Result of FASTA (omim) for
pFN21AE6754
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6754, 714 aa
1>>>pF1KE6754 714 - 714 aa - 714 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9230+/-0.000404; mu= 23.2324+/- 0.025
mean_var=82.9335+/-17.116, 0's: 0 Z-trim(112.8): 57 B-trim: 832 in 1/51
Lambda= 0.140835
statistics sampled from 21749 (21806) to 21749 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.256), width: 16
Scan time: 10.730
The best scores are: opt bits E(85289)
NP_001182412 (OMIM: 611316) solute carrier family ( 714) 4736 972.7 0
NP_078904 (OMIM: 611316) solute carrier family 12 ( 714) 4736 972.7 0
XP_011541890 (OMIM: 600840) PREDICTED: solute carr ( 628) 681 148.8 6.3e-35
NP_001243390 (OMIM: 600840) solute carrier family (1196) 681 149.1 9.8e-35
NP_001037 (OMIM: 600840) solute carrier family 12 (1212) 681 149.1 9.9e-35
XP_005254663 (OMIM: 600839,601678) PREDICTED: solu (1099) 425 97.0 4.2e-19
NP_000329 (OMIM: 600839,601678) solute carrier fam (1099) 419 95.8 9.8e-19
NP_001254743 (OMIM: 616861) solute carrier family ( 538) 415 94.7 1e-18
NP_001254741 (OMIM: 616861) solute carrier family ( 631) 415 94.7 1.2e-18
NP_001171761 (OMIM: 600839,601678) solute carrier (1099) 417 95.4 1.3e-18
XP_005250559 (OMIM: 616861) PREDICTED: solute carr ( 825) 415 94.9 1.4e-18
XP_006716117 (OMIM: 616861) PREDICTED: solute carr ( 825) 415 94.9 1.4e-18
NP_064631 (OMIM: 616861) solute carrier family 12 ( 914) 415 94.9 1.5e-18
XP_005256176 (OMIM: 263800,600968) PREDICTED: solu (1020) 401 92.1 1.2e-17
NP_001119580 (OMIM: 263800,600968) solute carrier (1021) 400 91.9 1.3e-17
NP_001119579 (OMIM: 263800,600968) solute carrier (1029) 400 91.9 1.4e-17
NP_000330 (OMIM: 263800,600968) solute carrier fam (1030) 400 91.9 1.4e-17
XP_011514716 (OMIM: 616861) PREDICTED: solute carr ( 722) 394 90.5 2.5e-17
XP_006716118 (OMIM: 616861) PREDICTED: solute carr ( 811) 394 90.6 2.7e-17
XP_006720856 (OMIM: 218000,604878) PREDICTED: solu (1101) 346 81.0 2.9e-14
XP_016864447 (OMIM: 604879) PREDICTED: solute carr (1020) 282 67.9 2.2e-10
XP_016864448 (OMIM: 604879) PREDICTED: solute carr (1020) 282 67.9 2.2e-10
XP_011512242 (OMIM: 604879) PREDICTED: solute carr (1074) 282 67.9 2.3e-10
NP_006589 (OMIM: 604879) solute carrier family 12 (1083) 282 67.9 2.3e-10
XP_011512241 (OMIM: 604879) PREDICTED: solute carr (1085) 282 67.9 2.3e-10
XP_005248288 (OMIM: 604879) PREDICTED: solute carr (1088) 282 68.0 2.3e-10
XP_011512243 (OMIM: 604879) PREDICTED: solute carr (1111) 282 68.0 2.4e-10
NP_065759 (OMIM: 606726,616645,616685) solute carr (1116) 282 68.0 2.4e-10
XP_016883470 (OMIM: 606726,616645,616685) PREDICTE (1134) 282 68.0 2.4e-10
NP_001128243 (OMIM: 606726,616645,616685) solute c (1139) 282 68.0 2.4e-10
XP_011520571 (OMIM: 218000,604878) PREDICTED: solu ( 680) 279 67.1 2.6e-10
NP_001139436 (OMIM: 604119) solute carrier family (1054) 281 67.7 2.6e-10
NP_001139433 (OMIM: 604119) solute carrier family (1079) 281 67.7 2.7e-10
