Result of FASTA (omim) for
pFN21AE9244
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9244, 1654 aa
1>>>pF1KE9244 1654 - 1654 aa - 1654 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.4757+/-0.000537; mu= -5.5588+/- 0.033
mean_var=433.5771+/-93.004, 0's: 0 Z-trim(116.3): 365 B-trim: 263 in 1/53
Lambda= 0.061594
statistics sampled from 28041 (28447) to 28041 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.308), width: 16
Scan time: 10.150
The best scores are: opt bits E(92320)
NP_055800 (OMIM: 613529,613823,614852) centrosomal (1654) 10833 979.5 0
XP_024305643 (OMIM: 613529,613823,614852) centroso (1644) 8427 765.7 0
XP_011519677 (OMIM: 613529,613823,614852) centroso (1397) 7530 685.9 7.1e-196
XP_011519680 (OMIM: 613529,613823,614852) centroso (1362) 7522 685.2 1.1e-195
XP_011519676 (OMIM: 613529,613823,614852) centroso (1401) 7522 685.2 1.2e-195
XP_011519681 (OMIM: 613529,613823,614852) centroso (1341) 7518 684.8 1.4e-195
XP_011519675 (OMIM: 613529,613823,614852) centroso (1700) 7518 684.9 1.7e-195
XP_006720500 (OMIM: 613529,613823,614852) centroso (1710) 7518 684.9 1.7e-195
NP_001181927 (OMIM: 613529,613823,614852) centroso (1710) 7518 684.9 1.7e-195
XP_016877505 (OMIM: 613529,613823,614852) centroso ( 834) 4988 459.8 4.9e-128
XP_011519683 (OMIM: 613529,613823,614852) centroso (1055) 3409 319.6 1e-85
XP_016877504 (OMIM: 613529,613823,614852) centroso (1055) 3409 319.6 1e-85
NP_002464 (OMIM: 155100,160775,603622) myosin-9 [H (1960) 391 51.7 8.4e-05
XP_016861684 (OMIM: 602500) golgin subfamily B mem (3016) 373 50.3 0.00034
NP_001243417 (OMIM: 602500) golgin subfamily B mem (3184) 373 50.3 0.00036
NP_001353213 (OMIM: 602500) golgin subfamily B mem (3189) 373 50.3 0.00036
XP_006713654 (OMIM: 602500) golgin subfamily B mem (3189) 373 50.3 0.00036
NP_001353212 (OMIM: 602500) golgin subfamily B mem (3223) 373 50.3 0.00036
XP_016861682 (OMIM: 602500) golgin subfamily B mem (3224) 373 50.3 0.00036
NP_001243416 (OMIM: 602500) golgin subfamily B mem (3225) 373 50.3 0.00036
XP_016861681 (OMIM: 602500) golgin subfamily B mem (3225) 373 50.3 0.00036
XP_005247430 (OMIM: 602500) golgin subfamily B mem (3228) 373 50.3 0.00036
XP_016861680 (OMIM: 602500) golgin subfamily B mem (3228) 373 50.3 0.00036
XP_005247429 (OMIM: 602500) golgin subfamily B mem (3230) 373 50.3 0.00036
NP_004478 (OMIM: 602500) golgin subfamily B member (3259) 373 50.3 0.00036
XP_016861679 (OMIM: 602500) golgin subfamily B mem (3263) 373 50.3 0.00036
XP_006713652 (OMIM: 602500) golgin subfamily B mem (3263) 373 50.3 0.00036
NP_001353211 (OMIM: 602500) golgin subfamily B mem (3264) 373 50.3 0.00036
XP_016861678 (OMIM: 602500) golgin subfamily B mem (3264) 373 50.3 0.00036
XP_006713651 (OMIM: 602500) golgin subfamily B mem (3264) 373 50.3 0.00036
XP_011511001 (OMIM: 602500) golgin subfamily B mem (3269) 373 50.3 0.00036
XP_005247428 (OMIM: 602500) golgin subfamily B mem (3269) 373 50.3 0.00036
NP_001243415 (OMIM: 602500) golgin subfamily B mem (3269) 373 50.3 0.00036
XP_011520056 (OMIM: 612516) uveal autoantigen with (1164) 341 47.0 0.0013
XP_005254586 (OMIM: 612516) uveal autoantigen with (1392) 341 47.1 0.0014
XP_016877884 (OMIM: 612516) uveal autoantigen with (1399) 341 47.1 0.0014
NP_001008225 (OMIM: 612516) uveal autoantigen with (1403) 341 47.1 0.0014
XP_016877883 (OMIM: 612516) uveal autoantigen with (1405) 341 47.1 0.0014
NP_060473 (OMIM: 612516) uveal autoantigen with co (1416) 341 47.1 0.0014
XP_011520055 (OMIM: 612516) uveal autoantigen with (1425) 341 47.1 0.0015
XP_011520054 (OMIM: 612516) uveal autoantigen with (1436) 341 47.1 0.0015
XP_011537117 (OMIM: 605070) early endosome antigen (1365) 339 46.9 0.0016
NP_003557 (OMIM: 605070) early endosome antigen 1 (1411) 339 46.9 0.0016
XP_016875507 (OMIM: 605070) early endosome antigen (1417) 339 46.9 0.0016
XP_011537116 (OMIM: 605070) early endosome antigen (1453) 339 46.9 0.0017
XP_011507384 (OMIM: 243605,600236) centromere prot (3055) 347 47.9 0.0017
XP_016855575 (OMIM: 243605,600236) centromere prot (3114) 347 48.0 0.0017
NP_057427 (OMIM: 243605,600236) centromere protein (3114) 347 48.0 0.0017
XP_006719615 (OMIM: 179838) CAP-Gly domain-contain (1429) 329 46.0 0.003
XP_016875275 (OMIM: 179838) CAP-Gly domain-contain (1427) 327 45.8 0.0034
>>NP_055800 (OMIM: 613529,613823,614852) centrosomal pro (1654 aa)
initn: 10833 init1: 10833 opt: 10833 Z-score: 5223.5 bits: 979.5 E(92320): 0
