Result of FASTA (omim) for
pFN21AE9568
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9568, 398 aa
1>>>pF1KE9568 398 - 398 aa - 398 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9674+/-0.000567; mu= 19.2438+/- 0.035
mean_var=127.9883+/-37.556, 0's: 0 Z-trim(107.6): 580 B-trim: 878 in 1/50
Lambda= 0.113368
statistics sampled from 14976 (15712) to 14976 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.519), E-opt: 0.2 (0.184), width: 16
Scan time: 6.760
The best scores are: opt bits E(85289)
NP_003292 (OMIM: 188545) thyrotropin-releasing hor ( 398) 2615 440.2 4.1e-123
XP_011515565 (OMIM: 188545) PREDICTED: thyrotropin ( 398) 2615 440.2 4.1e-123
XP_011508789 (OMIM: 604153) PREDICTED: neuromedin- ( 403) 448 85.8 2e-16
NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [ ( 426) 448 85.9 2.1e-16
NP_002522 (OMIM: 162651) neurotensin receptor type ( 418) 393 76.8 1e-13
NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 368 72.7 1.7e-12
NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 364 72.0 2.6e-12
NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 364 72.0 2.6e-12
XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 364 72.0 2.6e-12
NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 364 72.0 2.6e-12
XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 364 72.1 2.7e-12
XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 364 72.1 2.7e-12
XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 364 72.1 2.7e-12
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 364 72.2 3.2e-12
NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 361 71.6 3.9e-12
NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 361 71.6 4e-12
NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 361 71.7 4.5e-12
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 353 70.3 9.9e-12
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 353 70.3 9.9e-12
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 353 70.4 1e-11
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 353 70.4 1e-11
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 353 70.4 1e-11
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 353 70.4 1e-11
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 353 70.4 1e-11
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 353 70.4 1e-11
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 341 68.4 3.9e-11
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 341 68.4 3.9e-11
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 341 68.4 4.1e-11
XP_011535972 (OMIM: 605108) PREDICTED: neuromedin- ( 321) 339 67.8 4.1e-11
NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415) 339 68.0 4.8e-11
XP_016883344 (OMIM: 602548) PREDICTED: nociceptin ( 365) 336 67.4 6.2e-11
NP_001305783 (OMIM: 602548) nociceptin receptor is ( 365) 336 67.4 6.2e-11
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 336 67.5 6.7e-11
NP_795344 (OMIM: 118445) gastrin/cholecystokinin t ( 447) 335 67.4 7.8e-11
NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444) 334 67.2 8.7e-11
XP_016866287 (OMIM: 602393) PREDICTED: orexin rece ( 461) 334 67.3 8.9e-11
XP_016856596 (OMIM: 602392) PREDICTED: orexin rece ( 389) 328 66.2 1.6e-10
XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cho ( 516) 329 66.5 1.7e-10
NP_001516 (OMIM: 602392) orexin receptor type 1 [H ( 425) 328 66.2 1.7e-10
XP_016856594 (OMIM: 602392) PREDICTED: orexin rece ( 425) 328 66.2 1.7e-10
XP_016856595 (OMIM: 602392) PREDICTED: orexin rece ( 425) 328 66.2 1.7e-10
NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 326 65.9 2.1e-10
XP_016874005 (OMIM: 118445) PREDICTED: gastrin/cho ( 381) 322 65.2 3.1e-10
NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 320 64.8 3.9e-10
NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 320 64.9 4.1e-10
NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 316 64.2 6.1e-10
NP_620414 (OMIM: 607122) prokineticin receptor 1 [ ( 393) 314 63.9 7.8e-10
