Result of FASTA (omim) for
pFN21AE6729
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6729, 1085 aa
1>>>pF1KE6729 1085 - 1085 aa - 1085 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1136+/-0.000461; mu= 23.0063+/- 0.028
mean_var=74.1782+/-15.815, 0's: 0 Z-trim(109.4): 71 B-trim: 808 in 1/52
Lambda= 0.148914
statistics sampled from 17497 (17568) to 17497 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.539), E-opt: 0.2 (0.206), width: 16
Scan time: 10.530
The best scores are: opt bits E(85289)
NP_005063 (OMIM: 604119) solute carrier family 12 (1085) 7215 1560.7 0
NP_001139433 (OMIM: 604119) solute carrier family (1079) 7159 1548.7 0
NP_001139435 (OMIM: 604119) solute carrier family (1079) 6952 1504.2 0
NP_001139436 (OMIM: 604119) solute carrier family (1054) 6944 1502.5 0
NP_001139434 (OMIM: 604119) solute carrier family (1087) 6720 1454.4 0
NP_001035960 (OMIM: 218000,604878) solute carrier (1091) 5563 1205.8 0
NP_001035959 (OMIM: 218000,604878) solute carrier (1091) 5563 1205.8 0
NP_001035961 (OMIM: 218000,604878) solute carrier (1141) 5563 1205.8 0
NP_598408 (OMIM: 218000,604878) solute carrier fam (1150) 5563 1205.8 0
NP_005126 (OMIM: 218000,604878) solute carrier fam (1099) 5556 1204.3 0
NP_001035962 (OMIM: 218000,604878) solute carrier (1135) 5544 1201.7 0
NP_006589 (OMIM: 604879) solute carrier family 12 (1083) 5057 1097.1 0
XP_005248288 (OMIM: 604879) PREDICTED: solute carr (1088) 5037 1092.8 0
XP_011512241 (OMIM: 604879) PREDICTED: solute carr (1085) 5011 1087.2 0
XP_011512243 (OMIM: 604879) PREDICTED: solute carr (1111) 5011 1087.2 0
XP_011512242 (OMIM: 604879) PREDICTED: solute carr (1074) 5005 1085.9 0
XP_006720856 (OMIM: 218000,604878) PREDICTED: solu (1101) 4975 1079.5 0
XP_016864448 (OMIM: 604879) PREDICTED: solute carr (1020) 4943 1072.6 0
XP_016864447 (OMIM: 604879) PREDICTED: solute carr (1020) 4943 1072.6 0
XP_016883470 (OMIM: 606726,616645,616685) PREDICTE (1134) 4642 1008.0 0
NP_001128243 (OMIM: 606726,616645,616685) solute c (1139) 4642 1008.0 0
NP_065759 (OMIM: 606726,616645,616685) solute carr (1116) 4627 1004.7 0
XP_011520571 (OMIM: 218000,604878) PREDICTED: solu ( 680) 2929 639.8 1.6e-182
XP_005250559 (OMIM: 616861) PREDICTED: solute carr ( 825) 673 155.1 1.5e-36
XP_006716117 (OMIM: 616861) PREDICTED: solute carr ( 825) 673 155.1 1.5e-36
XP_011514716 (OMIM: 616861) PREDICTED: solute carr ( 722) 665 153.4 4.5e-36
NP_001243390 (OMIM: 600840) solute carrier family (1196) 628 145.6 1.6e-33
XP_016865260 (OMIM: 600840) PREDICTED: solute carr ( 626) 624 144.5 1.8e-33
NP_001254743 (OMIM: 616861) solute carrier family ( 538) 613 142.1 8.3e-33
XP_005254663 (OMIM: 600839,601678) PREDICTED: solu (1099) 583 135.9 1.2e-30
NP_001119579 (OMIM: 263800,600968) solute carrier (1029) 577 134.6 2.9e-30
NP_000330 (OMIM: 263800,600968) solute carrier fam (1030) 577 134.6 2.9e-30
XP_005256176 (OMIM: 263800,600968) PREDICTED: solu (1020) 545 127.7 3.4e-28
NP_001119580 (OMIM: 263800,600968) solute carrier (1021) 545 127.7 3.4e-28
XP_005250561 (OMIM: 616861) PREDICTED: solute carr ( 556) 499 117.6 2e-25
XP_011541890 (OMIM: 600840) PREDICTED: solute carr ( 628) 405 97.5 2.6e-19
NP_001037 (OMIM: 600840) solute carrier family 12 (1212) 405 97.7 4.3e-19
NP_001171761 (OMIM: 600839,601678) solute carrier (1099) 389 94.2 4.4e-18
NP_000329 (OMIM: 600839,601678) solute carrier fam (1099) 384 93.2 9.2e-18
NP_001254741 (OMIM: 616861) solute carrier family ( 631) 379 91.9 1.3e-17
NP_064631 (OMIM: 616861) solute carrier family 12 ( 914) 379 92.0 1.7e-17
XP_006716118 (OMIM: 616861) PREDICTED: solute carr ( 811) 367 89.4 9.2e-17
NP_078904 (OMIM: 611316) solute carrier family 12 ( 714) 281 70.9 3e-11
NP_001182412 (OMIM: 611316) solute carrier family ( 714) 281 70.9 3e-11
XP_016869236 (OMIM: 601872) PREDICTED: cationic am ( 657) 182 49.6 7.2e-05
NP_003037 (OMIM: 601872) cationic amino acid trans ( 697) 182 49.6 7.5e-05
NP_001253966 (OMIM: 604235) large neutral amino ac ( 311) 172 47.2 0.00018
XP_005273668 (OMIM: 601872) PREDICTED: cationic am ( 658) 170 47.0 0.00043
XP_016869235 (OMIM: 601872) PREDICTED: cationic am ( 658) 170 47.0 0.00043
XP_005273667 (OMIM: 601872) PREDICTED: cationic am ( 658) 170 47.0 0.00043
>>NP_005063 (OMIM: 604119) solute carrier family 12 memb (1085 aa)
initn: 7215 init1: 7215 opt: 7215 Z-score: 8371.3 bits: 1560.7 E(85289): 0
