FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6754, 714 aa 1>>>pF1KE6754 714 - 714 aa - 714 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9230+/-0.000404; mu= 23.2324+/- 0.025 mean_var=82.9335+/-17.116, 0's: 0 Z-trim(112.8): 57 B-trim: 832 in 1/51 Lambda= 0.140835 statistics sampled from 21749 (21806) to 21749 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.256), width: 16 Scan time: 10.730 The best scores are: opt bits E(85289) NP_001182412 (OMIM: 611316) solute carrier family ( 714) 4736 972.7 0 NP_078904 (OMIM: 611316) solute carrier family 12 ( 714) 4736 972.7 0 XP_011541890 (OMIM: 600840) PREDICTED: solute carr ( 628) 681 148.8 6.3e-35 NP_001243390 (OMIM: 600840) solute carrier family (1196) 681 149.1 9.8e-35 NP_001037 (OMIM: 600840) solute carrier family 12 (1212) 681 149.1 9.9e-35 XP_005254663 (OMIM: 600839,601678) PREDICTED: solu (1099) 425 97.0 4.2e-19 NP_000329 (OMIM: 600839,601678) solute carrier fam (1099) 419 95.8 9.8e-19 NP_001254743 (OMIM: 616861) solute carrier family ( 538) 415 94.7 1e-18 NP_001254741 (OMIM: 616861) solute carrier family ( 631) 415 94.7 1.2e-18 NP_001171761 (OMIM: 600839,601678) solute carrier (1099) 417 95.4 1.3e-18 XP_005250559 (OMIM: 616861) PREDICTED: solute carr ( 825) 415 94.9 1.4e-18 XP_006716117 (OMIM: 616861) PREDICTED: solute carr ( 825) 415 94.9 1.4e-18 NP_064631 (OMIM: 616861) solute carrier family 12 ( 914) 415 94.9 1.5e-18 XP_005256176 (OMIM: 263800,600968) PREDICTED: solu (1020) 401 92.1 1.2e-17 NP_001119580 (OMIM: 263800,600968) solute carrier (1021) 400 91.9 1.3e-17 NP_001119579 (OMIM: 263800,600968) solute carrier (1029) 400 91.9 1.4e-17 NP_000330 (OMIM: 263800,600968) solute carrier fam (1030) 400 91.9 1.4e-17 XP_011514716 (OMIM: 616861) PREDICTED: solute carr ( 722) 394 90.5 2.5e-17 XP_006716118 (OMIM: 616861) PREDICTED: solute carr ( 811) 394 90.6 2.7e-17 XP_006720856 (OMIM: 218000,604878) PREDICTED: solu (1101) 346 81.0 2.9e-14 XP_016864447 (OMIM: 604879) PREDICTED: solute carr (1020) 282 67.9 2.2e-10 XP_016864448 (OMIM: 604879) PREDICTED: solute carr (1020) 282 67.9 2.2e-10 XP_011512242 (OMIM: 604879) PREDICTED: solute carr (1074) 282 67.9 2.3e-10 NP_006589 (OMIM: 604879) solute carrier family 12 (1083) 282 67.9 2.3e-10 XP_011512241 (OMIM: 604879) PREDICTED: solute carr (1085) 282 67.9 2.3e-10 XP_005248288 (OMIM: 604879) PREDICTED: solute carr (1088) 282 68.0 2.3e-10 XP_011512243 (OMIM: 604879) PREDICTED: solute carr (1111) 282 68.0 2.4e-10 NP_065759 (OMIM: 606726,616645,616685) solute carr (1116) 282 68.0 2.4e-10 XP_016883470 (OMIM: 606726,616645,616685) PREDICTE (1134) 282 68.0 2.4e-10 NP_001128243 (OMIM: 606726,616645,616685) solute c (1139) 282 68.0 2.4e-10 XP_011520571 (OMIM: 218000,604878) PREDICTED: solu ( 680) 279 67.1 2.6e-10 NP_001139436 (OMIM: 604119) solute carrier family (1054) 281 67.7 2.6e-10 NP_001139433 (OMIM: 604119) solute carrier family (1079) 281 67.7 2.7e-10 NP_001139435 (OMIM: 604119) solute carrier family (1079) 281 67.7 2.7e-10 NP_005063 (OMIM: 604119) solute carrier family 12 (1085) 281 67.7 2.7e-10 NP_001139434 (OMIM: 604119) solute carrier family (1087) 281 67.7 2.7e-10 NP_001035960 (OMIM: 218000,604878) solute carrier (1091) 279 67.3 3.6e-10 NP_001035959 (OMIM: 218000,604878) solute carrier (1091) 279 67.3 3.6e-10 NP_005126 (OMIM: 218000,604878) solute carrier fam (1099) 279 67.3 3.6e-10 NP_001035962 (OMIM: 218000,604878) solute carrier (1135) 279 67.4 3.7e-10 NP_001035961 (OMIM: 218000,604878) solute carrier (1141) 279 67.4 3.7e-10 NP_598408 (OMIM: 218000,604878) solute carrier fam (1150) 279 67.4 3.7e-10 XP_016865260 (OMIM: 600840) PREDICTED: solute carr ( 626) 235 58.2 1.2e-07 NP_036376 (OMIM: 604235) large neutral amino acids ( 535) 188 48.5 8e-05 NP_062823 (OMIM: 607959) asc-type amino acid trans ( 523) 166 44.1 0.0017 >>NP_001182412 (OMIM: 611316) solute carrier family 12 m (714 aa) initn: 4736 init1: 4736 opt: 4736 Z-score: 5200.1 bits: 972.7 E(85289): 0 Smith-Waterman score: 4736; 99.9% identity (100.0% similar) in 714 aa overlap (1-714:1-714) 10 20 30 40 50 60 pF1KE6 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC 610 620 630 640 650 660 670 680 690 700 710 pF1KE6 RSLQSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY :::.:::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY 670 680 690 700 710 >>NP_078904 (OMIM: 611316) solute carrier family 12 memb (714 aa) initn: 4736 init1: 4736 opt: 4736 Z-score: 5200.1 bits: 972.7 E(85289): 0 Smith-Waterman score: 4736; 99.9% identity (100.0% similar) in 714 aa overlap (1-714:1-714) 10 20 30 40 50 60 pF1KE6 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 MTQMSQVQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 RTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 TIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLGINLAGVKWII 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 RLQLLLLFLLAVSTLDFVVGSFTHLDPEHGFIGYSPELLQNNTLPDYSPGESFFTVFGVF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 REGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 EGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEISDRLPAASWEGQESCWNKQTS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 KSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRRSTSFYTHMCNPWVSLL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 GAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLGSASNFSFFRWMRSLLLPSC 610 620 630 640 650 660 670 680 690 700 710 pF1KE6 RSLQSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY :::.:::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 RSLRSPQEQIILAPSLAKVDMEMTQLTQENADFATRDRYHHSSLVNREQLMPHY 670 680 690 700 710 >>XP_011541890 (OMIM: 600840) PREDICTED: solute carrier (628 aa) initn: 673 init1: 319 opt: 681 Z-score: 748.1 bits: 148.8 E(85289): 6.3e-35 Smith-Waterman score: 687; 36.4% identity (69.9% similar) in 316 aa overlap (37-340:283-598) 10 20 30 40 50 60 pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV : :: ::.. ::.::.::.::.: .:.: XP_011 EPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIV 260 270 280 290 300 310 70 80 90 100 110 120 pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY :..:. :..... .. .:. .: :: ... . . .::.: .:: :: . ::.:::.. XP_011 GQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIF 320 330 340 350 360 370 130 140 150 160 170 180 pF1KE6 VFGQCVAGAMYITGFAESISDLLG------LGNIWAVRGISVAVLLALLGINLAGVKWII .:.. :: :::..::::.. .:: . .: .: :.. ... ::::..::..: XP_011 AFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEA 380 390 400 410 420 430 190 200 210 220 230 pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH--GFIGYSPELLQNNTLPDYSPGESFFTVFG . :..:: .: .. :::.:.: :. .. ::.::. :....: ::. :.::.::. XP_011 KAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFA 440 450 460 470 480 490 240 250 260 270 280 290 pF1KE6 VFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRY- .:::::::..:: :..::: .: ..:: :.: :. :. ..:. .. .:. .:.: XP_011 IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNV 500 510 520 530 540 550 300 310 320 330 340 350 pF1KE6 -DFLIAEKVSLMGFLFLLGLYISSLAS--CMGGLYGAPRILQCIAQEKVIPALACLGQGK : ...: .. . :.. .:: : : ::.. . : : XP_011 NDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQSAFCSFQHIRPVCILLDLRVS 560 570 580 590 600 610 360 370 380 390 400 410 pF1KE6 GPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTP XP_011 IFILLNLNPYQLSSVF 620 >>NP_001243390 (OMIM: 600840) solute carrier family 12 m (1196 aa) initn: 842 init1: 319 opt: 681 Z-score: 744.6 bits: 149.1 E(85289): 9.8e-35 Smith-Waterman score: 846; 33.3% identity (67.4% similar) in 430 aa overlap (37-421:283-709) 10 20 30 40 50 60 pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV : :: ::.. ::.::.::.::.: .:.: NP_001 EPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIV 260 270 280 290 300 310 70 80 90 100 110 120 pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY :..:. :..... .. .:. .: :: ... . . .::.: .:: :: . ::.:::.. NP_001 GQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIF 320 330 340 350 360 370 130 140 150 160 170 180 pF1KE6 VFGQCVAGAMYITGFAESISDLLG------LGNIWAVRGISVAVLLALLGINLAGVKWII .:.. :: :::..::::.. .:: . .: .: :.. ... ::::..::..: NP_001 AFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEA 380 390 400 410 420 430 190 200 210 220 230 pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH--GFIGYSPELLQNNTLPDYSPGESFFTVFG . :..:: .: .. :::.:.: :. .. ::.::. :....: ::. :.::.::. NP_001 KAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFA 440 450 460 470 480 490 240 250 260 270 280 290 pF1KE6 VFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA---- .:::::::..:: :..::: .: ..:: :.: :. :. ..:. .. .:. .:.: NP_001 IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNV 500 510 520 530 540 550 300 310 320 pF1KE6 -----------------LRYDFLIAEK----VSLM----------GFLFLL--GLYISSL : .:: :. .:: :: :. :.. ..: NP_001 NDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATL 560 570 580 590 600 610 330 340 350 360 370 380 pF1KE6 ASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVN .: ...: .::.:.: . .... ::. ...: : :. :. . :: :....:......: NP_001 SSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELN 620 630 640 650 660 670 390 400 410 420 430 440 pF1KE6 VLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSY :.:::.. :. .:. ...: : :. . .: .:... NP_001 VIAPIISNFFLASYALINFSVFHASLAK---SPGWRPAFKYYNMWISLLGAILCCIVMFV 680 690 700 710 720 450 460 470 480 490 500 pF1KE6 GSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTL NP_001 INWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRP 730 740 750 760 770 780 >>NP_001037 (OMIM: 600840) solute carrier family 12 memb (1212 aa) initn: 842 init1: 319 opt: 681 Z-score: 744.5 bits: 149.1 E(85289): 9.9e-35 Smith-Waterman score: 846; 33.3% identity (67.4% similar) in 430 aa overlap (37-421:283-709) 10 20 30 40 50 60 pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV : :: ::.. ::.::.::.::.: .:.: NP_001 EPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIV 260 270 280 290 300 310 70 80 90 100 110 120 pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY :..:. :..... .. .:. .: :: ... . . .::.: .:: :: . ::.:::.. NP_001 GQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIF 320 330 340 350 360 370 130 140 150 160 170 180 pF1KE6 VFGQCVAGAMYITGFAESISDLLG------LGNIWAVRGISVAVLLALLGINLAGVKWII .:.. :: :::..::::.. .:: . .: .: :.. ... ::::..::..: NP_001 AFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEA 380 390 400 410 420 430 190 200 210 220 230 pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH--GFIGYSPELLQNNTLPDYSPGESFFTVFG . :..:: .: .. :::.:.: :. .. ::.::. :....: ::. :.::.::. NP_001 KAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFA 440 450 460 470 480 490 240 250 260 270 280 290 pF1KE6 VFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA---- .:::::::..:: :..::: .: ..:: :.: :. :. ..:. .. .:. .:.: NP_001 IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNV 500 510 