Smith-Waterman score: 10833; 100.0% identity (100.0% similar) in 1654 aa overlap (1-1654:1-1654)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE9 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE9 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE9 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE9 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE9 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS
1570 1580 1590 1600 1610 1620
1630 1640 1650
pF1KE9 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
::::::::::::::::::::::::::::::::::
NP_055 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
1630 1640 1650
>>XP_024305643 (OMIM: 613529,613823,614852) centrosomal (1644 aa)
initn: 8421 init1: 8421 opt: 8427 Z-score: 4068.1 bits: 765.7 E(92320): 0
Smith-Waterman score: 10744; 99.3% identity (99.4% similar) in 1654 aa overlap (1-1654:1-1644)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE9 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 HHAQPLALQATEAEAEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE9 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 PCSGGALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYL
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE9 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAV
::::::::::::::::::::::::::::::::::::::. :::::::::::
XP_024 ICLQQILQDDGKEGAEKKIMNAASKLATMAKLLETPIST----------LPLTSEMLIAV
1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KE9 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KKSKRNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGS
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420 1430 1440
pF1KE9 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 KETHLEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAY
1380 1390 1400 1410 1420 1430
1450 1460 1470 1480 1490 1500
pF1KE9 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 PFLGTLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLD
1440 1450 1460 1470 1480 1490
1510 1520 1530 1540 1550 1560
pF1KE9 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 VQEPPVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGY
1500 1510 1520 1530 1540 1550
1570 1580 1590 1600 1610 1620
pF1KE9 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_024 LSDTEESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSS
1560 1570 1580 1590 1600 1610
1630 1640 1650
pF1KE9 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
::::::::::::::::::::::::::::::::::
XP_024 TLPSSVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
1620 1630 1640
>>XP_011519677 (OMIM: 613529,613823,614852) centrosomal (1397 aa)
initn: 8416 init1: 7512 opt: 7530 Z-score: 3638.2 bits: 685.9 E(92320): 7.1e-196
Smith-Waterman score: 8305; 94.4% identity (95.0% similar) in 1380 aa overlap (1-1324:1-1380)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150
pF1KE9 HHAQPLALQATEAEA---------------------------------------------
:::::::::::::::
XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200
pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
1210 1220 1230 1240 1250 1260
1210 1220 1230 1240 1250 1260
pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
1270 1280 1290 1300 1310 1320
1270 1280 1290 1300 1310 1320
pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
::::::::::::::::::::::::::::::::::. .. . .::...:::
XP_011 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISKPDNLGGDGETARCILLLLITISKSK
1330 1340 1350 1360 1370 1380
1330 1340 1350 1360 1370 1380
pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
XP_011 NREGKLFGLGKLCHLNS
1390
>>XP_011519680 (OMIM: 613529,613823,614852) centrosomal (1362 aa)
initn: 8409 init1: 7512 opt: 7522 Z-score: 3634.5 bits: 685.2 E(92320): 1.1e-195
Smith-Waterman score: 8299; 95.4% identity (95.6% similar) in 1362 aa overlap (1-1306:1-1362)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150
pF1KE9 HHAQPLALQATEAEA---------------------------------------------
:::::::::::::::
XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200
pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
1210 1220 1230 1240 1250 1260
1210 1220 1230 1240 1250 1260
pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
1270 1280 1290 1300 1310 1320
1270 1280 1290 1300 1310 1320
pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
::::::::::::::::::::::::::::::::::. : ..