NP_001139435 (OMIM: 604119) solute carrier family (1079) 281 67.7 2.7e-10
NP_005063 (OMIM: 604119) solute carrier family 12 (1085) 281 67.7 2.7e-10
NP_001139434 (OMIM: 604119) solute carrier family (1087) 281 67.7 2.7e-10
NP_001035960 (OMIM: 218000,604878) solute carrier (1091) 279 67.3 3.6e-10
NP_001035959 (OMIM: 218000,604878) solute carrier (1091) 279 67.3 3.6e-10
NP_005126 (OMIM: 218000,604878) solute carrier fam (1099) 279 67.3 3.6e-10
NP_001035962 (OMIM: 218000,604878) solute carrier (1135) 279 67.4 3.7e-10
NP_001035961 (OMIM: 218000,604878) solute carrier (1141) 279 67.4 3.7e-10
NP_598408 (OMIM: 218000,604878) solute carrier fam (1150) 279 67.4 3.7e-10
XP_016865260 (OMIM: 600840) PREDICTED: solute carr ( 626) 235 58.2 1.2e-07
NP_036376 (OMIM: 604235) large neutral amino acids ( 535) 188 48.5 8e-05
NP_062823 (OMIM: 607959) asc-type amino acid trans ( 523) 166 44.1 0.0017
>>NP_001182412 (OMIM: 611316) solute carrier family 12 m (714 aa)
initn: 4736 init1: 4736 opt: 4736 Z-score: 5200.1 bits: 972.7 E(85289): 0
Smith-Waterman score: 4736; 99.9% identity (100.0% similar) in 714 aa overlap (1-714:1-714)
10 20 30 40 50 60
pF1KE6 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC
610 620 630 640 650 660
670 680 690 700 710
pF1KE6 RSLQSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
:::.::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
670 680 690 700 710
>>NP_078904 (OMIM: 611316) solute carrier family 12 memb (714 aa)
initn: 4736 init1: 4736 opt: 4736 Z-score: 5200.1 bits: 972.7 E(85289): 0
Smith-Waterman score: 4736; 99.9% identity (100.0% similar) in 714 aa overlap (1-714:1-714)
10 20 30 40 50 60
pF1KE6 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC
610 620 630 640 650 660
670 680 690 700 710
pF1KE6 RSLQSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
:::.::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY
670 680 690 700 710
>>XP_011541890 (OMIM: 600840) PREDICTED: solute carrier (628 aa)
initn: 673 init1: 319 opt: 681 Z-score: 748.1 bits: 148.8 E(85289): 6.3e-35
Smith-Waterman score: 687; 36.4% identity (69.9% similar) in 316 aa overlap (37-340:283-598)
10 20 30 40 50 60
pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV
: :: ::.. ::.::.::.::.: .:.:
XP_011 EPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIV
260 270 280 290 300 310
70 80 90 100 110 120
pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY
:..:. :..... .. .:. .: :: ... . . .::.: .:: :: . ::.:::..
XP_011 GQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIF
320 330 340 350 360 370
130 140 150 160 170 180
pF1KE6 VFGQCVAGAMYITGFAESISDLLG------LGNIWAVRGISVAVLLALLGINLAGVKWII
.:.. :: :::..::::.. .:: . .: .: :.. ... ::::..::..:
XP_011 AFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEA
380 390 400 410 420 430
190 200 210 220 230
pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH--GFIGYSPELLQNNTLPDYSPGESFFTVFG
. :..:: .: .. :::.:.: :. .. ::.::. :....: ::. :.::.::.
