Result of FASTA (omim) for
pFN21AE6743
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6743, 628 aa
1>>>pF1KE6743 628 - 628 aa - 628 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.8364+/-0.000664; mu= -4.8437+/- 0.041
mean_var=521.0895+/-105.333, 0's: 0 Z-trim(117.8): 230 B-trim: 0 in 0/55
Lambda= 0.056185
statistics sampled from 29834 (30074) to 29834 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.353), width: 16
Scan time: 9.860
The best scores are: opt bits E(85289)
NP_476429 (OMIM: 122100,148043) keratin, type II c ( 628) 4128 350.3 1.2e-95
NP_056932 (OMIM: 616671) keratin, type II cytoskel ( 638) 2559 223.1 2.4e-57
NP_000415 (OMIM: 131760,131800,131900,131960,14804 ( 590) 2280 200.4 1.5e-50
NP_000414 (OMIM: 146800,600194) keratin, type II c ( 639) 2257 198.6 5.6e-50
NP_006112 (OMIM: 113800,139350,144200,146590,60096 ( 644) 2257 198.6 5.6e-50
NP_005545 (OMIM: 148041,615726) keratin, type II c ( 564) 2169 191.4 7.2e-48
NP_005546 (OMIM: 148042,615728) keratin, type II c ( 564) 2167 191.3 8.1e-48
NP_775109 (OMIM: 612315,615735) keratin, type II c ( 564) 2157 190.4 1.4e-47
NP_002263 (OMIM: 123940,193900) keratin, type II c ( 520) 2034 180.4 1.4e-44
NP_778253 (OMIM: 611158) keratin, type II cytoskel ( 578) 1975 175.7 4e-43
NP_004684 (OMIM: 609025,612318) keratin, type II c ( 551) 1931 172.1 4.6e-42
NP_787028 (OMIM: 611160) keratin, type II cytoskel ( 535) 1886 168.4 5.6e-41
NP_778238 (OMIM: 608247) keratin, type II cytoskel ( 540) 1820 163.1 2.3e-39
NP_258259 (OMIM: 608245,615896) keratin, type II c ( 523) 1818 162.9 2.5e-39
NP_778223 (OMIM: 194300,608248,613981,614929) kera ( 529) 1745 157.0 1.5e-37
NP_542785 (OMIM: 608246) keratin, type II cytoskel ( 511) 1723 155.2 5.2e-37
NP_001139697 (OMIM: 608246) keratin, type II cytos ( 511) 1723 155.2 5.2e-37
XP_016874238 (OMIM: 608245,615896) PREDICTED: kera ( 441) 1700 153.3 1.7e-36
XP_016874323 (OMIM: 608246) PREDICTED: keratin, ty ( 442) 1658 149.9 1.8e-35
XP_016874325 (OMIM: 608246) PREDICTED: keratin, ty ( 419) 1652 149.3 2.5e-35
NP_002264 (OMIM: 148060) keratin, type II cytoskel ( 483) 1653 149.5 2.6e-35
NP_001243222 (OMIM: 148060) keratin, type II cytos ( 483) 1653 149.5 2.6e-35
NP_001243211 (OMIM: 148060) keratin, type II cytos ( 511) 1653 149.5 2.7e-35
NP_005547 (OMIM: 148059) keratin, type II cytoskel ( 469) 1615 146.4 2.1e-34
NP_775487 (OMIM: 611159) keratin, type II cytoskel ( 520) 1534 139.9 2.1e-32
NP_149034 (OMIM: 602766) keratin, type II cuticula ( 600) 1533 139.9 2.5e-32
XP_011536637 (OMIM: 602766) PREDICTED: keratin, ty ( 600) 1533 139.9 2.5e-32
XP_011536627 (OMIM: 148059) PREDICTED: keratin, ty ( 445) 1512 138.0 6.7e-32
XP_016874324 (OMIM: 608246) PREDICTED: keratin, ty ( 439) 1433 131.6 5.6e-30
XP_016874322 (OMIM: 608246) PREDICTED: keratin, ty ( 445) 1433 131.6 5.7e-30
NP_002274 (OMIM: 602032,602767) keratin, type II c ( 507) 1389 128.1 7.3e-29
NP_002272 (OMIM: 158000,602153) keratin, type II c ( 505) 1370 126.6 2.1e-28
NP_001307127 (OMIM: 158000,601928) keratin, type I ( 486) 1351 125.0 6e-28
XP_016874785 (OMIM: 158000,601928) PREDICTED: kera ( 486) 1351 125.0 6e-28
XP_005268923 (OMIM: 158000,601928) PREDICTED: kera ( 563) 1351 125.1 6.6e-28
NP_149022 (OMIM: 601078) keratin, type II cuticula ( 513) 1342 124.3 1e-27
NP_002273 (OMIM: 158000,602765) keratin, type II c ( 493) 1341 124.2 1.1e-27
XP_011536590 (OMIM: 611158) PREDICTED: keratin, ty ( 345) 1304 121.0 6.9e-27
NP_001287743 (OMIM: 611159) keratin, type II cytos ( 410) 1244 116.3 2.2e-25
NP_001139698 (OMIM: 608246) keratin, type II cytos ( 469) 1146 108.4 5.9e-23
