Result of FASTA (omim) for
pFN21AE9259
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9259, 1210 aa
1>>>pF1KE9259 1210 - 1210 aa - 1210 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.4619+/-0.000477; mu= -9.8166+/- 0.030
mean_var=483.1301+/-96.831, 0's: 0 Z-trim(123.0): 557 B-trim: 0 in 0/59
Lambda= 0.058350
statistics sampled from 41469 (42131) to 41469 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.775), E-opt: 0.2 (0.494), width: 16
Scan time: 17.300
The best scores are: opt bits E(85289)
NP_006700 (OMIM: 604599) histone-lysine N-methyltr (1210) 8278 712.6 3.9e-204
XP_006715039 (OMIM: 604599) PREDICTED: histone-lys (1217) 8254 710.5 1.6e-203
XP_005248881 (OMIM: 604599) PREDICTED: histone-lys (1267) 8205 706.4 2.9e-202
XP_006715037 (OMIM: 604599) PREDICTED: histone-lys (1274) 8181 704.4 1.2e-201
NP_001305762 (OMIM: 604599) histone-lysine N-methy (1008) 6869 593.9 1.7e-168
NP_079532 (OMIM: 604599) histone-lysine N-methyltr (1176) 5613 488.2 1.3e-136
NP_001276342 (OMIM: 604599) histone-lysine N-methy (1233) 5613 488.2 1.4e-136
XP_016865691 (OMIM: 604599) PREDICTED: histone-lys (1183) 5589 486.2 5.3e-136
XP_006715038 (OMIM: 604599) PREDICTED: histone-lys (1240) 5589 486.2 5.5e-136
XP_016870625 (OMIM: 607001,610253) PREDICTED: hist (1265) 3780 333.9 3.9e-90
XP_016870627 (OMIM: 607001,610253) PREDICTED: hist (1260) 3764 332.6 9.9e-90
XP_016870626 (OMIM: 607001,610253) PREDICTED: hist (1260) 3764 332.6 9.9e-90
XP_011517327 (OMIM: 607001,610253) PREDICTED: hist (1267) 3764 332.6 9.9e-90
XP_005266167 (OMIM: 607001,610253) PREDICTED: hist (1267) 3764 332.6 9.9e-90
XP_016870624 (OMIM: 607001,610253) PREDICTED: hist (1291) 3764 332.6 1e-89
XP_006717351 (OMIM: 607001,610253) PREDICTED: hist (1292) 3764 332.6 1e-89
XP_016870623 (OMIM: 607001,610253) PREDICTED: hist (1293) 3764 332.6 1e-89
XP_011517325 (OMIM: 607001,610253) PREDICTED: hist (1294) 3764 332.6 1e-89
XP_005266162 (OMIM: 607001,610253) PREDICTED: hist (1295) 3764 332.6 1e-89
NP_079033 (OMIM: 607001,610253) histone-lysine N-m (1298) 3764 332.6 1e-89
XP_011517324 (OMIM: 607001,610253) PREDICTED: hist (1300) 3764 332.6 1e-89
XP_011517323 (OMIM: 607001,610253) PREDICTED: hist (1301) 3764 332.6 1e-89
XP_011517326 (OMIM: 607001,610253) PREDICTED: hist (1275) 3754 331.7 1.8e-89
XP_011517331 (OMIM: 607001,610253) PREDICTED: hist ( 775) 3450 306.0 6.3e-82
XP_011517335 (OMIM: 607001,610253) PREDICTED: hist (1246) 3129 279.1 1.2e-73
XP_011517328 (OMIM: 607001,610253) PREDICTED: hist (1253) 3111 277.6 3.5e-73
XP_011517332 (OMIM: 607001,610253) PREDICTED: hist ( 559) 2483 224.4 1.6e-57
XP_011517333 (OMIM: 607001,610253) PREDICTED: hist ( 488) 2410 218.2 1e-55
XP_011517329 (OMIM: 607001,610253) PREDICTED: hist ( 930) 1748 162.8 9.7e-39
NP_001138999 (OMIM: 607001,610253) histone-lysine ( 808) 1207 117.2 4.5e-25
XP_011517330 (OMIM: 607001,610253) PREDICTED: hist ( 811) 1207 117.2 4.5e-25
XP_006717566 (OMIM: 606503) PREDICTED: histone-lys ( 350) 535 60.3 2.6e-08
NP_001180354 (OMIM: 606503) histone-lysine N-methy ( 350) 535 60.3 2.6e-08
XP_011517964 (OMIM: 606503) PREDICTED: histone-lys ( 350) 535 60.3 2.6e-08
XP_016872126 (OMIM: 606503) PREDICTED: histone-lys ( 350) 535 60.3 2.6e-08
NP_078946 (OMIM: 606503) histone-lysine N-methyltr ( 350) 535 60.3 2.6e-08
NP_001180353 (OMIM: 606503) histone-lysine N-methy ( 410) 535 60.3 2.9e-08
NP_003164 (OMIM: 300254) histone-lysine N-methyltr ( 412) 531 60.0 3.7e-08
NP_001269095 (OMIM: 300254) histone-lysine N-methy ( 423) 531 60.0 3.8e-08
NP_001263254 (OMIM: 609834) histone-lysine N-methy ( 365) 399 48.8 7.5e-05
NP_055757 (OMIM: 610583) ankyrin repeat domain-con ( 722) 400 49.2 0.00012
NP_001229740 (OMIM: 610583) ankyrin repeat domain- ( 727) 400 49.2 0.00012
XP_005248738 (OMIM: 610583) PREDICTED: ankyrin rep ( 727) 400 49.2 0.00012
NP_001229738 (OMIM: 610583) ankyrin repeat domain- ( 727) 400 49.2 0.00012
NP_006506 (OMIM: 609834) histone-lysine N-methyltr ( 684) 399 49.1 0.00012
XP_016865987 (OMIM: 610583) PREDICTED: ankyrin rep ( 687) 389 48.2 0.00021
NP_001229742 (OMIM: 610583) ankyrin repeat domain- ( 692) 389 48.2 0.00022
NP_001305310 (OMIM: 243305,602088) inversin isofor ( 969) 381 47.7 0.00044
XP_011533901 (OMIM: 610583) PREDICTED: ankyrin rep ( 694) 376 47.1 0.00046
NP_055240 (OMIM: 243305,602088) inversin isoform a (1065) 381 47.7 0.00047
>>NP_006700 (OMIM: 604599) histone-lysine N-methyltransf (1210 aa)
initn: 8278 init1: 8278 opt: 8278 Z-score: 3785.8 bits: 712.6 E(85289): 3.9e-204
Smith-Waterman score: 8278; 100.0% identity (100.0% similar) in 1210 aa overlap (1-1210:1-1210)
10 20 30 40 50 60
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
1150 1160 1170 1180 1190 1200
1210
pF1KE9 ELGSLPPVNT
::::::::::
NP_006 ELGSLPPVNT
1210
>>XP_006715039 (OMIM: 604599) PREDICTED: histone-lysine (1217 aa)