XP_011 KAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFA
440 450 460 470 480 490
240 250 260 270 280 290
pF1KE6 VFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRY-
.:::::::..:: :..::: .: ..:: :.: :. :. ..:. .. .:. .:.:
XP_011 IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNV
500 510 520 530 540 550
300 310 320 330 340 350
pF1KE6 -DFLIAEKVSLMGFLFLLGLYISSLAS--CMGGLYGAPRILQCIAQEKVIPALACLGQGK
: ...: .. . :.. .:: : : ::.. . : :
XP_011 NDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQSAFCSFQHIRPVCILLDLRVS
560 570 580 590 600 610
360 370 380 390 400 410
pF1KE6 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTP
XP_011 IFILLNLNPYQLSSVF
620
>>NP_001243390 (OMIM: 600840) solute carrier family 12 m (1196 aa)
initn: 842 init1: 319 opt: 681 Z-score: 744.6 bits: 149.1 E(85289): 9.8e-35
Smith-Waterman score: 846; 33.3% identity (67.4% similar) in 430 aa overlap (37-421:283-709)
10 20 30 40 50 60
pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV
: :: ::.. ::.::.::.::.: .:.:
NP_001 EPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIV
260 270 280 290 300 310
70 80 90 100 110 120
pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY
:..:. :..... .. .:. .: :: ... . . .::.: .:: :: . ::.:::..
NP_001 GQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIF
320 330 340 350 360 370
130 140 150 160 170 180
pF1KE6 VFGQCVAGAMYITGFAESISDLLG------LGNIWAVRGISVAVLLALLGINLAGVKWII
.:.. :: :::..::::.. .:: . .: .: :.. ... ::::..::..:
NP_001 AFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEA
380 390 400 410 420 430
190 200 210 220 230
pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH--GFIGYSPELLQNNTLPDYSPGESFFTVFG
. :..:: .: .. :::.:.: :. .. ::.::. :....: ::. :.::.::.
NP_001 KAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFA
440 450 460 470 480 490
240 250 260 270 280 290
pF1KE6 VFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA----
.:::::::..:: :..::: .: ..:: :.: :. :. ..:. .. .:. .:.:
NP_001 IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNV
500 510 520 530 540 550
300 310 320
pF1KE6 -----------------LRYDFLIAEK----VSLM----------GFLFLL--GLYISSL
: .:: :. .:: :: :. :.. ..:
NP_001 NDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATL
560 570 580 590 600 610
330 340 350 360 370 380
pF1KE6 ASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVN
.: ...: .::.:.: . .... ::. ...: : :. :. . :: :....:......:
NP_001 SSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELN
620 630 640 650 660 670
390 400 410 420 430 440
pF1KE6 VLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSY
:.:::.. :. .:. ...: : :. . .: .:...
NP_001 VIAPIISNFFLASYALINFSVFHASLAK---SPGWRPAFKYYNMWISLLGAILCCIVMFV
680 690 700 710 720
450 460 470 480 490 500
pF1KE6 GSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTL
NP_001 INWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRP
730 740 750 760 770 780
>>NP_001037 (OMIM: 600840) solute carrier family 12 memb (1212 aa)
initn: 842 init1: 319 opt: 681 Z-score: 744.5 bits: 149.1 E(85289): 9.9e-35
Smith-Waterman score: 846; 33.3% identity (67.4% similar) in 430 aa overlap (37-421:283-709)
10 20 30 40 50 60
pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV
: :: ::.. ::.::.::.::.: .:.:
NP_001 EPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIV
260 270 280 290 300 310
70 80 90 100 110 120
pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY
:..:. :..... .. .:. .: :: ... . . .::.: .:: :: . ::.:::..
NP_001 GQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIF
320 330 340 350 360 370
130 140 150 160 170 180
pF1KE6 VFGQCVAGAMYITGFAESISDLLG------LGNIWAVRGISVAVLLALLGINLAGVKWII
.:.. :: :::..::::.. .:: . .: .: :.. ... ::::..::..:
NP_001 AFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEA
380 390 400 410 420 430
190 200 210 220 230
pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH--GFIGYSPELLQNNTLPDYSPGESFFTVFG
. :..:: .: .. :::.:.: :. .. ::.::. :....: ::. :.::.::.