NP_872313 (OMIM: 611161) keratin, type II cytoskel ( 452) 1053 100.8 1.1e-20
NP_001074961 (OMIM: 611161) keratin, type II cytos ( 422) 1051 100.6 1.2e-20
XP_016874783 (OMIM: 148059) PREDICTED: keratin, ty ( 292) 1032 98.9 2.7e-20
NP_000412 (OMIM: 113800,148080,607602,609165) kera ( 584) 1033 99.4 3.9e-20
XP_005257400 (OMIM: 113800,148080,607602,609165) P ( 624) 1033 99.4 4e-20
XP_016874326 (OMIM: 608246) PREDICTED: keratin, ty ( 271) 1018 97.7 5.6e-20
XP_011536559 (OMIM: 608247) PREDICTED: keratin, ty ( 508) 999 96.5 2.4e-19
XP_011536591 (OMIM: 611158) PREDICTED: keratin, ty ( 322) 959 93.0 1.7e-18
XP_011536312 (OMIM: 611159) PREDICTED: keratin, ty ( 488) 871 86.1 3.1e-16
NP_001287739 (OMIM: 602032,602767) keratin, type I ( 295) 858 84.8 4.8e-16
>>NP_476429 (OMIM: 122100,148043) keratin, type II cytos (628 aa)
initn: 4128 init1: 4128 opt: 4128 Z-score: 1838.0 bits: 350.3 E(85289): 1.2e-95
Smith-Waterman score: 4128; 100.0% identity (100.0% similar) in 628 aa overlap (1-628:1-628)
10 20 30 40 50 60
pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRSGAGGFGSRSLYNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRSGAGGFGSRSLYNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 GGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGFG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 GAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSLL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 QPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 QPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 ISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 ENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 ENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 NNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 NNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 LNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 LNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLAR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 LLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 LLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 GYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGARYGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_476 GYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGARYGVS
550 560 570 580 590 600
610 620
pF1KE6 GGGFSSASNRGGSIKFSQSSQSSQRYSR
::::::::::::::::::::::::::::
NP_476 GGGFSSASNRGGSIKFSQSSQSSQRYSR
610 620
>>NP_056932 (OMIM: 616671) keratin, type II cytoskeletal (638 aa)
initn: 2604 init1: 1692 opt: 2559 Z-score: 1150.6 bits: 223.1 E(85289): 2.4e-57
Smith-Waterman score: 3018; 74.3% identity (86.7% similar) in 654 aa overlap (1-627:1-636)
10 20 30 40 50
pF1KE6 MSRQASKTS-GGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRSGAGGFGSRSLYN
:.::. : : .: :::::::::::::::::::::.:::::::: :::::::.::::::::
NP_056 MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGACGFRSGAGSFGSRSLYN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 LGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGF
::.:::::::::::.:::::::::::::.::::::::: ::..:::::::::.:.::
NP_056 LGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGF----GGSYGGGFGGGRGVGSGF
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 GGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSL
:::::::::::::: : :::::.::: :::::::::::::::: .::::
NP_056 GGAGGFGGAGGFGGPGVFGGPGSFGG------------PGGFGPGGFPGGIQEVIVNQSL
120 130 140 150 160
180 190 200 210 220 230
pF1KE6 LQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTS
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::: :.