initn: 8264 init1: 5490 opt: 8254 Z-score: 3774.9 bits: 710.5 E(85289): 1.6e-203
Smith-Waterman score: 8254; 99.4% identity (99.4% similar) in 1217 aa overlap (1-1210:1-1217)
10 20 30 40 50 60
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
730 740 750 760 770 780
790 800 810 820 830
pF1KE9 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN-------EENICLHWASFTGSAAI
:::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_006 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAI
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE9 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE9 RSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE9 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE9 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE9 DAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRF
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE9 PRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLD
1150 1160 1170 1180 1190 1200
1200 1210
pF1KE9 PHPELLPELGSLPPVNT
:::::::::::::::::
XP_006 PHPELLPELGSLPPVNT
1210
>>XP_005248881 (OMIM: 604599) PREDICTED: histone-lysine (1267 aa)
initn: 8205 init1: 8205 opt: 8205 Z-score: 3752.4 bits: 706.4 E(85289): 2.9e-202
Smith-Waterman score: 8205; 99.8% identity (100.0% similar) in 1198 aa overlap (13-1210:70-1267)
10 20 30 40
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLG
..::::::::::::::::::::::::::::
XP_005 RSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLG
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE9 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE9 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE9 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE9 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE9 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE9 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP
400 410 420 430 440 450
410 420 430 440 450 460
pF1KE9 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA
460 470 480 490 500 510
470 480 490 500 510 520
pF1KE9 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA
520 530 540 550 560 570
530 540 550 560 570 580
pF1KE9 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS
580 590 600 610 620 630
590 600 610 620 630 640
pF1KE9 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE
640 650 660 670 680 690
650 660 670 680 690 700
pF1KE9 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH
700 710 720 730 740 750
710 720 730 740 750 760
pF1KE9 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG
760 770 780 790 800 810
770 780 790 800 810 820
pF1KE9 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL
820 830 840 850 860 870
830 840 850 860 870 880
pF1KE9 HWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK
880 890 900 910 920 930
890 900 910 920 930 940
pF1KE9 EGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVD
940 950 960 970 980 990
950 960 970 980 990 1000
pF1KE9 GEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRL
1000 1010 1020 1030 1040 1050
1010 1020 1030 1040 1050 1060
pF1KE9 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGT
1060 1070 1080 1090 1100 1110
1070 1080 1090 1100 1110 1120
pF1KE9 FICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPV
1120 1130 1140 1150 1160 1170
1130 1140 1150 1160 1170 1180
pF1KE9 RVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAI
1180 1190 1200 1210 1220 1230
1190 1200 1210
pF1KE9 ALEQSRLARLDPHPELLPELGSLPPVNT
::::::::::::::::::::::::::::
XP_005 ALEQSRLARLDPHPELLPELGSLPPVNT
1240 1250 1260
>>XP_006715037 (OMIM: 604599) PREDICTED: histone-lysine (1274 aa)
initn: 8191 init1: 5417 opt: 8181 Z-score: 3741.4 bits: 704.4 E(85289): 1.2e-201
Smith-Waterman score: 8181; 99.3% identity (99.4% similar) in 1205 aa overlap (13-1210:70-1274)
10 20 30 40
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLG
..::::::::::::::::::::::::::::
XP_006 RSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLG
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE9 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE9 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE9 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE9 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE9 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE9 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP
400 410 420 430 440 450
410 420 430 440 450 460
pF1KE9 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA
460 470 480 490 500 510
470 480 490 500 510 520
pF1KE9 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA
520 530 540 550 560 570
530 540 550 560 570 580
pF1KE9 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS
580 590 600 610 620 630
590 600 610 620 630 640
pF1KE9 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE
640 650 660 670 680 690
650 660 670 680 690 700
pF1KE9 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH
700 710 720 730 740 750
710 720 730 740 750 760
pF1KE9 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG
760 770 780 790 800 810
770 780 790 800 810
pF1KE9 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLV
820 830 840 850 860 870
820 830 840 850 860 870
pF1KE9 -EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA
880 890 900 910 920 930
880 890 900 910 920 930
pF1KE9 NPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPI
940 950 960 970 980 990
940 950 960 970 980 990
pF1KE9 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCW
1000 1010 1020 1030 1040 1050
1000 1010 1020 1030 1040 1050
pF1KE9 YDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRAL
1060 1070 1080 1090 1100 1110
1060 1070 1080 1090 1100 1110
pF1KE9 QTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLC
1120 1130 1140 1150 1160 1170
1120 1130 1140 1150 1160 1170
pF1KE9 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC
1180 1190 1200 1210 1220 1230
1180 1190 1200 1210
pF1KE9 KHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT
:::::::::::::::::::::::::::::::::::
XP_006 KHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT
1240 1250 1260 1270
>>NP_001305762 (OMIM: 604599) histone-lysine N-methyltra (1008 aa)
initn: 6879 init1: 4105 opt: 6869 Z-score: 3145.8 bits: 593.9 E(85289): 1.7e-168
Smith-Waterman score: 6869; 99.3% identity (99.3% similar) in 1008 aa overlap (210-1210:1-1008)
180 190 200 210 220 230
pF1KE9 VHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEE
::::::::::::::::::::::::::::::
NP_001 MSDDVHSLGKVTSDLAKRRKLNSGGGLSEE
10 20 30
240 250 260 270 280 290
pF1KE9 LGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLS
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKR
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE9 RKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERG
160 170 180 190 200 210
420 430 440 450 460 470
pF1KE9 FEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMV
220 230 240 250 260 270
480 490 500 510 520 530
pF1KE9 LCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGED
280 290 300 310 320 330
540 550 560 570 580 590
pF1KE9 ASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPL
340 350 360 370 380 390
600 610 620 630 640 650
pF1KE9 ADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVK
400 410 420 430 440 450
660 670 680 690 700 710
pF1KE9 QGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQR
460 470 480 490 500 510
720 730 740 750 760 770
pF1KE9 TPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN
520 530 540 550 560 570
780 790 800 810 820 830
pF1KE9 AQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN-------EENICLHWASFTGSAA
::::::::::::::::::::::::::::::::::::: ::::::::::::::::
NP_001 AQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAA
580 590 600 610 620 630
840 850 860 870 880 890
pF1KE9 IAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP
640 650 660 670 680 690
900 910 920 930 940 950
pF1KE9 ERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKY
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KE9 ISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPP
760 770 780 790 800 810
1020 1030 1040 1050 1060 1070
pF1KE9 LIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELI
820 830 840 850 860 870
1080 1090 1100 1110 1120 1130
pF1KE9 SDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLR
880 890 900 910 920 930
1140 1150 1160 1170 1180 1190
pF1KE9 FPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARL
940 950 960 970 980 990
1200 1210
pF1KE9 DPHPELLPELGSLPPVNT
::::::::::::::::::
NP_001 DPHPELLPELGSLPPVNT
1000
>>NP_079532 (OMIM: 604599) histone-lysine N-methyltransf (1176 aa)
initn: 5613 init1: 5613 opt: 5613 Z-score: 2573.5 bits: 488.2 E(85289): 1.3e-136
Smith-Waterman score: 7974; 97.2% identity (97.2% similar) in 1210 aa overlap (1-1210:1-1176)
10 20 30 40 50 60
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
::::::::::::: :::::::::::::
NP_079 KREPPRAKEPRGV----------------------------------SNDTSSLETERGF
370 380
430 440 450 460 470 480
pF1KE9 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE9 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
450 460 470 480 490 500
550 560 570 580 590 600
pF1KE9 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE9 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
570 580 590 600 610 620
670 680 690 700 710 720
pF1KE9 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
630 640 650 660 670 680
730 740 750 760 770 780
pF1KE9 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
690 700 710 720 730 740
790 800 810 820 830 840
pF1KE9 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNA
750 760 770 780 790 800
