Result of FASTA (omim) for
pFN21AE9435
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9435, 617 aa
1>>>pF1KE9435 617 - 617 aa - 617 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.3700+/-0.000519; mu= -4.2858+/- 0.032
mean_var=318.2556+/-65.235, 0's: 0 Z-trim(117.2): 581 B-trim: 0 in 0/54
Lambda= 0.071893
statistics sampled from 28304 (28958) to 28304 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.34), width: 16
Scan time: 11.240
The best scores are: opt bits E(85289)
NP_004215 (OMIM: 300207) melatonin-related recepto ( 617) 4186 448.6 2.9e-125
XP_011529518 (OMIM: 300207) PREDICTED: melatonin-r ( 370) 2520 275.6 2e-73
NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350) 1153 133.8 9.4e-31
NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 1106 129.0 2.8e-29
XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 1106 129.0 2.8e-29
XP_016873266 (OMIM: 125853,600804) PREDICTED: mela ( 320) 992 117.1 9.4e-26
XP_011530304 (OMIM: 600665) PREDICTED: melatonin r ( 265) 895 107.0 8.7e-23
NP_001008505 (OMIM: 600018) mu-type opioid recepto ( 446) 475 63.6 1.7e-09
NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 471 63.2 2.1e-09
NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 468 62.8 2.5e-09
NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 468 62.8 2.5e-09
NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 468 62.8 2.5e-09
NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 468 62.8 2.5e-09
NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 468 62.8 2.6e-09
NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 468 62.9 2.6e-09
NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 468 62.9 2.6e-09
NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 468 62.9 2.6e-09
NP_001138751 (OMIM: 600018) mu-type opioid recepto ( 493) 468 62.9 3e-09
NP_001272453 (OMIM: 600018) mu-type opioid recepto ( 493) 468 62.9 3e-09
NP_001138753 (OMIM: 600018) mu-type opioid recepto ( 319) 418 57.6 7.8e-08
XP_011534164 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08
XP_011534158 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08
XP_016866394 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08
XP_011534155 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08
XP_016866392 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08
XP_011534153 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08
XP_016866393 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08
NP_001272456 (OMIM: 600018) mu-type opioid recepto ( 292) 410 56.7 1.3e-07
NP_001138752 (OMIM: 600018) mu-type opioid recepto ( 300) 410 56.7 1.3e-07
NP_001138759 (OMIM: 600018) mu-type opioid recepto ( 300) 410 56.7 1.3e-07
NP_001272455 (OMIM: 600018) mu-type opioid recepto ( 300) 410 56.7 1.3e-07
XP_016866395 (OMIM: 600018) PREDICTED: mu-type opi ( 300) 410 56.7 1.3e-07
NP_001272457 (OMIM: 600018) mu-type opioid recepto ( 314) 410 56.7 1.4e-07
NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 411 56.9 1.5e-07
NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 411 56.9 1.6e-07
NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 407 56.5 1.8e-07
NP_003848 (OMIM: 603691) galanin receptor type 2 [ ( 387) 401 55.9 3.1e-07
NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 397 55.4 3.9e-07
NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 397 55.4 3.9e-07
NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 396 55.4 4.4e-07
NP_005288 (OMIM: 601751) melanin-concentrating hor ( 422) 394 55.2 5.4e-07
NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 392 54.9 5.7e-07
NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 392 54.9 5.7e-07
XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 392 54.9 5.7e-07
NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 392 54.9 5.7e-07
XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 392 55.0 5.9e-07
XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 392 55.0 5.9e-07
XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 392 55.0 5.9e-07
NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 392 55.0 6e-07
NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 390 54.8 7e-07
>>NP_004215 (OMIM: 300207) melatonin-related receptor [H (617 aa)
initn: 4186 init1: 4186 opt: 4186 Z-score: 2369.9 bits: 448.6 E(85289): 2.9e-125
Smith-Waterman score: 4186; 99.8% identity (100.0% similar) in 617 aa overlap (1-617:1-617)
10 20 30 40 50 60
pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 VIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNEN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 FRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 VSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 HVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 ASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDY
550 560 570 580 590 600
610