XP_011 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISNLCCSPSS
1330 1340 1350 1360
1330 1340 1350 1360 1370 1380
pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
>>XP_011519676 (OMIM: 613529,613823,614852) centrosomal (1401 aa)
initn: 7512 init1: 7512 opt: 7522 Z-score: 3634.4 bits: 685.2 E(92320): 1.2e-195
Smith-Waterman score: 8353; 95.9% identity (95.9% similar) in 1364 aa overlap (1-1308:1-1364)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150
pF1KE9 HHAQPLALQATEAEA---------------------------------------------
:::::::::::::::
XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200
pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
1210 1220 1230 1240 1250 1260
1210 1220 1230 1240 1250 1260
pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
1270 1280 1290 1300 1310 1320
1270 1280 1290 1300 1310 1320
pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
::::::::::::::::::::::::::::::::::::::::::::
XP_011 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSGDGILLCHPGWRAVAQ
1330 1340 1350 1360 1370 1380
1330 1340 1350 1360 1370 1380
pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
XP_011 ITATEPRLQLLGSNDPPRSAS
1390 1400
>>XP_011519681 (OMIM: 613529,613823,614852) centrosomal (1341 aa)
initn: 8274 init1: 7512 opt: 7518 Z-score: 3632.7 bits: 684.8 E(92320): 1.4e-195
Smith-Waterman score: 8163; 95.3% identity (95.6% similar) in 1338 aa overlap (1-1282:1-1338)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150
pF1KE9 HHAQPLALQATEAEA---------------------------------------------
:::::::::::::::
XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200
pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
1210 1220 1230 1240 1250 1260
1210 1220 1230 1240 1250 1260
pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
1270 1280 1290 1300 1310 1320
1270 1280 1290 1300 1310 1320
pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
::::::::::. .. .:
XP_011 QILQDDGKEGTAPNFRDADCS
1330 1340
>>XP_011519675 (OMIM: 613529,613823,614852) centrosomal (1700 aa)
initn: 9858 init1: 7512 opt: 7518 Z-score: 3631.4 bits: 684.9 E(92320): 1.7e-195
Smith-Waterman score: 10523; 96.0% identity (96.1% similar) in 1696 aa overlap (1-1640:1-1686)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150
pF1KE9 HHAQPLALQATEAEA---------------------------------------------
:::::::::::::::
XP_011 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200
pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
1210 1220 1230 1240 1250 1260
1210 1220 1230 1240 1250 1260
pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
1270 1280 1290 1300 1310 1320
1270 1280 1290 1300 1310 1320
pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
::::::::::::::::::::::::::::::::::. :::::::::::::::
XP_011 QILQDDGKEGAEKKIMNAASKLATMAKLLETPIST----------LPLTSEMLIAVKKSK
1330 1340 1350 1360 1370
1330 1340 1350 1360 1370 1380
pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
1380 1390 1400 1410 1420 1430
1390 1400 1410 1420 1430 1440
pF1KE9 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG
1440 1450 1460 1470 1480 1490
1450 1460 1470 1480 1490 1500
pF1KE9 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP
1500 1510 1520 1530 1540 1550
1510 1520 1530 1540 1550 1560
pF1KE9 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT
1560 1570 1580 1590 1600 1610
1570 1580 1590 1600 1610 1620
pF1KE9 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS
1620 1630 1640 1650 1660 1670
1630 1640 1650
