Result of FASTA (omim) for
pFN21AE6751
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6751, 593 aa
1>>>pF1KE6751 593 - 593 aa - 593 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7009+/-0.000357; mu= 22.7200+/- 0.022
mean_var=71.2277+/-14.210, 0's: 0 Z-trim(114.0): 36 B-trim: 169 in 2/50
Lambda= 0.151967
statistics sampled from 23596 (23625) to 23596 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.277), width: 16
Scan time: 7.940
The best scores are: opt bits E(85289)
NP_612404 (OMIM: 609728,611390,616430) methionine- ( 593) 4124 913.7 0
XP_006719461 (OMIM: 156560,615486,616280) PREDICTE ( 666) 205 54.5 1.3e-06
NP_004981 (OMIM: 156560,615486,616280) methionine- ( 900) 205 54.7 1.6e-06
XP_016866735 (OMIM: 192150) PREDICTED: valine--tRN ( 682) 153 43.1 0.0035
XP_016866736 (OMIM: 192150) PREDICTED: valine--tRN ( 682) 153 43.1 0.0035
NP_006286 (OMIM: 192150) valine--tRNA ligase [Homo (1264) 153 43.4 0.0055
XP_005249419 (OMIM: 192150) PREDICTED: valine--tRN (1265) 153 43.4 0.0055
>>NP_612404 (OMIM: 609728,611390,616430) methionine--tRN (593 aa)
initn: 4124 init1: 4124 opt: 4124 Z-score: 4884.0 bits: 913.7 E(85289): 0
Smith-Waterman score: 4124; 100.0% identity (100.0% similar) in 593 aa overlap (1-593:1-593)
10 20 30 40 50 60
pF1KE6 MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 GHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 FQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 KVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 KVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 VVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 VVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 WPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 WPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 CLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 CLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSET
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 YPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 YPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 RQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLG
490 500 510 520 530 540
550 560 570 580 590
pF1KE6 VSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_612 VSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT
550 560 570 580 590
>>XP_006719461 (OMIM: 156560,615486,616280) PREDICTED: m (666 aa)
initn: 488 init1: 137 opt: 205 Z-score: 239.8 bits: 54.5 E(85289): 1.3e-06
Smith-Waterman score: 493; 24.8% identity (51.7% similar) in 572 aa overlap (48-584:35-575)
20 30 40 50 60 70
pF1KE6 LSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALL-ADALCRHR
:. . ::: .::.:.. . .: ::.. :.
XP_006 AWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYS
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE6 RLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFI
::: .: . ::::.: . : ::.: :.::. .... .:: :
XP_006 RLRQWNTL---YLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFG
70 80 90 100 110 120
140 150 160 170 180
pF1KE6 RTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFL---------PEAKVTQQPG
::: .. .: .. : .::.. . . : : :: : . :
XP_006 RTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARG
130 140 150 160 170 180
190 200 210 220 230
pF1KE6 PSGDSF-----PVSLESGH-------PVSWTKEENYIFRLSQFRKPLQRWL-RGNPQA-I
. :. : :.. . :: .... .. : ...: :..:: : : .
XP_006 DQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFL-DLPKLEKRLEEWLGRTLPGSDW
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE6 TPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVP--GDDSQTIYVWLDALVNYLTVIG
::. . .. .:: . : ..: :.:: ::: : .....:::.:: ..::.. .
XP_006 TPNA-QFITRSWLRDGLKPRCITR---DLKWGTPVPLEGFEDKVFYVWFDATIGYLSITA
250 260 270 280 290
300 310 320 330 340
pF1KE6 YPNAEFKSWWPATSHI-----IGKDILKFHAIYWPAFLLGA--GMSPPQRICVHSHWTVC
. ... :: .. ..:: . ::.. .: ::: ... ... . . .