NP_001 KAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFA
440 450 460 470 480 490
240 250 260 270 280 290
pF1KE6 VFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA----
.:::::::..:: :..::: .: ..:: :.: :. :. ..:. .. .:. .:.:
NP_001 IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNV
500 510 520 530 540 550
300 310 320
pF1KE6 -----------------LRYDFLIAEK----VSLM----------GFLFLL--GLYISSL
: .:: :. .:: :: :. :.. ..:
NP_001 NDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATL
560 570 580 590 600 610
330 340 350 360 370 380
pF1KE6 ASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVN
.: ...: .::.:.: . .... ::. ...: : :. :. . :: :....:......:
NP_001 SSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELN
620 630 640 650 660 670
390 400 410 420 430 440
pF1KE6 VLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSY
:.:::.. :. .:. ...: : :. . .: .:...
NP_001 VIAPIISNFFLASYALINFSVFHASLAK---SPGWRPAFKYYNMWISLLGAILCCIVMFV
680 690 700 710 720
450 460 470 480 490 500
pF1KE6 GSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTL
NP_001 INWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRP
730 740 750 760 770 780
>>XP_005254663 (OMIM: 600839,601678) PREDICTED: solute c (1099 aa)
initn: 820 init1: 340 opt: 425 Z-score: 464.0 bits: 97.0 E(85289): 4.2e-19
Smith-Waterman score: 813; 32.9% identity (65.1% similar) in 416 aa overlap (37-406:175-590)
10 20 30 40 50 60
pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV
: :: ::.. ::.::.::.::.: .:.:
XP_005 TPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIV
150 160 170 180 190 200
70 80 90 100 110 120
pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY
:..:. ::........ :. .: :: ... . . .::.: .:: :: . ::.:::..
XP_005 GEAGIGLGVIIIGLAVTVTGITGLSTSAIATNGCVRGGGAYYLISRSLGPEFGGSIGLIF
210 220 230 240 250 260
130 140 150 160 170 180
pF1KE6 VFGQCVAGAMYITGFAESISDLLGLGNIWAV------RGISVAVLLALLGINLAGVKWII
.:.. :: :::..::::.. ::: .. : : :. ... ::::..::..:
XP_005 AFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEA
270 280 290 300 310 320
190 200 210 220 230
pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH---GFIGYSPELLQNNTLPDYSPGESFFTVF
. :..:: .: .. .: .:. . :. ::..:. .. .: : .. ::.::.::
XP_005 KAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVF
330 340 350 360 370 380
240 250 260 270 280 290
pF1KE6 GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA---
..:::::::..:: :..:::..: .:: :.. :. :. :. .. .:: .:.:
XP_005 AIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGN
390 400 410 420 430 440
300 310 320
pF1KE6 ------------------LRYDF----------------LIAEKVSLMGFLFLLGLYISS
: ::: . :: .: :. :.. ..
XP_005 MNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSAT
450 460 470 480 490 500
330 340 350 360 370 380
pF1KE6 LASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQV
:.: ...: .::...: . .... :: ...: : :. :. . :: :..:::......
XP_005 LSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAEL
510 520 530 540 550 560
390 400 410 420 430 440
pF1KE6 NVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPS
:..:::.. :. .:. ...: : :
XP_005 NTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVIN
570 580 590 600 610 620
>>NP_000329 (OMIM: 600839,601678) solute carrier family (1099 aa)
initn: 911 init1: 334 opt: 419 Z-score: 457.4 bits: 95.8 E(85289): 9.8e-19
Smith-Waterman score: 807; 32.9% identity (64.7% similar) in 416 aa overlap (37-406:175-590)
10 20 30 40 50 60
pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV
: :: ::.. ::.::.::.::.: .:.:
NP_000 TPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIV
150 160 170 180 190 200
70 80 90 100 110 120
pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY
:..:. ::.... . .:. .: :: ... . . .::.: .:: :: . ::.:::..