pF1KE9 HDVVVVDVEDDPDEMAV
:::::.:::::::::::
NP_004 HDVVVIDVEDDPDEMAV
610
>>XP_011529518 (OMIM: 300207) PREDICTED: melatonin-relat (370 aa)
initn: 2520 init1: 2520 opt: 2520 Z-score: 1439.0 bits: 275.6 E(85289): 2e-73
Smith-Waterman score: 2520; 99.5% identity (100.0% similar) in 370 aa overlap (248-617:1-370)
220 230 240 250 260 270
pF1KE9 ARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYL
.:::::::::::::::::::::::::::::
XP_011 MCWCPINVLTVLVAVSPKEMAGKIPNWLYL
10 20 30
280 290 300 310 320 330
pF1KE9 AAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLAR
40 50 60 70 80 90
340 350 360 370 380 390
pF1KE9 ARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYR
100 110 120 130 140 150
400 410 420 430 440 450
pF1KE9 KSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDS
160 170 180 190 200 210
460 470 480 490 500 510
pF1KE9 VHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTT
220 230 240 250 260 270
520 530 540 550 560 570
pF1KE9 ADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAAS
280 290 300 310 320 330
580 590 600 610
pF1KE9 QLESDTIADLPDPTVVTTSTNDYHDVVVVDVEDDPDEMAV
::::::::::::::::::::::::::::.:::::::::::
XP_011 QLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV
340 350 360 370
>>NP_005949 (OMIM: 600665) melatonin receptor type 1A [H (350 aa)
initn: 1145 init1: 791 opt: 1153 Z-score: 673.1 bits: 133.8 E(85289): 9.4e-31
Smith-Waterman score: 1153; 51.5% identity (79.7% similar) in 305 aa overlap (24-326:23-327)
10 20 30 40 50 60
pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR
: : . :....:::::..:: .:::.: .:::::
NP_005 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLR
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV
:.::::::::.:::..::::::::.: .. .::.:. :.::. ::. ::::.::::::.
NP_005 NAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNIT
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF
.:::::::::::::.:....: .:. :... :..:. :::::. ::..:::: :.: :
NP_005 GIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTF
120 130 140 150 160 170
190 200 210 220 230
pF1KE9 NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARD--PAGQNPDNQLAEVRNFLT
. ..:...: .::..:..:: :::.::: :: .:. ..: . . :::.:
NP_005 AQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVT
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 MFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLN
:::.:.:::.:: :.: . . :: .: :. .::.::..:.:..:::::::::.::::::
NP_005 MFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLN
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE9 ENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAV
.:::.:: :. .. .:: .:.
NP_005 QNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
300 310 320 330 340 350
>>NP_005950 (OMIM: 125853,600804) melatonin receptor typ (362 aa)
initn: 1092 init1: 749 opt: 1106 Z-score: 646.5 bits: 129.0 E(85289): 2.8e-29
Smith-Waterman score: 1106; 48.3% identity (78.7% similar) in 315 aa overlap (6-315:17-329)
10 20 30 40
pF1KE9 MGPTLAVPTPYGCIGCKLP-QPEYPPALIIFMFCAMVITIVVDLIGNSM
:: .. : : . :: . . ....: .::..:: .
NP_005 MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT
:::.: .:.::::.::.:.:::..::..::.:::::.: :. :: :.. .:. .:.
NP_005 VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT
::::.::.:::.:::::::::::::. :.::. .: ... . :..::.:.:::...:.
NP_005 GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE9 IEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDN
.::::: :.: : . .:...: :::.::. .:.:::.:::. :: :: : .:..
NP_005 LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKA--KPES
190 200 210 220 230
230 240 250 260 270 280
pF1KE9 QL----AEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAY
.: ...:.::::::.:..::.:: :.: . . ::..:.::: .::. :....:..::
NP_005 RLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE9 FNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARD
:::::::..:::::.:::::: :. :. .:
NP_005 FNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQ
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE9 QAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHH
NP_005 ADAL
360
>>XP_011541141 (OMIM: 125853,600804) PREDICTED: melatoni (362 aa)
initn: 1092 init1: 749 opt: 1106 Z-score: 646.5 bits: 129.0 E(85289): 2.8e-29
Smith-Waterman score: 1106; 48.3% identity (78.7% similar) in 315 aa overlap (6-315:17-329)
10 20 30 40
pF1KE9 MGPTLAVPTPYGCIGCKLP-QPEYPPALIIFMFCAMVITIVVDLIGNSM
:: .. : : . :: . . ....: .::..:: .
XP_011 MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT
:::.: .:.::::.::.:.:::..::..::.:::::.: :. :: :.. .:. .:.
XP_011 VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT
::::.::.:::.:::::::::::::. :.::. .: ... . :..::.:.:::...:.
XP_011 GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE9 IEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDN
.::::: :.: : . .:...: :::.::. .:.:::.:::. :: :: : .:..
