): 2.2e-26
Smith-Waterman score: 1048; 48.2% identity (72.0% similar) in 357 aa overlap (5-361:4-341)
10 20 30 40 50 60
pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
: ..:.. :. . ::. :. : : ... : ...: ::: : ::.:::.
NP_000 MGQPGNGSAFLLAPNR-SHAPDHDVTQQRDEV-WVVGM-GIVMSLIVLAIVFGNVLVIT
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
::: ::::.:: :.:::: ::::::: ::: .:. : : .: ::.:::.::::
NP_000 AIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLC
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
:::::::::..:::::.:.:.:..: .:.:: ::. ...::.::. .:: ::. .:.:.
NP_000 VTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE9 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
. :: :..: :: : .:. :.. :: ::::.::..:.:::.::: : :::. .
NP_000 -THQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDK
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE9 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
::: . .:. . .: . : : . . :.::.:: :::.::::
NP_000 SEGRFHVQ--------NLSQVE------QDGRTGHGLRRSSKFCLKEHKALKTLGIIMGT
240 250 260 270 280
310 320 330 340 350 360
pF1KE9 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
:::::::::..:..... .:. ... :::.::.::.::::::::::::: ::..::
NP_000 FTLCWLPFFIVNIVHVIQD-NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELL
290 300 310 320 330 340
370 380 390 400
pF1KE9 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
:
NP_000 CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNID
350 360 370 380 390 400
>>NP_000785 (OMIM: 126449) D(1A) dopamine receptor [Homo (446 aa)
initn: 476 init1: 164 opt: 677 Z-score: 550.5 bits: 110.9 E(85289): 6.3e-24
Smith-Waterman score: 677; 33.2% identity (62.9% similar) in 367 aa overlap (39-395:25-378)
10 20 30 40 50 60
pF1KE9 SSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRL
:.. .:.: .:.:. :: :: .:. .:
NP_000 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHL
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 QT-MTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIET
.. .:: :: :::..::....::.: :. ..: ::.:. :..:.. :..: :::: .
NP_000 RSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILN
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 LCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVG----AD
::...:::: :...:.:: .: . : . ..:..:. .:: :.. .: .. .:
NP_000 LCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSD
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE9 AEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELG
..: . : . . :.. :: .:::.:. .:. .:.:.. .: .:.: . . :
NP_000 GNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI-AALE
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE9 RFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTL
: .. . . :: :. ::. .. :: ..: ::..:::.:.
NP_000 R-AAVHAKNCQTTTGNGKPV-ECSQPES-------SFKMSFKRETKVLKTLSVIMGVFVC
240 250 260 270 280
310 320 330 340 350
pF1KE9 CWLPFFLANVLRALGG-----PSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRR
::::::. : . . : : . . .: .. :.:.:::..::.:: . :::.::
NP_000 CWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFST
290 300 310 320 330 340
360 370 380 390 400
pF1KE9 LLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
:: : : : : .. .:. : :: .::
NP_000 LLG-CYRLCPATNNAIETVSINNNGA-AMFSSHHEPRGSISKECNLVYLIPHAVGSSEDL
350 360 370 380 390 400
NP_000 KKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
410 420 430 440
>>NP_000670 (OMIM: 104220) alpha-1B adrenergic receptor (520 aa)
initn: 672 init1: 390 opt: 654 Z-score: 531.6 bits: 107.6 E(85289): 7.2e-23
Smith-Waterman score: 745; 37.2% identity (66.5% similar) in 376 aa overlap (6-366:9-373)
10 20 30 40 50
pF1KE9 MAPWPHENSSLAPWPDLPT---LAPN-TANTSGLPGVPWEAALA-GALLALAVLATV
:..:. : : .: . .:: :...: :: . :.. : .:. .: ..
NP_000 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE9 GGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCEL
::.:::...: . .:.: :: :...:: :::.... :.: .:.: . :.: :: :..
NP_000 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE9 WTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAP
:..::::: :::: .:::...:::..: :.: .:::.: : :.. :::.:...:..:
NP_000 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE9 IMSQWWRVGADAEAQRCHSNPRCCAFASNMP-YVLLSSSVSFYLPLLVMLFVYARVFVVA
... :. : . ..: ... : :.:.:: :::.:: :.: .: ::..::
NP_000 LLG--WKEPAPNDDKECG--------VTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVA
190 200 210 220 230
240 250 260 270 280
pF1KE9 TRQLRLLR-GELGRFP--PEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPL-RE
: . :. : . .. : . :... ... . .: . ..:. . ::
NP_000 KRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSS-TKAKGHNPRSSIAVKLFKFSRE
240 250 260 270 280
290 300 310 320 330 340
pF1KE9 HRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY-
..: :::...: : :::::::.: : .: . : .: .. :::: :: .::.::
NP_000 KKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYP
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE9 CRSPDFRSAFRRLL-CRC---GRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDG
: : .:. :: :.: :.: :::
NP_000 CSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDD
350 360 370 380 390 400
>>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor (572 aa)
initn: 693 init1: 414 opt: 645 Z-score: 524.0 bits: 106.4 E(85289): 1.9e-22
Smith-Waterman score: 738; 37.7% identity (64.9% similar) in 382 aa overlap (7-371:64-429)
10 20 30
pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPG--VP
.: : : : . .. .:... : :
NP_000 GAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVS
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE9 WEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPA
... .:..:: .: .:.::::::...: . .:::.:: :...::.:::... :.: .
