Result of FASTA (omim) for
pFN21AE6774
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6774, 592 aa
1>>>pF1KE6774 592 - 592 aa - 592 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0943+/-0.000357; mu= 19.7464+/- 0.022
mean_var=64.3686+/-12.956, 0's: 0 Z-trim(113.0): 29 B-trim: 519 in 1/52
Lambda= 0.159859
statistics sampled from 22131 (22153) to 22131 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.26), width: 16
Scan time: 7.770
The best scores are: opt bits E(85289)
NP_068600 (OMIM: 236730,613469) inactive heparanas ( 592) 3935 916.7 0
NP_001159718 (OMIM: 236730,613469) inactive hepara ( 548) 3579 834.5 0
XP_016871984 (OMIM: 236730,613469) PREDICTED: inac ( 545) 3576 833.8 0
XP_011538331 (OMIM: 236730,613469) PREDICTED: inac ( 543) 3262 761.4 0
XP_016871986 (OMIM: 236730,613469) PREDICTED: inac ( 420) 2781 650.4 3.4e-186
XP_006718000 (OMIM: 236730,613469) PREDICTED: inac ( 420) 2781 650.4 3.4e-186
XP_011538333 (OMIM: 236730,613469) PREDICTED: inac ( 420) 2781 650.4 3.4e-186
XP_011538332 (OMIM: 236730,613469) PREDICTED: inac ( 538) 2594 607.4 4e-173
XP_016871985 (OMIM: 236730,613469) PREDICTED: inac ( 441) 2417 566.5 6.6e-161
NP_001159716 (OMIM: 236730,613469) inactive hepara ( 534) 2220 521.1 3.6e-147
NP_001159717 (OMIM: 236730,613469) inactive hepara ( 480) 2214 519.7 8.7e-147
XP_016871987 (OMIM: 236730,613469) PREDICTED: inac ( 324) 2162 507.6 2.6e-143
XP_011538335 (OMIM: 236730,613469) PREDICTED: inac ( 324) 2162 507.6 2.6e-143
NP_006656 (OMIM: 604724) heparanase isoform 1 prep ( 543) 978 234.7 6.2e-61
NP_001092010 (OMIM: 604724) heparanase isoform 1 p ( 543) 978 234.7 6.2e-61
NP_001186759 (OMIM: 604724) heparanase isoform 3 p ( 485) 693 168.9 3.5e-41
NP_001159970 (OMIM: 604724) heparanase isoform 2 p ( 469) 387 98.3 5.9e-20
>>NP_068600 (OMIM: 236730,613469) inactive heparanase-2 (592 aa)
initn: 3935 init1: 3935 opt: 3935 Z-score: 4900.0 bits: 916.7 E(85289): 0
Smith-Waterman score: 3935; 99.7% identity (100.0% similar) in 592 aa overlap (1-592:1-592)
10 20 30 40 50 60
pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_068 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSV
490 500 510 520 530 540
550 560 570 580 590
pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR
::::::::::::::::::::::::::::::::::::::.:::::::::::::
NP_068 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR
550 560 570 580 590
>>NP_001159718 (OMIM: 236730,613469) inactive heparanase (548 aa)
initn: 3579 init1: 3579 opt: 3579 Z-score: 4456.8 bits: 834.5 E(85289): 0
Smith-Waterman score: 3579; 99.6% identity (100.0% similar) in 539 aa overlap (1-539:1-539)
10 20 30 40 50 60
pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::.
NP_001 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKTQ
490 500 510 520 530 540
550 560 570 580 590
pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR
NP_001 RCQYCGII
>>XP_016871984 (OMIM: 236730,613469) PREDICTED: inactive (545 aa)
initn: 3576 init1: 3576 opt: 3576 Z-score: 4453.1 bits: 833.8 E(85289): 0
Smith-Waterman score: 3576; 99.6% identity (100.0% similar) in 539 aa overlap (1-539:1-539)
10 20 30 40 50 60
pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV
:::::::::::::::::::::::::::::::::.:::::::::::::::::::::::.:
XP_016 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSNSS
490 500 510 520 530 540
550 560 570 580 590
pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR
XP_016 CLKRI
>>XP_011538331 (OMIM: 236730,613469) PREDICTED: inactive (543 aa)
initn: 3608 init1: 3258 opt: 3262 Z-score: 4061.7 bits: 761.4 E(85289): 0
Smith-Waterman score: 3514; 91.6% identity (91.7% similar) in 592 aa overlap (1-592:1-543)
10 20 30 40 50 60
pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV
:::::::: :::
XP_011 YAHCTNHH-------------------------------------------------KSV
490
550 560 570 580 590
pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR
::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_011 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR
500 510 520 530 540
>>XP_016871986 (OMIM: 236730,613469) PREDICTED: inactive (420 aa)
initn: 2781 init1: 2781 opt: 2781 Z-score: 3463.8 bits: 650.4 E(85289): 3.4e-186
Smith-Waterman score: 2781; 99.5% identity (100.0% similar) in 420 aa overlap (173-592:1-420)
150 160 170 180 190 200
pF1KE6 YLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQMHLVLLKEQFSNTYSNLIL
::::::::::::::::::::::::::::::
XP_016 MLELQREKAAQMHLVLLKEQFSNTYSNLIL
10 20 30
210 220 230 240 250 260
pF1KE6 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE6 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE6 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE6 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE6 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE6 NLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP
340 350 360 370 380 390
570 580 590
pF1KE6 LRAGRTLVIPPVTMGFFVVKNVNALACRYR
::::::::::::::::.:::::::::::::
XP_016 LRAGRTLVIPPVTMGFYVVKNVNALACRYR
400 410 420
>>XP_006718000 (OMIM: 236730,613469) PREDICTED: inactive (420 aa)
initn: 2781 init1: 2781 opt: 2781 Z-score: 3463.8 bits: 650.4 E(85289): 3.4e-186
Smith-Waterman score: 2781; 99.5% identity (100.0% similar) in 420 aa overlap (173-592:1-420)
