Result of FASTA (omim) for
pFN21AE9563
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9563, 479 aa
1>>>pF1KE9563 479 - 479 aa - 479 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8550+/-0.000385; mu= 21.0971+/- 0.024
mean_var=94.2634+/-21.711, 0's: 0 Z-trim(114.1): 650 B-trim: 2204 in 2/49
Lambda= 0.132100
statistics sampled from 22932 (23704) to 22932 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.278), width: 16
Scan time: 6.720
The best scores are: opt bits E(85289)
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 3247 629.6 5.9e-180
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 2918 566.8 4.2e-161
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 2916 566.4 5.4e-161
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 797 162.7 2.3e-39
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 782 159.7 1.4e-38
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 782 159.7 1.4e-38
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 782 159.8 1.5e-38
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 782 159.8 1.5e-38
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 782 159.8 1.5e-38
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 782 159.8 1.5e-38
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 782 159.8 1.5e-38
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 782 159.8 1.5e-38
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 753 154.4 8e-37
NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 709 145.7 2e-34
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 695 143.0 1.2e-33
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 695 143.0 1.2e-33
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 695 143.1 1.3e-33
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 695 143.1 1.3e-33
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 695 143.1 1.4e-33
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 695 143.3 1.7e-33
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 686 141.3 3.9e-33
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 685 141.1 4.3e-33
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 685 141.1 4.4e-33
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 685 141.1 4.6e-33
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 685 141.2 4.8e-33
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 685 141.2 4.8e-33
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 626 130.1 1.4e-29
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 608 126.6 1.4e-28
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 597 124.5 6.1e-28
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 541 113.8 9.6e-25
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 535 112.6 1.9e-24
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 535 112.6 1.9e-24
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 523 110.3 9.6e-24
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 523 110.3 9.8e-24
XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 517 109.1 2.1e-23
NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 517 109.1 2.1e-23
XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 517 109.1 2.1e-23
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 517 109.1 2.1e-23
NP_000857 (OMIM: 182134) 5-hydroxytryptamine recep ( 366) 517 109.1 2.1e-23
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 517 109.1 2.1e-23
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 506 107.1 9.6e-23
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 506 107.1 1e-22
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 506 107.1 1e-22
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 476 101.5 5.5e-21
NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 475 101.2 5.5e-21
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 469 100.0 1.2e-20
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 469 100.0 1.2e-20
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 469 100.0 1.2e-20
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 469 100.0 1.2e-20
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 469 100.1 1.3e-20
>>NP_062873 (OMIM: 182137) 5-hydroxytryptamine receptor (479 aa)
initn: 3247 init1: 3247 opt: 3247 Z-score: 3351.7 bits: 629.6 E(85289): 5.9e-180
Smith-Waterman score: 3247; 100.0% identity (100.0% similar) in 479 aa overlap (1-479:1-479)
10 20 30 40 50 60
pF1KE9 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
370 380 390 400 410 420
430 440 450 460 470
pF1KE9 LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
430 440 450 460 470
>>NP_000863 (OMIM: 182137) 5-hydroxytryptamine receptor (445 aa)
initn: 2940 init1: 2917 opt: 2918 Z-score: 3013.2 bits: 566.8 E(85289): 4.2e-161
Smith-Waterman score: 2918; 98.2% identity (98.9% similar) in 441 aa overlap (1-438:1-441)
10 20 30 40 50 60
pF1KE9 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
370 380 390 400 410 420
430 440 450 460 470
pF1KE9 LAERPERPEFVLRA---CTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMI
::::::::::::. : ..
NP_000 LAERPERPEFVLQNADYCRKKGHDS
430 440
>>NP_062874 (OMIM: 182137) 5-hydroxytryptamine receptor (432 aa)
initn: 2916 init1: 2916 opt: 2916 Z-score: 3011.3 bits: 566.4 E(85289): 5.4e-161
Smith-Waterman score: 2916; 100.0% identity (100.0% similar) in 432 aa overlap (1-432:1-432)
10 20 30 40 50 60
pF1KE9 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_062 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK
370 380 390 400 410 420
430 440 450 460 470
pF1KE9 LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
::::::::::::
NP_062 LAERPERPEFVL
430
>>NP_000670 (OMIM: 104220) alpha-1B adrenergic receptor (520 aa)
initn: 626 init1: 268 opt: 797 Z-score: 827.9 bits: 162.7 E(85289): 2.3e-39
Smith-Waterman score: 797; 36.4% identity (69.3% similar) in 352 aa overlap (64-409:28-373)
40 50 60 70 80 90
pF1KE9 DGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITL
:...:. . . .. . .: .: . :
NP_000 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFIL
10 20 30 40 50
100 110 120 130 140 150
pF1KE9 LTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHF
..:.:: ::..:: ..:: :.::.::.::.::: .. .:.:: .. ...: :..:..
NP_000 FAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG-YWVLGRI
60 70 80 90 100 110
160 170 180 190 200 210
pF1KE9 FCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI
::... :.::.::::::..::.::::::.:. : ::. . . .::::.::. :
NP_000 FCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVI
120 130 140 150 160 170
220 230 240 250 260 270
pF1KE9 TLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAK
.. ::.:: . . :::: : .... :...:. .::::..:.: :: ..: .:.... :
NP_000 SIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTT-K
180 190 200 210 220 230
280 290 300 310 320
pF1KE9 HKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHE-RKNISI----FKREQKAAT
. : . : .. :. .. .. :. . .. :. :..:.. :.::.:::
NP_000 NLEAGVMK-EMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAK
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE9 TLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFF
::::.:: : .::::::. : :. : : : .. .:::: :: .::.::
NP_000 TLGIVVGMFILCWLPFFI---ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCS
300 310 320 330 340 350
390 400 410 420 430 440
pF1KE9 NRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRP
..... .. .: :: :. .:.