NP_000 AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE9 ATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCA
::. . : : .: . :..:..::::: :::: .::...::::..: . :.: :..:.: :
NP_000 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE9 RTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFY
. ..:.:::. .:: .:... :. . . : :... . :...:: :::
NP_000 AAILALLWVVALVVSVGPLLG--WK-------EPVPPDERFCGITEEAGYAVFSSVCSFY
220 230 240 250 260
220 230 240 250 260 270
pF1KE9 LPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPA
::. :.. .: ::.::: : :.. . : : : : :. . .: :
NP_000 LPMAVIVVMYCRVYVVARSTTRSLEAGVKR----ERGKASEVVLRIHCRGAATGADG--A
270 280 290 300 310
280 290 300 310 320
pF1KE9 CGRRPA-----------RLLPL-REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSL
: : : ::: . ::..: ::....:.:.:::.:::.. : .: :.:
NP_000 HGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLF-PQL
320 330 340 350 360 370
330 340 350 360 370
pF1KE9 VPGPA-FLALNWLGYANSAFNPLIY-CRSPDFRSAFRRLL-CRCGRRLPPEPCAAARPAL
:. . : .. :::: :: ::::: : : .:. :: ::: :.: :: .:
NP_000 KPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHH
380 390 400 410 420 430
380 390 400
pF1KE9 FPSGVPAARSSPAQPRLCQRLDGASWGVS
NP_000 WRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREW
440 450 460 470 480 490
>>NP_000612 (OMIM: 103780,164230,181500,182135,606788,60 (471 aa)
initn: 524 init1: 201 opt: 562 Z-score: 459.1 bits: 94.1 E(85289): 7.8e-19
Smith-Waterman score: 562; 30.0% identity (58.7% similar) in 387 aa overlap (20-399:61-429)
10 20 30 40
pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVL
:.:. . : : : :. :....
NP_000 DFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLT----AVVII
40 50 60 70 80
50 60 70 80 90 100
pF1KE9 ATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH-WPLGAT
:..::.:::.:.. .::. :: :. ::: ::...:.::.: . : :. ::: .
NP_000 LTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSK
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE9 GCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAV
: .: .::: :::: :::...:::.:. ::.... . .. : .. ::..:...
NP_000 LCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGI
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE9 SFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVF
:. :: . . :... . : : .:.. .::..: :::..:: .:...: ..
NP_000 SM-PI--PVFGLQDDSKVFKEGS----CLLADDN-FVLIGSFVSFFIPLTIMVITYFLTI
210 220 230 240 250
230 240 250 260 270 280
pF1KE9 VVATRQLRLLRGELGRFPPEESPP-APSRSLAPAPV-GTCAPPEGVPACGRRPARLLPLR
.. : ..:: : :. ::. . : ::: . .
NP_000 KSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSIS-N
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE9 EHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSL---VPGPAFLALNWLGYANSAFNP
:..: .::... :.. : :::..:.. .. : : : . .. :.:: .:: ::
NP_000 EQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNP
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE9 LIYCR-SPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDG
:.: . .:::: : . .: . .: .. . .:: . .: .. :.
NP_000 LVYTLFNKTYRSAFSRYI-QCQYKENKKPLQL----ILVNTIPALAYKSSQLQMGQKKNS
380 390 400 410 420 430
pF1KE9 ASWGVS
NP_000 KQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
440 450 460 470
>>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept (458 aa)
initn: 548 init1: 203 opt: 542 Z-score: 443.4 bits: 91.1 E(85289): 5.9e-18
Smith-Waterman score: 542; 32.3% identity (57.7% similar) in 381 aa overlap (10-371:26-393)
10 20 30 40
pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTS--GLP-GVPWEAALAG
:..: . : ::.. . .: :: ::.
NP_001 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALS-
10 20 30 40 50
50 60 70 80 90 100
pF1KE9 ALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTG
... .. :.:::.:::.:.. .:.. :: :. ::: ::...::::.: . :
NP_001 --IVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYD
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE9 H-WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVL
. ::: : .: :.::: :::: :::...:::.:. ::.... . .. : ...