Smith-Waterman score: 7215; 100.0% identity (100.0% similar) in 1085 aa overlap (1-1085:1-1085)
10 20 30 40 50 60
pF1KE6 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE6 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE6 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE6 HLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE6 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE6 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV
1030 1040 1050 1060 1070 1080
pF1KE6 ITIYS
:::::
NP_005 ITIYS
>>NP_001139433 (OMIM: 604119) solute carrier family 12 m (1079 aa)
initn: 7167 init1: 6058 opt: 7159 Z-score: 8306.3 bits: 1548.7 E(85289): 0
Smith-Waterman score: 7159; 99.4% identity (99.4% similar) in 1085 aa overlap (1-1085:1-1079)
10 20 30 40 50 60
pF1KE6 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE6 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHER
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE6 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLY
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE6 HLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL
::::::: :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLRLEAE------HNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSAL
910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE6 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMH
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE6 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREV
1020 1030 1040 1050 1060 1070
pF1KE6 ITIYS
:::::
NP_001 ITIYS
>>NP_001139435 (OMIM: 604119) solute carrier family 12 m (1079 aa)
initn: 6940 init1: 6940 opt: 6952 Z-score: 8066.0 bits: 1504.2 E(85289): 0
Smith-Waterman score: 6952; 98.6% identity (99.0% similar) in 1067 aa overlap (20-1085:13-1079)
10 20 30 40 50
pF1KE6 MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAELDDSD-GHGNHRESSPFLSPLEASRGI
::: .:. . : . :::::::::::::::::::::
NP_001 MAAEGAVCGFVYLEGTAWAVPEDTEPLASCTLGHGNHRESSPFLSPLEASRGI
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 DYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 TLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 VPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 AHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSI
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE6 FDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFML
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE6 NNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATS
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE6 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEG
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE6 VVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNII
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE6 PFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQ
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE6 TLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEK
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE6 EWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLK
660 670 680 690 700 710
720 730 740 750 760 770
pF1KE6 AGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQ
720 730 740 750 760 770
780 790 800 810 820 830
pF1KE6 SCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHE
780 790 800 810 820 830
840 850 860 870 880 890
pF1KE6 RYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFL
840 850 860 870 880 890
900 910 920 930 940 950
pF1KE6 YHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSA
900 910 920 930 940 950
960 970 980 990 1000 1010
pF1KE6 LRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRM
960 970 980 990 1000 1010
1020 1030 1040 1050 1060 1070
pF1KE6 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGRE
1020 1030 1040 1050 1060 1070
1080
pF1KE6 VITIYS
::::::
NP_001 VITIYS
>>NP_001139436 (OMIM: 604119) solute carrier family 12 m (1054 aa)
initn: 6944 init1: 6944 opt: 6944 Z-score: 8056.8 bits: 1502.5 E(85289): 0
Smith-Waterman score: 6944; 99.9% identity (99.9% similar) in 1049 aa overlap (37-1085:6-1054)
10 20 30 40 50 60
pF1KE6 VPVDGPRRGDYDNLEGLSWVDYGERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNL
: ::::::::::::::::::::::::::::
NP_001 MGDTLSPGHGNHRESSPFLSPLEASRGIDYYDRNL
10 20 30
70 80 90 100 110 120
pF1KE6 ALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 PCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSY
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE6 FMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNA
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE6 TLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFP
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE6 VCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIP
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE6 GIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGI
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE6 FFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKY
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE6 GDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFG
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE6 HGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPN
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE6 WRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIR
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE6 GLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTI
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE6 VGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGM
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE6 RHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHI
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE6 DVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEA
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE6 EVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLY
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE6 SDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLN
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE6 EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
1000 1010 1020 1030 1040 1050
>>NP_001139434 (OMIM: 604119) solute carrier family 12 m (1087 aa)
initn: 6720 init1: 6720 opt: 6720 Z-score: 7796.6 bits: 1454.4 E(85289): 0
Smith-Waterman score: 6720; 100.0% identity (100.0% similar) in 1015 aa overlap (71-1085:73-1087)
50 60 70 80 90 100
pF1KE6 GNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHE
::::::::::::::::::::::::::::::
NP_001 WTGRGAATMTTSRGSVGWTTGSAPSWMTRTEELDIRPKVSSLLGKLVSYTNLTQGAKEHE
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE6 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE6 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE6 IEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE6 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWS
290 300 310 320 330 340
350 360 370 380 390 400
pF1KE6 FFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSAD
350 360 370 380 390 400
410 420 430 440 450 460
pF1KE6 APSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAII
410 420 430 440 450 460
470 480 490 500 510 520
pF1KE6 TTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGL
470 480 490 500 510 520
530 540 550 560 570 580
pF1KE6 QSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPI
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE6 LSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALV
590 600 610 620 630 640
650 660 670 680 690 700
pF1KE6 AMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKL
650 660 670 680 690 700
710 720 730 740 750 760
pF1KE6 DEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKG
710 720 730 740 750 760
770 780 790 800 810 820
pF1KE6 FCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTA
770 780 790 800 810 820
830 840 850 860 870 880
pF1KE6 AHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFT
830 840 850 860 870 880
890 900 910 920 930 940
pF1KE6 VAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMR
890 900 910 920 930 940
950 960 970 980 990 1000
pF1KE6 LTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAP
950 960 970 980 990 1000
1010 1020 1030 1040 1050 1060
pF1KE6 DNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFL
1010 1020 1030 1040 1050 1060
1070 1080
pF1KE6 EVLTEGLERVLLVRGGGREVITIYS
:::::::::::::::::::::::::
NP_001 EVLTEGLERVLLVRGGGREVITIYS
1070 1080
>>NP_001035960 (OMIM: 218000,604878) solute carrier fami (1091 aa)
initn: 5528 init1: 3874 opt: 5563 Z-score: 6453.2 bits: 1205.8 E(85289): 0
Smith-Waterman score: 5563; 76.8% identity (91.2% similar) in 1087 aa overlap (4-1085:11-1091)
10 20 30 40
pF1KE6 MPHFTVVPVDGPR-RGDY--DNLEGLSWVDY-GERAELDDSDGHGNHRESSPF
...: .: : : .. : .: :: . ::...: : ::: . :.. .