NP_056 LQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTG
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 SISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTA
:: ..::: ::..:..: . ::..::::: :..:::.:.:::::::::::::::::::
NP_056 --SGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTA
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE6 AENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSM
:::::: ::::::.:.:::::::::::.: ::..::::::. :::::::: :::::::::
NP_056 AENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSM
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE6 DNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEII
:::: ::: :::::::::::.::::::.:::::::::::::::::::::::::::::::.
NP_056 DNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIM
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE6 ELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLA
::::::::::::::.:::::::::::::::::.:::::::::::::.::.:::.::::::
NP_056 ELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLA
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE6 RLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYG
::::::::::::::::::::::::::::::: :::::: ::: :::::. :......: .
NP_056 RLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSS
470 480 490 500 510 520
540 550 560 570 580
pF1KE6 GGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGG-------------
: ::..:. .::...:..:.:. : : .:: :.:.:: ::: .::
NP_056 RGVFGGVSGSGSGGYKGGSSSSSSSGYGVSGGSGSGYGGVSSGSTGGRGSSGSYQSSSSG
530 540 550 560 570 580
590 600 610 620
pF1KE6 -------------SGFGSISGARYGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR
::.:: ::. .:.:..:... . ::.:::...:::. :
NP_056 SRLGGAGSISVSHSGMGSSSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK
590 600 610 620 630
>>NP_000415 (OMIM: 131760,131800,131900,131960,148040,17 (590 aa)
initn: 1535 init1: 1535 opt: 2280 Z-score: 1028.8 bits: 200.4 E(85289): 1.5e-50
Smith-Waterman score: 2423; 64.6% identity (82.1% similar) in 636 aa overlap (1-625:1-586)
10 20 30 40 50
pF1KE6 MSRQASKT-SGGGSQGFSGRSAVVSGSSRMS--CVAHSGGAGGGAYGFRS-----GAGGF
::::.: . .:::..:: ::.. . :: : :..:::.:::..: : :.::.
NP_000 MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSGGGGGGGFGRVSLAGACGVGGY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 GSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGG
::::::::::.: ::::...:. : .: ::.: :::. :::::
NP_000 GSRSLYNLGGSKRISISTSGGSFR------NR------------FGAGAGGGY--GFGGG
70 80 90 100
120 130 140 150 160 170
pF1KE6 RGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQE
: : :::: :..:::: .:: .::: ::::::: : ::::::
NP_000 AGSGFGFGG----GAGGGFG----LGGGAGFG--GGFGGPGFPVCP--------PGGIQE
110 120 130 140
180 190 200 210 220 230
pF1KE6 VTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNL
::.::::: :::..:::.: .:...:::::::::::::::::::::::::::::.:::.:
NP_000 VTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTL
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE6 LQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYED
::.:::... .:::::::..:: :: ::.:.::::::::::.::.:::::::.::::
NP_000 LQEQGTKTV--RQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYED
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE6 EINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISD
::::::.:::::: ::::::.::::::::.::::::.:::.:.. ..::::::::.:.::
NP_000 EINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSD
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE6 TSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLR
:::::::::::.::::::::::.::::.::.::..:::. :::: ::: ::::::::::
NP_000 TSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLR
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE6 NTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQ
::: :: :.:::::::::::..:::: ::::.:::.:::.::.::::: :: ::. :::
NP_000 NTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQ
390 400 410 420 430 440
480 490 500 510 520 530
pF1KE6 QAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTS
.::.:.:::::.::::::.::::::::::::::::::: :.::: . :.::::.::..:
NP_000 KAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSS
450 460 470 480 490 500
540 550 560 570 580
pF1KE6 A--SAGGYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGG-GIGGGFGGGSSGFSGGSGF
. :..::::: :::.:::::::. :::.::: .. ..:: :.:::.. :.::::..::
NP_000 GYGSGSGYGGGLGGGLGGGLGGGL-AGGSSGSYYSSSSGGVGLGGGLSVGGSGFSASSGR
510 520 530 540 550
590 600 610 620
pF1KE6 GSISGARYGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR
: :. .: :::: :: :.:: ....::..