NP_000 GEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIF
210 220 230 240 250 260
130 140 150 160 170 180
pF1KE6 VFGQCVAGAMYITGFAESISDLLGLGNIWAV------RGISVAVLLALLGINLAGVKWII
.:.. :: :::..::::.. ::: .. : : :. ... ::::..::..:
NP_000 AFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEA
270 280 290 300 310 320
190 200 210 220 230
pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH---GFIGYSPELLQNNTLPDYSPGESFFTVF
. :..:: .: .. .: .:. . :. ::..:. .. .: : .. ::.::.::
NP_000 KAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVF
330 340 350 360 370 380
240 250 260 270 280 290
pF1KE6 GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA---
..:::::::..:: :..:::..: .:: :.. :. :. :. .. .:: .:.:
NP_000 AIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGN
390 400 410 420 430 440
300 310 320
pF1KE6 ------------------LRYDF----------------LIAEKVSLMGFLFLLGLYISS
: ::: . :: .: :. :.. ..
NP_000 MNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSAT
450 460 470 480 490 500
330 340 350 360 370 380
pF1KE6 LASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQV
:.: ...: .::...: . .... :: ...: : :. :. . :: :..:::......
NP_000 LSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAEL
510 520 530 540 550 560
390 400 410 420 430 440
pF1KE6 NVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPS
:..:::.. :. .:. ...: : :
NP_000 NTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVIN
570 580 590 600 610 620
>>NP_001254743 (OMIM: 616861) solute carrier family 12 m (538 aa)
initn: 420 init1: 384 opt: 415 Z-score: 456.8 bits: 94.7 E(85289): 1e-18
Smith-Waterman score: 428; 29.4% identity (59.6% similar) in 344 aa overlap (92-409:18-354)
70 80 90 100 110 120
pF1KE6 TGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGT
:... .. : ::. . :.. : . :
NP_001 MASESSPLLAYRLLGEEGVALPANGAGGPGGASARKLSTFLGVVVPT
10 20 30 40
130 140 150 160 170 180
pF1KE6 IGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLG-INLAGVKWII
. : .:. : . :: : .: : : . . ..::.:.: . :.
NP_001 V--LSMFSIVVFLRIDATG--PSGLRVLPQGYGWNL--LYGSLLLGLVGGVCTLGAGLYA
50 60 70 80 90 100
190 200 210 220
pF1KE6 RLQLLLLFLLAVSTLDFVVGSF------------------THLDPEHG-FIGYSPELLQN
: ..: :::. ..: :. :: . : :. : : :.. :..
NP_001 RASFLT-FLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKD
110 120 130 140 150 160
230 240 250 260 270
pF1KE6 NT----LPDYSPGE--SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGIS
: ::. : .: .::.:.: . ::.::: ::.:.:..:. .::::...::. .
NP_001 NLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYT
170 180 190 200 210 220
280 290 300 310 320 330
pF1KE6 WFLYIVFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRIL
.:.:... :: . : : :. :. . . .:: : :.:.: ..:.. :..: :: :::
NP_001 FFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRIL
230 240 250 260 270 280
340 350 360 370 380 390
pF1KE6 QCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTY
. .:.. .. .. .. . . .: ::. . ... ...:..:.:: .::. ....:
NP_001 HALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAY
290 300 310 320 330 340
400 410 420 430 440 450
pF1KE6 VAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTL
.::: : .:: :
NP_001 AAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLA
350 360 370 380 390 400
>>NP_001254741 (OMIM: 616861) solute carrier family 12 m (631 aa)
initn: 647 init1: 384 opt: 415 Z-score: 456.0 bits: 94.7 E(85289): 1.2e-18
Smith-Waterman score: 632; 31.4% identity (65.0% similar) in 411 aa overlap (39-409:37-443)
10 20 30 40 50 60
pF1KE6 ELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGN
..:. :: . ....:..:.::: :..::.