NP_001 MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLD-DGHKKARNA--Y
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 LSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTR
:. . .: .:.:.::::::::.: ::::::::.....:::::::::::::::. .
NP_001 LNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGK
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 RRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI
.. ...:.:::.::::::::::::::::::::::.:::::::::. :::::::::.::::
NP_001 KKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA
::::::::::::::::::::::.:::::::::::::::::::::::::::::::.:.::.
NP_001 SMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISIL
: ::::. . : : : ::::::::: ::..:.::::.::.::::::::::::::.:::
NP_001 PRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSIL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE6 SIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLT
.::::.::: : :: :::::::::::: ..:.:.:: ..: :: ..::.:::.: ..
NP_001 AIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFF
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE6 TDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLP
. .:: ::. :::: : :::: :.:.. ::::: :: ::.:.:: ::: . .. ::
NP_001 NATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLN
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE6 L-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFS
::..::.::::.::::::::::::::::::::::.:::::::.::::::.:::.::.:
NP_001 HEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE6 SVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPR
.::::::::::::::::.::.:. :::::::.::::::::::::::::::::::::::::
NP_001 NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPR
480 490 500 510 520 530
530 540 550 560 570 580
pF1KE6 LLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMC
:::::::::::::::::::.:.:::::::::::: ::::::::::::.::::::::::::
NP_001 LLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMC
540 550 560 570 580 590
590 600 610 620 630 640
pF1KE6 YLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMI
:::::::::.:::::::::::::.::::::::.:::.::::::.::::::.:::.:::::
NP_001 YLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMI
600 610 620 630 640 650
650 660 670 680 690 700
pF1KE6 YKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKY
::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::.
NP_001 YKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKH
660 670 680 690 700 710
710 720 730 740 750 760
pF1KE6 PRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVAS
::::::::::::::::::::::: :.:::.:::: :::::::..:: ::::::::.:::.
NP_001 PRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAA
720 730 740 750 760 770
770 780 790 800 810 820
pF1KE6 KVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVP
:.:::..:::::::::::.::.::.::: ::::::: ::::::: ::: ::::::::::
NP_001 KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVA
780 790 800 810 820 830
830 840 850 860 870 880
pF1KE6 KNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNS
:::.:.::: :.. ::.::::::::::::::::::::.:::::::: .:::::::..:::
NP_001 KNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNS
840 850 860 870 880 890
890 900 910 920 930 940
pF1KE6 IQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERER
::::::::.::::::.::::::::::.::::::::::::::::::::::.:::.::::.:
NP_001 IQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDR
900 910 920 930 940 950
950 960 970 980 990 1000
pF1KE6 EAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVH
::::::::.: ::: :. :::..:. . .:..::::.::::. . ... ..:..:..
NP_001 EAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLN
960 970 980 990 1000 1010
1010 1020 1030 1040 1050 1060
pF1KE6 IKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLE
..::::::::::::::::::::..::.:.:::::::::::: ::::::::::::::::::
NP_001 MRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLE
1020 1030 1040 1050 1060 1070
1070 1080
pF1KE6 RVLLVRGGGREVITIYS
::::::::: :::::::
NP_001 RVLLVRGGGSEVITIYS
1080 1090
>>NP_001035959 (OMIM: 218000,604878) solute carrier fami (1091 aa)
initn: 5528 init1: 3874 opt: 5563 Z-score: 6453.2 bits: 1205.8 E(85289): 0
Smith-Waterman score: 5563; 76.8% identity (91.2% similar) in 1087 aa overlap (4-1085:11-1091)
10 20 30 40
pF1KE6 MPHFTVVPVDGPR-RGDY--DNLEGLSWVDY-GERAELDDSDGHGNHRESSPF
...: .: : : .. : .: :: . ::...: : ::: . :.. .
NP_001 MSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITGEHSQLLD-DGHKKARNA--Y
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 LSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTR
:. . .: .:.:.::::::::.: ::::::::.....:::::::::::::::. .