NP_000 G--LGVGFG-SGGGSSS------SVKFVSTTSSSRKSFKS
560 570 580 590
>>NP_000414 (OMIM: 146800,600194) keratin, type II cytos (639 aa)
initn: 2070 init1: 1442 opt: 2257 Z-score: 1018.3 bits: 198.6 E(85289): 5.6e-50
Smith-Waterman score: 2379; 64.8% identity (80.3% similar) in 631 aa overlap (10-613:16-606)
10 20 30 40
pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR-----MSCVAHSGGAGGGAYGFRSGA
::: .:::. ::::::.:: .::... ::.::: : :.
NP_000 MSCQISCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGG---F--GG
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 GGFGSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGG-
:::::::: .:::.::::::::.:: ::::. :::.:: :::::::
NP_000 GGFGSRSLVGLGGTKSISISVAGGG---GGFGA-------AGGFGG-----RGGGFGGGS
60 70 80 90 100
110 120 130 140 150 160
pF1KE6 -FGGGRGM-GGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGF
:::: :. :::::: ::::: : ::: :::::: :: :: ::::::::.
NP_000 SFGGGSGFSGGGFGG-GGFGG-GRFGG---FGGPGGVGGLGG---------PGGFGPGGY
110 120 130 140
170 180 190 200 210 220
pF1KE6 PGGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVL
::::.::..::::::::::..::.: .::::::::::::::::::::::::::::::.::
NP_000 PGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVL
150 160 170 180 190 200
230 240 250 260 270 280
pF1KE6 ETKWNLLQQQ--GTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVE
.:::.::::. :: : ::::.:...:. :. :::.. .:: .:::.::.::::
NP_000 QTKWELLQQMNVGTRPI----NLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVE
210 220 230 240 250 260
290 300 310 320 330 340
pF1KE6 DFKKKYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELS
:.::::::::::::::::.:::::::::.::: :::::.::: : .::.::..:::::.:
NP_000 DYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEIS
270 280 290 300 310 320
350 360 370 380 390 400
pF1KE6 QMQSHISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTA
:... ..::.:.:::::.:.::::::::::.::::.:::::: ::::::..: :::.:.
NP_000 QIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTV
330 340 350 360 370 380
410 420 430 440 450 460
pF1KE6 GRHGDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKL
:::::.:.. : :: ::::.::::..:: :::: :.: :::.:::.:: ::::: ::
NP_000 GRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKL
390 400 410 420 430 440
470 480 490 500 510 520
pF1KE6 QELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSIS
..:. ::::::.:::::::::::::::::::::::::::::::::: ::::. : :..:
NP_000 NDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVS
450 460 470 480 490 500
530 540 550 560 570
pF1KE6 VVSSSTTS--ASAGGYGGGYGGGMGGGLGGGFSAG------GG--SGSGFGRGGGGGI-G
:.::. .: :: ...::. :: :.. :::.:.: :: ::: : ::::.: :
NP_000 VTSSTISSNVASKAAFGGS--GGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISG
510 520 530 540 550 560
580 590 600 610 620
pF1KE6 GGFG-----GGSSGFSGGSGFGSISGARYGVSGGGFSSAS-NRGGSIKFSQSSQSSQRYS
::.: :: : .::: :::::. :: .:: ::.. .::::
NP_000 GGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSS
570 580 590 600 610 620
pF1KE6 R
NP_000 SVKGSSGEAFGSSVTFSFR
630
>>NP_006112 (OMIM: 113800,139350,144200,146590,600962,60 (644 aa)
initn: 1563 init1: 1563 opt: 2257 Z-score: 1018.3 bits: 198.6 E(85289): 5.6e-50
Smith-Waterman score: 2366; 64.8% identity (81.5% similar) in 628 aa overlap (1-613:1-591)
10 20 30 40
pF1KE6 MSRQASKTSG---GGSQGFS-GRSAVVSGSSRM--SCVAHSGGAGG-----GAYGFRSGA
:::: :. :: :: ::: : ..... . : : . .:::.:: :. : ::
NP_006 MSRQFSSRSGYRSGG--GFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGA
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 GG-FGSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGG
:: :::::: ::::.:::::::: ::.:..::::: :::: :.::: :
NP_006 GGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGG---------YGGG---GFGGG---G
60 70 80 90 100
110 120 130 140 150 160
pF1KE6 FGGGRGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPG
:::: :.::: :.::::: :. :.::::: ::::: ::.:: :.:: ::
NP_006 FGGG-GFGGGGIGGGGFGGFGS--GGGGFGG-GGFGG-GGYGG--------GYGPVCPPG
110 120 130 140 150
170 180 190 200 210 220
pF1KE6 GIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLET
:::::::::::::::::::::.: .::..::::::.:::.:::::::::::::::.::.:
NP_006 GIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQT
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE6 KWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKK
::.:::: :: . :.:::: ::. :: :: .:.. ....:::::::::.:.:::...