XP_011 LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKA--KPES
190 200 210 220 230
230 240 250 260 270 280
pF1KE9 QL----AEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAY
.: ...:.::::::.:..::.:: :.: . . ::..:.::: .::. :....:..::
XP_011 RLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE9 FNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARD
:::::::..:::::.:::::: :. :. .:
XP_011 FNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQ
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE9 QAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHH
XP_011 ADAL
360
>>XP_016873266 (OMIM: 125853,600804) PREDICTED: melatoni (320 aa)
initn: 976 init1: 633 opt: 992 Z-score: 583.4 bits: 117.1 E(85289): 9.4e-26
Smith-Waterman score: 992; 49.1% identity (80.1% similar) in 277 aa overlap (44-315:13-287)
20 30 40 50 60 70
pF1KE9 IGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMV-ILAVTKNKKLRNSGNIFVVSLSV
.: ::. .. .. : . ::.:.:::..
XP_016 MATVFFCFPNSSMGISMAGAMSFIHHCVLLECGNLFLVSLAL
10 20 30 40
80 90 100 110 120 130
pF1KE9 ADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICH
::..::.:::::.: :. :: :.. .:. .:. ::::.::.:::.::::::::::::
XP_016 ADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICH
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE9 SLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTI
:. :.::. .: ... . :..::.:.:::...:..::::: :.: : . .:...
XP_016 SMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAV
110 120 130 140 150 160
200 210 220 230 240
pF1KE9 VCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQL----AEVRNFLTMFVIFLLFAV
: :::.::. .:.:::.:::. :: :: : .:...: ...:.::::::.:..::.
XP_016 VVIHFLLPIAVVSFCYLRIWVLVLQARRKA--KPESRLCLKPSDLRSFLTMFVVFVIFAI
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE9 CWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTI
:: :.: . . ::..:.::: .::. :....:..:::::::::..:::::.:::::: :
XP_016 CWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRI
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE9 FHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNV
. :. .:
XP_016 LLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
290 300 310 320
>>XP_011530304 (OMIM: 600665) PREDICTED: melatonin recep (265 aa)
initn: 888 init1: 534 opt: 895 Z-score: 530.1 bits: 107.0 E(85289): 8.7e-23
Smith-Waterman score: 895; 49.6% identity (78.1% similar) in 242 aa overlap (89-326:1-242)
60 70 80 90 100 110
pF1KE9 LRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSI--GGWDLSQLQCQMVGFITGLSVVGSI
::: .::.:. :.::. ::. ::::.:::
XP_011 MSIFNNGWNLGYLHCQVSGFLMGLSVIGSI
10 20 30
120 130 140 150 160 170
pF1KE9 FNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTY
:::..:::::::::::::.:....: .:. :... :..:. :::::. ::..:::: :
XP_011 FNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIY
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE9 TCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARD--PAGQNPDNQLAEVR
.: : . ..:...: .::..:..:: :::.::: :: .:. ..: . . :
XP_011 SCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFR
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE9 NFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIY
::.::::.:.:::.:: :.: . . :: .: :. .::.::..:.:..:::::::::.::
XP_011 NFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIY
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE9 GLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHA
::::.:::.:: :. .. .:: .:.
XP_011 GLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
220 230 240 250 260
360 370 380 390 400 410
pF1KE9 CPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAA
>>NP_001008505 (OMIM: 600018) mu-type opioid receptor is (446 aa)
initn: 383 init1: 136 opt: 475 Z-score: 291.6 bits: 63.6 E(85289): 1.7e-09
Smith-Waterman score: 475; 27.2% identity (58.5% similar) in 371 aa overlap (21-372:61-414)
10 20 30 40
pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALI--IFMFCAMVITIVVDLIGNSM
: :..: : .. . :. :: :.:: .
NP_001 WVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT
:. .... :.... ::.. .:..:: : : :.. . .: : .. . :..: :
NP_001 VMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID
100 110 120 130 140
110 120 130 140 150 160
pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT
.. :::.. .....:: .:: .. . . ::. : : .::.. :: :...:
NP_001 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAT
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE9 IEYDPRTYTCIFNYLNNPVF---TVTIVCIH---FVLPLLIVGFCYVRIWTKVLAARDPA
.: . : ... ..:.. .. .:. :..:.::. :: . .. ..: .