NP_001 LNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGK
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 RRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI
.. ...:.:::.::::::::::::::::::::::.:::::::::. :::::::::.::::
NP_001 KKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA
::::::::::::::::::::::.:::::::::::::::::::::::::::::::.:.::.
NP_001 SMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIV
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISIL
: ::::. . : : : ::::::::: ::..:.::::.::.::::::::::::::.:::
NP_001 PRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSIL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE6 SIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLT
.::::.::: : :: :::::::::::: ..:.:.:: ..: :: ..::.:::.: ..
NP_001 AIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFF
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE6 TDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLP
. .:: ::. :::: : :::: :.:.. ::::: :: ::.:.:: ::: . .. ::
NP_001 NATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAKSSDVLGSLN
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE6 L-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFS
::..::.::::.::::::::::::::::::::::.:::::::.::::::.:::.::.:
NP_001 HEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS
420 430 440 450 460 470
470 480 490 500 510 520
pF1KE6 SVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPR
.::::::::::::::::.::.:. :::::::.::::::::::::::::::::::::::::
NP_001 NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPR
480 490 500 510 520 530
530 540 550 560 570 580
pF1KE6 LLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMC
:::::::::::::::::::.:.:::::::::::: ::::::::::::.::::::::::::
NP_001 LLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMC
540 550 560 570 580 590
590 600 610 620 630 640
pF1KE6 YLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMI
:::::::::.:::::::::::::.::::::::.:::.::::::.::::::.:::.:::::
NP_001 YLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMI
600 610 620 630 640 650
650 660 670 680 690 700
pF1KE6 YKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKY
::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::.
NP_001 YKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKH
660 670 680 690 700 710
710 720 730 740 750 760
pF1KE6 PRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVAS
::::::::::::::::::::::: :.:::.:::: :::::::..:: ::::::::.:::.
NP_001 PRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAA
720 730 740 750 760 770
770 780 790 800 810 820
pF1KE6 KVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVP
:.:::..:::::::::::.::.::.::: ::::::: ::::::: ::: ::::::::::
NP_001 KLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVA
780 790 800 810 820 830
830 840 850 860 870 880
pF1KE6 KNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNS
:::.:.::: :.. ::.::::::::::::::::::::.:::::::: .:::::::..:::
NP_001 KNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNS
840 850 860 870 880 890
890 900 910 920 930 940
pF1KE6 IQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERER
::::::::.::::::.::::::::::.::::::::::::::::::::::.:::.::::.:
NP_001 IQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDR
900 910 920 930 940 950
950 960 970 980 990 1000
pF1KE6 EAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVH
::::::::.: ::: :. :::..:. . .:..::::.::::. . ... ..:..:..
NP_001 EAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLN
960 970 980 990 1000 1010
1010 1020 1030 1040 1050 1060
pF1KE6 IKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLE
..::::::::::::::::::::..::.:.:::::::::::: ::::::::::::::::::
NP_001 MRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLE
1020 1030 1040 1050 1060 1070
1070 1080
pF1KE6 RVLLVRGGGREVITIYS
::::::::: :::::::
NP_001 RVLLVRGGGSEVITIYS
1080 1090
>>NP_001035961 (OMIM: 218000,604878) solute carrier fami (1141 aa)
initn: 5528 init1: 3874 opt: 5563 Z-score: 6452.9 bits: 1205.8 E(85289): 0
Smith-Waterman score: 5563; 76.8% identity (91.2% similar) in 1087 aa overlap (4-1085:61-1141)
10 20
pF1KE6 MPHFTVVPVDGPR-RGDY--DNLEGLSWVDY-G
...: .: : : .. : .: :: . :
NP_001 SSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITG
40 50 60 70 80 90
30 40 50 60 70 80
pF1KE6 ERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSY
:...: : ::: . :.. .:. . .: .:.:.::::::::.: ::::::::.....:
NP_001 EHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANY
100 110 120 130 140
90 100 110 120 130 140
pF1KE6 TNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAG
::::::::::::::. ... ...:.:::.::::::::::::::::::::::.:::::
NP_001 TNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAG
150 160 170 180 190 200
150 160 170 180 190 200
pF1KE6 VLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGT
::::. :::::::::.::::::::::::::::::::::::::.:::::::::::::::::
NP_001 VLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGT
210 220 230 240 250 260
210 220 230 240 250 260
pF1KE6 TFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVG
::::::::::::::.:.::.: ::::. . : : : ::::::::: ::..:.::::.:
NP_001 TFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIG
270 280 290 300 310 320
270 280 290 300 310 320
pF1KE6 VKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVV
:.::::::::::::::.:::.::::.::: : :: :::::::::::: ..:.:.:: .
