Result of FASTA (omim) for
pFN21AE6737
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6737, 866 aa
1>>>pF1KE6737 866 - 866 aa - 866 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0591+/-0.000424; mu= 22.6731+/- 0.026
mean_var=78.2703+/-16.049, 0's: 0 Z-trim(111.0): 37 B-trim: 473 in 1/53
Lambda= 0.144969
statistics sampled from 19491 (19523) to 19491 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.229), width: 16
Scan time: 8.900
The best scores are: opt bits E(85289)
NP_037523 (OMIM: 605849,605850) dimethylglycine de ( 866) 5824 1228.6 0
XP_011541657 (OMIM: 605849,605850) PREDICTED: dime ( 750) 5077 1072.4 0
XP_011541656 (OMIM: 605849,605850) PREDICTED: dime ( 757) 5077 1072.4 0
XP_006714660 (OMIM: 605849,605850) PREDICTED: dime ( 774) 5077 1072.4 0
NP_001128179 (OMIM: 268900,604455) sarcosine dehyd ( 918) 572 130.2 4.2e-29
NP_009032 (OMIM: 268900,604455) sarcosine dehydrog ( 918) 572 130.2 4.2e-29
XP_016869856 (OMIM: 268900,604455) PREDICTED: sarc ( 878) 562 128.1 1.7e-28
XP_016869857 (OMIM: 268900,604455) PREDICTED: sarc ( 837) 461 107.0 3.9e-22
NP_000472 (OMIM: 238310,605899) aminomethyltransfe ( 403) 340 81.4 9.4e-15
NP_001158183 (OMIM: 238310,605899) aminomethyltran ( 347) 326 78.4 6.4e-14
NP_001158184 (OMIM: 238310,605899) aminomethyltran ( 386) 320 77.2 1.6e-13
NP_001158182 (OMIM: 238310,605899) aminomethyltran ( 359) 273 67.3 1.4e-10
NP_057602 (OMIM: 616713) peroxisomal sarcosine oxi ( 390) 202 52.5 4.5e-06
XP_016880211 (OMIM: 616713) PREDICTED: peroxisomal ( 294) 164 44.5 0.0009
XP_006718944 (OMIM: 252010,256000,613622) PREDICTE ( 275) 159 43.4 0.0018
XP_016873492 (OMIM: 252010,256000,613622) PREDICTE ( 275) 159 43.4 0.0018
XP_016873494 (OMIM: 252010,256000,613622) PREDICTE ( 275) 159 43.4 0.0018
XP_016873493 (OMIM: 252010,256000,613622) PREDICTE ( 275) 159 43.4 0.0018
XP_011541197 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002
XP_016873490 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002
XP_006718942 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002
XP_016873491 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002
XP_011541198 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002
XP_016873495 (OMIM: 252010,256000,613622) PREDICTE ( 274) 153 42.1 0.0042
>>NP_037523 (OMIM: 605849,605850) dimethylglycine dehydr (866 aa)
initn: 5824 init1: 5824 opt: 5824 Z-score: 6580.2 bits: 1228.6 E(85289): 0
Smith-Waterman score: 5824; 100.0% identity (100.0% similar) in 866 aa overlap (1-866:1-866)
10 20 30 40 50 60
pF1KE6 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE6 DVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 DVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPA
790 800 810 820 830 840
850 860
pF1KE6 VIIQEPLVLTEPTRNRLQKKGGKDKT
::::::::::::::::::::::::::
NP_037 VIIQEPLVLTEPTRNRLQKKGGKDKT
850 860
>>XP_011541657 (OMIM: 605849,605850) PREDICTED: dimethyl (750 aa)
initn: 5077 init1: 5077 opt: 5077 Z-score: 5736.6 bits: 1072.4 E(85289): 0
Smith-Waterman score: 5077; 100.0% identity (100.0% similar) in 750 aa overlap (1-750:1-750)
10 20 30 40 50 60
pF1KE6 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD
::::::::::::::::::::::::::::::
XP_011 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNK
730 740 750
>>XP_011541656 (OMIM: 605849,605850) PREDICTED: dimethyl (757 aa)
initn: 5077 init1: 5077 opt: 5077 Z-score: 5736.6 bits: 1072.4 E(85289): 0
Smith-Waterman score: 5077; 100.0% identity (100.0% similar) in 750 aa overlap (1-750:1-750)
10 20 30 40 50 60
pF1KE6 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD
::::::::::::::::::::::::::::::
XP_011 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKGSMDLRN
730 740 750
>>XP_006714660 (OMIM: 605849,605850) PREDICTED: dimethyl (774 aa)
initn: 5077 init1: 5077 opt: 5077 Z-score: 5736.5 bits: 1072.4 E(85289): 0