850 860 870 880 890 900
pF1KE9 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFA
810 820 830 840 850 860
910 920 930 940 950 960
pF1KE9 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETS
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KE9 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 TMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQA
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KE9 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KE9 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFS
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KE9 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLP
1110 1120 1130 1140 1150 1160
1210
pF1KE9 ELGSLPPVNT
::::::::::
NP_079 ELGSLPPVNT
1170
>>NP_001276342 (OMIM: 604599) histone-lysine N-methyltra (1233 aa)
initn: 5613 init1: 5613 opt: 5613 Z-score: 2573.3 bits: 488.2 E(85289): 1.4e-136
Smith-Waterman score: 7901; 97.0% identity (97.2% similar) in 1198 aa overlap (13-1210:70-1233)
10 20 30 40
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLG
..::::::::::::::::::::::::::::
NP_001 RSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLG
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE9 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE9 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE9 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE9 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE9 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE9 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP
:::::::::::::::::::::::::::::::
NP_001 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGV-----------------------------
400 410 420 430
410 420 430 440 450 460
pF1KE9 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----SNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA
440 450 460 470 480
470 480 490 500 510 520
pF1KE9 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE9 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE9 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE9 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE9 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE9 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICL
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE9 HWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNK
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE9 EGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVD
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE9 GEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRL
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE9 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGT
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE9 FICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE9 RVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAI
1150 1160 1170 1180 1190 1200
1190 1200 1210
pF1KE9 ALEQSRLARLDPHPELLPELGSLPPVNT
::::::::::::::::::::::::::::
NP_001 ALEQSRLARLDPHPELLPELGSLPPVNT
1210 1220 1230
>>XP_016865691 (OMIM: 604599) PREDICTED: histone-lysine (1183 aa)
initn: 5599 init1: 2825 opt: 5589 Z-score: 2562.6 bits: 486.2 E(85289): 5.3e-136
Smith-Waterman score: 7950; 96.6% identity (96.6% similar) in 1217 aa overlap (1-1210:1-1183)
10 20 30 40 50 60
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 KREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGF
::::::::::::: :::::::::::::
XP_016 KREPPRAKEPRGV----------------------------------SNDTSSLETERGF
370 380
430 440 450 460 470 480
pF1KE9 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRETMRPSSRVALMVL
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE9 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDA
450 460 470 480 490 500
550 560 570 580 590 600
pF1KE9 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLA
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE9 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQ
570 580 590 600 610 620
670 680 690 700 710 720
pF1KE9 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT
630 640 650 660 670 680
730 740 750 760 770 780
pF1KE9 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNA
690 700 710 720 730 740
790 800 810 820 830
pF1KE9 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN-------EENICLHWASFTGSAAI
:::::::::::::::::::::::::::::::::::: :::::::::::::::::
XP_016 QDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLVEEENICLHWASFTGSAAI
750 760 770 780 790 800
840 850 860 870 880 890
pF1KE9 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPE
810 820 830 840 850 860
900 910 920 930 940 950
pF1KE9 RSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYI
870 880 890 900 910 920
960 970 980 990 1000 1010
pF1KE9 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPL
930 940 950 960 970 980