XP_006 NYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYE
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE6 GQKMSKSLG-NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADAL
:.::: : .: . . .: .:..:: . : . .. :::: . :
XP_006 DGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNL
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE6 GGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADH
:...:: : . : : : : . .: :.. :. .. .
XP_006 GNFINRAGM-----------FVSKFF---GGYV-PEMVLTPDDQRLLAHVTLELQHYHQL
420 430 440 450 460
470 480 490 500 510 520
pF1KE6 YDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTL
.. :: ::... . :. : ..: . ::: : .: ::: .:.. .....
XP_006 LEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVM
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE6 LQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFE-GRRLGPETGLLFPRLDQ
::: :... . ..: . :. :: : . :...: . : : .:..
XP_006 LQPYMPTVSATIQAQLQLPPPACSILLTNFL-------CTLPAGHQIGTVSPL-FQKLEN
530 540 550 560 570
590
pF1KE6 SRTWLVKAHRT
..
XP_006 DQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKN
580 590 600 610 620 630
>>NP_004981 (OMIM: 156560,615486,616280) methionine--tRN (900 aa)
initn: 488 init1: 137 opt: 205 Z-score: 238.1 bits: 54.7 E(85289): 1.6e-06
Smith-Waterman score: 493; 24.8% identity (51.7% similar) in 572 aa overlap (48-584:269-809)
20 30 40 50 60 70
pF1KE6 LSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALL-ADALCRHR
:. . ::: .::.:.. . .: ::.. :.
NP_004 AWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYS
240 250 260 270 280 290
80 90 100 110 120 130
pF1KE6 RLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFI
::: .: . ::::.: . : ::.: :.::. .... .:: :
NP_004 RLRQWNTL---YLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFG
300 310 320 330 340 350
140 150 160 170 180
pF1KE6 RTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFL---------PEAKVTQQPG
::: .. .: .. : .::.. . . : : :: : . :
NP_004 RTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARG
360 370 380 390 400 410
190 200 210 220 230
pF1KE6 PSGDSF-----PVSLESGH-------PVSWTKEENYIFRLSQFRKPLQRWL-RGNPQA-I
. :. : :.. . :: .... .. : ...: :..:: : : .
NP_004 DQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFL-DLPKLEKRLEEWLGRTLPGSDW
420 430 440 450 460 470
240 250 260 270 280 290
pF1KE6 TPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVP--GDDSQTIYVWLDALVNYLTVIG
::. . .. .:: . : ..: :.:: ::: : .....:::.:: ..::.. .
NP_004 TPNA-QFITRSWLRDGLKPRCITR---DLKWGTPVPLEGFEDKVFYVWFDATIGYLSITA
480 490 500 510 520 530
300 310 320 330 340
pF1KE6 YPNAEFKSWWPATSHI-----IGKDILKFHAIYWPAFLLGA--GMSPPQRICVHSHWTVC
. ... :: .. ..:: . ::.. .: ::: ... ... . . .
NP_004 NYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYE
540 550 560 570 580 590
350 360 370 380 390 400
pF1KE6 GQKMSKSLG-NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADAL
:.::: : .: . . .: .:..:: . : . .. :::: . :
NP_004 DGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNL
600 610 620 630 640 650
410 420 430 440 450 460
pF1KE6 GGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADH
:...:: : . : : : : . .: :.. :. .. .
NP_004 GNFINRAGM-----------FVSKFF---GGYV-PEMVLTPDDQRLLAHVTLELQHYHQL
660 670 680 690
470 480 490 500 510 520
pF1KE6 YDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTL
.. :: ::... . :. : ..: . ::: : .: ::: .:.. .....
NP_004 LEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVM
700 710 720 730 740 750
530 540 550 560 570 580
pF1KE6 LQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFE-GRRLGPETGLLFPRLDQ
::: :... . ..: . :. :: : . :...: . : : .:..
NP_004 LQPYMPTVSATIQAQLQLPPPACSILLTNFL-------CTLPAGHQIGTVSPL-FQKLEN
760 770 780 790 800
590
pF1KE6 SRTWLVKAHRT
..