Smith-Waterman score: 5077; 100.0% identity (100.0% similar) in 750 aa overlap (1-750:1-750)
10 20 30 40 50 60
pF1KE6 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD
::::::::::::::::::::::::::::::
XP_006 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKDQNSCFAHFKEENGWVSRWAIRPY
730 740 750 760 770
>>NP_001128179 (OMIM: 268900,604455) sarcosine dehydroge (918 aa)
initn: 1465 init1: 448 opt: 572 Z-score: 643.4 bits: 130.2 E(85289): 4.2e-29
Smith-Waterman score: 1514; 33.1% identity (61.9% similar) in 902 aa overlap (15-858:38-915)
10 20 30 40
pF1KE6 MLRPGAQLLRGLLLRSCPLQGS--PGRPRSVCGREGEEKPPLSA
.: : : . :. :: . .: .: :.
NP_001 LRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVA-QGPSRPLPST
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 ETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPG
:..:.:::: .: . ::::: ::. .::::. .::.:.:::.::: ..:.
NP_001 -------ANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE6 -INLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQ
.... . . . ..:::::: .:. : :.. .:.. :.::.: :. ...:.
NP_001 DVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 YLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTS
... : . . ..::.:.. . . :: : :: .:: . .:: .: :: . :::.
NP_001 HVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTG
180 190 200 210 220 230
230 240 250 260 270
pF1KE6 LKARSDG-----TWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTS
... .: . ::: .::... .:: :: :: ::.: :.. ::. ..: ::::
NP_001 IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE6 TISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKE
: .. ..: .:: ..: ::: . :.: : ::.. . : . .::
NP_001 RIEGIQ----NMPNVRDHDASVYLRLQGDALSVGGYEANPIF-----WEEVSDKFAFG--
300 310 320 330 340
340 350 360 370 380 390
pF1KE6 LFESDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG
::. : . . .::..:.. ::::.:. : ..: :: ...:: :..: .:..... :
NP_001 LFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCG
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE6 FGY-GIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQ--YTEAKARESYGFNN
:. :.. .:: :. :. ::.::.: :. : :. . : . . . ...:::. :
NP_001 FNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNY
410 420 430 440 450 460
460 470 480 490 500
pF1KE6 IVGYPKEERFAGRPTQRVSGLYQRLESK-CSMGFHAGWEQPHWFYKPG------------
: .:..: .::: .: . :...: .. : . . :::.: ::. :
NP_001 SVVFPHDEPLAGRNMRR-DPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGA
470 480 490 500 510 520
510 520 530 540
pF1KE6 ------QDTQYRPSF--RRTNWFEPVGSEYKQ--VMQR--VAVTDLSPFGKFNIKGQDSI
.: :: . . : : : . :. . : .:: :.: :::: . : :.
NP_001 YGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDAR
530 540 550 560 570 580
550 560 570 580 590
pF1KE6 RLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVS-----HQ-SP------GE-FLLI
. : :: :.: : : . ::. .: . ..:::: :: :: :. . :
NP_001 KAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLA
590 600 610 620 630 640
600 610 620 630 640 650
pF1KE6 TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVF
:.. :. : . .. . ...::.... :: .: .::.. . :::...:
NP_001 MGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAF
650 660 670 680 690 700
660 670 680 690 700 710
pF1KE6 KFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA
: : :.... : :.:.:..:::::::. . . : .: :.: :: ..:. : : :
NP_001 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRA
710 720 730 740 750 760
720 730 740 750 760 770
pF1KE6 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVC
...: .::..: : .. : .:::::: . ::..:. :.:..::.: .: ::.:::::
NP_001 IDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVC
770 780 790 800 810 820
780 790 800 810 820
pF1KE6 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYV------PVQLSEVGQ-
.:. : : : :.:: ::.:::.. ......:.:..:..:. ::.:. : .