520 530 540 550 300 310 320 pF1KE6 -----------------LRYDFLIAEK----VSLM----------GFLFLL--GLYISSL : .:: :. .:: :: :. :.. ..: NP_001 NDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATL 560 570 580 590 600 610 330 340 350 360 370 380 pF1KE6 ASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVN .: ...: .::.:.: . .... ::. ...: : :. :. . :: :....:......: NP_001 SSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELN 620 630 640 650 660 670 390 400 410 420 430 440 pF1KE6 VLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSY :.:::.. :. .:. ...: : :. . .: .:... NP_001 VIAPIISNFFLASYALINFSVFHASLAK---SPGWRPAFKYYNMWISLLGAILCCIVMFV 680 690 700 710 720 450 460 470 480 490 500 pF1KE6 GSEGPAQRVLEGTLLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTL NP_001 INWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRP 730 740 750 760 770 780 >>XP_005254663 (OMIM: 600839,601678) PREDICTED: solute c (1099 aa) initn: 820 init1: 340 opt: 425 Z-score: 464.0 bits: 97.0 E(85289): 4.2e-19 Smith-Waterman score: 813; 32.9% identity (65.1% similar) in 416 aa overlap (37-406:175-590) 10 20 30 40 50 60 pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV : :: ::.. ::.::.::.::.: .:.: XP_005 TPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIV 150 160 170 180 190 200 70 80 90 100 110 120 pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY :..:. ::........ :. .: :: ... . . .::.: .:: :: . ::.:::.. XP_005 GEAGIGLGVIIIGLAVTVTGITGLSTSAIATNGCVRGGGAYYLISRSLGPEFGGSIGLIF 210 220 230 240 250 260 130 140 150 160 170 180 pF1KE6 VFGQCVAGAMYITGFAESISDLLGLGNIWAV------RGISVAVLLALLGINLAGVKWII .:.. :: :::..::::.. ::: .. : : :. ... ::::..::..: XP_005 AFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEA 270 280 290 300 310 320 190 200 210 220 230 pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH---GFIGYSPELLQNNTLPDYSPGESFFTVF . :..:: .: .. .: .:. . :. ::..:. .. .: : .. ::.::.:: XP_005 KAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVF 330 340 350 360 370 380 240 250 260 270 280 290 pF1KE6 GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA--- ..:::::::..:: :..:::..: .:: :.. :. :. :. .. .:: .:.: XP_005 AIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGN 390 400 410 420 430 440 300 310 320 pF1KE6 ------------------LRYDF----------------LIAEKVSLMGFLFLLGLYISS : ::: . :: .: :. :.. .. XP_005 MNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSAT 450 460 470 480 490 500 330 340 350 360 370 380 pF1KE6 LASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQV :.: ...: .::...: . .... :: ...: : :. :. . :: :..:::...... XP_005 LSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAEL 510 520 530 540 550 560 390 400 410 420 430 440 pF1KE6 NVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPS :..:::.. :. .:. ...: : : XP_005 NTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVIN 570 580 590 600 610 620 >>NP_000329 (OMIM: 600839,601678) solute carrier family (1099 aa) initn: 911 init1: 334 opt: 419 Z-score: 457.4 bits: 95.8 E(85289): 9.8e-19 Smith-Waterman score: 807; 32.9% identity (64.7% similar) in 416 aa overlap (37-406:175-590) 10 20 30 40 50 60 pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV : :: ::.. ::.::.::.::.: .:.: NP_000 TPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIV 150 160 170 180 190 200 70 80 90 100 110 120 pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY :..:. ::.... . .:. .: :: ... . . .::.: .:: :: . ::.:::.. NP_000 GEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIF 210 220 230 240 250 260 130 140 150 160 170 180 pF1KE6 VFGQCVAGAMYITGFAESISDLLGLGNIWAV------RGISVAVLLALLGINLAGVKWII .:.. :: :::..::::.. ::: .. : : :. ... ::::..::..: NP_000 AFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEA 270 280 290 300 310 320 190 200 210 220 230 pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH---GFIGYSPELLQNNTLPDYSPGESFFTVF . :..:: .: .. .: .:. . :. ::..:. .. .: : .. ::.::.:: NP_000 KAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVF 330 340 350 360 370 380 240 250 260 270 280 290 pF1KE6 GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA--- ..:::::::..:: :..:::..: .:: :.. :. :. :. .. .:: .:.: NP_000 AIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGN 390 400 410 420 430 440 300 310 320 pF1KE6 ------------------LRYDF----------------LIAEKVSLMGFLFLLGLYISS : ::: . :: .: :. :.. .. NP_000 MNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSAT 450 460 470 480 490 500 330 340 350 360 370 380 pF1KE6 LASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQV :.: ...: .::...: . .... :: ...: : :. :. . :: :..:::...... NP_000 LSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAEL 510 520 530 540 550 560 390 400 410 420 430 440 pF1KE6 NVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPS :..:::.. :. .:. ...: : : NP_000 NTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVIN 570 580 590 600 610 620 >>NP_001254743 (OMIM: 616861) solute carrier family 12 m (538 aa) initn: 420 init1: 384 opt: 415 Z-score: 456.8 bits: 94.7 E(85289): 1e-18 Smith-Waterman score: 428; 29.4% identity (59.6% similar) in 344 aa overlap (92-409:18-354) 70 80 90 100 110 120 pF1KE6 TGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGT :... .. : ::. . :.. : . : NP_001 MASESSPLLAYRLLGEEGVALPANGAGGPGGASARKLSTFLGVVVPT 10 20 30 40 130 140 150 160 170 180 pF1KE6 IGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISVAVLLALLG-INLAGVKWII . : .:. : . :: : .: : : . . ..::.:.: . :. NP_001 V--LSMFSIVVFLRIDATG--PSGLRVLPQGYGWNL--LYGSLLLGLVGGVCTLGAGLYA 50 60 70 80 90 100 190 200 210 220 pF1KE6 RLQLLLLFLLAVSTLDFVVGSF------------------THLDPEHG-FIGYSPELLQN : ..: :::. ..: :. :: . : :. : : :.. :.. NP_001 RASFLT-FLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKD 110 120 130 140 150 160 230 240 250 260 270 pF1KE6 NT----LPDYSPGE--SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGIS : ::. : .: .::.:.: . ::.::: ::.:.:..:. .::::...::. . NP_001 NLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYT 170 180 190 200 210 220 280 290 300 310 320 330 pF1KE6 WFLYIVFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRIL .:.:... :: . : : :. :. . . .:: : :.:.: ..:.. :..: :: ::: NP_001 FFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRIL 230 240 250 260 270 280 340 350 360 370 380 390 pF1KE6 QCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTY . .:.. .. .. .. . . .: ::. . ... ...:..:.:: .::. ....: NP_001 HALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAY 290 300 310 320 330 340 400 410 420 430 440 450 pF1KE6 VAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGTL .::: : .:: : NP_001 AAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLA 350 360 370 380 390 400 >>NP_001254741 (OMIM: 616861) solute carrier family 12 m (631 aa) initn: 647 init1: 384 opt: 415 Z-score: 456.0 bits: 94.7 E(85289): 1.2e-18 Smith-Waterman score: 632; 31.4% identity (65.0% similar) in 411 aa overlap (39-409:37-443) 10 20 30 40 50 60 pF1KE6 ELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLVGN ..:. :: . ....:..:.::: :..::. NP_001 PLLAYRLLGEEGVALPANGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 TGVL--LGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY .:.: :.:.::.. ::. .:::: ... ... .::.: ::: .:: ..::.:::.. NP_001 AGLLQALAMLLVAYFILA--LTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMF 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 VFGQCVAGAMYITGFAESISDLLGLGNIWAVRGISV------------AVLLALLG-INL ... . :. . :..::. :..: .. . :. : ..::.:.: . NP_001 YLANVCGCAVSLLGLVESVLDVFG-ADATGPSGLRVLPQGYGWNLLYGSLLLGLVGGVCT 130 140 150 160 170 180 180 190 200 210 pF1KE6 AGVKWIIRLQLLLLFLLAVSTLDFVVGSF------------------THLDPEHG-FIGY :. : ..: :::. ..: :. :: . : :. : : :. NP_001 LGAGLYARASFLT-FLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFTGF 190 200 210 220 230 240 220 230 240 250 260 pF1KE6 SPELLQNNT----LPDYSPGE--SFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGS . :..: ::. : .: .::.:.: . ::.::: ::.:.:..:. .::::. NP_001 NSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGT 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE6 LAAVGISWFLYIVFVFLLGAICTREALRYDFLIAEKVSLMGFLFLLGLYISSLASCMGGL ..::. ..:.:... :: . : : :. :. . . .:: : :.:.: ..:.. :..: NP_001 IVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMSSL 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE6 YGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVT :: :::. .:.. .. .. .. . . .: ::. . ... ...:..:.:: .:: NP_001 IGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVT 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE6 INFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQ . ....:.::: : .:: : NP_001 VFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSL 430 440 450 460 470 480 >>NP_001171761 (OMIM: 600839,601678) solute carrier fami (1099 aa) initn: 812 init1: 332 opt: 417 Z-score: 455.2 bits: 95.4 E(85289): 1.3e-18 Smith-Waterman score: 805; 32.7% identity (64.9% similar) in 416 aa overlap (37-406:175-590) 10 20 30 40 50 60 pF1KE6 VQELFHEAAQQDALAQPQPWWKTQLFMWEPVLFGTWDGVFTSCMINIFGVVLFLRTGWLV : :: ::.. ::.::.::.::.: .:.: NP_001 TPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIV 150 160 170 180 190 200 70 80 90 100 110 120 pF1KE6 GNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSGGVYSMISSVLGGQTGGTIGLLY :..:. ::...... ..:. .: .: .. . . .::.: .:: :: . ::.:::.. NP_001 GEAGIGLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIF 210 220 230 240 250 260 130 140 150 160 170 180 pF1KE6 VFGQCVAGAMYITGFAESISDLLGLGNIWAV------RGISVAVLLALLGINLAGVKWII .:.. :: :::..::::.. ::: .. : : :. ... ::::..::..: NP_001 AFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEA 270 280 290 300 310 320 190 200 210 220 230 pF1KE6 RLQLLLLFLLAVSTLDFVVGSFTHLDPEH---GFIGYSPELLQNNTLPDYSPGESFFTVF . :..:: .: .. .: .:. . :. ::..:. .. .: : .. ::.::.:: NP_001 KAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVF 330 340 350 360 370 380 240 250 260 270 280 290 pF1KE6 GVFFPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREA--- ..:::::::..:: :..:::..: .:: :.. :. :. :. .. .:: .:.: NP_001 AIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGN 390 400 410 420 430 440 300 310 320 pF1KE6 ------------------LRYDF----------------LIAEKVSLMGFLFLLGLYISS : ::: . :: .: :. :.. .. NP_001 MNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSAT 450 460 470 480 490 500 330 340 350 360 370 380 pF1KE6 LASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQV :.: ...: .::...: . .... :: ...: : :. :. . :: :..:::...... NP_001 LSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAEL 510 520 530 540 550 560 390 400 410 420 430 440 pF1KE6 NVLAPIVTINFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPS :..:::.. :. .:. ...: : : NP_001 NTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVIN 570 580 590 600 610 620 714 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:03:13 2016 done: Tue Nov 8 16:03:15 2016 Total Scan time: 10.730 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]