XP_011508791 (OMIM: 604153) PREDICTED: neuromedin- ( 313) 312 63.4 8.7e-10
XP_006712259 (OMIM: 604153) PREDICTED: neuromedin- ( 333) 312 63.5 9e-10
XP_006712258 (OMIM: 604153) PREDICTED: neuromedin- ( 370) 312 63.5 9.5e-10
>>NP_003292 (OMIM: 188545) thyrotropin-releasing hormone (398 aa)
initn: 2615 init1: 2615 opt: 2615 Z-score: 2331.4 bits: 440.2 E(85289): 4.1e-123
Smith-Waterman score: 2615; 100.0% identity (100.0% similar) in 398 aa overlap (1-398:1-398)
10 20 30 40 50 60
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
310 320 330 340 350 360
370 380 390
pF1KE9 DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
::::::::::::::::::::::::::::::::::::::
NP_003 DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
370 380 390
>>XP_011515565 (OMIM: 188545) PREDICTED: thyrotropin-rel (398 aa)
initn: 2615 init1: 2615 opt: 2615 Z-score: 2331.4 bits: 440.2 E(85289): 4.1e-123
Smith-Waterman score: 2615; 100.0% identity (100.0% similar) in 398 aa overlap (1-398:1-398)
10 20 30 40 50 60
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
310 320 330 340 350 360
370 380 390
pF1KE9 DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
::::::::::::::::::::::::::::::::::::::
XP_011 DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
370 380 390
>>XP_011508789 (OMIM: 604153) PREDICTED: neuromedin-U re (403 aa)
initn: 367 init1: 150 opt: 448 Z-score: 415.8 bits: 85.8 E(85289): 2e-16
Smith-Waterman score: 449; 29.5% identity (57.4% similar) in 376 aa overlap (3-351:18-367)
10 20 30 40
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIM
: : : : :. . . .: ::.... : ::: .
XP_011 MACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVV---GAVGNGL
10 20 30 40 50
50 60 70 80 90 100
pF1KE9 VVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSW-----VYGYVGCLC
. ::..: : :::::: :: ::::.::.::.. ::: .: : . : ::
XP_011 TCLVILRHKAMRTPTNYYLFSLAVSDLLVLLV-GLPL---ELYEMWHNYPFLLGVGGCYF
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE9 ITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLW
: : . :: ..::...:::.:. ::..:. . : ....... ::.. .. : :
XP_011 RTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGL-AMLCSLP
120 130 140 150 160 170
170 180 190 200 210
pF1KE9 FFLL----DLNI---STYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGF
: .:.. . :. : : : :. . .:. .:: . .::: .
XP_011 NTSLHGIRQLHVPCRGPVPDSAV--CMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLL
180 190 200 210 220 230
220 230 240 250 260
pF1KE9 IA------RILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKM
:. :.:.. ...: . .... . .. .: .:.:::::
XP_011 IGLRLRRERLLLM--------QEAKGRGSAAARSRYTCRLQQHDR-------GRRQVTKM
240 250 260 270
270 280 290 300 310 320
pF1KE9 LAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICI------YLNSAINPVIYN
: :.:..:.. : :... :. : .:. . .. : : .. . ::.:: :::.:.
XP_011 LFVLVVVFGICWAPFHADRVMWSVVSQ-WTDGLHLAFQHVHVISGIFFYLGSAANPVLYS
280 290 300 310 320 330
330 340 350 360 370
pF1KE9 LMSQKFRAAFRK-LC--NCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLS
:::..:: .:.. :: : .. . ...:..
XP_011 LMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGP
340 350 360 370 380 390
380 390
pF1KE9 ATKVSFDDTCLASEVSFSQS
XP_011 EAQQETDPS
400
>>NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [Homo (426 aa)
initn: 367 init1: 150 opt: 448 Z-score: 415.6 bits: 85.9 E(85289): 2.1e-16
Smith-Waterman score: 449; 29.5% identity (57.4% similar) in 376 aa overlap (3-351:41-390)
10 20 30
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLV
: : : : :. . . .: ::.
NP_006 LPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLI
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE9 LIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSW-
... : ::: .. ::..: : :::::: :: ::::.::.::.. ::: .: :
NP_006 FVV---GAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLV-GLPL---ELYEMWH
80 90 100 110 120
100 110 120 130 140
pF1KE9 ----VYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIII
. : :: : : . :: ..::...:::.:. ::..:. . : .......