1020 1030 1040 1050 1060 1070
pF1KE9 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELIS
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120 1130
pF1KE9 DAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRF
1050 1060 1070 1080 1090 1100
1140 1150 1160 1170 1180 1190
pF1KE9 PRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLD
1110 1120 1130 1140 1150 1160
1200 1210
pF1KE9 PHPELLPELGSLPPVNT
:::::::::::::::::
XP_016 PHPELLPELGSLPPVNT
1170 1180
>>XP_006715038 (OMIM: 604599) PREDICTED: histone-lysine (1240 aa)
initn: 5599 init1: 2825 opt: 5589 Z-score: 2562.3 bits: 486.2 E(85289): 5.5e-136
Smith-Waterman score: 7877; 96.4% identity (96.6% similar) in 1205 aa overlap (13-1210:70-1240)
10 20 30 40
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLG
..::::::::::::::::::::::::::::
XP_006 RSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKETRGATERVHGSLG
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE9 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE9 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGGRILLGHATKSFPSSPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAA
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE9 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTS
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE9 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSYSVDER
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE9 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKA
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE9 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSP
:::::::::::::::::::::::::::::::
XP_006 KKKWRKDSPWVKPSRKRRKREPPRAKEPRGV-----------------------------
400 410 420 430
410 420 430 440 450 460
pF1KE9 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 -----SNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAA
440 450 460 470 480
470 480 490 500 510 520
pF1KE9 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKA
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE9 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPGRADTSQPS
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE9 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESE
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE9 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICH
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE9 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG
730 740 750 760 770 780
770 780 790 800 810
pF1KE9 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDN------
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNVSERLV
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE9 -EENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGA
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE9 NPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPI
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE9 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCW
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE9 YDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRAL
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE9 QTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLC
1090 1100 1110 1120 1130 1140
1120 1130 1140 1150 1160 1170
pF1KE9 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKC
1150 1160 1170 1180 1190 1200
1180 1190 1200 1210
pF1KE9 KHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT
:::::::::::::::::::::::::::::::::::
XP_006 KHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT
1210 1220 1230 1240
>>XP_016870625 (OMIM: 607001,610253) PREDICTED: histone- (1265 aa)
initn: 4011 init1: 2862 opt: 3780 Z-score: 1739.2 bits: 333.9 E(85289): 3.9e-90
Smith-Waterman score: 3825; 48.2% identity (72.8% similar) in 1261 aa overlap (1-1204:32-1258)
10 20 30
pF1KE9 MAAAAGAAAAAAAEGEAPAEMGALLLEKET
::: :.: :.: :.:.: . ::
XP_016 AAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGE----AHMAA---DGET
10 20 30 40 50
40 50 60 70 80
pF1KE9 RGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGA---DTPVGATP
:. : .: :. . : : :: . ..:.. ... . ....:. :. ..
XP_016 NGSCENSDAS------SHANAAKHTQDSAR-VNPQDGTNTLTRIAENGVSERDSEAAKQN
60 70 80 90 100
90 100 110 120 130 140
pF1KE9 LI-GDESENLEGDGDLRGGRILLGHATKSFP--SSPSKGGSCPSRAKMSMTG-AGKS-PP
. .:. . :. .: :: : .. : .. . ..: :..: .. : :::. :
XP_016 HVTADDFVQTSVIGS--NGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTP
110 120 130 140 150 160
150 160 170 180 190 200
pF1KE9 SVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKVHRARKTMSKPGNGQPPVPEKRP
: .. . . :.. : ..: .: .: .. ::::::::: : : . : :
XP_016 S--AFPQTPAAPPATLGEGSADTEDRK-LPAPGADVKVHRARKTMPKSVVGLH-AASKDP
170 180 190 200 210 220
210 220 230 240
pF1KE9 PEIQHFR-MSDDVHSLGKVTSDLAKRRKLNSGGGLSEELGSA------------------
:... : .. . ..: ::..... : .: . : .