NP_001 VRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEI
330 340 350 360 370 380
330 340 350 360 370 380
pF1KE6 DNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGD
.: :: ..::.:::.: .. . .:: ::. :::: : :::: :.:.. ::::: :: ::.
NP_001 NNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGE
390 400 410 420 430 440
390 400 410 420 430 440
pF1KE6 IVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQ
:.:: ::: . .. :: ::..::.::::.::::::::::::::::::::::.:::
NP_001 IIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ
450 460 470 480 490 500
450 460 470 480 490 500
pF1KE6 KSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIV
::::.::::::.:::.::.:.::::::::::::::::.::.:. :::::::.::::::::
NP_001 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIV
510 520 530 540 550 560
510 520 530 540 550 560
pF1KE6 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELG
:::::::::::::::::::::::::::::::::::::::.:.:::::::::::: :::::
NP_001 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELG
570 580 590 600 610 620
570 580 590 600 610 620
pF1KE6 ILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLA
:::::::.:::::::::::::::::::::.:::::::::::::.::::::::.:::.:::
NP_001 ILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLA
630 640 650 660 670 680
630 640 650 660 670 680
pF1KE6 LMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTK
:::.::::::.:::.:::::::::::::::::::::::::::::::.:::::::::::::
NP_001 LMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTK
690 700 710 720 730 740
690 700 710 720 730 740
pF1KE6 NWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQT
:::::::::::::::::::.::::::::::::::::::::::: :.:::.:::: :::::
NP_001 NWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQT
750 760 770 780 790 800
750 760 770 780 790 800
pF1KE6 IKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAW
::..:: ::::::::.:::.:.:::..:::::::::::.::.::.::: ::::::: :::
NP_001 IKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAW
810 820 830 840 850 860
810 820 830 840 850 860
pF1KE6 KTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQH
:::: ::: :::::::::: :::.:.::: :.. ::.::::::::::::::::::::.::
NP_001 KTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQH
870 880 890 900 910 920
870 880 890 900 910 920
pF1KE6 KVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLM
:::::: .:::::::..:::::::::::.::::::.::::::::::.:::::::::::::
NP_001 KVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLM
930 940 950 960 970 980
930 940 950 960 970 980
pF1KE6 MEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDK
:::::::::.:::.::::.:::::::::.: ::: :. :::..:. . .:..::::.::
NP_001 MEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDK
990 1000 1010 1020 1030 1040
990 1000 1010 1020 1030 1040
pF1KE6 YMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPR
::. . ... ..:..:....::::::::::::::::::::..::.:.:::::::::::
NP_001 YMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPR
1050 1060 1070 1080 1090 1100
1050 1060 1070 1080
pF1KE6 NSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
: ::::::::::::::::::::::::::: :::::::
NP_001 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
1110 1120 1130 1140
>>NP_598408 (OMIM: 218000,604878) solute carrier family (1150 aa)
initn: 5528 init1: 3874 opt: 5563 Z-score: 6452.8 bits: 1205.8 E(85289): 0
Smith-Waterman score: 5563; 76.8% identity (91.2% similar) in 1087 aa overlap (4-1085:70-1150)
10 20
pF1KE6 MPHFTVVPVDGPR-RGDY--DNLEGLSWVDY-G
...: .: : : .. : .: :: . :
NP_598 SSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQNSITG
40 50 60 70 80 90
30 40 50 60 70 80
pF1KE6 ERAELDDSDGHGNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSY
:...: : ::: . :.. .:. . .: .:.:.::::::::.: ::::::::.....:
NP_598 EHSQLLD-DGHKKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANY
100 110 120 130 140 150
90 100 110 120 130 140
pF1KE6 TNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAG
::::::::::::::. ... ...:.:::.::::::::::::::::::::::.:::::
NP_598 TNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAG
160 170 180 190 200 210
150 160 170 180 190 200
pF1KE6 VLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGT
::::. :::::::::.::::::::::::::::::::::::::.:::::::::::::::::
NP_598 VLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGT
220 230 240 250 260 270
210 220 230 240 250 260
pF1KE6 TFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVG
::::::::::::::.:.::.: ::::. . : : : ::::::::: ::..:.::::.:
NP_598 TFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIG
280 290 300 310 320 330
270 280 290 300 310 320
pF1KE6 VKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVV
:.::::::::::::::.:::.::::.::: : :: :::::::::::: ..:.:.:: .