NP_006 KWELLQQVDTS--TRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRN
220 230 240 250 260
290 300 310 320 330 340
pF1KE6 KYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQS
:::::::::: :::::::.:::::.:::.::.::::.: : .::::: .::.:::::::.
NP_006 KYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQT
270 280 290 300 310 320
350 360 370 380 390 400
pF1KE6 HISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHG
.::.:.:.::::::::::::::::::.::::::::.::::::.:::.: ::: ::::::
NP_006 QISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHG
330 340 350 360 370 380
410 420 430 440 450 460
pF1KE6 DDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQ
:..::.: :: ::::.:::::.::..:::: .::: .:..:::.:: :::::. ::..:.
NP_006 DSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLE
390 400 410 420 430 440
470 480 490 500 510 520
pF1KE6 AALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSS
::::::.::::::::::::::.:::::.:::::: :::::: :::::: ::.:: :.
NP_006 DALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGECAPNVSVSV-ST
450 460 470 480 490 500
530 540 550 560 570 580
pF1KE6 STTSASAGGYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIG-GGFG-GGSSGFSGG
: :. :.:: :: :::.:.: :.....:::: .: ::::: : :..: :::: :::
NP_006 SHTTISGGGSRGGGGGGYGSG-GSSYGSGGGS---YGSGGGGGGGRGSYGSGGSSYGSGG
510 520 530 540 550 560
590 600 610 620
pF1KE6 SGFGSISGAR-YGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR
...:: .:. .: :.: ::.. ::::
NP_006 GSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGV
570 580 590 600 610 620
>>NP_005545 (OMIM: 148041,615726) keratin, type II cytos (564 aa)
initn: 2038 init1: 1559 opt: 2169 Z-score: 980.4 bits: 191.4 E(85289): 7.2e-48
Smith-Waterman score: 2249; 64.0% identity (80.5% similar) in 606 aa overlap (7-610:9-560)
10 20 30 40 50
pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR--MSCVAHSGGAGGGAYGFRSGAGGFGSRS
.. ... .:::. :: . : :: .: :. : . :.:. : :..::::::
NP_005 MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 LYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMG
::.:::.: ::: ::: :::..:::: : ::..: :::. :
NP_005 LYGLGGSKRISI------------GGG--SCAISGGYG----SRAGGSYG--FGGA---G
70 80 90
120 130 140 150 160 170
pF1KE6 GGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTIN
.:: ::::..:.: :: :: : .::::::: : ::::::::.:
NP_005 SGF----GFGGGAGIG----FGLGGGAGLAGGFGGPGFPVCP--------PGGIQEVTVN
100 110 120 130 140
180 190 200 210 220 230
pF1KE6 QSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQ
:::: :::..::: : .:.:.:::::::::::::::::::::::::::::::::.:::.:
NP_005 QSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQ
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE6 GTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINK
::... .:::::::..:: :: ::.:.::::::::::..:.:::::::.::::::::
NP_005 GTKTV--RQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINK
210 220 230 240 250
300 310 320 330 340 350
pF1KE6 RTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVV
::::::::::::::::.:::::::::::.:.: :::.:::.::::::::::.::::::::
NP_005 RTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVV
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE6 LSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKS
:::::::.::::::::::.::::.:::::.::::. :::: :::.:::::::::::::.