pF1KE9 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
::::::::::::::::
XP_011 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
1680 1690 1700
>>XP_006720500 (OMIM: 613529,613823,614852) centrosomal (1710 aa)
initn: 7512 init1: 7512 opt: 7518 Z-score: 3631.3 bits: 684.9 E(92320): 1.7e-195
Smith-Waterman score: 10554; 96.7% identity (96.7% similar) in 1686 aa overlap (1-1630:1-1686)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150
pF1KE9 HHAQPLALQATEAEA---------------------------------------------
:::::::::::::::
XP_006 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200
pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
1210 1220 1230 1240 1250 1260
1210 1220 1230 1240 1250 1260
pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
1270 1280 1290 1300 1310 1320
1270 1280 1290 1300 1310 1320
pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
1330 1340 1350 1360 1370 1380
1330 1340 1350 1360 1370 1380
pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
1390 1400 1410 1420 1430 1440
1390 1400 1410 1420 1430 1440
pF1KE9 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG
1450 1460 1470 1480 1490 1500
1450 1460 1470 1480 1490 1500
pF1KE9 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP
1510 1520 1530 1540 1550 1560
1510 1520 1530 1540 1550 1560
pF1KE9 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT
1570 1580 1590 1600 1610 1620
1570 1580 1590 1600 1610 1620
pF1KE9 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS
1630 1640 1650 1660 1670 1680
1630 1640 1650
pF1KE9 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
::::::
XP_006 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
1690 1700 1710
>>NP_001181927 (OMIM: 613529,613823,614852) centrosomal (1710 aa)
initn: 7512 init1: 7512 opt: 7518 Z-score: 3631.3 bits: 684.9 E(92320): 1.7e-195
Smith-Waterman score: 10554; 96.7% identity (96.7% similar) in 1686 aa overlap (1-1630:1-1686)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKIKEKLIQQLEKEWQSKLDQT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKAMKKKTLDCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKGAMKKLE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVSVNKRIS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAVSEAKEKWKSELENMRKNILPGKELEEKIHSLQKELELKNEEVPVVIRAELAKARSEW
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE9 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKEKQEEIHRIQEQNEQDYRQFLDDHRNKINEVLAAAKEDFMKQKTELLLQKETELQTCL
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE9 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQSRREWTMQEAKRIQLEIYQYEEDILTVLGVLLSDTQKEHISDSEDKQLLEIMSTCSSK
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE9 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WMSVQYFEKLKGCIQKAFQDTLPLLVENADPEWKKRNMAELSKDSASQGTGQGDPGPAAG
1090 1100 1110 1120 1130 1140
1150
pF1KE9 HHAQPLALQATEAEA---------------------------------------------
:::::::::::::::
NP_001 HHAQPLALQATEAEADKKKVLEIKDLCCGHCFQELEKAKQECQDLKGKLEKCCRHLQHLE
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200
pF1KE9 -----------EENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKHKAVVEKIGEENNKVVEELIEENNDMKNKLEELQTLCKTPPRSLSAGAIENACLPCSG
1210 1220 1230 1240 1250 1260
1210 1220 1230 1240 1250 1260
pF1KE9 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GALEELRGQYIKAVKKIKCDMLRYIQESKERAAEMVKAEVLRERQETARKMRKYYLICLQ
1270 1280 1290 1300 1310 1320
1270 1280 1290 1300 1310 1320