NP_001 PLLAYRLLGEEGVALPANGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 TGVL--LGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY
.:.: :.:.::.. ::. .:::: ... ... .::.: ::: .:: ..::.:::..
NP_001 AGLLQALAMLLVAYFILA--LTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMF
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 VFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISV------------AVLLALLG-INL
... . :. . :..::. :..: .. . :. : ..::.:.: .
NP_001 YLANVCGCAVSLLGLVESVLDVFG-ADATGPSGLRVLPQGYGWNLLYGSLLLGLVGGVCT
130 140 150 160 170 180
180 190 200 210
pF1KE6 AGVKWIIRLQLLLLFLLAVSTLDFVVGSF------------------THLDPEHG-FIGY
:. : ..: :::. ..: :. :: . : :. : : :.
NP_001 LGAGLYARASFLT-FLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFTGF
190 200 210 220 230 240
220 230 240 250 260
pF1KE6 SPELLQNNT----LPDYSPGE--SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGS
. :..: ::. : .: .::.:.: . ::.::: ::.:.:..:. .::::.
NP_001 NSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGT
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE6 LAAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGL
..::. ..:.:... :: . : : :. :. . . .:: : :.:.: ..:.. :..:
NP_001 IVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMSSL
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE6 YGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVT
:: :::. .:.. .. .. .. . . .: ::. . ... ...:..:.:: .::
NP_001 IGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVT
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE6 INFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQ
. ....:.::: : .:: :
NP_001 VFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSL
430 440 450 460 470 480
>>NP_001171761 (OMIM: 600839,601678) solute carrier fami (1099 aa)
initn: 812 init1: 332 opt: 417 Z-score: 455.2 bits: 95.4 E(85289): 1.3e-18
Smith-Waterman score: 805; 32.7% identity (64.9% similar) in 416 aa overlap (37-406:175-590)
10 20 30 40 50 60
pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV
: :: ::.. ::.::.::.::.: .:.:
NP_001 TPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIV
150 160 170 180 190 200
70 80 90 100 110 120
pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY
:..:. ::...... ..:. .: .: .. . . .::.: .:: :: . ::.:::..
NP_001 GEAGIGLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIF
210 220 230 240 250 260
130 140 150 160 170 180
pF1KE6 VFGQCVAGAMYITGFAESISDLLGLGNIWAV------RGISVAVLLALLGINLAGVKWII
.:.. :: :::..::::.. ::: .. : : :. ... ::::..::..:
NP_001 AFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEA
270 280 290 300 310 320
190 200 210 220 230
pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH---GFIGYSPELLQNNTLPDYSPGESFFTVF
. :..:: .: .. .: .:. . :. ::..:. .. .: : .. ::.::.::
NP_001 KAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVF
330 340 350 360 370 380
240 250 260 270 280 290
pF1KE6 GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA---
..:::::::..:: :..:::..: .:: :.. :. :. :. .. .:: .:.:
NP_001 AIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGN
390 400 410 420 430 440
300 310 320
pF1KE6 ------------------LRYDF----------------LIAEKVSLMGFLFLLGLYISS
: ::: . :: .: :. :.. ..
NP_001 MNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSAT
450 460 470 480 490 500
330 340 350 360 370 380
pF1KE6 LASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQV
:.: ...: .::...: . .... :: ...: : :. :. . :: :..:::......
NP_001 LSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAEL
510 520 530 540 550 560
390 400 410 420 430 440
pF1KE6 NVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPS
:..:::.. :. .:. ...: : :
NP_001 NTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVIN
570 580 590 600 610 620
714 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:03:13 2016 done: Tue Nov 8 16:03:15 2016
Total Scan time: 10.730 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]