NP_001 FTME-DKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSG
830 840 850 860 870 880
830 840 850 860
pF1KE6 QVEVELLGKNYPAVI-IQEPLVLTEPTRNRLQKKGGKDKT
. .: .: .: : .. :. .:. .:..
NP_001 DYALERMGVTYGAQAHLKSPF---DPNNKRVKGIY
890 900 910
>>NP_009032 (OMIM: 268900,604455) sarcosine dehydrogenas (918 aa)
initn: 1465 init1: 448 opt: 572 Z-score: 643.4 bits: 130.2 E(85289): 4.2e-29
Smith-Waterman score: 1514; 33.1% identity (61.9% similar) in 902 aa overlap (15-858:38-915)
10 20 30 40
pF1KE6 MLRPGAQLLRGLLLRSCPLQGS--PGRPRSVCGREGEEKPPLSA
.: : : . :. :: . .: .: :.
NP_009 LRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVA-QGPSRPLPST
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 ETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPG
:..:.:::: .: . ::::: ::. .::::. .::.:.:::.::: ..:.
NP_009 -------ANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE6 -INLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQ
.... . . . ..:::::: .:. : :.. .:.. :.::.: :. ...:.
NP_009 DVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 YLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTS
... : . . ..::.:.. . . :: : :: .:: . .:: .: :: . :::.
NP_009 HVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTG
180 190 200 210 220 230
230 240 250 260 270
pF1KE6 LKARSDG-----TWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTS
... .: . ::: .::... .:: :: :: ::.: :.. ::. ..: ::::
NP_009 IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE6 TISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKE
: .. ..: .:: ..: ::: . :.: : ::.. . : . .::
NP_009 RIEGIQ----NMPNVRDHDASVYLRLQGDALSVGGYEANPIF-----WEEVSDKFAFG--
300 310 320 330 340
340 350 360 370 380 390
pF1KE6 LFESDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG
::. : . . .::..:.. ::::.:. : ..: :: ...:: :..: .:..... :
NP_009 LFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCG
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE6 FGY-GIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQ--YTEAKARESYGFNN
:. :.. .:: :. :. ::.::.: :. : :. . : . . . ...:::. :
NP_009 FNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNY
410 420 430 440 450 460
460 470 480 490 500
pF1KE6 IVGYPKEERFAGRPTQRVSGLYQRLESK-CSMGFHAGWEQPHWFYKPG------------
: .:..: .::: .: . :...: .. : . . :::.: ::. :
NP_009 SVVFPHDEPLAGRNMRR-DPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGA
470 480 490 500 510 520
510 520 530 540
pF1KE6 ------QDTQYRPSF--RRTNWFEPVGSEYKQ--VMQR--VAVTDLSPFGKFNIKGQDSI
.: :: . . : : : . :. . : .:: :.: :::: . : :.
NP_009 YGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDAR
530 540 550 560 570 580
550 560 570 580 590
pF1KE6 RLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVS-----HQ-SP------GE-FLLI
. : :: :.: : : . ::. .: . ..:::: :: :: :. . :
NP_009 KAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLA
590 600 610 620 630 640
600 610 620 630 640 650
pF1KE6 TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVF
:.. :. : . .. . ...::.... :: .: .::.. . :::...:
NP_009 MGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAF
650 660 670 680 690 700
660 670 680 690 700 710
pF1KE6 KFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA
: : :.... : :.:.:..:::::::. . . : .: :.: :: ..:. : : :
NP_009 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRA
710 720 730 740 750 760
720 730 740 750 760 770
pF1KE6 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVC
...: .::..: : .. : .:::::: . ::..:. :.:..::.: .: ::.:::::
NP_009 IDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVC
770 780 790 800 810 820
780 790 800 810 820
pF1KE6 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYV------PVQLSEVGQ-
.:. : : : :.:: ::.:::.. ......:.:..:..:. ::.:. : .