pF1KE9 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QILQDDGKEGAEKKIMNAASKLATMAKLLETPISSKSQSKTTQSALPLTSEMLIAVKKSK
1330 1340 1350 1360 1370 1380
1330 1340 1350 1360 1370 1380
pF1KE9 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNDVNQKIPCCIESKSNSVNTITRTLCEQAPKRRAACNLQRLLENSEHQSIKHVGSKETH
1390 1400 1410 1420 1430 1440
1390 1400 1410 1420 1430 1440
pF1KE9 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEFQFGDGSCKHLNSLPRNVSPEFVPCEGEGGFGLHKKKDLLSDNGSESLPHSAAYPFLG
1450 1460 1470 1480 1490 1500
1450 1460 1470 1480 1490 1500
pF1KE9 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGNKPSPRCTPGPSESGCMHITFRDSNERLGLKVYKCNPLMESENAASEKSQGLDVQEP
1510 1520 1530 1540 1550 1560
1510 1520 1530 1540 1550 1560
pF1KE9 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVKDGGDLSDCLGWPSSSATLSFDSREASFVHGRPQGTLEIPSESVKSKQFSPSGYLSDT
1570 1580 1590 1600 1610 1620
1570 1580 1590 1600 1610 1620
pF1KE9 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EESNMICQTMKCQRYQTPYLSEETTYLEPGKISVNCGHPSRHKADRLKSDFKKLSSTLPS
1630 1640 1650 1660 1670 1680
1630 1640 1650
pF1KE9 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
::::::
NP_001 SVCQQPSRKLIVPLSSQQDSGFDSPFVNLD
1690 1700 1710
>>XP_016877505 (OMIM: 613529,613823,614852) centrosomal (834 aa)
initn: 4954 init1: 4954 opt: 4988 Z-score: 2420.3 bits: 459.8 E(92320): 4.9e-128
Smith-Waterman score: 4988; 95.2% identity (97.2% similar) in 813 aa overlap (1-807:1-813)
10 20 30 40 50 60
pF1KE9 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLDFGSVALPVQNEDEEYDEEDYEREKELQQLLTDLPHDMLDDDLSSPELQYSDCSEDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDGQPHHPEQLEMSWNEQMLPKSQSVNGYNEIQSLYAGEKCGNVWEENRSKTEDRHPVYH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEEGGDEGGSGYSPPSKCEQTDLYHLPENFRPYTNGQKQEFNNQATNVIKFSDPQWNHFQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSCQGLEPYNKVTYKPYQSSAQNNGSPAQEITGSDTFEGLQQQFLGANENSAENMQIIQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQVLNKAKERQLENLIEKLNESERQIRYLNHQLVIIKDEKDGLTLSLRESQKLFQNGKER
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIQLEAQIKALETQIQALKVNEEQMIKKSRTTEMALESLKQQLVDLHHSESLQRAREQHE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIVMGLTKKYEEQVLSLQKNLDATVTALKEQEDICSRLKDHVKQLERNQEAIKLEKTEII
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKLTRSLEESQKQCAHLLQSGSVQEVAQLQFQLQQAQKAHAMSANMNKALQEELTELKDE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISLYESAAKLGIHPSDSEGELNIELTESYVDLGIKKVNWKKSKVTSIVQEEDPNEELSKD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFILKLKAEVQRLLGSNSMKRHLVSQLQNDLKDCHKKIEDLHQVKKDEKSIEVETKTDTS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKPKNQLWPESSTSDVVRDDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDFDHDKQEAVDRCERTYQQHHEAMKTQIRESLLAKHALEKQQLFEAYERTHLQLRSELD
670 680 690 700 710 720
730 740 750 760 770
pF1KE9 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKI-----KEKLIQQLEKEWQS
:::::::::::::::::::::::::::::::::::::::: .:. ...:. : ..
XP_016 KLNKEVTAVQECYLEVCREKDNLELTLRKTTEKEQQTQEKRQLLEEREEYVSKLQVELEK
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE9 KLDQTIKAMKKKTL-DCGSQTDQVTTSDVISKKEMAIMIEEQKCTIQQNLEQEKDIAIKG
: ..:. :.: : : .. : . :.:: :
XP_016 KYQDTLMMEKSKWLKDQETDIKQQVESEVILAKAHWDKEEQEVWIKISFWSPHF
790 800 810 820 830
840 850 860 870 880 890
pF1KE9 AMKKLEIELELKHCENITKQVEIAVQNAHQRWLGELPELAEYQALVKAEQKKWEEQHEVS
1654 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 3 17:22:39 2019 done: Thu Oct 3 17:22:41 2019
Total Scan time: 10.150 Total Display time: 0.510
Function used was FASTA [36.3.4 Apr, 2011]