NP_005 LSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQ
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE6 EIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKD
:: :.::::::::.::. :::: ::::.:::.:::.::::::::. ::. :. :::.::.
NP_005 EIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQ
380 390 400 410 420 430
480 490 500 510 520 530
pF1KE6 DLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAG
::::::..:::::::::::::::::::::::::: :..:: . :.::::.:...:
NP_005 DLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSS----
440 450 460 470 480 490
540 550 560 570 580 590
pF1KE6 GYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGAR
::::. : : : ::::: :... :.: :.::::.. ::: . :.:..:..:.
NP_005 GYGGASGVGSGLGLGGG--------SSYSYGSGLGVGGGFSS-SSGRAIGGGLSSVGGGS
500 510 520 530 540
600 610 620
pF1KE6 YGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR
.. ::.: .
NP_005 STIKYTTTSSSSRKSYKH
550 560
>>NP_005546 (OMIM: 148042,615728) keratin, type II cytos (564 aa)
initn: 2033 init1: 1558 opt: 2167 Z-score: 979.5 bits: 191.3 E(85289): 8.1e-48
Smith-Waterman score: 2251; 63.9% identity (80.4% similar) in 606 aa overlap (7-610:9-560)
10 20 30 40 50
pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR--MSCVAHSGGAGGGAYGFRSGAGGFGSRS
.. ... .:::. :: . : :: .: .. : . :.:. : :..::::::
NP_005 MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 LYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMG
::.:::.: ::: ::: :::..:::: : ::..: :::. :
NP_005 LYGLGGSKRISI------------GGG--SCAISGGYG----SRAGGSYG--FGGA---G
70 80 90
120 130 140 150 160 170
pF1KE6 GGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTIN
.:: ::::..:.: :: :: : .::::::: : ::::::::.:
NP_005 SGF----GFGGGAGIG----FGLGGGAGLAGGFGGPGFPVCP--------PGGIQEVTVN
100 110 120 130 140
180 190 200 210 220 230
pF1KE6 QSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQ
:::: :::..::: : .:.:.:::::::::::::::::::::::::::::.:::.:::.:
NP_005 QSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQ
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE6 GTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINK
::... .:::::::..:: :: ::::.::::::::::.::.:::::.:.::::::::
NP_005 GTKTV--RQNLEPLFEQYINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINK
210 220 230 240 250
300 310 320 330 340 350
pF1KE6 RTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVV
::::::::::::::::.:::::::::::.:.: :::.:::.::::::::::.::::::::
NP_005 RTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVV
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE6 LSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKS
:::::::.::::::::::.::::.:::::.::::. :::: ::: :::::::::::::.
NP_005 LSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQ
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE6 EIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKD
:: :.::::::::.::. :::: ::::.:::.:::.::::::::. ::. :. :::.::.
NP_005 EIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQ
380 390 400 410 420 430
480 490 500 510 520 530
pF1KE6 DLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAG
::::::..:::::::::::::::::::::::::: :..:: . :.::::.:...:
NP_005 DLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSS----
440 450 460 470 480 490
540 550 560 570 580 590
pF1KE6 GYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGAR
::::. : : : ::::: :... :.: :.::::.. ::: . :.:..:..:.
NP_005 GYGGASGVGSGLGLGGG--------SSYSYGSGLGVGGGFSS-SSGRATGGGLSSVGGGS
500 510 520 530 540
600 610 620
pF1KE6 YGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR
.. ::.: .