NP_001 TKYRQGSIDCTLTF-SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE9 G-QNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVA-VSPKEMAGKIPNWLYLAAY
: .. : .: .. .. .:. .: ::: ::.. ... : :. : . . .: . :
NP_001 GSKEKDRNLRRITRMV--LVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA-
270 280 290 300 310 320
290 300 310 320 330 340
pF1KE9 FIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARA
..: ::::: :.:..:.:::.: . :. : : :.:.... .: .:
NP_001 -LGYTNSCLNPVLYAFLDENFKRCF-------REFCIPTS---SNIEQQNSTRIRQNTRD
330 340 350 360 370
350 360 370 380 390
pF1KE9 HARDQAREQDRA-HAC-P-------AVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSR
: . : ::. : : : :.:. . : :: :
NP_001 HP-STANTVDRTNHQCLPIPSLSCWALEQGCLVVYPGPLQGPLVRYDLPAILHSSCLRGN
380 390 400 410 420 430
400 410 420 430 440 450
pF1KE9 SSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSV
NP_001 TAPSPSGGAFLLS
440
>>NP_001008503 (OMIM: 600018) mu-type opioid receptor is (418 aa)
initn: 408 init1: 136 opt: 471 Z-score: 289.8 bits: 63.2 E(85289): 2.1e-09
Smith-Waterman score: 471; 26.9% identity (59.3% similar) in 361 aa overlap (21-369:61-404)
10 20 30 40
pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALI--IFMFCAMVITIVVDLIGNSM
: :..: : .. . :. :: :.:: .
NP_001 WVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT
:. .... :.... ::.. .:..:: : : :.. . .: : .. . :..: :
NP_001 VMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID
100 110 120 130 140
110 120 130 140 150 160
pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT
.. :::.. .....:: .:: .. . . ::. : : .::.. :: :...:
NP_001 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAT
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE9 IEYDPRTYTCIFNYLNNPVF---TVTIVCIH---FVLPLLIVGFCYVRIWTKVLAARDPA
.: . : ... ..:.. .. .:. :..:.::. :: . .. ..: .
NP_001 TKYRQGSIDCTLTF-SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE9 G-QNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVA-VSPKEMAGKIPNWLYLAAY
: .. : .: .. .. .:. .: ::: ::.. ... : :. : . . .: . :
NP_001 GSKEKDRNLRRITRMV--LVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA-
270 280 290 300 310 320
290 300 310 320 330 340
pF1KE9 FIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARA
..: ::::: :.:..:.:::.: . :. : : :.:.... .: .:
NP_001 -LGYTNSCLNPVLYAFLDENFKRCF-------REFCIPTS---SNIEQQNSTRIRQNTRD
330 340 350 360 370
350 360 370 380 390
pF1KE9 HARDQAREQDRAHACP--AVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRK
: . : ::.. : :: . . .: :
NP_001 HP-STANTVDRTNHQPPLAVSMAQIFTRYPPPTHREKTCNDYMKR
380 390 400 410
400 410 420 430 440 450
pF1KE9 SASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSV
>>NP_001138757 (OMIM: 600018) mu-type opioid receptor is (389 aa)
initn: 383 init1: 136 opt: 468 Z-score: 288.5 bits: 62.8 E(85289): 2.5e-09
Smith-Waterman score: 468; 27.5% identity (62.4% similar) in 295 aa overlap (21-305:61-349)
10 20 30 40
pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALI--IFMFCAMVITIVVDLIGNSM
: :..: : .. . :. :: :.:: .
NP_001 WVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT
:. .... :.... ::.. .:..:: : : :.. . .: : .. . :..: :
NP_001 VMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID
100 110 120 130 140
110 120 130 140 150 160
pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT
.. :::.. .....:: .:: .. . . ::. : : .::.. :: :...:
NP_001 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAT
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE9 IEYDPRTYTCIFNYLNNPVF---TVTIVCIH---FVLPLLIVGFCYVRIWTKVLAARDPA
.: . : ... ..:.. .. .:. :..:.::. :: . .. ..: .
NP_001 TKYRQGSIDCTLTF-SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE9 G-QNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVA-VSPKEMAGKIPNWLYLAAY
: .. : .: .. .. .:. .: ::: ::.. ... : :. : . . .: . :
NP_001 GSKEKDRNLRRITRMV--LVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA-
270 280 290 300 310 320
290 300 310 320 330 340
pF1KE9 FIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARA
..: ::::: :.:..:.:::.: .
NP_001 -LGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDR
330 340 350 360 370 380
617 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 10:49:10 2016 done: Sun Nov 6 10:49:12 2016
Total Scan time: 11.240 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]