NP_000 SKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSG
360 370 380 390 400 410
>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa)
initn: 644 init1: 324 opt: 782 Z-score: 813.4 bits: 159.7 E(85289): 1.4e-38
Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397)
40 50 60 70 80 90
pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL
..:.: . . : ...: :: . :.
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF
10 20 30
100 110 120 130 140 150
pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF
. :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. :
NP_150 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS
::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: ::
NP_150 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA
:.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. .
NP_150 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG
: :. . :: . : . . . . : : : . :.::.::: :::
NP_150 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD
:.:: :..:::::::. :. . : : . .:::: :: :::.:: ...
NP_150 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE
280 290 300 310 320 330
400 410 420 430 440
pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR
.. .....: :: :. . : : : .: . .: .. . . .:... : :
NP_150 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT
340 350 360 370 380 390
450 460 470
pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
: :
NP_150 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARGHTPMT
400 410 420
>>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa)
initn: 644 init1: 324 opt: 782 Z-score: 813.4 bits: 159.7 E(85289): 1.4e-38
Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397)
40 50 60 70 80 90
pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL
..:.: . . : ...: :: . :.
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF
10 20 30
100 110 120 130 140 150
pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF
. :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. :
XP_006 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS
::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: ::
XP_006 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA
:.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. .
XP_006 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG
: :. . :: . : . . . . : : : . :.::.::: :::
XP_006 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD
:.:: :..:::::::. :. . : : . .:::: :: :::.:: ...
XP_006 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE
280 290 300 310 320 330
400 410 420 430 440
pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR
.. .....: :: :. . : : : .: . .: .. . . .:... : :
XP_006 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT
340 350 360 370 380 390
450 460 470
pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
: :
XP_006 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARGHTPMT
400 410 420
>>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa)
initn: 644 init1: 324 opt: 782 Z-score: 813.1 bits: 159.8 E(85289): 1.5e-38
Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397)
40 50 60 70 80 90
pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL
..:.: . . : ...: :: . :.
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF
10 20 30
100 110 120 130 140 150
pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF
. :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. :
NP_150 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS
::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: ::
NP_150 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA
:.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. .
NP_150 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG
: :. . :: . : . . . . : : : . :.::.::: :::
NP_150 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD
:.:: :..:::::::. :. . : : . .:::: :: :::.:: ...
NP_150 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE
280 290 300 310 320 330
400 410 420 430 440
pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR
.. .....: :: :. . : : : .: . .: .. . . .:... : :
NP_150 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT
340 350 360 370 380 390
450 460 470
pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
: :
NP_150 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARRGMDCRYFTKNCREHIKHVNFMMPPWRK
400 410 420 430 440 450
>>NP_000671 (OMIM: 104221) alpha-1A adrenergic receptor (466 aa)
initn: 644 init1: 324 opt: 782 Z-score: 813.0 bits: 159.8 E(85289): 1.5e-38
Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397)
40 50 60 70 80 90
pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL
..:.: . . : ...: :: . :.
NP_000 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF
10 20 30
100 110 120 130 140 150
pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF
. :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. :
NP_000 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS
::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: ::
NP_000 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA
:.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. .
NP_000 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG
: :. . :: . : . . . . : : : . :.::.::: :::
NP_000 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD
:.:: :..:::::::. :. . : : . .:::: :: :::.:: ...
NP_000 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE
280 290 300 310 320 330
400 410 420 430 440
pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR
.. .....: :: :. . : : : .: . .: .. . . .:... : :
NP_000 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT
340 350 360 370 380 390
450 460 470
pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
: :
NP_000 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPT
400 410 420 430 440 450
>>NP_150646 (OMIM: 104221) alpha-1A adrenergic receptor (475 aa)
initn: 644 init1: 324 opt: 782 Z-score: 812.9 bits: 159.8 E(85289): 1.5e-38
Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397)
40 50 60 70 80 90
pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL
..:.: . . : ...: :: . :.
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF
10 20 30
100 110 120 130 140 150
pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF
. :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. :
NP_150 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS
::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: ::
NP_150 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA
:.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. .
NP_150 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG
: :. . :: . : . . . . : : : . :.::.::: :::
NP_150 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD
:.:: :..:::::::. :. . : : . .:::: :: :::.:: ...
NP_150 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE
280 290 300 310 320 330
400 410 420 430 440
pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR
.. .....: :: :. . : : : .: . .: .. . . .:... : :
NP_150 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT
340 350 360 370 380 390
450 460 470
pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
: :
NP_150 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARTKSRSVTRLECSGMILAHCNLRLPGSRD
400 410 420 430 440 450
>>XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 644 init1: 324 opt: 782 Z-score: 812.9 bits: 159.8 E(85289): 1.5e-38
Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397)
40 50 60 70 80 90
pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL
..:.: . . : ...: :: . :.
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF
10 20 30
100 110 120 130 140 150
pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF
. :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. :
XP_016 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS
::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: ::
XP_016 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA
:.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. .
XP_016 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG
: :. . :: . : . . . . : : : . :.::.::: :::
XP_016 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD
:.:: :..:::::::. :. . : : . .:::: :: :::.:: ...
XP_016 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE
280 290 300 310 320 330
400 410 420 430 440
pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR
.. .....: :: :. . : : : .: . .: .. . . .:... : :
XP_016 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT
340 350 360 370 380 390
450 460 470
pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
: :
XP_016 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARTKSRSVTRLECSGMILAHCNLRLPGSRD
400 410 420 430 440 450
479 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 15:23:58 2016 done: Sun Nov 6 15:23:59 2016
Total Scan time: 6.720 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]