NP_009 FTME-DKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSG
830 840 850 860 870 880
830 840 850 860
pF1KE6 QVEVELLGKNYPAVI-IQEPLVLTEPTRNRLQKKGGKDKT
. .: .: .: : .. :. .:. .:..
NP_009 DYALERMGVTYGAQAHLKSPF---DPNNKRVKGIY
890 900 910
>>XP_016869856 (OMIM: 268900,604455) PREDICTED: sarcosin (878 aa)
initn: 1465 init1: 448 opt: 562 Z-score: 632.4 bits: 128.1 E(85289): 1.7e-28
Smith-Waterman score: 1504; 33.7% identity (62.3% similar) in 854 aa overlap (15-818:38-870)
10 20 30 40
pF1KE6 MLRPGAQLLRGLLLRSCPLQGS--PGRPRSVCGREGEEKPPLSA
.: : : . :. :: . .: .: :.
XP_016 LRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVA-QGPSRPLPST
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 ETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPG
:..:.:::: .: . ::::: ::. .::::. .::.:.:::.::: ..:.
XP_016 -------ANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE6 -INLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQ
.... . . . ..:::::: .:. : :.. .:.. :.::.: :. ...:.
XP_016 DVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 YLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTS
... : . . ..::.:.. . . :: : :: .:: . .:: .: :: . :::.
XP_016 HVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTG
180 190 200 210 220 230
230 240 250 260 270
pF1KE6 LKARSDG-----TWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTS
... .: . ::: .::... .:: :: :: ::.: :.. ::. ..: ::::
XP_016 IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE6 TISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKE
: .. ..: .:: ..: ::: . :.: : ::.. . : . .::
XP_016 RIEGIQ----NMPNVRDHDASVYLRLQGDALSVGGYEANPIF-----WEEVSDKFAFG--
300 310 320 330 340
340 350 360 370 380 390
pF1KE6 LFESDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG
::. : . . .::..:.. ::::.:. : ..: :: ...:: :..: .:..... :
XP_016 LFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCG
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE6 FGY-GIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQ--YTEAKARESYGFNN
:. :.. .:: :. :. ::.::.: :. : :. . : . . . ...:::. :
XP_016 FNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNY
410 420 430 440 450 460
460 470 480 490 500
pF1KE6 IVGYPKEERFAGRPTQRVSGLYQRLESK-CSMGFHAGWEQPHWFYKPG------------
: .:..: .::: .: . :...: .. : . . :::.: ::. :
XP_016 SVVFPHDEPLAGRNMRR-DPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGA
470 480 490 500 510 520
510 520 530 540
pF1KE6 ------QDTQYRPSF--RRTNWFEPVGSEYKQ--VMQR--VAVTDLSPFGKFNIKGQDSI
.: :: . . : : : . :. . : .:: :.: :::: . : :.
XP_016 YGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDAR
530 540 550 560 570 580
550 560 570 580 590
pF1KE6 RLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVS-----HQ-SP------GE-FLLI
. : :: :.: : : . ::. .: . ..:::: :: :: :. . :
XP_016 KAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLA
590 600 610 620 630 640
600 610 620 630 640 650
pF1KE6 TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVF
:.. :. : . .. . ...::.... :: .: .::.. . :::...:
XP_016 MGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAF
650 660 670 680 690 700
660 670 680 690 700 710
pF1KE6 KFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA
: : :.... : :.:.:..:::::::. . . : .: :.: :: ..:. : : :
XP_016 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRA
710 720 730 740 750 760
720 730 740 750 760 770
pF1KE6 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVC
...: .::..: : .. : .:::::: . ::..:. :.:..::.: .: ::.:::::
XP_016 IDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVC
770 780 790 800 810 820
780 790 800 810 820 830
pF1KE6 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELL
.:. : : : :.:: ::.:::.. ......:.:..:..:.