NP_001 YVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE9 VWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVM
::..: .:: .:: .: : . .: : : .::..: :.:..:: .:
NP_001 VWAISIGVS-VPIPV----IGLRDEEKVFVNNTTCVLNDPN--FVLIGSFVAFFIPLTIM
180 190 200 210 220 230
230 240 250 260 270
pF1KE9 LFVYARVFVVATRQ-LRLLRGELGRFPPEESPP---APSRSLAPAPVGTCAPPEGVPACG
...: .. : :: : ::.:. . :: : .:. : .. : . :
NP_001 VITYCLTIYVLRRQALMLLHGHT-EEPPGLSLDFLKCCKRNTAEEE-NSANPNQDQNARR
240 250 260 270 280
280 290 300 310 320
pF1KE9 RRPARLLPL-------REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFL
:. . : :..: .::... .: . : :::..:.: .: :
NP_001 RKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEK
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE9 ALN---WLGYANSAFNPLIYCR-SPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVP
:: :.::. :..:::.: . .: :: : ::. .. .:
NP_001 LLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYL-RCNYKVEKKPPVRQIPRVAATALS
350 360 370 380 390 400
390 400
pF1KE9 AARSSPAQPRLCQRLDGASWGVS
NP_001 GRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
410 420 430 440 450
>>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor (458 aa)
initn: 548 init1: 203 opt: 542 Z-score: 443.4 bits: 91.1 E(85289): 5.9e-18
Smith-Waterman score: 542; 32.3% identity (57.7% similar) in 381 aa overlap (10-371:26-393)
10 20 30 40
pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTS--GLP-GVPWEAALAG
:..: . : ::.. . .: :: ::.
NP_000 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALS-
10 20 30 40 50
50 60 70 80 90 100
pF1KE9 ALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTG
... .. :.:::.:::.:.. .:.. :: :. ::: ::...::::.: . :
NP_000 --IVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYD
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE9 H-WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVL
. ::: : .: :.::: :::: :::...:::.:. ::.... . .. : ...
NP_000 YVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE9 VWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVM
::..: .:: .:: .: : . .: : : .::..: :.:..:: .:
NP_000 VWAISIGVS-VPIPV----IGLRDEEKVFVNNTTCVLNDPN--FVLIGSFVAFFIPLTIM
180 190 200 210 220 230
230 240 250 260 270
pF1KE9 LFVYARVFVVATRQ-LRLLRGELGRFPPEESPP---APSRSLAPAPVGTCAPPEGVPACG
...: .. : :: : ::.:. . :: : .:. : .. : . :
NP_000 VITYCLTIYVLRRQALMLLHGHT-EEPPGLSLDFLKCCKRNTAEEE-NSANPNQDQNARR
240 250 260 270 280
280 290 300 310 320
pF1KE9 RRPARLLPL-------REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFL
:. . : :..: .::... .: . : :::..:.: .: :
NP_000 RKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEK
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE9 ALN---WLGYANSAFNPLIYCR-SPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVP
:: :.::. :..:::.: . .: :: : ::. .. .:
NP_000 LLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYL-RCNYKVEKKPPVRQIPRVAATALS
350 360 370 380 390 400
390 400
pF1KE9 AARSSPAQPRLCQRLDGASWGVS
NP_000 GRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
410 420 430 440 450
>>XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B adrene (366 aa)
initn: 594 init1: 390 opt: 529 Z-score: 434.1 bits: 89.1 E(85289): 1.9e-17
Smith-Waterman score: 620; 36.1% identity (67.3% similar) in 327 aa overlap (6-322:9-324)
10 20 30 40 50
pF1KE9 MAPWPHENSSLAPWPDLPT---LAPN-TANTSGLPGVPWEAALA-GALLALAVLATV
:..:. : : .: . .:: :...: :: . :.. : .:. .: ..
XP_005 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE9 GGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCEL
::.:::...: . .:.: :: :...:: :::.... :.: .:.: . :.: :: :..
XP_005 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE9 WTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAP
:..::::: :::: .:::...:::..: :.: .:::.: : :.. :::.:...:..:
XP_005 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE9 IMSQWWRVGADAEAQRCHSNPRCCAFASNMP-YVLLSSSVSFYLPLLVMLFVYARVFVVA
... :. : . ..: ... : :.:.:: :::.:: :.: .: ::..::
XP_005 LLG--WKEPAPNDDKECG--------VTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVA
190 200 210 220 230
240 250 260 270 280
pF1KE9 TRQLRLLR-GELGRFP--PEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPL-RE
: . :. : . .. : . :... ... . .: . ..:. . ::
XP_005 KRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSS-TKAKGHNPRSSIAVKLFKFSRE
240 250 260 270 280
290 300 310 320 330 340
pF1KE9 HRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC
..: :::...: : :::::::.: :.. :. ::
XP_005 KKAAKTLGIVVGMFILCWLPFFIALPLESKGSLSLKTLNACCKSRKEMNEHNLNLSSLES
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE9 RSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGV
XP_005 GHVRDTGATLHHHIIRY
350 360
408 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:09:48 2016 done: Sun Nov 6 16:09:49 2016
Total Scan time: 8.430 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]