NP_598 VRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEI
340 350 360 370 380 390
330 340 350 360 370 380
pF1KE6 DNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGD
.: :: ..::.:::.: .. . .:: ::. :::: : :::: :.:.. ::::: :: ::.
NP_598 NNMTVPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGE
400 410 420 430 440 450
390 400 410 420 430 440
pF1KE6 IVEKHGLPSADAPSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQ
:.:: ::: . .. :: ::..::.::::.::::::::::::::::::::::.:::
NP_598 IIEK---PSAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQ
460 470 480 490 500 510
450 460 470 480 490 500
pF1KE6 KSIPVGTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIV
::::.::::::.:::.::.:.::::::::::::::::.::.:. :::::::.::::::::
NP_598 KSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIV
520 530 540 550 560 570
510 520 530 540 550 560
pF1KE6 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELG
:::::::::::::::::::::::::::::::::::::::.:.:::::::::::: :::::
NP_598 IGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELG
580 590 600 610 620 630
570 580 590 600 610 620
pF1KE6 ILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLA
:::::::.:::::::::::::::::::::.:::::::::::::.::::::::.:::.:::
NP_598 ILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLA
640 650 660 670 680 690
630 640 650 660 670 680
pF1KE6 LMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTK
:::.::::::.:::.:::::::::::::::::::::::::::::::.:::::::::::::
NP_598 LMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTK
700 710 720 730 740 750
690 700 710 720 730 740
pF1KE6 NWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQT
:::::::::::::::::::.::::::::::::::::::::::: :.:::.:::: :::::
NP_598 NWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQT
760 770 780 790 800 810
750 760 770 780 790 800
pF1KE6 IKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAW
::..:: ::::::::.:::.:.:::..:::::::::::.::.::.::: ::::::: :::
NP_598 IKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAW
820 830 840 850 860 870
810 820 830 840 850 860
pF1KE6 KTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQH
:::: ::: :::::::::: :::.:.::: :.. ::.::::::::::::::::::::.::
NP_598 KTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQH
880 890 900 910 920 930
870 880 890 900 910 920
pF1KE6 KVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLM
:::::: .:::::::..:::::::::::.::::::.::::::::::.:::::::::::::
NP_598 KVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLM
940 950 960 970 980 990
930 940 950 960 970 980
pF1KE6 MEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDK
:::::::::.:::.::::.:::::::::.: ::: :. :::..:. . .:..::::.::
NP_598 MEQRSQMLRHMRLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDK
1000 1010 1020 1030 1040 1050
990 1000 1010 1020 1030 1040
pF1KE6 YMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPR
::. . ... ..:..:....::::::::::::::::::::..::.:.:::::::::::
NP_598 YMASRGQKAKSMEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPR
1060 1070 1080 1090 1100 1110
1050 1060 1070 1080
pF1KE6 NSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
: ::::::::::::::::::::::::::: :::::::
NP_598 NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
1120 1130 1140 1150
>>NP_005126 (OMIM: 218000,604878) solute carrier family (1099 aa)
initn: 5582 init1: 3874 opt: 5556 Z-score: 6445.0 bits: 1204.3 E(85289): 0
Smith-Waterman score: 5569; 75.9% identity (89.9% similar) in 1106 aa overlap (1-1085:1-1099)
10 20 30 40
pF1KE6 MPHFTVVPVDGPRRG-------------------DYDNLEGLSWVDY-GERAELDDSDGH
::::::. :. :..: : :. :: . ::...: : :::
NP_005 MPHFTVTKVEDPEEGAAASISQEPSLADIKARIQDSDE-PDLSQNSITGEHSQLLD-DGH
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 GNHRESSPFLSPLEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHE
. :.. .:. . .: .:.:.::::::::.: ::::::::.....::::::::::::
NP_005 KKARNA--YLNNSNYEEGDEYFDKNLALFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 EAESGEGTRRRAAEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLIC
:::. ... ...:.:::.::::::::::::::::::::::.:::::::::. :::::
NP_005 EAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLIC
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 CCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGA
::::.::::::::::::::::::::::::::.::::::::::::::::::::::::::::
NP_005 CCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 IEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLF
:::.:.::.: ::::. . : : : ::::::::: ::..:.::::.::.:::::::::
NP_005 IEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLF
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE6 LACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWS
:::::.:::.::::.::: : :: :::::::::::: ..:.:.:: ..: :: ..::.