XP_016 REVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTAAAVSRK
230 240 250 260 270 280
250 260 270 280 290 300
pF1KE9 --RRSGEVTLTKGDPGSLEEWETVVGDDFSLYYDSY-SVDERVDSDSKSEVEALTEQLSE
:: : .:. .. . .::. :. ... : :. . :. .:.. . ...
XP_016 KKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDS
290 300 310 320 330 340
310 320 330 340
pF1KE9 EEEEEEEEEEEEEEEEEE------EEEEEDEESGNQSDRSGSSGRRKAKKKWRK-----D
.:.. :: ::.. . :. :. . ..:: ...::. .:.. . :::. : :
XP_016 DEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKSSESSIKKKFLKRKGKTD
350 360 370 380 390 400
350 360 370 380 390
pF1KE9 SPWVKPSRKRRKREPPRAKEPRGVNGV----GSSGPSE---------YMEVPLGSLELPS
:::.::.::::.: :.: :. : .:.: .: :::: : ::.:
XP_016 SPWIKPARKRRRRS---RKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRV
410 420 430 440 450
400 410 420 430 440 450
pF1KE9 EGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGEL
.: :: . :..: . :::. :..:.::::::::.:: .:. :...:::::::: ::
XP_016 KGILSSQAEGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQCMATESVDHEL
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE9 SGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVA
. :. ...: : ::::... :.:::: ::.:::::.::::::::::::.:.::.:. ..
XP_016 GRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSIS
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE9 HRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAP-PPLSQDVPGR
::::: :.:..:. .::::::..:.:.:::: ..: .. :..:.: .. . ::
XP_016 HRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTS----TVTPVPGQEKGSALEGR
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE9 ADTSQPSARMRGHGEPRRPPCDPLADTIDS--SGPSLTLPNGGCLSAVGLPLGPGREALE
:::. :: : : : : . . : . : : : . :: :::.:.::
XP_016 ADTTTGSA----AGPPLSED-DKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLE
640 650 660 670 680
640 650 660 670 680 690
pF1KE9 KALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAA
.::. .::. :::::::.:::.:..:::::::.:::.:..::::. ..:.::.::::::
XP_016 SALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAA
690 700 710 720 730 740
700 710 720 730 740 750
pF1KE9 QKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGST
. : :.:::.:.::::::.. ...::::::::. :::::...:... :. : :. .:::
XP_016 EAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGST
750 760 770 780 790 800
760 770 780 790 800 810
pF1KE9 CLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL
::: ::: :. :.:. :::.::.::: ::.:::::.:::.:.::......::..:.:...
XP_016 CLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINI
810 820 830 840 850 860
820 830 840 850 860 870
pF1KE9 TDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFLSR
:::::::::::.:.: . :::.:: :.::::::: :::.::::::::. .:::.:::::
XP_016 RDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSR
870 880 890 900 910 920
880 890 900 910 920 930
pF1KE9 GANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENV
.. :.::::.: . . :.:: :::... :. .. .: .:.:. ::.::::: .
XP_016 DSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERI
930 940 950 960 970 980
940 950 960 970 980 990
pF1KE9 PIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIR
::::::.::.:::: .:::.:.:: :: :::::::::::.:.:.::::::::.:::::.:
XP_016 PIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMR
990 1000 1010 1020 1030 1040
1000 1010 1020 1030 1040 1050
pF1KE9 CWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVR
:::::::::: ::: :::::::::.::::::::.:::::.:...::::::: ::::::
XP_016 CWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVR
1050 1060 1070 1080 1090 1100
1060 1070 1080 1090 1100 1110
pF1KE9 ALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINH
.:: :: :::.::::::::::.::::::.::::::::::::::::::::.:::.::::::
XP_016 SLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINH
1110 1120 1130 1140 1150 1160
1120 1130 1140 1150 1160 1170
pF1KE9 LCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSE
:.::..:::::: :::::::::::::.: :..::.::::::.::::::.: :.:.:::
XP_016 HCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSP
1170 1180 1190 1200 1210 1220
1180 1190 1200 1210
pF1KE9 KCKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT
::.::. :.: .:. :. . . . ::. .:
XP_016 KCRHSSAALAQRQASAAQ-EAQEDGLPDTSSAAAADPL
1230 1240 1250 1260
1210 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:22:13 2016 done: Sat Nov 5 22:22:16 2016
Total Scan time: 17.300 Total Display time: 0.520
Function used was FASTA [36.3.4 Apr, 2011]