NP_006 NYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLG
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE9 FVWAFTSLYCMLWFFLL----DLNI---STYKDAIVISCGYKISRNYYSPIYLMDFGVFY
::.. .. : : : .:.. . :. : : : :. . .:.
NP_006 AVWGL-AMLCSLPNTSLHGIRQLHVPCRGPVPDSAV--CMLVRPRALYNMVVQTTALLFF
190 200 210 220 230 240
210 220 230 240 250
pF1KE9 VVPMILATVLYGFIA------RILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCF
.:: . .::: .:. :.:.. ...: . .... . .. .:
NP_006 CLPMAIMSVLYLLIGLRLRRERLLLM--------QEAKGRGSAAARSRYTCRLQQHDR--
250 260 270 280 290
260 270 280 290 300
pF1KE9 NSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICI-----
.:.:::::: :.:..:.. : :... :. : .:. . .. : : .. .
NP_006 -----GRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQ-WTDGLHLAFQHVHVISGIF
300 310 320 330 340
310 320 330 340 350 360
pF1KE9 -YLNSAINPVIYNLMSQKFRAAFRK-LC--NCKQKPTEKPANYSVALNYSVIKESDHFST
::.:: :::.:.:::..:: .:.. :: : .. . ...:..
NP_006 FYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSL
350 360 370 380 390 400
370 380 390
pF1KE9 ELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
NP_006 GSWVHPLAGNDGPEAQQETDPS
410 420
>>NP_002522 (OMIM: 162651) neurotensin receptor type 1 [ (418 aa)
initn: 323 init1: 186 opt: 393 Z-score: 367.1 bits: 76.8 E(85289): 1e-13
Smith-Waterman score: 393; 24.6% identity (59.4% similar) in 362 aa overlap (3-346:43-394)
10 20 30
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLV
.: : ...:. . . . :... :.
NP_002 TPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLA
20 30 40 50 60 70
40 50 60 70 80
pF1KE9 LIICGLGIVGNIMVVLVVMRTKHMRT---PTNCYLVSLAVADLMVLVAAGLPNITDSIY-
:.. .: ::: ...... : : ... .. .: :::..::..:. : .. . :.
NP_002 LFV--VGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWV
80 90 100 110 120 130
90 100 110 120 130 140
pF1KE9 -GSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIII
:..: .:: .:. :.. .......:::.:::::.::. : . ::.::.:
NP_002 HHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFIS
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE9 FVWAFTSLYCMLWFFLL-DLNISTY-KDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMI
.: ..: . .: . . : :. . : . : : . . .. . .. ::.
NP_002 AIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMV
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE9 LATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVT
. .:: .:: : . . . :.... . :.. .. .. . :.. .. .
NP_002 VISVLNTIIANKLTV--MVRQAAEQGQVCTVGGEHSTFSMAIEPGR------VQALRHGV
260 270 280 290 300
270 280 290 300 310
pF1KE9 KMLAVVVILFALLWMPYRTLVVVNSFLS----SPFQENWFLLFCRIC---IYLNSAINPV
..: .::: :.. :.::.. .. ..: .:: ... : . .:..:.:::.
NP_002 RVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPI
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE9 IYNLMSQKFRAAFRK----LCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTD
.:::.: .:: : :: .. ..::
NP_002 LYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
370 380 390 400 410
380 390
pF1KE9 TYLSATKVSFDDTCLASEVSFSQS
>>NP_001305782 (OMIM: 602548) nociceptin receptor isofor (399 aa)
initn: 335 init1: 132 opt: 368 Z-score: 345.2 bits: 72.7 E(85289): 1.7e-12
Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335)
10 20 30 40
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV
: . : .:. . : : .: :..:: .:.
NP_001 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY
:..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..:
NP_001 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL
.. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. .
NP_001 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI
.. . : : .: ..:..:.. . . .: ..::... .: :... : : .
NP_001 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL
200 210 220 230 240
230 240 250 260 270 280
pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR
: .:... :: ...:... ::: .:. : : .