NP_005 LACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWG
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE6 FFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSAD
:::.: .. . .:: ::. :::: : :::: :.:.. ::::: :: ::.:.:: :::
NP_005 FFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEK---PSAK
360 370 380 390 400 410
410 420 430 440 450
pF1KE6 APSLKESLPL-YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAI
. .. :: ::..::.::::.::::::::::::::::::::::.:::::::.::::::
NP_005 SSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAI
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE6 ITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAG
.:::.::.:.::::::::::::::::.::.:. :::::::.:::::::::::::::::::
NP_005 LTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAG
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE6 LQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAP
::::::::::::::::::::::::::::.:.:::::::::::: ::::::::::::.:::
NP_005 LQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAP
540 550 560 570 580 590
580 590 600 610 620 630
pF1KE6 ILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYAL
::::::::::::::::::.:::::::::::::.::::::::.:::.::::::.::::::.
NP_005 ILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAI
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE6 VAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLK
:::.:::::::::::::::::::::::::::::::.::::::::::::::::::::::::
NP_005 VAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLK
660 670 680 690 700 710
700 710 720 730 740 750
pF1KE6 LDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVK
::::::::.::::::::::::::::::::::: :.:::.:::: :::::::..:: ::::
NP_005 LDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEAEKVK
720 730 740 750 760 770
760 770 780 790 800 810
pF1KE6 GFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTT
::::.:::.:.:::..:::::::::::.::.::.::: ::::::: ::::::: ::: ::
NP_005 GFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTT
780 790 800 810 820 830
820 830 840 850 860 870
pF1KE6 AAHLALLVPKNIAFYPSNHERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIF
:::::::: :::.:.::: :.. ::.::::::::::::::::::::.:::::::: .:::
NP_005 AAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIF
840 850 860 870 880 890
880 890 900 910 920 930
pF1KE6 TVAQMDDNSIQMKKDLAVFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQM
::::..:::::::::::.::::::.::::::::::.::::::::::::::::::::::.:
NP_005 TVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHM
900 910 920 930 940 950
940 950 960 970 980 990
pF1KE6 RLTKTEREREAQLVKDRHSALRLESLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHA
::.::::.:::::::::.: ::: :. :::..:. . .:..::::.::::. . ...
NP_005 RLSKTERDREAQLVKDRNSMLRLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKS
960 970 980 990 1000 1010
1000 1010 1020 1030 1040 1050
pF1KE6 PDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEF
..:..:....::::::::::::::::::::..::.:.:::::::::::: :::::::::
NP_005 MEGFQDLLNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEF
1020 1030 1040 1050 1060 1070
1060 1070 1080
pF1KE6 LEVLTEGLERVLLVRGGGREVITIYS
:::::::::::::::::: :::::::
NP_005 LEVLTEGLERVLLVRGGGSEVITIYS
1080 1090
1085 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:47:02 2016 done: Tue Nov 8 15:47:04 2016
Total Scan time: 10.530 Total Display time: 0.480
Function used was FASTA [36.3.4 Apr, 2011]