150 160 170 180 190 200
pF1KE6 YLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQMHLVLLKEQFSNTYSNLIL
::::::::::::::::::::::::::::::
XP_006 MLELQREKAAQMHLVLLKEQFSNTYSNLIL
10 20 30
210 220 230 240 250 260
pF1KE6 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE6 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE6 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE6 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE6 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE6 NLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP
340 350 360 370 380 390
570 580 590
pF1KE6 LRAGRTLVIPPVTMGFFVVKNVNALACRYR
::::::::::::::::.:::::::::::::
XP_006 LRAGRTLVIPPVTMGFYVVKNVNALACRYR
400 410 420
>>XP_011538333 (OMIM: 236730,613469) PREDICTED: inactive (420 aa)
initn: 2781 init1: 2781 opt: 2781 Z-score: 3463.8 bits: 650.4 E(85289): 3.4e-186
Smith-Waterman score: 2781; 99.5% identity (100.0% similar) in 420 aa overlap (173-592:1-420)
150 160 170 180 190 200
pF1KE6 YLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREKAAQMHLVLLKEQFSNTYSNLIL
::::::::::::::::::::::::::::::
XP_011 MLELQREKAAQMHLVLLKEQFSNTYSNLIL
10 20 30
210 220 230 240 250 260
pF1KE6 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSSALSLLKYSASKKYNISWELGNE
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE6 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRASLYGPNIGRPRKNVIALLDGFMK
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE6 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQIRKIQKVVNTYTPGKKIWLEGV
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE6 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIRHSFFDHGYNHLVDQNFNPLPDY
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE6 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRIYAHCTNHHNHNYVRGSITLFII
280 290 300 310 320 330
510 520 530 540 550 560
pF1KE6 NLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSVQLNGQPLVMVDDGTLPELKPRP
340 350 360 370 380 390
570 580 590
pF1KE6 LRAGRTLVIPPVTMGFFVVKNVNALACRYR
::::::::::::::::.:::::::::::::
XP_011 LRAGRTLVIPPVTMGFYVVKNVNALACRYR
400 410 420
>>XP_011538332 (OMIM: 236730,613469) PREDICTED: inactive (538 aa)
initn: 3577 init1: 2594 opt: 2594 Z-score: 3229.2 bits: 607.4 E(85289): 4e-173
Smith-Waterman score: 3473; 90.5% identity (90.9% similar) in 592 aa overlap (1-592:1-538)
10 20 30 40 50 60
pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
:::::::::::::::::::::::::::::
XP_011 DFLQFQNLRNPAKSRGGPGPDYYLKNYED-------------------------------
130 140
190 200 210 220 230 240
pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
:::::::::::::::::::::::::::::::::::::
XP_011 -----------------------ARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
150 160 170 180
250 260 270 280 290 300
pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
310 320 330 340 350 360
430 440 450 460 470 480
pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
370 380 390 400 410 420
490 500 510 520 530 540
pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSV
430 440 450 460 470 480
550 560 570 580 590
pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR
::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_011 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR
490 500 510 520 530
>>XP_016871985 (OMIM: 236730,613469) PREDICTED: inactive (441 aa)
initn: 2417 init1: 2417 opt: 2417 Z-score: 3009.8 bits: 566.5 E(85289): 6.6e-161
Smith-Waterman score: 2417; 100.0% identity (100.0% similar) in 366 aa overlap (1-366:1-366)
10 20 30 40 50 60
pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
::::::
XP_016 IRKIQKHPASVSVPPLHVTIMLFSAHGRYRVHKPPTVPQTHASGLLPITTSPTSEGKTTN
370 380 390 400 410 420
>>NP_001159716 (OMIM: 236730,613469) inactive heparanase (534 aa)
initn: 3539 init1: 2212 opt: 2220 Z-score: 2763.1 bits: 521.1 E(85289): 3.6e-147
Smith-Waterman score: 3427; 89.9% identity (90.2% similar) in 592 aa overlap (1-592:1-534)
10 20 30 40 50 60
pF1KE6 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
:::::::::::::::::::::::
NP_001 AAQMHLVLLKEQFSNTYSNLILT-------------------------------------
190 200
250 260 270 280 290 300
pF1KE6 ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
:::::::::::::::::::::::::::::::::::::::
NP_001 ---------------------EPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
210 220 230 240
310 320 330 340 350 360
pF1KE6 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE6 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
310 320 330 340 350 360
430 440 450 460 470 480
pF1KE6 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
370 380 390 400 410 420
490 500 510 520 530 540
pF1KE6 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLTGTLRDKLVHQYLLQPYGQEGLKSKSV
:::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_001 YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSV
430 440 450 460 470 480
550 560 570 580 590
pF1KE6 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFFVVKNVNALACRYR
::::::::::::::::::::::::::::::::::::::.:::::::::::::
NP_001 QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR
490 500 510 520 530
592 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:15:20 2016 done: Tue Nov 8 16:15:21 2016
Total Scan time: 7.770 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]