NP_004 DQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKN
810 820 830 840 850 860
>>XP_016866735 (OMIM: 192150) PREDICTED: valine--tRNA li (682 aa)
initn: 137 init1: 92 opt: 153 Z-score: 178.0 bits: 43.1 E(85289): 0.0035
Smith-Waterman score: 153; 31.2% identity (60.7% similar) in 112 aa overlap (272-375:201-308)
250 260 270 280 290
pF1KE6 VLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNA--EFKS
: ... .:... . :...:.:: ...
XP_016 YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSV
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE6 WWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRI---CVHSHWTV---CGQKMSKSLG
..:.: :.::: : : : .. :.. :. :. : : :.:::::::
XP_016 FYPGTLLETGHDILFF----WVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLG
240 250 260 270 280
360 370 380 390 400 410
pF1KE6 NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAK
::.:: . ...:.. ::
XP_016 NVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCA
290 300 310 320 330 340
>>XP_016866736 (OMIM: 192150) PREDICTED: valine--tRNA li (682 aa)
initn: 137 init1: 92 opt: 153 Z-score: 178.0 bits: 43.1 E(85289): 0.0035
Smith-Waterman score: 153; 31.2% identity (60.7% similar) in 112 aa overlap (272-375:201-308)
250 260 270 280 290
pF1KE6 VLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNA--EFKS
: ... .:... . :...:.:: ...
XP_016 YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSV
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE6 WWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRI---CVHSHWTV---CGQKMSKSLG
..:.: :.::: : : : .. :.. :. :. : : :.:::::::
XP_016 FYPGTLLETGHDILFF----WVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLG
240 250 260 270 280
360 370 380 390 400 410
pF1KE6 NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAK
::.:: . ...:.. ::
XP_016 NVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCA
290 300 310 320 330 340
>>NP_006286 (OMIM: 192150) valine--tRNA ligase [Homo sap (1264 aa)
initn: 168 init1: 92 opt: 153 Z-score: 174.6 bits: 43.4 E(85289): 0.0055
Smith-Waterman score: 153; 31.2% identity (60.7% similar) in 112 aa overlap (272-375:783-890)
250 260 270 280 290
pF1KE6 VLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNA--EFKS
: ... .:... . :...:.:: ...
NP_006 YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSV
760 770 780 790 800 810
300 310 320 330 340 350
pF1KE6 WWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRI---CVHSHWTV---CGQKMSKSLG
..:.: :.::: : : : .. :.. :. :. : : :.:::::::
NP_006 FYPGTLLETGHDILFF----WVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLG
820 830 840 850 860
360 370 380 390 400 410
pF1KE6 NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAK
::.:: . ...:.. ::
NP_006 NVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCA
870 880 890 900 910 920
>>XP_005249419 (OMIM: 192150) PREDICTED: valine--tRNA li (1265 aa)
initn: 168 init1: 92 opt: 153 Z-score: 174.6 bits: 43.4 E(85289): 0.0055
Smith-Waterman score: 153; 31.2% identity (60.7% similar) in 112 aa overlap (272-375:784-891)
250 260 270 280 290
pF1KE6 VLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNA--EFKS
: ... .:... . :...:.:: ...
XP_005 YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSV
760 770 780 790 800 810
300 310 320 330 340 350
pF1KE6 WWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRI---CVHSHWTV---CGQKMSKSLG
..:.: :.::: : : : .. :.. :. :. : : :.:::::::
XP_005 FYPGTLLETGHDILFF----WVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLG
820 830 840 850 860
360 370 380 390 400 410
pF1KE6 NVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAK
::.:: . ...:.. ::
XP_005 NVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCA
870 880 890 900 910 920
593 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:01:19 2016 done: Tue Nov 8 16:01:20 2016
Total Scan time: 7.940 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]