XP_016 FTME-DKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPA
830 840 850 860 870
840 850 860
pF1KE6 GKNYPAVIIQEPLVLTEPTRNRLQKKGGKDKT
>>XP_016869857 (OMIM: 268900,604455) PREDICTED: sarcosin (837 aa)
initn: 1361 init1: 448 opt: 461 Z-score: 518.5 bits: 107.0 E(85289): 3.9e-22
Smith-Waterman score: 1403; 33.6% identity (61.6% similar) in 813 aa overlap (15-777:38-830)
10 20 30 40
pF1KE6 MLRPGAQLLRGLLLRSCPLQGS--PGRPRSVCGREGEEKPPLSA
.: : : . :. :: . .: .: :.
XP_016 LRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVA-QGPSRPLPST
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 ETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPG
:..:.:::: .: . ::::: ::. .::::. .::.:.:::.::: ..:.
XP_016 -------ANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPS
70 80 90 100 110
110 120 130 140 150 160
pF1KE6 -INLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQ
.... . . . ..:::::: .:. : :.. .:.. :.::.: :. ...:.
XP_016 DVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 YLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTS
... : . . ..::.:.. . . :: : :: .:: . .:: .: :: . :::.
XP_016 HVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTG
180 190 200 210 220 230
230 240 250 260 270
pF1KE6 LKARSDG-----TWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTS
... .: . ::: .::... .:: :: :: ::.: :.. ::. ..: ::::
XP_016 IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTE
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE6 TISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKE
: .. ..: .:: ..: ::: . :.: : ::.. . : . .::
XP_016 RIEGIQ----NMPNVRDHDASVYLRLQGDALSVGGYEANPIF-----WEEVSDKFAFG--
300 310 320 330 340
340 350 360 370 380 390
pF1KE6 LFESDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG
::. : . . .::..:.. ::::.:. : ..: :: ...:: :..: .:..... :
XP_016 LFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCG
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE6 FGY-GIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQ--YTEAKARESYGFNN
:. :.. .:: :. :. ::.::.: :. : :. . : . . . ...:::. :
XP_016 FNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNY
410 420 430 440 450 460
460 470 480 490 500
pF1KE6 IVGYPKEERFAGRPTQRVSGLYQRLESK-CSMGFHAGWEQPHWFYKPG------------
: .:..: .::: .: . :...: .. : . . :::.: ::. :
XP_016 SVVFPHDEPLAGRNMRR-DPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGA
470 480 490 500 510 520
510 520 530 540
pF1KE6 ------QDTQYRPSF--RRTNWFEPVGSEYKQ--VMQR--VAVTDLSPFGKFNIKGQDSI
.: :: . . : : : . :. . : .:: :.: :::: . : :.
XP_016 YGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDAR
530 540 550 560 570 580
550 560 570 580 590
pF1KE6 RLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVS-----HQ-SP------GE-FLLI
. : :: :.: : : . ::. .: . ..:::: :: :: :. . :
XP_016 KAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLA
590 600 610 620 630 640
600 610 620 630 640 650
pF1KE6 TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVF
:.. :. : . .. . ...::.... :: .: .::.. . :::...:
XP_016 MGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAF
650 660 670 680 690 700
660 670 680 690 700 710
pF1KE6 KFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA
: : :.... : :.:.:..:::::::. . . : .: :.: :: ..:. : : :
XP_016 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRA
710 720 730 740 750 760
720 730 740 750 760 770
pF1KE6 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVC
...: .::..: : .. : .:::::: . ::..:. :.:..::.: .: ::.:::::
XP_016 IDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVC
770 780 790 800 810 820
780 790 800 810 820 830
pF1KE6 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELL
.:.
XP_016 FTMEDLPTAL
830
>>NP_000472 (OMIM: 238310,605899) aminomethyltransferase (403 aa)
initn: 175 init1: 104 opt: 340 Z-score: 385.9 bits: 81.4 E(85289): 9.4e-15
Smith-Waterman score: 343; 26.6% identity (55.4% similar) in 395 aa overlap (470-850:34-397)
440 450 460 470 480 490
pF1KE6 YTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQ-RLESKCSMGFHAGWEQPHWFYK
: . ::. .: .: ::: :
NP_000 AVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLP-----
10 20 30 40 50
500 510 520 530 540 550
pF1KE6 PGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKFNIKGQDSIRLLDHL----
.::: : .. .. :. .. :.: . . .: :.: ..:.. :
NP_000 ----VQYRDSHTDSHL---------HTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGD
60 70 80 90 100
560 570 580 590 600 610
pF1KE6 FANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEE---EA
.:.. :. : ..: . . : . .: :.. : :.. .....: .:: ... :
NP_000 IAELRPNQG--TLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVREL
110 120 130 140 150 160
620 630 640 650 660 670
pF1KE6 VKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIPVTA
. : :: .. . . : :.. :: : .::: ...:: . :. . ..: ..