NP_005 STIKYTTTSSSSRKSYKH
550 560
>>NP_775109 (OMIM: 612315,615735) keratin, type II cytos (564 aa)
initn: 2025 init1: 1550 opt: 2157 Z-score: 975.1 bits: 190.4 E(85289): 1.4e-47
Smith-Waterman score: 2237; 63.5% identity (80.4% similar) in 606 aa overlap (7-610:9-560)
10 20 30 40 50
pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR--MSCVAHSGGAGGGAYGFRSGAGGFGSRS
.. ... .:::. :: . : :: .: .. : . :.:. : :..::::::
NP_775 MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 LYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMG
::.:::.: ::: ::: :::..:::: : ::..: :::. :
NP_775 LYGLGGSKRISI------------GGG--SCAISGGYG----SRAGGSYG--FGGA---G
70 80 90
120 130 140 150 160 170
pF1KE6 GGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTIN
.:: ::::..:.: :: :: : .::::::: : ::::::::.:
NP_775 SGF----GFGGGAGIG----FGLGGGAGLAGGFGGPGFPVCP--------PGGIQEVTVN
100 110 120 130 140
180 190 200 210 220 230
pF1KE6 QSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQ
:::: :::..::: : .:.:.:::::::::::::::::::::::::::::.:::.:::.:
NP_775 QSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQ
150 160 170 180 190 200
240 250 260 270 280 290
pF1KE6 GTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINK
::... .:::::::..:: :: ::.:.::::::::::.::.:::::.:.::::::::
NP_775 GTKTV--RQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINK
210 220 230 240 250
300 310 320 330 340 350
pF1KE6 RTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVV
::::::::::::::::.:::::::::::.:.: :::.:::.::::::::::.::::::::
NP_775 RTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVV
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE6 LSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKS
:::::::.::::::::::.::::.:::::.::::. :::: :::.:::::::::::::.
NP_775 LSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQ
320 330 340 350 360 370
420 430 440 450 460 470
pF1KE6 EIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKD
:: :.::::::::.::. :::: :.::.:::.:::.::::::::. ::. :. :::.::.
NP_775 EIAEINRMIQRLRSEIDHVKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQ
380 390 400 410 420 430
480 490 500 510 520 530
pF1KE6 DLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAG
::::::..:::::::::::::::::::::::::: :..:: . :..:::.:. .:
NP_775 DLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNVSVVQSTISS----
440 450 460 470 480 490
540 550 560 570 580 590
pF1KE6 GYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGAR
::::. : : : ::::: :... :.: ::::::.. ::: . :.:..:..:.
NP_775 GYGGASGVGSGLGLGGG--------SSYSYGSGLGIGGGFSS-SSGRAIGGGLSSVGGGS
500 510 520 530 540
600 610 620
pF1KE6 YGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR
.. ::.: .
NP_775 STIKYTTTSSSSRKSYKH
550 560
>>NP_002263 (OMIM: 123940,193900) keratin, type II cytos (520 aa)
initn: 1806 init1: 1400 opt: 2034 Z-score: 921.6 bits: 180.4 E(85289): 1.4e-44
Smith-Waterman score: 2111; 65.5% identity (80.5% similar) in 560 aa overlap (11-568:10-500)
10 20 30 40 50
pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR--MSCVAHSGGAGGGAYGFRSGAGGFGSRSLY
:: .::: ::.:.:..: .: :. ::::: : ..:::::::::
NP_002 MIARQQCVRGGPRGFSCGSAIVGGGKRGAFSSVSMSGGAG------RCSSGGFGSRSLY
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 NLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGG
:: ::::::.::: ::: : .:
NP_002 NLRGNKSISMSVA--GSRQG-------AC-------------------------------
60 70
120 130 140 150 160 170
pF1KE6 FGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQS
:::::::: .:::: :::: :.:.:. :::: :.: ::::::::::
NP_002 FGGAGGFG-TGGFG--GGFG--GSFSGK---GGPGFPVCPAG--------GIQEVTINQS
80 90 100 110
180 190 200 210 220 230
pF1KE6 LLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGT
:: ::.:::::.: .:...:::::: ::::::::::::.::::::::::::::::::: :
NP_002 LLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTT
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE6 SSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRT
.. : .:::::::.... ::. ::.. ...:::.::::.:.: ::::: :::.::::::
NP_002 TTSS--KNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRT
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE6 AAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLS
::::.::.::::::.::.:::::.::::.: :::.::..::::::::::.:.::::::::
NP_002 AAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLS
240 250 260 270 280 290
360 370 380 390 400 410
pF1KE6 MDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEI
:::::.:::::::::::::::.::::::::::::::::. .:: .. .:::.:.::::::
NP_002 MDNNRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEI
300 310 320 330 340 350
420 430 440 450 460 470
pF1KE6 IELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDL
::::::::::::::..::: .::...:.:::.:: :::::..: ::.:::::::..:
NP_002 AELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEEL
360 370 380 390 400 410
480 490 500 510 520 530
pF1KE6 ARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGY
::.::.:::::.::::::.:::::::::::::::::::: :::::::::.:: :.::
NP_002 ARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGST---STGGI
420 430 440 450 460 470
540 550 560 570 580 590
pF1KE6 GGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGARYG
.:: :.: : ::..:: :.::::::: ::
NP_002 SGGLGSGSGFGLSSGF--GSGSGSGFGFGGSVSGSSSSKIISTTTLNKRR
480 490 500 510 520
>>NP_778253 (OMIM: 611158) keratin, type II cytoskeletal (578 aa)
initn: 1934 init1: 1301 opt: 1975 Z-score: 895.2 bits: 175.7 E(85289): 4e-43
Smith-Waterman score: 2064; 60.4% identity (78.5% similar) in 596 aa overlap (1-591:14-559)
10 20 30 40
pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRS
:::.. .::.....: .: :: :: : :. : :::.::...
NP_778 MSHQFSSQSAFSSMSRRVYSTSSSAGSG-GGSPAV--GSV---CYAR-GRCGGGGYGIHG
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 GAGGFGSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGG
::::::::::::..::::.. :::. .: ::: :
NP_778 --RGFGSRSLYNLGGSRSISINLM-----------GRSTSGFC--QGGGVG---------
60 70 80
110 120 130 140 150 160
pF1KE6 GFGGGRGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFP
:::::::.: : ::::::: ::::::: :: :. :: ::::: :
NP_778 GFGGGRGFGVGSTGAGGFGG-GGFGGAG-------FGTSN-FGL-------GGFGPYCPP
90 100 110 120 130
170 180 190 200 210 220
pF1KE6 GGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLE
:::::::::::::.::..:.::.: ..:.:::::: .:::::::::::::::::::.::.
NP_778 GGIQEVTINQSLLEPLHLEVDPEIQRIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQ
140 150 160 170 180 190
230 240 250 260 270 280
pF1KE6 TKWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFK
:::.:::: .:: .::::::::.::.:. :: .: . .:. : ..:...:.:.:::.:
NP_778 TKWELLQQVNTS--TGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYK
200 210 220 230 240 250
290 300 310 320 330 340
pF1KE6 KKYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQ
.::::::::::..::.::.::::::.::..::.:...::.: :..::. :. .::::.:
NP_778 SKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQ
260 270 280 290 300 310
350 360 370 380 390 400
pF1KE6 SHISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRH
.:::::.:.::::::::::::::: ::.::: :::::: ::::::::: ::: :::::
NP_778 THISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRH
320 330 340 350 360 370
410 420 430 440 450 460
pF1KE6 GDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQEL
::::.:.: :: :::: .:::.::: .:::: ..:. :..::..::.::.:: :::.:
NP_778 GDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDL
380 390 400 410 420 430
470 480 490 500 510 520
pF1KE6 QAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVS
. ::::.:..::::::::: ...:::.:::::::::.:::::: ::::: : ::::: .
NP_778 EEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQN
440 450 460 470 480 490
530 540 550 560 570 580
pF1KE6 SSTT-SASAGG---YG-GGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSG
:... ...::: :: :::::: ::: ::: : ::.. : . ::: : : : :::: :
NP_778 SQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGRS-GGGYGSGCGGGGGSYG
500 510 520 530 540 550
590 600 610 620
pF1KE6 FSGGSGFGSISGARYGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR
:: :: ::
NP_778 GSGRSGRGSSRVQIIQTSTNTSHRRILE
560 570
628 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:56:33 2016 done: Tue Nov 8 15:56:34 2016
Total Scan time: 9.860 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]