NP_001 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ
250 260 270 280
290 300 310 320 330 340
pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP
..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: :
NP_001 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL
290 300 310 320 330
350 360 370 380 390
pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
NP_001 RRDVQVSDRVRSIAKDVALACKTSETVPRPAXLGVDLPMVPVSPQSPSTPNTELTQVTAL
340 350 360 370 380 390
>>NP_001186948 (OMIM: 602548) nociceptin receptor isofor (370 aa)
initn: 368 init1: 132 opt: 364 Z-score: 342.0 bits: 72.0 E(85289): 2.6e-12
Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335)
10 20 30 40
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV
: . : .:. . : : .: :..:: .:.
NP_001 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY
:..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..:
NP_001 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL
.. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. .
NP_001 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI
.. . : : .: ..:..:.. . . .: ..::... .: :... : : .
NP_001 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL
200 210 220 230 240
230 240 250 260 270 280
pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR
: .:... :: ...:... ::: .:. : : .
NP_001 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ
250 260 270 280
290 300 310 320 330 340
pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP
..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: :
NP_001 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL
290 300 310 320 330
350 360 370 380 390
pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
NP_001 RRDVQVSDRVRSIAKDVALACKTSETVPRPA
340 350 360 370
>>NP_000904 (OMIM: 602548) nociceptin receptor isoform 1 (370 aa)
initn: 368 init1: 132 opt: 364 Z-score: 342.0 bits: 72.0 E(85289): 2.6e-12
Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335)
10 20 30 40
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV
: . : .:. . : : .: :..:: .:.
NP_000 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY
:..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..:
NP_000 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL
.. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. .
NP_000 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI
.. . : : .: ..:..:.. . . .: ..::... .: :... : : .
NP_000 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL
200 210 220 230 240
230 240 250 260 270 280
pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR
: .:... :: ...:... ::: .:. : : .
NP_000 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ
250 260 270 280
290 300 310 320 330 340
pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP
..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: :
NP_000 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL
290 300 310 320 330
350 360 370 380 390
pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
NP_000 RRDVQVSDRVRSIAKDVALACKTSETVPRPA
340 350 360 370
>>XP_016883343 (OMIM: 602548) PREDICTED: nociceptin rece (370 aa)
initn: 368 init1: 132 opt: 364 Z-score: 342.0 bits: 72.0 E(85289): 2.6e-12
Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335)
10 20 30 40
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV
: . : .:. . : : .: :..:: .:.
XP_016 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY
:..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..:
XP_016 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL
.. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. .
XP_016 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI
.. . : : .: ..:..:.. . . .: ..::... .: :... : : .
XP_016 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL
200 210 220 230 240
230 240 250 260 270 280
pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR
: .:... :: ...:... ::: .:. : : .
XP_016 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ
250 260 270 280
290 300 310 320 330 340
pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP
..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: :
XP_016 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL
290 300 310 320 330
350 360 370 380 390
pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
XP_016 RRDVQVSDRVRSIAKDVALACKTSETVPRPA
340 350 360 370
>>NP_872588 (OMIM: 602548) nociceptin receptor isoform 1 (370 aa)
initn: 368 init1: 132 opt: 364 Z-score: 342.0 bits: 72.0 E(85289): 2.6e-12
Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335)
10 20 30 40
pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV
: . : .:. . : : .: :..:: .:.
NP_872 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM
20 30 40 50 60 70
50 60 70 80 90 100
pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY
:..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..:
NP_872 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL
.. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. .
NP_872 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI
.. . : : .: ..:..:.. . . .: ..::... .: :... : : .
NP_872 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL
200 210 220 230 240
230 240 250 260 270 280
pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR
: .:... :: ...:... ::: .:. : : .
NP_872 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ
250 260 270 280
290 300 310 320 330 340
pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP
..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: :
NP_872 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL
290 300 310 320 330
350 360 370 380 390
pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
NP_872 RRDVQVSDRVRSIAKDVALACKTSETVPRPA
340 350 360 370
398 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:04:22 2016 done: Sun Nov 6 16:04:23 2016
Total Scan time: 6.760 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]