NP_000 QNQGRDVGLEVLDNAL--LALQGPTAAQVLQAGVADDLRK--LPFMTSAVMEVFGVSGCR
170 180 190 200 210
680 690 700 710 720 730
pF1KE6 I-RISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRLEKAFRAWGLE
. : .:::: : :. .: : ::.. . . : : ..:::: .. .: .
NP_000 VTRCGYTGEDGVEISVPVAGAVHLATAILKNPE---VKLAGLAARDSLRLEAGLCLYGND
220 230 240 250 260 270
740 750 760 770 780
pF1KE6 MNCDTNPLEAGLEYFVKLNKPA--DFIGKQAL-KQIKAKGLKRR--LVCLTLATDDVDPE
.. :.:.:..: . . . : :: : ... :.:.. .:: :.: .:
NP_000 IDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPI
280 290 300 310 320 330
790 800 810 820 830 840
pF1KE6 GNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPAVIIQE
: ..: .:..::: : :..:..:..::: . :. : .. ::. :. ::. .
NP_000 LN----MEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKM
340 350 360 370 380 390
850 860
pF1KE6 PLVLTEPTRNRLQKKGGKDKT
:.: :
NP_000 PFVPTNYYTLK
400
>>NP_001158183 (OMIM: 238310,605899) aminomethyltransfer (347 aa)
initn: 173 init1: 104 opt: 326 Z-score: 370.9 bits: 78.4 E(85289): 6.4e-14
Smith-Waterman score: 326; 27.6% identity (58.1% similar) in 322 aa overlap (542-850:33-341)
520 530 540 550 560
pF1KE6 TNWFEPVGSEYKQVMQRVAVTDLSPFGKFNIKGQDSIRLLDHL----FANVIPKVGFTNI
: :.: ..:.. : .:.. :. : ..
NP_001 RAVSVVARLGFRLQAFPPALCRPLSCAQTKILGSDRVKLMESLVVGDIAELRPNQG--TL
10 20 30 40 50 60
570 580 590 600 610 620
pF1KE6 SHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEE---EAVKGGYDVEIKNIT
: . . : . .: :.. : :.. .....: .:: ... : . : :: .. .
NP_001 SLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLD
70 80 90 100 110 120
630 640 650 660 670 680
pF1KE6 DELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIPVTAI-RISYTGELGWE
. : :.. :: : .::: ...:: . :. . ..: .. . : .:::: : :
NP_001 NAL--LALQGPTAAQVLQAGVADDLRK--LPFMTSAVMEVFGVSGCRVTRCGYTGEDGVE
130 140 150 160 170
690 700 710 720 730 740
pF1KE6 LYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRLEKAFRAWGLEMNCDTNPLEAGLE
. .: : ::.. . . : : ..:::: .. .: ... :.:.:..:
NP_001 ISVPVAGAVHLATAILKNPE---VKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLS
180 190 200 210 220 230
750 760 770 780 790
pF1KE6 YFVKLNKPA--DFIGKQAL-KQIKAKGLKRR--LVCLTLATDDVDPEGNESIWYNGKVVG
. . . : :: : ... :.:.. .:: :.: .: : ..: .:
NP_001 WTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILN----MEGTKIG
240 250 260 270 280
800 810 820 830 840 850
pF1KE6 NTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPAVIIQEPLVLTEPTRNRLQ
..::: : :..:..:..::: . :. : .. ::. :. ::. . :.: :
NP_001 TVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
290 300 310 320 330 340
860
pF1KE6 KKGGKDKT
866 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:52:37 2016 done: Tue Nov 8 15:52:39 2016
Total Scan time: 8.900 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]